DE69711519D1 - Carbazolanaloge als selektive beta3-adrenergische Agonisten - Google Patents
Carbazolanaloge als selektive beta3-adrenergische AgonistenInfo
- Publication number
- DE69711519D1 DE69711519D1 DE69711519T DE69711519T DE69711519D1 DE 69711519 D1 DE69711519 D1 DE 69711519D1 DE 69711519 T DE69711519 T DE 69711519T DE 69711519 T DE69711519 T DE 69711519T DE 69711519 D1 DE69711519 D1 DE 69711519D1
- Authority
- DE
- Germany
- Prior art keywords
- carbazole
- analogues
- adrenergic agonists
- beta3
- selective
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2581896P | 1996-09-05 | 1996-09-05 | |
US2922896P | 1996-10-30 | 1996-10-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69711519D1 true DE69711519D1 (de) | 2002-05-08 |
DE69711519T2 DE69711519T2 (de) | 2002-10-31 |
Family
ID=26700197
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69711519T Expired - Lifetime DE69711519T2 (de) | 1996-09-05 | 1997-08-27 | Carbazolanaloge als selektive beta3-adrenergische Agonisten |
Country Status (13)
Country | Link |
---|---|
US (4) | US6140352A (de) |
EP (1) | EP0827746B1 (de) |
JP (1) | JP4212117B2 (de) |
AR (2) | AR009519A1 (de) |
AT (1) | ATE215369T1 (de) |
AU (1) | AU4094197A (de) |
CO (1) | CO4910132A1 (de) |
DE (1) | DE69711519T2 (de) |
ES (1) | ES2171839T3 (de) |
ID (1) | ID17182A (de) |
MY (1) | MY132626A (de) |
PE (1) | PE109398A1 (de) |
WO (1) | WO1998009625A1 (de) |
Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69711519T2 (de) * | 1996-09-05 | 2002-10-31 | Lilly Co Eli | Carbazolanaloge als selektive beta3-adrenergische Agonisten |
EP1036064A4 (de) * | 1997-12-05 | 2002-11-27 | Lilly Co Eli | Selektive beta 3-adrenergische antagonisten |
CO5011072A1 (es) * | 1997-12-05 | 2001-02-28 | Lilly Co Eli | Etanolaminas pirazinil substituidas como agfonistas de los receptores |
AU751833B2 (en) * | 1998-12-15 | 2002-08-29 | Asahi Kasei Kabushiki Kaisha | Novel heterocyclic compounds and drug compositions containing the same |
WO2001007026A2 (en) * | 1999-07-22 | 2001-02-01 | Eli Lilly And Company | Improved method of treating type ii diabetes and obesity |
WO2001007025A2 (en) * | 1999-07-22 | 2001-02-01 | Eli Lilly And Company | Treatment of cardiac abnormalities with aryloxy propanolamines |
EA200200569A1 (ru) * | 1999-11-15 | 2003-06-26 | Эли Лилли Энд Компани | Арилоксипропаноламины для улучшения продуктивности домашнего скота |
US6841563B1 (en) | 1999-11-15 | 2005-01-11 | Eli Lilly And Company | Aryloxy propanolamines for improving livestock production |
AU1580001A (en) * | 1999-11-15 | 2001-05-30 | Eli Lilly And Company | Process for the preparation of aryloxy propanolamines |
AU1572701A (en) * | 1999-11-15 | 2001-05-30 | Eli Lilly And Company | Treating wasting syndromes with aryloxy propanolamines |
DK1741447T3 (da) | 2000-01-21 | 2013-12-09 | Novartis Ag | Kombinationer omfattende dipeptidylpeptidase-IV-inhibitorer og antidiabetiske midler |
US20030018061A1 (en) * | 2000-01-28 | 2003-01-23 | Kohei Ogawa | Novel remedies with the use of beta 3 agonist |
AUPQ585000A0 (en) * | 2000-02-28 | 2000-03-16 | Fujisawa Pharmaceutical Co., Ltd. | Aminoalcohol derivatives |
EP1134221A1 (de) * | 2000-03-15 | 2001-09-19 | Aventis Pharma Deutschland GmbH | Substituierte beta-Carboline als lkB-Kinasehemmer |
ATE465161T1 (de) * | 2000-03-15 | 2010-05-15 | Sanofi Aventis Deutschland | Substituierte beta-carboline mit ikb-kinase hemmender wirkung |
MXPA03000308A (es) | 2000-07-13 | 2003-06-06 | Lilly Co Eli | Agonistas beta3 adrenergicos. |
US6525202B2 (en) | 2000-07-17 | 2003-02-25 | Wyeth | Cyclic amine phenyl beta-3 adrenergic receptor agonists |
US6498170B2 (en) * | 2000-07-17 | 2002-12-24 | Wyeth | Cyclamine sulfonamides as β-3 adrenergic receptor agonists |
US6537994B2 (en) * | 2000-07-17 | 2003-03-25 | Wyeth | Heterocyclic β3 adrenergic receptor agonists |
JP2004513164A (ja) | 2000-11-10 | 2004-04-30 | イーライ・リリー・アンド・カンパニー | 3−置換オキシインドールβ3アゴニスト |
KR100408122B1 (ko) * | 2000-12-08 | 2003-12-01 | 한국디디에스제약 주식회사 | 광학 입체 이성질체의 성질을 갖는 베타 아드레날린 길항제의 제조 방법 |
ATE325119T1 (de) | 2001-08-14 | 2006-06-15 | Lilly Co Eli | 3-substituierte oxindol-beta-3-agonisten |
ATE340794T1 (de) | 2001-08-14 | 2006-10-15 | Lilly Co Eli | Indol derivate als beta-3-adrenerge agonisten zur behandlung von typ 2 diabetes |
WO2003044016A1 (en) | 2001-11-20 | 2003-05-30 | Eli Lilly And Company | 3-SUBSTITUTED OXINDOLE β3 AGONISTS |
ES2299618T3 (es) | 2001-11-20 | 2008-06-01 | Eli Lilly And Company | Agonistas beta-3-adrenergicos. |
JP2005520805A (ja) | 2002-01-11 | 2005-07-14 | イーライ・リリー・アンド・カンパニー | 2−オキソ−ベンズイミダゾリル置換型エタノールアミン誘導体およびβ3アゴニストとしてのその使用 |
SI2208727T1 (sl) * | 2002-09-19 | 2012-11-30 | Lilly Co Eli | Diaril etri kot antagonisti opioidnega receptorja |
ATE377589T1 (de) | 2003-03-07 | 2007-11-15 | Lilly Co Eli | 6-substituierte nikotinamidderivate als opioidrezeptorantagonisten |
US7321065B2 (en) * | 2003-04-18 | 2008-01-22 | The Regents Of The University Of California | Thyronamine derivatives and analogs and methods of use thereof |
ES2337576T3 (es) * | 2003-04-23 | 2010-04-27 | Japan Tobacco Inc. | Antagonista decasr. |
US7375100B2 (en) | 2003-06-04 | 2008-05-20 | Pfizer Inc | 2-amino-pyridine derivatives useful for the treatment of diseases |
JP2007516256A (ja) | 2003-12-12 | 2007-06-21 | イーライ リリー アンド カンパニー | オピオイド受容体拮抗物質 |
CA2549089A1 (en) * | 2003-12-22 | 2005-07-21 | Eli Lilly And Company | Opioid receptor antagonists |
WO2005080329A2 (en) | 2004-02-23 | 2005-09-01 | Cadila Healthcar Limited | Process for manufacture of racemic carvedilol |
BRPI0513569A2 (pt) | 2004-07-22 | 2012-10-09 | Lilly Co Eli | hidrato variável cristalino, composição farmacêutica, métodos para tratar o diabete tipo2 e a obesidade, e, uso de um hidrato ou de uma composição |
ES2265276B1 (es) | 2005-05-20 | 2008-02-01 | Laboratorios Almirall S.A. | Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor beta2 adrenergico. |
EP1931350B2 (de) | 2005-09-14 | 2021-08-04 | Takeda Pharmaceutical Company Limited | Verabreichung von dipeptidyl-peptidase-hemmern |
JP2009511562A (ja) | 2005-10-13 | 2009-03-19 | オーキッド リサーチ ラボラトリーズ リミティド | pSTAT3/IL−6インヒビターとしての新規ヘテロ環式化合物 |
WO2007077111A1 (en) * | 2005-12-30 | 2007-07-12 | F. Hoffmann-La Roche Ag | Compounds and methods for carbazole synthesis |
ES2296516B1 (es) * | 2006-04-27 | 2009-04-01 | Laboratorios Almirall S.A. | Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor beta2 adrenergico. |
WO2008032156A1 (en) | 2006-09-08 | 2008-03-20 | Pfizer Products Inc. | Diaryl ether derivatives and uses thereof |
ES2306595B1 (es) * | 2007-02-09 | 2009-09-11 | Laboratorios Almirall S.A. | Sal de napadisilato de 5-(2-((6-(2,2-difluoro-2-feniletoxi)hexil)amino)-1-hidroxietil)-8-hidroxiquinolin-2(1h)-ona como agonista del receptor adrenergico beta2. |
ES2320961B1 (es) * | 2007-11-28 | 2010-03-17 | Laboratorios Almirall, S.A. | Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor adrenergico beta2. |
EP2096105A1 (de) * | 2008-02-28 | 2009-09-02 | Laboratorios Almirall, S.A. | 4-(2-Amino-1-hydroxyethyl)Phenol-Derivate als Agonisten des b2-adrenergen Rezeptors |
UY32297A (es) | 2008-12-22 | 2010-05-31 | Almirall Sa | Sal mesilato de 5-(2-{[6-(2,2-difluoro-2-fenilitoxi) hexil]amino}-1-hidroxietil)-8-hidroxiquinolin-2( 1h)-ona como agonista del receptor b(beta)2 acrenérgico |
EP2228368A1 (de) | 2009-03-12 | 2010-09-15 | Almirall, S.A. | Verfahren zur Herstellung von 5-(2-{[6-(2,2-Difluor-2-phenylethoxy)hexyl]amino}-1-hydroxyethyl)-8-hydroxychinolin-2(1H)-on |
WO2011035142A1 (en) * | 2009-09-18 | 2011-03-24 | Adolor Corporation | Use of opioid receptor antagonist for gastrointestinal tract disorders |
WO2011041293A1 (en) | 2009-09-30 | 2011-04-07 | Takeda Pharmaceutical Company Limited | Pyrazolo [1, 5-a] pyrimidine derivatives as apoptosis signal-regulating kinase 1 inhibitors |
WO2011075777A1 (en) | 2009-12-21 | 2011-06-30 | The University Of Queensland | Neuronal stimulation |
SI2531501T1 (sl) | 2010-02-03 | 2014-04-30 | Takeda Pharmaceutical Company Limited | Inhibitorji kinaze-1, ki regulirajo signal apoptoze |
CN103476593B (zh) * | 2011-01-20 | 2016-02-24 | 录象射流技术公司 | 用于测量色带张力的系统 |
EP2578570A1 (de) | 2011-10-07 | 2013-04-10 | Almirall, S.A. | Neues Verfahren zur Herstellung von 5-(2-{[6-(2,2-Difluor-2-phenylethoxy)hexyl]amino}-1(R)-hydroxyethyl)-8-hydroxychinolin-2(1H)-on mittels neuen Synthesezwischenstoffen |
EP2641900A1 (de) | 2012-03-20 | 2013-09-25 | Almirall, S.A. | Neuartige polymorphe Kristallformen von 5-(2-{[6-(2,2-difluor-2-phenylethoxy)hexyl]amino}-1-hydroxyethyl)-8-hydroxychinolin-2(1H)-on, Heminapadisylat als Agonist des beta2-adrenergen Rezeptors |
US20130317068A1 (en) * | 2012-05-08 | 2013-11-28 | Dow Agrosciences Llc | Substituted 1,2,4-triazole compounds as a seed treatment to control pests |
ES2394349B1 (es) | 2012-08-29 | 2013-11-04 | Fundación Centro Nacional De Investigaciones Cardiovasculares Carlos Iii | Uso de agonistas selectivos de receptores beta-3 adrenérgicos para el tratamiento de hipertensión pulmonar |
AU2013327689B2 (en) | 2012-10-02 | 2016-03-17 | Eli Lilly And Company | Methods for improving chicken production |
JP6980534B2 (ja) | 2015-06-25 | 2021-12-15 | ザ チルドレンズ メディカル センター コーポレーション | 造血幹細胞の増大、富化、および維持に関する方法および組成物 |
EP4049665A1 (de) | 2016-03-15 | 2022-08-31 | Children's Medical Center Corporation | Verfahren und zusammensetzungen im zusammenhang mit der expansion hämatopoetischer stammzellen |
US10865163B2 (en) | 2017-12-20 | 2020-12-15 | The University Of Toledo | Carbon dioxide as a directing group for C—H functionalization reactions involving Lewis basic amines, alcohols, thiols, and phosphines for the synthesis of compounds |
CN110668994A (zh) * | 2019-11-12 | 2020-01-10 | 山东创新药物研发有限公司 | 左旋卡维地洛盐晶型、其制备方法及应用 |
CN115611752A (zh) * | 2022-10-21 | 2023-01-17 | 江苏天和制药有限公司 | 一种卢巴贝隆中间体的合成精制方法 |
Family Cites Families (86)
Publication number | Priority date | Publication date | Assignee | Title |
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FR2516E (fr) | 1903-08-17 | 1904-04-27 | Joseph Henri Desgeorge | Perfectionnement aux appareils photographiques |
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-
1997
- 1997-08-27 DE DE69711519T patent/DE69711519T2/de not_active Expired - Lifetime
- 1997-08-27 ES ES97306613T patent/ES2171839T3/es not_active Expired - Lifetime
- 1997-08-27 EP EP97306613A patent/EP0827746B1/de not_active Expired - Lifetime
- 1997-08-27 AT AT97306613T patent/ATE215369T1/de not_active IP Right Cessation
- 1997-08-28 WO PCT/US1997/015230 patent/WO1998009625A1/en active Application Filing
- 1997-08-28 US US09/068,192 patent/US6140352A/en not_active Expired - Lifetime
- 1997-08-28 AU AU40941/97A patent/AU4094197A/en not_active Abandoned
- 1997-08-28 JP JP51275698A patent/JP4212117B2/ja not_active Expired - Fee Related
- 1997-09-02 PE PE1997000778A patent/PE109398A1/es not_active Application Discontinuation
- 1997-09-03 CO CO97051043A patent/CO4910132A1/es unknown
- 1997-09-03 AR ARP970104012A patent/AR009519A1/es active IP Right Grant
- 1997-09-03 AR ARP970104011A patent/AR009518A1/es unknown
- 1997-09-04 ID IDP973089A patent/ID17182A/id unknown
- 1997-09-04 MY MYPI97004098A patent/MY132626A/en unknown
-
2000
- 2000-06-30 US US09/610,096 patent/US6413991B1/en not_active Expired - Fee Related
-
2002
- 2002-04-10 US US10/120,302 patent/US6686372B2/en not_active Expired - Fee Related
-
2003
- 2003-10-27 US US10/694,467 patent/US7041684B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US6413991B1 (en) | 2002-07-02 |
WO1998009625A1 (en) | 1998-03-12 |
EP0827746A1 (de) | 1998-03-11 |
US6686372B2 (en) | 2004-02-03 |
DE69711519T2 (de) | 2002-10-31 |
JP4212117B2 (ja) | 2009-01-21 |
MY132626A (en) | 2007-10-31 |
ATE215369T1 (de) | 2002-04-15 |
CO4910132A1 (es) | 2000-04-24 |
AR009519A1 (es) | 2000-04-26 |
US6140352A (en) | 2000-10-31 |
JP2002513387A (ja) | 2002-05-08 |
PE109398A1 (es) | 1999-01-15 |
ES2171839T3 (es) | 2002-09-16 |
AU4094197A (en) | 1998-03-26 |
AR009518A1 (es) | 2000-04-26 |
EP0827746B1 (de) | 2002-04-03 |
US20050043337A1 (en) | 2005-02-24 |
ID17182A (id) | 1997-12-04 |
US7041684B2 (en) | 2006-05-09 |
US20020165234A1 (en) | 2002-11-07 |
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Legal Events
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8328 | Change in the person/name/address of the agent |
Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336 |
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8328 | Change in the person/name/address of the agent |
Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN |