DE69705295D1 - Kombinatorische festphasensynthese einer bibliothek von benzofuranderivaten - Google Patents

Kombinatorische festphasensynthese einer bibliothek von benzofuranderivaten

Info

Publication number
DE69705295D1
DE69705295D1 DE69705295T DE69705295T DE69705295D1 DE 69705295 D1 DE69705295 D1 DE 69705295D1 DE 69705295 T DE69705295 T DE 69705295T DE 69705295 T DE69705295 T DE 69705295T DE 69705295 D1 DE69705295 D1 DE 69705295D1
Authority
DE
Germany
Prior art keywords
combinative
library
solid
phase synthesis
benzofuran derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69705295T
Other languages
English (en)
Other versions
DE69705295T2 (de
Inventor
Daniele Fancelli
Dino Severino
Chiara Fagnola
Angelo Bedeschi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Pharmacia and Upjohn SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn SpA filed Critical Pharmacia and Upjohn SpA
Application granted granted Critical
Publication of DE69705295D1 publication Critical patent/DE69705295D1/de
Publication of DE69705295T2 publication Critical patent/DE69705295T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Structural Engineering (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69705295T 1996-05-23 1997-05-13 Kombinatorische festphasensynthese einer bibliothek von benzofuranderivaten Expired - Fee Related DE69705295T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9610813.9A GB9610813D0 (en) 1996-05-23 1996-05-23 Combinatorial solid phase synthesis of a library of benzufuran derivatives
PCT/EP1997/002601 WO1997044338A1 (en) 1996-05-23 1997-05-13 Combinatorial solid phase synthesis of a library of benzofuran derivatives

Publications (2)

Publication Number Publication Date
DE69705295D1 true DE69705295D1 (de) 2001-07-26
DE69705295T2 DE69705295T2 (de) 2002-05-02

Family

ID=10794203

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69705295T Expired - Fee Related DE69705295T2 (de) 1996-05-23 1997-05-13 Kombinatorische festphasensynthese einer bibliothek von benzofuranderivaten

Country Status (6)

Country Link
US (1) US5919955A (de)
EP (1) EP0858454B1 (de)
JP (1) JPH11510520A (de)
DE (1) DE69705295T2 (de)
GB (1) GB9610813D0 (de)
WO (1) WO1997044338A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4647780B2 (ja) * 1998-02-26 2011-03-09 マサチューセッツ インスティテュート オブ テクノロジー ヒドラジン、ヒドラゾン、ヒドロキシルアミンおよびオキシムの金属−触媒アリール化およびビニル化
FR2779723B1 (fr) * 1998-06-12 2000-07-13 Cird Galderma Composes biaryles heterocycliques aromatiques, compositions pharmaceutiques et cosmetiques les contenant et utilisations
EP1326892A2 (de) 2000-10-12 2003-07-16 University of Rochester Zusammensetzungen die die proliferation von krebszellen hemmen
US6583153B2 (en) 2000-12-12 2003-06-24 Ortho-Mcneil Pharmaceutical, Inc. 7-heterocyclyl quinoline and thieno[2,3-b]yridine derivatives useful as antagonists of gonadotropin releasing hormone
JP2005506039A (ja) * 2000-12-29 2005-03-03 ネオジェネシス ファーマシューティカルズ インコーポレイテッド アフィニティ選択に基づいた疎水性タンパク質のスクリーニング
CA2455027A1 (en) * 2001-07-26 2003-02-20 University Of Utah Research Foundation In vitro assays for inhibitors of hiv capsid conformational changes and for hiv capsid formation
AU2003209030B2 (en) 2002-02-06 2009-02-05 Stasys Technologies, Inc. Anti-infarction molecules
EP2116604A1 (de) 2002-08-05 2009-11-11 University of Rochester Proteinumwandlungsdomäne / Deaminasechimäre Proteine, zugehörige Verbindungen und Verwendungen davon
US20040214232A1 (en) * 2002-08-16 2004-10-28 Burke Martin D. Generation of skeletal diversity within a combinatorial library
US7592352B2 (en) 2003-05-06 2009-09-22 Smithkline Beecham Corporation Substituted thieno and furo-pyridines
WO2005110985A2 (en) * 2004-05-03 2005-11-24 Janssen Pharmaceutica N.V. Indole, benzofuran and benzothiophene derivatives as selective androgen receptor modulators (sarms)
WO2006044378A2 (en) * 2004-10-12 2006-04-27 University Of Iowa Research Foundation Rapid computational identification of targets
CN103983772A (zh) 2005-04-05 2014-08-13 康宁股份有限公司 一种测定刺激事件对细胞产生的影响的方法
EP2371843B1 (de) 2005-05-19 2014-09-17 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services Funktionelle Epitope des Pneumokokken-Antigens und deren Nutzung
US8080534B2 (en) 2005-10-14 2011-12-20 Phigenix, Inc Targeting PAX2 for the treatment of breast cancer
EP2402435A3 (de) 2005-10-14 2012-03-28 MUSC Foundation For Research Development Targeting von PAX2 zur Induktion der DEFB1-vermittelten Tumorimmunität und Krebstherapie
EP2560001B1 (de) 2006-09-21 2016-04-13 University of Rochester Zusammensetzungen und Verfahren für eine Proteinverlagerungstherapie für myotone Dystrophie
US8999317B2 (en) 2006-11-01 2015-04-07 University Of Rochester Methods and compositions related to the structure and function of APOBEC3G
EP2117575A4 (de) * 2007-01-03 2013-06-05 Burnham Inst Medical Research Verfahren und zusammensetzungen in verbindung mit gerinnselbindenden verbindungen
US9381226B2 (en) 2007-02-08 2016-07-05 University Of Utah Research Foundation Methods and compositions related to inhibition of viral entry
US20120058105A1 (en) 2008-06-27 2012-03-08 Martin Kean Chong Ng Method of treatment of vascular complications
WO2010019963A2 (en) * 2008-08-15 2010-02-18 Georgetown University Na channels, disease, and related assays and compositions
EP2370080A1 (de) 2008-12-02 2011-10-05 University of Utah Research Foundation Pde1 als zieltherapeutikum bei herzkrankheiten
US20120149663A1 (en) 2009-08-18 2012-06-14 Georgetown University Boronic acid compositions and methods related to cancer
CA2775747A1 (en) 2009-10-07 2011-04-14 Sanford Burnham Medical Research Institute Methods and compositions related to clot-binding lipid compounds
US8912136B2 (en) 2009-12-18 2014-12-16 Sanford-Burnham Medical Research Institute Methods and compositions related to clot-binding compounds
WO2012087833A1 (en) 2010-12-22 2012-06-28 Abbott Laboratories Hepatitis c inhibitors and uses thereof
WO2012135385A1 (en) 2011-03-28 2012-10-04 University Of Utah Research Foundation Methods and compositions related to inhibition of viral entry
WO2019055618A1 (en) 2017-09-15 2019-03-21 Arizona Board Of Regents On Behalf Of Arizona State University METHODS OF CLASSIFYING RESPONSES TO ANTICANCER IMMUNOTHERAPY
EP4038222A4 (de) 2019-10-02 2023-10-18 Arizona Board of Regents on behalf of Arizona State University Verfahren und zusammensetzungen zur identifizierung von neoantigenen zur verwendung bei der behandlung und vorbeugung von krebs

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ267843A (en) * 1993-05-27 1997-10-24 Selectide Corp Libraries of synthetic test compound attached to separate phase synthesis supports

Also Published As

Publication number Publication date
EP0858454B1 (de) 2001-06-20
EP0858454A1 (de) 1998-08-19
GB9610813D0 (en) 1996-07-31
DE69705295T2 (de) 2002-05-02
JPH11510520A (ja) 1999-09-14
WO1997044338A1 (en) 1997-11-27
US5919955A (en) 1999-07-06

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee