DE69514724D1 - Verfahren zur Herstellung von 20-oxo, 17-alpha, 21-dihydroxy Steroidederivate und neue Zwischenprodukte dafür - Google Patents

Verfahren zur Herstellung von 20-oxo, 17-alpha, 21-dihydroxy Steroidederivate und neue Zwischenprodukte dafür

Info

Publication number
DE69514724D1
DE69514724D1 DE69514724T DE69514724T DE69514724D1 DE 69514724 D1 DE69514724 D1 DE 69514724D1 DE 69514724 T DE69514724 T DE 69514724T DE 69514724 T DE69514724 T DE 69514724T DE 69514724 D1 DE69514724 D1 DE 69514724D1
Authority
DE
Germany
Prior art keywords
oxo
alpha
preparation
new intermediates
steroid derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69514724T
Other languages
English (en)
Other versions
DE69514724T2 (de
Inventor
Robert Lett
Oleg Melnyk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Hoechst Marion Roussel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel filed Critical Hoechst Marion Roussel
Application granted granted Critical
Publication of DE69514724D1 publication Critical patent/DE69514724D1/de
Publication of DE69514724T2 publication Critical patent/DE69514724T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
DE69514724T 1994-07-01 1995-06-28 Verfahren zur Herstellung von 20-oxo, 17-alpha, 21-dihydroxy Steroidederivate und neue Zwischenprodukte dafür Expired - Fee Related DE69514724T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9408140A FR2721927B1 (fr) 1994-07-01 1994-07-01 Nouveau procede de preparation de derives steroides 20-oxo 17 alpha, 21-dihydroxyles et nouveaux intermediaires

Publications (2)

Publication Number Publication Date
DE69514724D1 true DE69514724D1 (de) 2000-03-02
DE69514724T2 DE69514724T2 (de) 2000-08-03

Family

ID=9464901

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69514724T Expired - Fee Related DE69514724T2 (de) 1994-07-01 1995-06-28 Verfahren zur Herstellung von 20-oxo, 17-alpha, 21-dihydroxy Steroidederivate und neue Zwischenprodukte dafür

Country Status (5)

Country Link
US (2) US5723638A (de)
EP (1) EP0690069B1 (de)
DE (1) DE69514724T2 (de)
FR (1) FR2721927B1 (de)
HU (1) HU215270B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE473759T1 (de) 1998-05-22 2010-07-15 Univ Leland Stanford Junior Bifunktionelle moleküle sowie darauf basierende therapien.
DE60234057D1 (de) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
EP2392258B1 (de) 2005-04-28 2014-10-08 Proteus Digital Health, Inc. Pharma-Informatiksystem
US9062126B2 (en) 2005-09-16 2015-06-23 Raptor Pharmaceuticals Inc. Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof
AU2010216512B2 (en) 2009-02-20 2016-06-30 2-Bbb Medicines B.V. Glutathione-based drug delivery system
WO2010129819A2 (en) 2009-05-06 2010-11-11 Laboratory Skin Care, Inc. Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR531212A (fr) * 1921-02-22 1922-01-09 Meuse Const Atel Transmission électrique de force motrice
US2702291A (en) * 1952-08-02 1955-02-15 Syntex Sa Process for producing 11alpha-hydroxy steroids
US2802840A (en) * 1952-11-19 1957-08-13 Syntex Sa Process for producing delta4-pregnene-11alpha, 21-diol-3, 20-dione
US2781365A (en) * 1953-04-25 1957-02-12 Syntex Sa 17alpha-hydroxy-19-norprogesterone, process therefor and intermediates obtained thereby
US2842543A (en) * 1953-04-25 1958-07-08 Syntex Sa Process for the production of cyclopentanophenanthrene derivatives
US2773868A (en) * 1954-05-10 1956-12-11 Pfizer & Co C Steroid ketal
US2863862A (en) * 1954-12-10 1958-12-09 Syntex Sa 1-methyl steroid derivatives and method for the production thereof
US2947762A (en) * 1956-01-31 1960-08-02 Syntex Sa 2-aralkyl derivatives of delta4-pregnene-3, 20-dione and process for their production
GB1053045A (de) * 1963-03-14 1900-01-01
US3159621A (en) * 1963-05-07 1964-12-01 Syntex Corp 6-keto pregnenes
US3171844A (en) * 1963-05-24 1965-03-02 Syntex Corp 20-(aliphatic hydrocarbonthio) and 20-(substituted aliphatic hydrocarbonthio) pregnane derivatives
US3325484A (en) * 1963-11-15 1967-06-13 American Home Prod Process for preparing periplogenia and intermediates secured therein
DE2521231A1 (de) 1975-05-09 1976-11-18 Schering Ag Verfahren zur herstellung von 21- hydroxy-16-pregnen-20-on-derivaten
DE2603266A1 (de) 1976-01-29 1977-08-11 Hoechst Ag 17-hydroxyacetylsteroide und verfahren zu ihrer herstellung
DE2655104A1 (de) 1976-12-04 1978-06-08 Hoechst Ag Verfahren zur herstellung von 17alpha-hydroxy-21-acetoxy-progesteron
FR2681069B1 (fr) * 1991-09-06 1995-04-28 Roussel Uclaf Nouveau procede de preparation de l'hydrocortisone et nouveaux intermediaires.

Also Published As

Publication number Publication date
HU215270B (hu) 1998-11-30
EP0690069B1 (de) 2000-01-26
HU9501983D0 (en) 1995-09-28
DE69514724T2 (de) 2000-08-03
FR2721927A1 (fr) 1996-01-05
EP0690069A1 (de) 1996-01-03
HUT72227A (en) 1996-04-29
FR2721927B1 (fr) 1996-08-09
US5723638A (en) 1998-03-03
US5792859A (en) 1998-08-11

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee