DE69637536D1 - Wachstumsfaktoren aus zerbellum und deren verwendungen - Google Patents

Wachstumsfaktoren aus zerbellum und deren verwendungen

Info

Publication number
DE69637536D1
DE69637536D1 DE69637536T DE69637536T DE69637536D1 DE 69637536 D1 DE69637536 D1 DE 69637536D1 DE 69637536 T DE69637536 T DE 69637536T DE 69637536 T DE69637536 T DE 69637536T DE 69637536 D1 DE69637536 D1 DE 69637536D1
Authority
DE
Germany
Prior art keywords
zerbellum
growth factors
cdgf
vertebrates
discovery
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69637536T
Other languages
English (en)
Inventor
Han Chang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harvard College
Leland Stanford Junior University
Original Assignee
Harvard College
Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College, Leland Stanford Junior University filed Critical Harvard College
Application granted granted Critical
Publication of DE69637536D1 publication Critical patent/DE69637536D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/4756—Neuregulins, i.e. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Luminescent Compositions (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pyrane Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Fats And Perfumes (AREA)
DE69637536T 1995-09-08 1996-09-09 Wachstumsfaktoren aus zerbellum und deren verwendungen Expired - Lifetime DE69637536D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/525,864 US5912326A (en) 1995-09-08 1995-09-08 Cerebellum-derived growth factors
PCT/US1996/014484 WO1997009425A1 (en) 1995-09-08 1996-09-09 Cerebellum-derived growth factors, and uses related thereto

Publications (1)

Publication Number Publication Date
DE69637536D1 true DE69637536D1 (de) 2008-07-03

Family

ID=24094914

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69637536T Expired - Lifetime DE69637536D1 (de) 1995-09-08 1996-09-09 Wachstumsfaktoren aus zerbellum und deren verwendungen

Country Status (12)

Country Link
US (1) US5912326A (de)
EP (1) EP0850304B1 (de)
JP (2) JP4642943B2 (de)
KR (1) KR19990044527A (de)
AT (1) ATE396261T1 (de)
AU (1) AU728614B2 (de)
CA (1) CA2228590C (de)
DE (1) DE69637536D1 (de)
DK (1) DK0850304T3 (de)
ES (1) ES2308780T3 (de)
PT (1) PT850304E (de)
WO (1) WO1997009425A1 (de)

Families Citing this family (38)

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US20020127594A1 (en) * 2000-06-22 2002-09-12 Gearing David P. Don-1 gene and polypeptides and uses therefor
US6074841A (en) * 1996-08-19 2000-06-13 Millennium Biotherapeutics, Inc. Don-1 gene and polypeptides and uses therefor
ZA986077B (en) 1997-07-09 2000-01-10 Genentech Inc ErbB4 receptor-specific neuregulin related ligands and uses therefor.
US6121415A (en) * 1997-07-09 2000-09-19 Genentech, Inc. ErbB4 receptor-specific neuregolin related ligands and uses therefor
US6994856B1 (en) 1997-07-24 2006-02-07 Genentech, Inc. ErbB4 receptor-specific neuregulin related ligands and uses therefor
US7973156B2 (en) * 1997-08-21 2011-07-05 Quark Pharmaceuticals Inc. Hypoxia-regulated genes
US20030104973A1 (en) * 1997-08-21 2003-06-05 Quark Biotech, Inc. Hypoxia-regulated genes
AUPP785098A0 (en) 1998-12-21 1999-01-21 Victor Chang Cardiac Research Institute, The Treatment of heart disease
US6635249B1 (en) 1999-04-23 2003-10-21 Cenes Pharmaceuticals, Inc. Methods for treating congestive heart failure
WO2001089568A1 (en) 2000-05-23 2001-11-29 Cenes Pharmaceuticals, Inc. Nrg-2 nucleic acid molecules, polypeptides, and diagnostic and therapeutic methods
WO2003099320A1 (en) 2002-05-24 2003-12-04 Zensun (Shanghai) Sci-Tech.Ltd Neuregulin based methods and compositions for treating viral myocarditis and dilated cardiomyopathy
US20070213264A1 (en) 2005-12-02 2007-09-13 Mingdong Zhou Neuregulin variants and methods of screening and using thereof
AU2006332340B2 (en) 2005-12-30 2013-09-26 Zensun (Shanghai) Science & Technology, Co., Ltd. Extended release of neuregulin for improved cardiac function
US9580515B2 (en) 2006-08-21 2017-02-28 Zensun (Shanghai) Science & Technology, Co., Ltd. Neukinase, a downstream protein of neuregulin
US20090156488A1 (en) 2007-09-12 2009-06-18 Zensun (Shanghai) Science & Technology Limited Use of neuregulin for organ preservation
PL3120863T3 (pl) 2008-02-29 2021-02-22 Acorda Therapeutics, Inc. Kompozycje do osiągnięcia pożądanych poziomów glejowego czynnika wzrostu 2 w osoczu
WO2010030317A2 (en) 2008-07-17 2010-03-18 Acorda Therapeutics, Inc. Therapeutic dosing of a neuregulin or a subsequence thereof for treatment or prophylaxis of heart failure
ES2827923T3 (es) 2008-08-15 2021-05-25 Acorda Therapeutics Inc Composiciones y métodos de tratamiento durante los períodos no agudos después de una lesión neurológica del CNS
EP2808339B1 (de) 2008-11-28 2017-02-15 Zensun (Shanghai) Science & Technology, Co., Ltd. Neuregulin-Peptide und deren Verwendung
ES2748886T3 (es) 2009-06-09 2020-03-18 Zensun Shanghai Science & Tech Co Ltd Métodos basados en Neuregulina para el tratamiento de la insuficiencia cardíaca
WO2010142141A1 (en) 2009-06-09 2010-12-16 Zensun (Shanghai) Science & Technology Limited Neuregulin based methods for treating heart failure
JP6096262B2 (ja) 2009-08-25 2017-03-15 ゼンサン （シャンハイ） サイエンス アンド テクノロジー，シーオー．，エルティーディー． ニューレグリンに基づく心不全の治療方法
CN102139095A (zh) 2010-01-29 2011-08-03 上海泽生科技开发有限公司 神经调节蛋白用于预防、治疗或延迟心脏缺血再灌注损伤的方法和组合物
WO2013053076A1 (en) 2011-10-10 2013-04-18 Zensun （Shanghai）Science & Technology Limited Compositions and methods for treating heart failure
EP2903632A4 (de) 2012-10-08 2016-07-13 Zensun Shanghai Science And Technology Ltd Zusammensetzungen und verfahren zur behandlung von herzversagen bei diabetespatienten
CA2904055A1 (en) 2013-03-06 2014-09-12 Acorda Therapeutics, Inc. Therapeutic dosing of a neuregulin or a fragment thereof for treatment or prophylaxis of heart failure
ES2743617T3 (es) 2013-05-22 2020-02-20 Zensun Shanghai Science & Tech Co Ltd Liberación prolongada de neuregulina para tratar la insuficiencia cardíaca
CN110946993A (zh) 2014-01-03 2020-04-03 上海泽生科技开发股份有限公司 纽兰格林制剂的配方
WO2015140351A1 (en) 2014-03-21 2015-09-24 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for enhancing myelination
CN105497876B (zh) 2014-09-24 2021-01-15 上海泽生科技开发股份有限公司 神经调节蛋白用于预防、治疗或延迟心脏室性心律失常的方法和组合物
CN111407882A (zh) 2014-10-17 2020-07-14 上海泽生科技开发股份有限公司 神经调节蛋白用于预防、治疗或延迟射血分数保留的心力衰竭的方法和组合物
JP7181084B2 (ja) 2015-09-25 2022-11-30 ダグラス ビー． ソーヤー， 心臓傷害を処置するための方法
EA202092458A1 (ru) 2018-04-11 2021-02-08 Салюбрис Байотерапьютикс, Инк. Композиции на основе рекомбинантного слитого белка, содержащего нейрегулин-1 (nrg-1) человека, и способы их применения
CN111407881A (zh) 2019-01-07 2020-07-14 上海泽生科技开发股份有限公司 神经调节蛋白用于预防、治疗或延迟心肌损伤的方法和组合物
WO2021052277A1 (zh) 2019-09-16 2021-03-25 上海泽生科技开发股份有限公司 重组人神经调节蛋白衍生物及其用途
CN113289002A (zh) 2020-02-24 2021-08-24 上海泽生科技开发股份有限公司 神经调节蛋白用于预防、治疗或延缓心力衰竭的方法和组合物
AR126114A1 (es) 2021-06-10 2023-09-13 Amgen Inc VARIANTES GENOMODIFICADAS DE LA NRG-1 CON UNA SELECTIVIDAD MEJORADA FRENTE AL ErbB4 PERO NO FRENTE AL ErbB3
WO2023178086A1 (en) 2022-03-15 2023-09-21 Salubris Biotherapeutics, Inc. Methods of treating fibrosis and arrhythmia with a neuregulin-1 fusion protein

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991018921A1 (en) * 1990-05-25 1991-12-12 Georgetown University GROWTH FACTOR WHICH INHIBITS THE GROWTH OF CELLS OVEREXPRESSING THE HUMAN ONCOGENE erbB-2
KR930703359A (ko) * 1991-01-14 1993-11-29 조지 알. 라스니어 이알비비- 2(erbB-2) 수용체 단백질에 결합하고 세포 반응을 유도하는 리간드 성장인자
US5530109A (en) * 1991-04-10 1996-06-25 Ludwig Institute For Cancer Research DNA encoding glial mitogenic factors
GB9107566D0 (en) * 1991-04-10 1991-05-29 Ludwig Inst Cancer Res Glial mitogenic factors,their preparation and use
IL101943A0 (en) * 1991-05-24 1992-12-30 Genentech Inc Structure,production and use of heregulin
US5367060A (en) * 1991-05-24 1994-11-22 Genentech, Inc. Structure, production and use of heregulin
US5237056A (en) * 1991-05-29 1993-08-17 President And Fellows Of Harvard College DNA encoding a protein which copurifies with acetylcholine receptor inducing activity and uses therefor
AU693767B2 (en) * 1992-08-10 1998-07-09 Cambridge Neuroscience, Inc. Inhibitors of cell proliferation, their preparation and use
GB9217316D0 (en) * 1992-08-14 1992-09-30 Ludwig Inst Cancer Res Schwann cell mitogenic factor,its preparation and use
WO1994008007A1 (en) * 1992-09-29 1994-04-14 President And Fellows Of Harvard College Trophic factor having ion channel-inducing activity in neuronal cells
AU7042994A (en) * 1993-05-21 1994-12-20 Amgen, Inc. Recombinant (neu) differentiation factors

Also Published As

Publication number Publication date
AU728614B2 (en) 2001-01-11
JP2011036260A (ja) 2011-02-24
PT850304E (pt) 2008-10-09
EP0850304B1 (de) 2008-05-21
EP0850304A1 (de) 1998-07-01
DK0850304T3 (da) 2008-09-29
CA2228590A1 (en) 1997-03-13
ES2308780T3 (es) 2008-12-01
AU7156396A (en) 1997-03-27
KR19990044527A (ko) 1999-06-25
WO1997009425A1 (en) 1997-03-13
CA2228590C (en) 2003-08-05
JP4642943B2 (ja) 2011-03-02
US5912326A (en) 1999-06-15
JPH11512285A (ja) 1999-10-26
ATE396261T1 (de) 2008-06-15

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