DE69709091T2 - Verbessertes verfahren zur herstellung von diestern aus 2,5-dioxo-4,4-diphenyl-imidazolidin-1-ylmethyl phosphorsäureester - Google Patents

Verbessertes verfahren zur herstellung von diestern aus 2,5-dioxo-4,4-diphenyl-imidazolidin-1-ylmethyl phosphorsäureester

Info

Publication number
DE69709091T2
DE69709091T2 DE69709091T DE69709091T DE69709091T2 DE 69709091 T2 DE69709091 T2 DE 69709091T2 DE 69709091 T DE69709091 T DE 69709091T DE 69709091 T DE69709091 T DE 69709091T DE 69709091 T2 DE69709091 T2 DE 69709091T2
Authority
DE
Germany
Prior art keywords
diphenyl
imidazolidin
dioxo
phosphoric acid
pct
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69709091T
Other languages
German (de)
English (en)
Other versions
DE69709091D1 (de
Inventor
Mark Davis
E Ellis
A Katonak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of DE69709091D1 publication Critical patent/DE69709091D1/de
Application granted granted Critical
Publication of DE69709091T2 publication Critical patent/DE69709091T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Saccharide Compounds (AREA)
DE69709091T 1996-04-30 1997-04-01 Verbessertes verfahren zur herstellung von diestern aus 2,5-dioxo-4,4-diphenyl-imidazolidin-1-ylmethyl phosphorsäureester Expired - Fee Related DE69709091T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1651596P 1996-04-30 1996-04-30
PCT/US1997/005307 WO1997041132A1 (fr) 1996-04-30 1997-04-01 Procede perfectionne pour la synthese de diesters de l'ester 2,5-dioxo-4,4-diphenyl-imidazolidin-1-ylmethylique de l'acide phosphorique

Publications (2)

Publication Number Publication Date
DE69709091D1 DE69709091D1 (de) 2002-01-24
DE69709091T2 true DE69709091T2 (de) 2002-06-20

Family

ID=21777523

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69709091T Expired - Fee Related DE69709091T2 (de) 1996-04-30 1997-04-01 Verbessertes verfahren zur herstellung von diestern aus 2,5-dioxo-4,4-diphenyl-imidazolidin-1-ylmethyl phosphorsäureester

Country Status (15)

Country Link
US (2) US6022975A (fr)
EP (1) EP0900227B1 (fr)
JP (1) JP4035642B2 (fr)
KR (1) KR100453867B1 (fr)
AT (1) ATE210670T1 (fr)
AU (1) AU708127B2 (fr)
BR (1) BR9709198B1 (fr)
DE (1) DE69709091T2 (fr)
DK (1) DK0900227T3 (fr)
ES (1) ES2169375T3 (fr)
NZ (1) NZ332115A (fr)
PT (1) PT900227E (fr)
SI (1) SI0900227T1 (fr)
WO (1) WO1997041132A1 (fr)
ZA (1) ZA973713B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997041132A1 (fr) 1996-04-30 1997-11-06 Warner-Lambert Company Procede perfectionne pour la synthese de diesters de l'ester 2,5-dioxo-4,4-diphenyl-imidazolidin-1-ylmethylique de l'acide phosphorique
WO2005075488A1 (fr) * 2004-02-05 2005-08-18 Cilag Ag Procede de fabrication de fosphenytoine, sel de sodium
CH696765A5 (de) * 2004-06-02 2007-11-30 Cilag Ltd Verfahren zur Herstellung von Natrium-fosphenytoin.
DE102004046356A1 (de) * 2004-09-24 2006-03-30 Clariant Gmbh Verfahren zur Herstellung von Alk(en)ylphosphorsäureestersalzen
NZ597107A (en) 2009-06-25 2013-12-20 Alkermes Pharma Ireland Ltd Heterocyclic compounds for the treatment of neurological and psychological disorders
ES2885698T3 (es) * 2009-06-25 2021-12-15 Alkermes Pharma Ireland Ltd Profármacos de compuestos nh-ácidos
ES2715562T3 (es) 2011-12-15 2019-06-04 Alkermes Pharma Ireland Ltd Profármacos de compuestos de amina secundaria
JP6861430B2 (ja) * 2016-09-29 2021-04-21 ノーベルファーマ株式会社 ホスフェニトインナトリウム水和物及びその合成中間体の製法
CN112423754A (zh) 2018-03-05 2021-02-26 奥克梅斯制药爱尔兰有限公司 阿立哌唑的给药策略

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE489216A (fr) * 1948-06-05 1900-01-01
US3741978A (en) * 1971-04-21 1973-06-26 Hercules Inc Certain o,o-di (c1 and c2 alkyl) phosphorodithioate and phosphorothioate esters useful as insecticides and acaricides
US3925406A (en) * 1972-04-04 1975-12-09 Ciba Geigy Corp Dialkoxyphosphonomethyl derivatives of hydantoins
US3980647A (en) * 1972-08-10 1976-09-14 Ciba-Geigy Corporation Adducts of polyglycidyl compounds and dialkoxyphosphono-methyl derivatives of cyclic ureides
CH573948A5 (fr) * 1972-12-12 1976-03-31 Ciba Geigy Ag
US4260769A (en) * 1977-04-22 1981-04-07 Interx Research Corporation 5,5-Diphenylhydantoins
DE3126390A1 (de) * 1981-07-03 1983-01-13 Bayer Ag, 5090 Leverkusen S-azolyl-methyl-di(tri)-thiophosphorsaeureester, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel
US4925860A (en) * 1987-08-05 1990-05-15 E. I. Du Pont De Nemours And Company Stable pharmaceutical composition of 3-(hydroxymethyl)-5,5-diphenylhydantoin disodium phosphate ester
WO1997041132A1 (fr) 1996-04-30 1997-11-06 Warner-Lambert Company Procede perfectionne pour la synthese de diesters de l'ester 2,5-dioxo-4,4-diphenyl-imidazolidin-1-ylmethylique de l'acide phosphorique

Also Published As

Publication number Publication date
NZ332115A (en) 2000-05-26
KR20000065111A (ko) 2000-11-06
DK0900227T3 (da) 2002-04-08
ZA973713B (en) 1997-12-01
BR9709198B1 (pt) 2008-11-18
PT900227E (pt) 2002-05-31
ES2169375T3 (es) 2002-07-01
DE69709091D1 (de) 2002-01-24
SI0900227T1 (en) 2002-04-30
KR100453867B1 (ko) 2005-01-15
US6255492B1 (en) 2001-07-03
WO1997041132A1 (fr) 1997-11-06
ATE210670T1 (de) 2001-12-15
BR9709198A (pt) 1999-08-10
AU708127B2 (en) 1999-07-29
EP0900227B1 (fr) 2001-12-12
AU2600997A (en) 1997-11-19
JP4035642B2 (ja) 2008-01-23
JP2000509071A (ja) 2000-07-18
US6022975A (en) 2000-02-08
EP0900227A1 (fr) 1999-03-10

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee