DE69701319T2 - Bioverträgliche zusammensetzungen - Google Patents
Bioverträgliche zusammensetzungenInfo
- Publication number
- DE69701319T2 DE69701319T2 DE69701319T DE69701319T DE69701319T2 DE 69701319 T2 DE69701319 T2 DE 69701319T2 DE 69701319 T DE69701319 T DE 69701319T DE 69701319 T DE69701319 T DE 69701319T DE 69701319 T2 DE69701319 T2 DE 69701319T2
- Authority
- DE
- Germany
- Prior art keywords
- heparin
- polymer
- coated
- methacrylate
- monomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 title 1
- 229920000642 polymer Polymers 0.000 abstract 4
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 3
- 229920000669 heparin Polymers 0.000 abstract 3
- 229960002897 heparin Drugs 0.000 abstract 3
- 239000000178 monomer Substances 0.000 abstract 3
- GYXOHPLRXDQGBP-UHFFFAOYSA-M 2-hydroxyethyl(trimethyl)azanium;2-methylprop-2-enoate Chemical compound CC(=C)C([O-])=O.C[N+](C)(C)CCO GYXOHPLRXDQGBP-UHFFFAOYSA-M 0.000 abstract 1
- 229920002683 Glycosaminoglycan Polymers 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 125000002091 cationic group Chemical group 0.000 abstract 1
- 239000008199 coating composition Substances 0.000 abstract 1
- GMSCBRSQMRDRCD-UHFFFAOYSA-N dodecyl 2-methylprop-2-enoate Chemical compound CCCCCCCCCCCCOC(=O)C(C)=C GMSCBRSQMRDRCD-UHFFFAOYSA-N 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000002607 heparin antagonist Substances 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- 229920001897 terpolymer Polymers 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/0005—Use of materials characterised by their function or physical properties
- A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
- A61L33/0029—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using an intermediate layer of polymer
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Materials Engineering (AREA)
- Chemical & Material Sciences (AREA)
- Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Manufacture Of Macromolecular Shaped Articles (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9624130.2A GB9624130D0 (en) | 1996-11-20 | 1996-11-20 | Biocompatible compositions |
| PCT/GB1997/003189 WO1998022516A1 (en) | 1996-11-20 | 1997-11-20 | Biocompatible compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69701319D1 DE69701319D1 (de) | 2000-03-30 |
| DE69701319T2 true DE69701319T2 (de) | 2000-07-13 |
Family
ID=10803229
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69711913T Expired - Lifetime DE69711913T2 (de) | 1996-11-20 | 1997-11-20 | Anionenaustauschmaterialien und verfahren |
| DE69701319T Expired - Lifetime DE69701319T2 (de) | 1996-11-20 | 1997-11-20 | Bioverträgliche zusammensetzungen |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69711913T Expired - Lifetime DE69711913T2 (de) | 1996-11-20 | 1997-11-20 | Anionenaustauschmaterialien und verfahren |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US6251964B1 (de) |
| EP (2) | EP0866815B1 (de) |
| JP (2) | JP4051414B2 (de) |
| AT (2) | ATE215971T1 (de) |
| AU (3) | AU728887B2 (de) |
| CA (1) | CA2271132C (de) |
| DE (2) | DE69711913T2 (de) |
| ES (1) | ES2143301T3 (de) |
| GB (1) | GB9624130D0 (de) |
| WO (3) | WO1998022516A1 (de) |
| ZA (3) | ZA9710468B (de) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6743878B2 (en) | 1991-07-05 | 2004-06-01 | Biocompatibles Uk Limited | Polymeric surface coatings |
| GB9522332D0 (en) | 1995-11-01 | 1996-01-03 | Biocompatibles Ltd | Braided stent |
| US6258371B1 (en) * | 1998-04-03 | 2001-07-10 | Medtronic Inc | Method for making biocompatible medical article |
| WO2000001424A1 (fr) * | 1998-07-07 | 2000-01-13 | Nof Corporation | Preparation et materiau pour pansement, et methode de traitement des plaies |
| NZ512100A (en) * | 1998-12-11 | 2003-09-26 | Biocompatibles Uk Ltd | Crosslinked polymers and refractive devices formed therefrom |
| WO2001001957A1 (en) * | 1999-05-27 | 2001-01-11 | Biocompatibles Limited | Local drug delivery |
| EP1189956B1 (de) * | 1999-05-27 | 2003-07-23 | Biocompatibles UK Limited | Lösungen von polymeren |
| ATE310542T1 (de) * | 2000-01-24 | 2005-12-15 | Biocompatibles Uk Ltd | Beschichtete implantate |
| US6852816B2 (en) | 2000-10-06 | 2005-02-08 | Biocompatibles Uk Limited | Zwitterionic polymers |
| GB0100761D0 (en) | 2001-01-11 | 2001-02-21 | Biocompatibles Ltd | Drug delivery from stents |
| EP1391519B1 (de) * | 2001-04-26 | 2006-10-25 | Nof Corporation | Nichtspezifische hybridisierungsinhibitoren, reagenzien für klinische untersuchungen und klinische untersuchungsverfahren |
| US6844028B2 (en) | 2001-06-26 | 2005-01-18 | Accelr8 Technology Corporation | Functional surface coating |
| WO2003074090A2 (en) | 2002-03-07 | 2003-09-12 | Biocompatibles Uk Limited | Compositions of polymers |
| WO2005027991A1 (en) * | 2003-09-19 | 2005-03-31 | Cambridge University Technical Services Ltd | Orthopaedic devices |
| US20050208093A1 (en) * | 2004-03-22 | 2005-09-22 | Thierry Glauser | Phosphoryl choline coating compositions |
| US7892284B2 (en) * | 2005-02-28 | 2011-02-22 | Hoya Corporation | Intraocular lens and process for producing the same |
| WO2008006912A2 (en) * | 2006-07-14 | 2008-01-17 | Biocompatibles Uk Limited | Polymer |
| EP2097119A4 (de) | 2006-11-21 | 2012-10-17 | Abbott Lab | Verwendung eines terpolymers von tetrafluorethylen, hexafluorpropylen und vinylidenfluorid in medikamentenbeschichtungen |
| US20080286332A1 (en) | 2007-05-14 | 2008-11-20 | Pacetti Stephen D | Implantable medical devices with a topcoat layer of phosphoryl choline acrylate polymer for reduced thrombosis, and improved mechanical properties |
| JP5019524B2 (ja) * | 2007-06-01 | 2012-09-05 | 国立大学法人 東京大学 | 新規ポリ（メタ）アクリレート共重合体ならびに小胞体及びゴルジ体への送達方法 |
| WO2010065958A1 (en) | 2008-12-05 | 2010-06-10 | Semprus Biosciences Corp. | Layered non-fouling, antimicrobial, antithrombogenic coatings |
| EP2579908A4 (de) | 2010-06-09 | 2016-03-23 | Arrow Int Inc | Bewuchsfreie antimikrobielle antithrombogene graft-from-zusammensetzungen |
| WO2011156590A2 (en) | 2010-06-09 | 2011-12-15 | Semprus Biosciences Corp. | Non-fouling, anti-microbial, anti-thrombogenic graft compositions |
| US8519189B2 (en) | 2011-06-01 | 2013-08-27 | University Of British Columbia | Polymers for reversing heparin-based anticoagulation |
| CA2859047C (en) | 2011-12-14 | 2017-03-21 | Semprus Biosciences Corp. | Redox processes for contact lens modification |
| CA2859195C (en) | 2011-12-14 | 2016-09-27 | Semprus Biosciences Corp. | Imbibing process for contact lens surface modification |
| AU2012351991B2 (en) | 2011-12-14 | 2015-09-24 | Semprus Biosciences Corp. | Multistep UV process to create surface modified contact lenses |
| CA2858730C (en) | 2011-12-14 | 2017-07-18 | Semprus Biosciences Corp. | Surface modified contact lenses |
| JP2015502437A (ja) | 2011-12-14 | 2015-01-22 | センプラス・バイオサイエンシーズ・コーポレイションＳｅｍｐｒｕｓ Ｂｉｏｓｃｉｅｎｃｅｓ Ｃｏｒｐ． | ランタニド又は遷移金属酸化剤を用いて改質したシリコーンヒドロゲルコンタクトレンズ |
| CN103193927B (zh) * | 2013-04-27 | 2016-01-20 | 南京构友生物材料有限公司 | 可键合的血液友好聚合物及其制法与用途 |
| US10597540B2 (en) * | 2013-05-27 | 2020-03-24 | Jsr Corporation | Surface treatment agent for surface configured from inorganic material, tool and device having modified surface, and method for manufacturing tool and device |
| US10384167B2 (en) | 2013-11-21 | 2019-08-20 | Oasys Water LLC | Systems and methods for improving performance of osmotically driven membrane systems |
| CN111359036A (zh) | 2014-10-02 | 2020-07-03 | 旭化成医疗株式会社 | 源自生物体的液体处理过滤器及过滤器装置 |
| KR20180076552A (ko) * | 2016-12-28 | 2018-07-06 | 주식회사 엘지화학 | 친수성 코팅 조성물 |
| WO2020231797A1 (en) * | 2019-05-10 | 2020-11-19 | Trustees Of Tufts College | Zwitterionic charged copolymer membranes |
| IL308577A (en) | 2021-05-27 | 2024-01-01 | Metro Int Biotech Llc | Crystalline solids of nicotinic acid mononucleotides and their esters and methods for their preparation and use |
| CN113476661B (zh) * | 2021-07-05 | 2022-08-05 | 中国医学科学院生物医学工程研究所 | 一种三层结构复合型自愈合人造血管及其制备方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE306597B (de) | 1964-12-17 | 1968-12-02 | Incentive Ab | |
| US3861948A (en) * | 1972-05-22 | 1975-01-21 | Kendall & Co | Pressure sensitive adhesive tape |
| US3839237A (en) * | 1972-05-31 | 1974-10-01 | Ici Australia Ltd | Ion exchange resins having both acidic and basic ion-exchange sites |
| SE8200751L (sv) | 1982-02-09 | 1983-08-10 | Olle Larm | Forfarande for kovalent koppling for framstellning av konjugat och hervid erhallna produkter |
| SE456347B (sv) | 1982-02-09 | 1988-09-26 | Ird Biomaterial Ab | Ytmodifierat fast substrat samt forfarande for framstellning derav |
| US4517241A (en) * | 1982-12-02 | 1985-05-14 | Alpert Andrew J | Chromatographic support material |
| US4704324A (en) * | 1985-04-03 | 1987-11-03 | The Dow Chemical Company | Semi-permeable membranes prepared via reaction of cationic groups with nucleophilic groups |
| US4865870A (en) | 1988-07-07 | 1989-09-12 | Becton, Dickinson And Company | Method for rendering a substrate surface antithrombogenic |
| JP2890316B2 (ja) * | 1989-07-07 | 1999-05-10 | 科学技術振興事業団 | 生体適合性医療デバイス用材料 |
| GB9023498D0 (en) | 1990-10-29 | 1990-12-12 | Biocompatibles Ltd | Soft contact lens material |
| US5075399A (en) * | 1990-11-15 | 1991-12-24 | Phillips Petroleum Company | Superabsorbent crosslinked ampholytic ion pair copolymers |
| CA2112411C (en) | 1991-07-05 | 2001-01-02 | Roderick W. J. Bowers | Polymeric surface coatings |
| WO1993014127A1 (en) | 1992-01-21 | 1993-07-22 | University Of Utah | Method and composition for heparin binding using polyaminocations covalently immobilised on polymeric surfaces with polyethylene oxide spacers |
| DK0639989T3 (da) | 1992-04-24 | 2001-10-01 | Biocompatibles Ltd | Fremgangsmåde til at reducere mikroorganismeadhæsion |
| US5342621A (en) | 1992-09-15 | 1994-08-30 | Advanced Cardiovascular Systems, Inc. | Antithrombogenic surface |
| GB9226791D0 (en) * | 1992-12-23 | 1993-02-17 | Biocompatibles Ltd | New materials |
| JPH07184989A (ja) | 1993-12-28 | 1995-07-25 | Kuraray Co Ltd | 血液適合性医療用高分子材料および医療材料 |
| JPH07285831A (ja) * | 1994-04-18 | 1995-10-31 | Mitsubishi Chem Corp | 毛髪化粧料組成物 |
-
1996
- 1996-11-20 GB GBGB9624130.2A patent/GB9624130D0/en active Pending
-
1997
- 1997-11-20 AU AU50608/98A patent/AU728887B2/en not_active Ceased
- 1997-11-20 CA CA002271132A patent/CA2271132C/en not_active Expired - Fee Related
- 1997-11-20 DE DE69711913T patent/DE69711913T2/de not_active Expired - Lifetime
- 1997-11-20 AT AT97913311T patent/ATE215971T1/de not_active IP Right Cessation
- 1997-11-20 ES ES97913308T patent/ES2143301T3/es not_active Expired - Lifetime
- 1997-11-20 DE DE69701319T patent/DE69701319T2/de not_active Expired - Lifetime
- 1997-11-20 WO PCT/GB1997/003189 patent/WO1998022516A1/en active IP Right Grant
- 1997-11-20 AU AU50610/98A patent/AU5061098A/en not_active Abandoned
- 1997-11-20 JP JP52336498A patent/JP4051414B2/ja not_active Expired - Fee Related
- 1997-11-20 ZA ZA9710468A patent/ZA9710468B/xx unknown
- 1997-11-20 EP EP97913308A patent/EP0866815B1/de not_active Expired - Lifetime
- 1997-11-20 ZA ZA9710467A patent/ZA9710467B/xx unknown
- 1997-11-20 WO PCT/GB1997/003192 patent/WO1998022517A1/en active IP Right Grant
- 1997-11-20 ZA ZA9710466A patent/ZA9710466B/xx unknown
- 1997-11-20 AT AT97913308T patent/ATE189899T1/de not_active IP Right Cessation
- 1997-11-20 JP JP52336298A patent/JP4295359B2/ja not_active Expired - Lifetime
- 1997-11-20 AU AU50611/98A patent/AU5061198A/en not_active Abandoned
- 1997-11-20 US US09/117,729 patent/US6251964B1/en not_active Expired - Lifetime
- 1997-11-20 WO PCT/GB1997/003191 patent/WO1998022162A1/en active Application Filing
- 1997-11-20 EP EP97913311A patent/EP0939779B1/de not_active Expired - Lifetime
- 1997-11-20 US US09/308,496 patent/US6432314B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP4295359B2 (ja) | 2009-07-15 |
| ATE189899T1 (de) | 2000-03-15 |
| ZA9710467B (en) | 1998-11-20 |
| AU5060898A (en) | 1998-06-10 |
| EP0866815A2 (de) | 1998-09-30 |
| DE69701319D1 (de) | 2000-03-30 |
| EP0939779B1 (de) | 2002-04-10 |
| ES2143301T3 (es) | 2000-05-01 |
| DE69711913D1 (de) | 2002-05-16 |
| US6432314B1 (en) | 2002-08-13 |
| CA2271132A1 (en) | 1998-05-28 |
| AU5061098A (en) | 1998-06-10 |
| JP4051414B2 (ja) | 2008-02-27 |
| JP2001506915A (ja) | 2001-05-29 |
| WO1998022516A1 (en) | 1998-05-28 |
| EP0866815A3 (de) | 1998-10-21 |
| DE69711913T2 (de) | 2002-10-10 |
| ZA9710466B (en) | 1998-11-20 |
| WO1998022162A1 (en) | 1998-05-28 |
| AU728887B2 (en) | 2001-01-18 |
| US6251964B1 (en) | 2001-06-26 |
| GB9624130D0 (en) | 1997-01-08 |
| JP2001504877A (ja) | 2001-04-10 |
| CA2271132C (en) | 2007-04-17 |
| ZA9710468B (en) | 1998-11-20 |
| ATE215971T1 (de) | 2002-04-15 |
| AU5061198A (en) | 1998-06-10 |
| WO1998022517A1 (en) | 1998-05-28 |
| EP0939779A1 (de) | 1999-09-08 |
| EP0866815B1 (de) | 2000-02-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: BIOCOMPATIBLES UK LTD., FARNHAM, SURREY, GB |