DE69637812D1 - Schützende Epitope von Adenylate-Zyklase-Hämolysin(AC-Hly) und ihre Verwendung zur Behandlung oder Verhütung von Bordetella-Infektionen - Google Patents
Schützende Epitope von Adenylate-Zyklase-Hämolysin(AC-Hly) und ihre Verwendung zur Behandlung oder Verhütung von Bordetella-InfektionenInfo
- Publication number
- DE69637812D1 DE69637812D1 DE69637812T DE69637812T DE69637812D1 DE 69637812 D1 DE69637812 D1 DE 69637812D1 DE 69637812 T DE69637812 T DE 69637812T DE 69637812 T DE69637812 T DE 69637812T DE 69637812 D1 DE69637812 D1 DE 69637812D1
- Authority
- DE
- Germany
- Prior art keywords
- hly
- prevention
- treatment
- adenylate cyclase
- protective epitopes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000001681 protective effect Effects 0.000 title abstract 3
- 108010083528 Adenylate Cyclase Toxin Proteins 0.000 title 2
- 208000018150 Bordetella infection Diseases 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 abstract 3
- 108020004707 nucleic acids Proteins 0.000 abstract 3
- 150000007523 nucleic acids Chemical class 0.000 abstract 3
- 241000894006 Bacteria Species 0.000 abstract 2
- 241000588779 Bordetella bronchiseptica Species 0.000 abstract 2
- 241000588780 Bordetella parapertussis Species 0.000 abstract 2
- 241000588832 Bordetella pertussis Species 0.000 abstract 2
- 208000015181 infectious disease Diseases 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- GFFGJBXGBJISGV-UHFFFAOYSA-N adenyl group Chemical group N1=CN=C2N=CNC2=C1N GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000003228 hemolysin Substances 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/825—Bacteria
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9507945A FR2736064B1 (fr) | 1995-06-30 | 1995-06-30 | Epitopes protecteurs de l'adenyl cyclase-hemolysine(ac-hty). leur application au traitement ou a la prevention des infections par bordetella |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE69637812D1 true DE69637812D1 (de) | 2009-03-05 |
Family
ID=9480602
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69637812T Expired - Lifetime DE69637812D1 (de) | 1995-06-30 | 1996-06-25 | Schützende Epitope von Adenylate-Zyklase-Hämolysin(AC-Hly) und ihre Verwendung zur Behandlung oder Verhütung von Bordetella-Infektionen |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US6309648B1 (de) |
| EP (1) | EP0787796B9 (de) |
| JP (1) | JP4302784B2 (de) |
| AT (1) | ATE420951T1 (de) |
| AU (1) | AU5625796A (de) |
| CA (1) | CA2180280A1 (de) |
| DE (1) | DE69637812D1 (de) |
| DK (1) | DK0787796T3 (de) |
| ES (1) | ES2320392T3 (de) |
| FR (1) | FR2736064B1 (de) |
| PT (1) | PT787796E (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2646776B1 (fr) * | 1989-05-12 | 1994-06-03 | Pasteur Institut | Utilisation de preparations vaccinantes a base d'adenyl cyclase ou de bacteries les produisant en tant qu'antigenes protecteurs contre les effets des bordetella |
| FR2728170A1 (fr) * | 1994-12-15 | 1996-06-21 | Pasteur Institut | Vaccin de type acellulaire anti-bordetella |
| US7462472B2 (en) * | 2001-11-02 | 2008-12-09 | The University Of Chicago | Methods and compositions relating to anthrax pathogenesis |
| EP1489092A1 (de) * | 2003-06-18 | 2004-12-22 | Institut Pasteur | Modifizierte Bordetella Adenylatcyclase mit oder ohne CD11b/CD18 Interaktionsdomäne und seine Verwendungen |
| WO2008121171A1 (en) * | 2007-01-12 | 2008-10-09 | Cornell Research Foundation, Inc. | Adenylyl cyclases as novel targets for antibacterial interventions |
| US9095578B2 (en) * | 2007-01-12 | 2015-08-04 | Cornell Research Foundation, Inc. | Adenylyl cyclases as novel targets for the treatment of infection by eukaryotic pathogens |
| US20100112009A1 (en) * | 2008-11-03 | 2010-05-06 | Institut Pasteur | Acellular antibordetella vaccine |
| US20190071706A1 (en) | 2016-04-04 | 2019-03-07 | University Of Virginia Patent Foundation | Compositions and methods for preventing and treating disease |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8412207D0 (en) * | 1984-05-12 | 1984-06-20 | Wellcome Found | Antigenic preparations |
| FR2590483B1 (fr) | 1985-11-22 | 1988-12-09 | Pasteur Institut | Antigenes purifies ayant des proprietes vaccinantes contre b. pertussis, moyens notamment adns recombinants pour les produire et compositions de vaccins les contenant |
| FR2606789B1 (fr) | 1986-11-17 | 1991-05-31 | Pasteur Institut | Preparations d'adenylate cyclase purifiees, procede d'obtention de ces preparations et leurs applications biologiques |
| ATE80179T1 (de) | 1986-12-23 | 1992-09-15 | Univ Leland Stanford Junior | Modifiziertes pertussistoxin. |
| ES2091186T3 (es) | 1988-04-19 | 1996-11-01 | Pasteur Institut | Procedimiento para obtener antigenos protectores contra infecciones y procesos toxicos de bordetella. |
| EP0338170A1 (de) | 1988-04-19 | 1989-10-25 | Institut Pasteur | Immunschutz gewährendes antigenes Protein gegen pathogene Bakterien |
| FR2638169B1 (fr) * | 1988-10-25 | 1991-01-11 | Pasteur Institut | Derives d'adenyl cyclase et leurs utilisations biologiques |
| FR2646776B1 (fr) | 1989-05-12 | 1994-06-03 | Pasteur Institut | Utilisation de preparations vaccinantes a base d'adenyl cyclase ou de bacteries les produisant en tant qu'antigenes protecteurs contre les effets des bordetella |
| FR2728170A1 (fr) * | 1994-12-15 | 1996-06-21 | Pasteur Institut | Vaccin de type acellulaire anti-bordetella |
-
1995
- 1995-06-30 FR FR9507945A patent/FR2736064B1/fr not_active Expired - Fee Related
-
1996
- 1996-06-25 AT AT96401402T patent/ATE420951T1/de not_active IP Right Cessation
- 1996-06-25 PT PT96401402T patent/PT787796E/pt unknown
- 1996-06-25 ES ES96401402T patent/ES2320392T3/es not_active Expired - Lifetime
- 1996-06-25 DK DK96401402T patent/DK0787796T3/da active
- 1996-06-25 EP EP96401402A patent/EP0787796B9/de not_active Expired - Lifetime
- 1996-06-25 DE DE69637812T patent/DE69637812D1/de not_active Expired - Lifetime
- 1996-06-27 US US08/669,785 patent/US6309648B1/en not_active Expired - Fee Related
- 1996-06-28 AU AU56257/96A patent/AU5625796A/en not_active Abandoned
- 1996-06-28 CA CA002180280A patent/CA2180280A1/fr not_active Abandoned
- 1996-07-01 JP JP20403896A patent/JP4302784B2/ja not_active Expired - Fee Related
-
2001
- 2001-07-19 US US09/907,951 patent/US6994854B1/en not_active Expired - Fee Related
-
2005
- 2005-07-11 US US11/177,488 patent/US7902349B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU5625796A (en) | 1997-01-23 |
| FR2736064B1 (fr) | 1997-09-05 |
| EP0787796B9 (de) | 2009-08-05 |
| US20060292161A1 (en) | 2006-12-28 |
| EP0787796A1 (de) | 1997-08-06 |
| CA2180280A1 (fr) | 1996-12-31 |
| PT787796E (pt) | 2009-04-03 |
| FR2736064A1 (fr) | 1997-01-03 |
| US7902349B2 (en) | 2011-03-08 |
| JP4302784B2 (ja) | 2009-07-29 |
| DK0787796T3 (da) | 2009-04-20 |
| ATE420951T1 (de) | 2009-01-15 |
| JPH09187284A (ja) | 1997-07-22 |
| US6994854B1 (en) | 2006-02-07 |
| EP0787796B1 (de) | 2009-01-14 |
| US6309648B1 (en) | 2001-10-30 |
| ES2320392T3 (es) | 2009-05-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |