DE69635504T2 - Herstellung von rekombinantem Faktor VIII in Gegenwart von Liposom-ähnliche Verbindung-Zusammensetzungen - Google Patents

Herstellung von rekombinantem Faktor VIII in Gegenwart von Liposom-ähnliche Verbindung-Zusammensetzungen Download PDF

Info

Publication number
DE69635504T2
DE69635504T2 DE1996635504 DE69635504T DE69635504T2 DE 69635504 T2 DE69635504 T2 DE 69635504T2 DE 1996635504 DE1996635504 DE 1996635504 DE 69635504 T DE69635504 T DE 69635504T DE 69635504 T2 DE69635504 T2 DE 69635504T2
Authority
DE
Germany
Prior art keywords
liposome
factor viii
recombinant factor
preparation
compound compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE1996635504
Other languages
English (en)
Other versions
DE69635504D1 (de
Inventor
Sham-Yuen Chan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/434,900 external-priority patent/US5679549A/en
Application filed by Bayer Corp filed Critical Bayer Corp
Application granted granted Critical
Publication of DE69635504D1 publication Critical patent/DE69635504D1/de
Publication of DE69635504T2 publication Critical patent/DE69635504T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C12N5/0037—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/36—Lipids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
DE1996635504 1995-05-04 1996-04-25 Herstellung von rekombinantem Faktor VIII in Gegenwart von Liposom-ähnliche Verbindung-Zusammensetzungen Expired - Lifetime DE69635504T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/434,900 US5679549A (en) 1995-05-04 1995-05-04 Production of recombinant factor VIII in the presence of liposome-like substances of mixed composition
US08/634,001 US5952198A (en) 1995-05-04 1996-04-17 Production of recombinant Factor VIII in the presence of liposome-like substances of mixed composition

Publications (2)

Publication Number Publication Date
DE69635504D1 DE69635504D1 (de) 2006-01-05
DE69635504T2 true DE69635504T2 (de) 2006-06-14

Family

ID=27030345

Family Applications (1)

Application Number Title Priority Date Filing Date
DE1996635504 Expired - Lifetime DE69635504T2 (de) 1995-05-04 1996-04-25 Herstellung von rekombinantem Faktor VIII in Gegenwart von Liposom-ähnliche Verbindung-Zusammensetzungen

Country Status (7)

Country Link
US (1) US5952198A (de)
EP (1) EP0745672B1 (de)
JP (1) JP3996655B2 (de)
AT (1) ATE311447T1 (de)
AU (1) AU710853B2 (de)
CA (1) CA2175628C (de)
DE (1) DE69635504T2 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6200560B1 (en) * 1998-10-20 2001-03-13 Avigen, Inc. Adeno-associated virus vectors for expression of factor VIII by target cells
US6358703B1 (en) * 1998-12-10 2002-03-19 Bayer Corporation Expression system for factor VIII
WO2002061036A2 (en) * 2000-11-30 2002-08-08 The Research Foundation Of State University Of New York Method of complexing a protein by the use of a dispersed system and proteins thereof
WO2002043665A2 (en) * 2000-11-30 2002-06-06 The Research Foundation Of State University Of New York Ahf associated dispersion system and method for preparation
US8110218B2 (en) * 2000-11-30 2012-02-07 The Research Foundation Of State University Of New York Compositions and methods for less immunogenic protein-lipid complexes
US7625584B2 (en) * 2000-11-30 2009-12-01 The Research Foundation Of State University Of New York Method of complexing a protein by the use of a dispersed system and proteins thereof
US20050221414A1 (en) * 2004-03-31 2005-10-06 Katalin Varadi Kit for measuring the thrombin generation in a sample of a patient's blood or plasma
EP1988101A1 (de) * 2007-05-04 2008-11-05 Novo Nordisk A/S Verbesserung von Faktor-VIII-Polypeptid-Titern in Zellkulturen
CN104411323A (zh) * 2012-04-24 2015-03-11 诺和诺德A/S（股份有限公司） 适用于治疗血友病的药物组合物
KR20160125352A (ko) * 2013-12-20 2016-10-31 이센셜 파마수티컬스 엘엘씨 세포 배양용 배지
JP2018023356A (ja) * 2016-08-04 2018-02-15 三洋化成工業株式会社 有用物質の生産方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5198349A (en) * 1986-01-03 1993-03-30 Genetics Institute, Inc. Method for producing factor VIII:C and analogs
WO1987004187A1 (en) * 1986-01-03 1987-07-16 Genetics Institute, Inc. METHOD FOR PRODUCING FACTOR VIII:c-TYPE PROTEINS
US5250421A (en) * 1986-01-03 1993-10-05 Genetics Institute, Inc. Method for producing factor VIII:C-type proteins
ATE63335T1 (de) * 1986-07-11 1991-05-15 Miles Inc Herstellung von rekombinantem protein.

Also Published As

Publication number Publication date
AU5207196A (en) 1996-11-28
CA2175628A1 (en) 1996-11-05
ATE311447T1 (de) 2005-12-15
EP0745672B1 (de) 2005-11-30
AU710853B2 (en) 1999-09-30
US5952198A (en) 1999-09-14
DE69635504D1 (de) 2006-01-05
EP0745672A3 (de) 1998-05-20
CA2175628C (en) 2007-02-20
EP0745672A2 (de) 1996-12-04
JPH0998796A (ja) 1997-04-15
JP3996655B2 (ja) 2007-10-24

Similar Documents

Publication Publication Date Title
DE69635504D1 (de) Herstellung von rekombinantem Faktor VIII in Gegenwart von Liposom-ähnliche Verbindung-Zusammensetzungen
EP0759694A4 (de) Verfahren zur in-vivo abgabe therapeutischer agenzien mittels liposomen
GR1000247B (el) Σταθεραι λυοφιλιωμεναι διαμορφωσεις περιεχουσαι παραγοντας αναπτυξεως.
NZ216768A (en) Liposome compositions containing a hydrating agent
CA2318566A1 (en) Gelled foods and process for producing the same
HK160895A (en) Complexes of saponins with phospholipids and pharmaceutical and cosmetic compositions containing them
CA2097199A1 (en) Preparation of prothrombin time reagents from recombinant human tissue factor and purified natural and synthetic phospholipids
CA2250219A1 (en) Materials and methods for making improved liposome compositions
NZ306156A (en) Stable protein-phospholipid composition and its use as a carrier
NO975674L (no) Fremgangsmåte for å regulere sialyleringen av proteiner fremstilt av pattedyrceller i kultur
CA2270396A1 (en) Cationic reagents for transfection
ES8607906A1 (es) Procedimiento para la obtencion de composiciones farmaceuti-cas conteniendo liposomas unilamilares
ATE226430T1 (de) Verfahren zur herstellung hydro-monobenzoporhyrin photosensibilisatoren enthaltender liposomen
AP9400683A0 (en) Vaccines.
CA2079685A1 (en) Synthetic membrane vesicles containing functionally active fusion peptides as drug delivery systems
DE3879803D1 (de) Reinigung von faktor viii:c durch phospholipid-affinitaet.
DE69332276T2 (de) Liposomenzusammensetzung
IL75315A0 (en) Vesicle stabilization
AU588994B2 (en) Novel benzodiazepine derivatives and their preparation and use
ES2086802T3 (es) Formulaciones liposomicas de principios activos y procedimiento para su preparacion.
AU9532198A (en) Ribonucleoside-derivative and method for preparing the same
AU2255488A (en) Lipid microemulsions for culture media
ES8701491A1 (es) Procedimiento para la preparacion de substancias secas obte-nibles por liofilizacion
AU629445B2 (en) Improvements in or relating to topical compositions containing 1 alpha 25-dihydroxycholecalciferol
DE69128455T2 (de) Liposomale Mittel sowie Verfahren zu deren Herstellung

Legal Events

Date Code Title Description
8364 No opposition during term of opposition