DE69637536D1 - Wachstumsfaktoren aus zerbellum und deren verwendungen - Google Patents

Wachstumsfaktoren aus zerbellum und deren verwendungen

Info

Publication number
DE69637536D1
DE69637536D1 DE69637536T DE69637536T DE69637536D1 DE 69637536 D1 DE69637536 D1 DE 69637536D1 DE 69637536 T DE69637536 T DE 69637536T DE 69637536 T DE69637536 T DE 69637536T DE 69637536 D1 DE69637536 D1 DE 69637536D1
Authority
DE
Germany
Prior art keywords
zerbellum
growth factors
cdgf
vertebrates
discovery
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69637536T
Other languages
English (en)
Inventor
Han Chang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harvard College
Leland Stanford Junior University
Original Assignee
Harvard College
Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College, Leland Stanford Junior University filed Critical Harvard College
Application granted granted Critical
Publication of DE69637536D1 publication Critical patent/DE69637536D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/4756—Neuregulins, i.e. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cephalosporin Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Luminescent Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Fats And Perfumes (AREA)
  • Pyrane Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
DE69637536T 1995-09-08 1996-09-09 Wachstumsfaktoren aus zerbellum und deren verwendungen Expired - Lifetime DE69637536D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/525,864 US5912326A (en) 1995-09-08 1995-09-08 Cerebellum-derived growth factors
PCT/US1996/014484 WO1997009425A1 (en) 1995-09-08 1996-09-09 Cerebellum-derived growth factors, and uses related thereto

Publications (1)

Publication Number Publication Date
DE69637536D1 true DE69637536D1 (de) 2008-07-03

Family

ID=24094914

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69637536T Expired - Lifetime DE69637536D1 (de) 1995-09-08 1996-09-09 Wachstumsfaktoren aus zerbellum und deren verwendungen

Country Status (12)

Country Link
US (1) US5912326A (de)
EP (1) EP0850304B1 (de)
JP (2) JP4642943B2 (de)
KR (1) KR19990044527A (de)
AT (1) ATE396261T1 (de)
AU (1) AU728614B2 (de)
CA (1) CA2228590C (de)
DE (1) DE69637536D1 (de)
DK (1) DK0850304T3 (de)
ES (1) ES2308780T3 (de)
PT (1) PT850304E (de)
WO (1) WO1997009425A1 (de)

Families Citing this family (38)

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US6074841A (en) * 1996-08-19 2000-06-13 Millennium Biotherapeutics, Inc. Don-1 gene and polypeptides and uses therefor
US20020127594A1 (en) * 2000-06-22 2002-09-12 Gearing David P. Don-1 gene and polypeptides and uses therefor
US6121415A (en) * 1997-07-09 2000-09-19 Genentech, Inc. ErbB4 receptor-specific neuregolin related ligands and uses therefor
ZA986077B (en) 1997-07-09 2000-01-10 Genentech Inc ErbB4 receptor-specific neuregulin related ligands and uses therefor.
US6994856B1 (en) 1997-07-24 2006-02-07 Genentech, Inc. ErbB4 receptor-specific neuregulin related ligands and uses therefor
US20030104973A1 (en) * 1997-08-21 2003-06-05 Quark Biotech, Inc. Hypoxia-regulated genes
US7973156B2 (en) * 1997-08-21 2011-07-05 Quark Pharmaceuticals Inc. Hypoxia-regulated genes
AUPP785098A0 (en) 1998-12-21 1999-01-21 Victor Chang Cardiac Research Institute, The Treatment of heart disease
US6635249B1 (en) 1999-04-23 2003-10-21 Cenes Pharmaceuticals, Inc. Methods for treating congestive heart failure
JP5324732B2 (ja) * 2000-05-23 2013-10-23 スネス ファーマシューティカルズ インコーポレイテッド Ｎｒｇ−２核酸分子、ポリペプチド、ならびに診断および治療法
AU2002304965A1 (en) 2002-05-24 2003-12-12 Zensun (Shanghai) Sci-Tech.Ltd Neuregulin based methods and compositions for treating viral myocarditis and dilated cardiomyopathy
US20070213264A1 (en) 2005-12-02 2007-09-13 Mingdong Zhou Neuregulin variants and methods of screening and using thereof
JP5738516B2 (ja) 2005-12-30 2015-06-24 ゼンサン （シャンハイ） サイエンス アンド テクノロジー リミテッド 心機能改善のためのニューレグリンの徐放
US9580515B2 (en) 2006-08-21 2017-02-28 Zensun (Shanghai) Science & Technology, Co., Ltd. Neukinase, a downstream protein of neuregulin
US20090156488A1 (en) 2007-09-12 2009-06-18 Zensun (Shanghai) Science & Technology Limited Use of neuregulin for organ preservation
ES2811127T3 (es) 2008-02-29 2021-03-10 Acorda Therapeutics Inc Composiciones para lograr niveles plasmáticos deseados del factor 2 de crecimiento glial
JP5797112B2 (ja) 2008-07-17 2015-10-21 アコーダ セラピューティクス インコーポレイテッド 心不全の治療または予防のためのニューレグリンまたはそのサブ配列の治療的投与方法
CN104707130A (zh) 2008-08-15 2015-06-17 阿索尔达治疗公司 在cns神经性损伤后非-急性期间处理的组合物及方法
JP5743898B2 (ja) 2008-11-28 2015-07-01 ゼンサン （シャンハイ） サイエンス アンド テクノロジー リミテッド ニューレグリンペプチド及びその使用
CN102470161A (zh) 2009-06-09 2012-05-23 上海泽生科技开发有限公司 神经调节蛋白用于治疗心力衰竭的有效剂量
EP2440236B1 (de) 2009-06-09 2016-05-04 Zensun (Shanghai) Science and Technology Limited Verfahren basierend auf neuregulin zur behandlung von herzfehlern
JP6096262B2 (ja) 2009-08-25 2017-03-15 ゼンサン （シャンハイ） サイエンス アンド テクノロジー，シーオー．，エルティーディー． ニューレグリンに基づく心不全の治療方法
CN102139095A (zh) 2010-01-29 2011-08-03 上海泽生科技开发有限公司 神经调节蛋白用于预防、治疗或延迟心脏缺血再灌注损伤的方法和组合物
WO2013053076A1 (en) 2011-10-10 2013-04-18 Zensun （Shanghai）Science & Technology Limited Compositions and methods for treating heart failure
CA2884051A1 (en) 2012-10-08 2014-04-17 Zensun (Shanghai) Science & Technology, Ltd. Compositions and methods for treating heart failure in diabetic patients
IL281376B (en) 2013-03-06 2022-08-01 Acorda Therapeutics Inc Medicinal peptides of neuregulin for the treatment or prevention of heart failure
EP3895724A1 (de) 2013-05-22 2021-10-20 Zensun (Shanghai) Science and Technology, Co., Ltd. Verlängerte freisetzung von neuregulin zur behandlung von herzinsuffizienz
CN104758922A (zh) 2014-01-03 2015-07-08 上海泽生科技开发有限公司 纽兰格林制剂的配方
WO2015140351A1 (en) 2014-03-21 2015-09-24 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for enhancing myelination
CN105497876B (zh) 2014-09-24 2021-01-15 上海泽生科技开发股份有限公司 神经调节蛋白用于预防、治疗或延迟心脏室性心律失常的方法和组合物
CN111407882A (zh) 2014-10-17 2020-07-14 上海泽生科技开发股份有限公司 神经调节蛋白用于预防、治疗或延迟射血分数保留的心力衰竭的方法和组合物
EP3353546A1 (de) 2015-09-25 2018-08-01 Douglas B. Sawyer Verfahren zur behandlung von herzverletzungen
BR112020020646A2 (pt) 2018-04-11 2021-02-23 Salubris Biotherapeutics, Inc. composições de proteína de fusão recombinante de neuregulina-1 (nrg-1) humana e métodos de uso destas
CN111407881A (zh) 2019-01-07 2020-07-14 上海泽生科技开发股份有限公司 神经调节蛋白用于预防、治疗或延迟心肌损伤的方法和组合物
AU2020348436A1 (en) 2019-09-16 2022-04-07 Zensun (Shanghai) Science & Technology, Co., Ltd. Recombinant human neuregulin derivatives and use thereof
CN113289002A (zh) 2020-02-24 2021-08-24 上海泽生科技开发股份有限公司 神经调节蛋白用于预防、治疗或延缓心力衰竭的方法和组合物
US20220402985A1 (en) 2021-06-10 2022-12-22 Amgen Inc. ENGINEERED NRG-1 VARIANTS WITH IMPROVED SELECTIVITY TOWARD ErbB4 BUT NOT AGAINST ErbB3
WO2023178086A1 (en) 2022-03-15 2023-09-21 Salubris Biotherapeutics, Inc. Methods of treating fibrosis and arrhythmia with a neuregulin-1 fusion protein

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0597845A1 (de) * 1990-05-25 1994-05-25 Georgetown University Wachstumsfaktor der den wachstum von zellen, die das onkogen erbb-2 aus dem menschen überexpremieren, inhibiert
DE69229597D1 (de) * 1991-01-14 1999-08-19 Univ Georgetown Wachstumsfaktor-ligand, der an den erbb-2-rezeptor bindet und die zellulären reaktionen induziert
GB9107566D0 (en) * 1991-04-10 1991-05-29 Ludwig Inst Cancer Res Glial mitogenic factors,their preparation and use
US5530109A (en) * 1991-04-10 1996-06-25 Ludwig Institute For Cancer Research DNA encoding glial mitogenic factors
US5367060A (en) * 1991-05-24 1994-11-22 Genentech, Inc. Structure, production and use of heregulin
IL101943A0 (en) * 1991-05-24 1992-12-30 Genentech Inc Structure,production and use of heregulin
US5237056A (en) * 1991-05-29 1993-08-17 President And Fellows Of Harvard College DNA encoding a protein which copurifies with acetylcholine receptor inducing activity and uses therefor
AU693767B2 (en) * 1992-08-10 1998-07-09 Cambridge Neuroscience, Inc. Inhibitors of cell proliferation, their preparation and use
GB9217316D0 (en) * 1992-08-14 1992-09-30 Ludwig Inst Cancer Res Schwann cell mitogenic factor,its preparation and use
EP0663007A1 (de) * 1992-09-29 1995-07-19 The President And Fellows Of Harvard College Trophischer faktor mit ion-kanal-induzierender aktivität in neuronalen zellen
AU7042994A (en) * 1993-05-21 1994-12-20 Amgen, Inc. Recombinant (neu) differentiation factors

Also Published As

Publication number Publication date
US5912326A (en) 1999-06-15
JP2011036260A (ja) 2011-02-24
PT850304E (pt) 2008-10-09
JPH11512285A (ja) 1999-10-26
EP0850304A1 (de) 1998-07-01
JP4642943B2 (ja) 2011-03-02
ATE396261T1 (de) 2008-06-15
DK0850304T3 (da) 2008-09-29
CA2228590C (en) 2003-08-05
ES2308780T3 (es) 2008-12-01
KR19990044527A (ko) 1999-06-25
WO1997009425A1 (en) 1997-03-13
EP0850304B1 (de) 2008-05-21
AU728614B2 (en) 2001-01-11
AU7156396A (en) 1997-03-27
CA2228590A1 (en) 1997-03-13

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Legal Events

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