DE69718761D1 - Kombinatorische festphasensynthese einer bibliothek von indolderivaten - Google Patents

Kombinatorische festphasensynthese einer bibliothek von indolderivaten

Info

Publication number
DE69718761D1
DE69718761D1 DE69718761T DE69718761T DE69718761D1 DE 69718761 D1 DE69718761 D1 DE 69718761D1 DE 69718761 T DE69718761 T DE 69718761T DE 69718761 T DE69718761 T DE 69718761T DE 69718761 D1 DE69718761 D1 DE 69718761D1
Authority
DE
Germany
Prior art keywords
combinative
library
solid
phase synthesis
indolder derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69718761T
Other languages
English (en)
Other versions
DE69718761T2 (de
Inventor
Chiara Fagnola
Angelo Bedeschi
Ilaria Candiani
Giuseppina Visentin
Nicola Mongelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Pharmacia Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Italia SpA filed Critical Pharmacia Italia SpA
Application granted granted Critical
Publication of DE69718761D1 publication Critical patent/DE69718761D1/de
Publication of DE69718761T2 publication Critical patent/DE69718761T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
DE69718761T 1996-05-23 1997-05-13 Kombinatorische festphasensynthese einer bibliothek von indolderivaten Expired - Fee Related DE69718761T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9610811.3A GB9610811D0 (en) 1996-05-23 1996-05-23 Combinatorial solid phase synthesis of a library of indole derivatives
PCT/EP1997/002600 WO1997044319A1 (en) 1996-05-23 1997-05-13 Combinatorial solid phase synthesis of a library of indole derivatives

Publications (2)

Publication Number Publication Date
DE69718761D1 true DE69718761D1 (de) 2003-03-06
DE69718761T2 DE69718761T2 (de) 2003-11-13

Family

ID=10794201

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69718761T Expired - Fee Related DE69718761T2 (de) 1996-05-23 1997-05-13 Kombinatorische festphasensynthese einer bibliothek von indolderivaten

Country Status (7)

Country Link
US (1) US5856496A (de)
EP (1) EP0854865B1 (de)
JP (1) JPH11510519A (de)
DE (1) DE69718761T2 (de)
ES (1) ES2191839T3 (de)
GB (1) GB9610811D0 (de)
WO (1) WO1997044319A1 (de)

Families Citing this family (45)

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AR017256A1 (es) * 1997-08-21 2001-09-05 American Home Prod Compuestos de indol sustituidos, metodo para la sintesis en fase solida de los mismos, conjuntos de combinacion para ser empleados en dicho metodo, uso delos compuestos para preparar un medicamento y composiciones farmaceuticas que los comprenden
US6495539B1 (en) 1998-02-19 2002-12-17 Washington University B-lactam-like chaperone inhibitors
JP4647780B2 (ja) * 1998-02-26 2011-03-09 マサチューセッツ インスティテュート オブ テクノロジー ヒドラジン、ヒドラゾン、ヒドロキシルアミンおよびオキシムの金属−触媒アリール化およびビニル化
US6251689B1 (en) 1998-05-14 2001-06-26 Telik, Inc. Methods for the solid phase synthesis of combinatorial libraries of benzimidazoles benzoxazoles benzothiazoles and derivatives thereof
WO2001002355A2 (en) * 1999-07-01 2001-01-11 Axys Pharmaceuticals, Inc. Indole synthesis
US6677160B1 (en) * 1999-09-29 2004-01-13 Pharmacia & Upjohn Company Methods for creating a compound library and identifying lead chemical templates and ligands for target molecules
ATE437845T1 (de) * 1999-09-29 2009-08-15 Nerviano Medical Sciences Srl Verfahren zur herstellung einer verbindungsbibliothek und identifizierung von lead chemischen templaten und liganden von zielmolekülen
US6764858B2 (en) 1999-09-29 2004-07-20 Pharmacia & Upjohn Company Methods for creating a compound library
US6872834B2 (en) 2000-03-31 2005-03-29 Ortho-Mcneil Pharmaceutical, Inc. Phenyl-substituted indoles and indazoles
US20010051333A1 (en) * 2000-04-17 2001-12-13 Pharmacia & Upjohn Company Nuclear magnetic resonance methods for identifying sites in papillomavirus E2 protein
EP1326892A2 (de) 2000-10-12 2003-07-16 University of Rochester Zusammensetzungen die die proliferation von krebszellen hemmen
JP2005506039A (ja) * 2000-12-29 2005-03-03 ネオジェネシス ファーマシューティカルズ インコーポレイテッド アフィニティ選択に基づいた疎水性タンパク質のスクリーニング
EP2335700A1 (de) 2001-07-25 2011-06-22 Boehringer Ingelheim (Canada) Ltd. Hepatitis C Virus Polymerase Inhibitoren mit heterobicylischer Struktur
CA2455027A1 (en) * 2001-07-26 2003-02-20 University Of Utah Research Foundation In vitro assays for inhibitors of hiv capsid conformational changes and for hiv capsid formation
AU2003209030B2 (en) 2002-02-06 2009-02-05 Stasys Technologies, Inc. Anti-infarction molecules
EP1534729A2 (de) * 2002-02-26 2005-06-01 University of Utah Research Foundation Mit bluthochdruck und virusknospung assoziierte nedd4l-varianten
EP2116604A1 (de) 2002-08-05 2009-11-11 University of Rochester Proteinumwandlungsdomäne / Deaminasechimäre Proteine, zugehörige Verbindungen und Verwendungen davon
US20040214232A1 (en) * 2002-08-16 2004-10-28 Burke Martin D. Generation of skeletal diversity within a combinatorial library
US7582770B2 (en) 2004-02-20 2009-09-01 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
JP2007527539A (ja) * 2004-03-05 2007-09-27 ザ スクリプス リサーチ インスティテュート ハイスループットグリカンマイクロアレイ
UY28945A1 (es) 2004-06-09 2006-01-31 Glaxo Group Ltd Derivados de pirrolopiridina
WO2006002382A2 (en) * 2004-06-24 2006-01-05 The Scripps Research Institute Arrays with cleavable linkers
TW200616967A (en) 2004-06-24 2006-06-01 Smithkline Beecham Corp Novel indazole carboxamides and their use
WO2006068758A2 (en) * 2004-11-19 2006-06-29 The Scripps Research Institute Detection, prevention and treatment of breast cancer
CN103983772A (zh) 2005-04-05 2014-08-13 康宁股份有限公司 一种测定刺激事件对细胞产生的影响的方法
EP2371843B1 (de) 2005-05-19 2014-09-17 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services Funktionelle Epitope des Pneumokokken-Antigens und deren Nutzung
US8063071B2 (en) 2007-10-31 2011-11-22 GlaxoSmithKline, LLC Chemical compounds
US8080534B2 (en) 2005-10-14 2011-12-20 Phigenix, Inc Targeting PAX2 for the treatment of breast cancer
EP2402435A3 (de) 2005-10-14 2012-03-28 MUSC Foundation For Research Development Targeting von PAX2 zur Induktion der DEFB1-vermittelten Tumorimmunität und Krebstherapie
US20070265170A1 (en) * 2006-05-15 2007-11-15 Ola Blixt Detection, prevention and treatment of ovarian cancer
EP2560001B1 (de) 2006-09-21 2016-04-13 University of Rochester Zusammensetzungen und Verfahren für eine Proteinverlagerungstherapie für myotone Dystrophie
US8999317B2 (en) 2006-11-01 2015-04-07 University Of Rochester Methods and compositions related to the structure and function of APOBEC3G
EP2117575A4 (de) * 2007-01-03 2013-06-05 Burnham Inst Medical Research Verfahren und zusammensetzungen in verbindung mit gerinnselbindenden verbindungen
US9381226B2 (en) 2007-02-08 2016-07-05 University Of Utah Research Foundation Methods and compositions related to inhibition of viral entry
PE20081889A1 (es) 2007-03-23 2009-03-05 Smithkline Beecham Corp Indol carboxamidas como inhibidores de ikk2
US20120058105A1 (en) 2008-06-27 2012-03-08 Martin Kean Chong Ng Method of treatment of vascular complications
WO2010019963A2 (en) * 2008-08-15 2010-02-18 Georgetown University Na channels, disease, and related assays and compositions
EP2370080A1 (de) 2008-12-02 2011-10-05 University of Utah Research Foundation Pde1 als zieltherapeutikum bei herzkrankheiten
US8354539B2 (en) 2009-03-10 2013-01-15 Glaxo Group Limited Indole derivatives as IKK2 inhibitors
US20120149663A1 (en) 2009-08-18 2012-06-14 Georgetown University Boronic acid compositions and methods related to cancer
CA2775747A1 (en) 2009-10-07 2011-04-14 Sanford Burnham Medical Research Institute Methods and compositions related to clot-binding lipid compounds
US8912136B2 (en) 2009-12-18 2014-12-16 Sanford-Burnham Medical Research Institute Methods and compositions related to clot-binding compounds
WO2012135385A1 (en) 2011-03-28 2012-10-04 University Of Utah Research Foundation Methods and compositions related to inhibition of viral entry
WO2019055618A1 (en) 2017-09-15 2019-03-21 Arizona Board Of Regents On Behalf Of Arizona State University METHODS OF CLASSIFYING RESPONSES TO ANTICANCER IMMUNOTHERAPY
EP4038222A4 (de) 2019-10-02 2023-10-18 Arizona Board of Regents on behalf of Arizona State University Verfahren und zusammensetzungen zur identifizierung von neoantigenen zur verwendung bei der behandlung und vorbeugung von krebs

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5096724A (en) * 1988-06-03 1992-03-17 Aquanautics Corporation Methods, compositions, and systems for ligand extraction

Also Published As

Publication number Publication date
DE69718761T2 (de) 2003-11-13
WO1997044319A1 (en) 1997-11-27
EP0854865B1 (de) 2003-01-29
ES2191839T3 (es) 2003-09-16
US5856496A (en) 1999-01-05
JPH11510519A (ja) 1999-09-14
EP0854865A1 (de) 1998-07-29
GB9610811D0 (en) 1996-07-31

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee