DE69634003D1 - Hybrid-moleküle aus hitzelabilem enterotoxin und choleratoxin-b-untereinheiten - Google Patents

Hybrid-moleküle aus hitzelabilem enterotoxin und choleratoxin-b-untereinheiten

Info

Publication number
DE69634003D1
DE69634003D1 DE1996634003 DE69634003T DE69634003D1 DE 69634003 D1 DE69634003 D1 DE 69634003D1 DE 1996634003 DE1996634003 DE 1996634003 DE 69634003 T DE69634003 T DE 69634003T DE 69634003 D1 DE69634003 D1 DE 69634003D1
Authority
DE
Germany
Prior art keywords
amino
enterotoxin
pct
ltb
disclosed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE1996634003
Other languages
English (en)
Other versions
DE69634003T2 (de
Inventor
Jan Holmgren
Michael Richard Lebens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Valneva Sweden AB
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of DE69634003D1 publication Critical patent/DE69634003D1/de
Publication of DE69634003T2 publication Critical patent/DE69634003T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE69634003T 1995-05-05 1996-05-02 Hybrid-moleküle aus hitzelabilem enterotoxin und choleratoxin-b-untereinheiten Expired - Lifetime DE69634003T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9501682 1995-05-05
SE9501682A SE9501682D0 (sv) 1995-05-05 1995-05-05 Hybrid molecules between heat-labile enterotoxin and cholera toxin B subunits
PCT/SE1996/000570 WO1996034893A1 (en) 1995-05-05 1996-05-02 Hybrid molecules between heat-labile enterotoxin and cholera toxin b subunits

Publications (2)

Publication Number Publication Date
DE69634003D1 true DE69634003D1 (de) 2005-01-13
DE69634003T2 DE69634003T2 (de) 2005-12-29

Family

ID=20398217

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69634003T Expired - Lifetime DE69634003T2 (de) 1995-05-05 1996-05-02 Hybrid-moleküle aus hitzelabilem enterotoxin und choleratoxin-b-untereinheiten

Country Status (15)

Country Link
US (1) US6019973A (de)
EP (1) EP0824548B1 (de)
JP (1) JP4081140B2 (de)
KR (1) KR100492305B1 (de)
CN (1) CN1154660C (de)
AT (1) ATE284416T1 (de)
AU (1) AU702637B2 (de)
CA (1) CA2219943C (de)
DE (1) DE69634003T2 (de)
DK (1) DK0824548T3 (de)
ES (1) ES2233968T3 (de)
IL (1) IL118136A (de)
PT (1) PT824548E (de)
SE (1) SE9501682D0 (de)
WO (1) WO1996034893A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR19990067153A (ko) * 1995-10-31 1999-08-16 사지게이쪼 프로스타글란딘 디 신타아제에 특이적인 단일클론항체
US7914791B1 (en) * 1998-05-08 2011-03-29 Trident Pharmaceuticals, Inc. Vaccine
AUPQ242899A0 (en) * 1999-08-25 1999-09-16 Aristocrat Leisure Industries Pty Ltd Gaming machine with buy feature games
US7041296B1 (en) * 1999-11-12 2006-05-09 The United States Of America As Represented By The Department Of Health And Human Services Methods of treating inflammatory bowel disease using cholera toxin B subunit
US7063852B2 (en) 2000-05-19 2006-06-20 The Administrators Of The Tulane Educational Fund Hybrid LT-A/CT-B holotoxin for use as an adjuvant
ATE504312T1 (de) * 2003-07-21 2011-04-15 Intervet Int Bv Hybrid-toxine mit shiga-artigen toxin- untereinheiten, verbunden mit escherichia coli wärmeinstabilen enterotoxin-untereinheiten und vakzine daraus
US20090304733A1 (en) * 2004-07-28 2009-12-10 Jacob Pitcovski Vaccine comprising recombinant ct or lt toxin
WO2013037397A1 (en) 2011-09-12 2013-03-21 Scandinavian Biopharma Holding Ab Vaccine for protection against etec induced diarrhea comprising dmlt.
JP6828949B2 (ja) 2015-11-30 2021-02-10 出光興産株式会社 免疫原性が増強されたワクチン抗原
CN113813398B (zh) * 2021-04-23 2023-11-07 天津医科大学 一种向表面富含神经节苷脂的细胞递送重组蛋白质的方法
CN114409804B (zh) * 2022-01-07 2022-10-21 湖北神地生物科技有限公司 一种大肠杆菌肠毒素多表位融合蛋白及其制备方法和应用
CN114456240B (zh) * 2022-03-04 2023-08-15 青岛农业大学 一种非洲猪瘟病毒基因工程亚单位口服疫苗

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4758655A (en) * 1983-01-03 1988-07-19 Scripps Clinic And Research Foundation Synthetic polypeptide corresponding to a portion of the heat-labile enterotoxin of escherichia coli, compositions and methods of therewith

Also Published As

Publication number Publication date
KR100492305B1 (ko) 2006-01-12
JPH11504811A (ja) 1999-05-11
ATE284416T1 (de) 2004-12-15
US6019973A (en) 2000-02-01
CA2219943A1 (en) 1996-11-07
CN1154660C (zh) 2004-06-23
DE69634003T2 (de) 2005-12-29
AU5708596A (en) 1996-11-21
IL118136A (en) 2006-04-10
DK0824548T3 (da) 2005-04-11
JP4081140B2 (ja) 2008-04-23
WO1996034893A1 (en) 1996-11-07
ES2233968T3 (es) 2005-06-16
SE9501682D0 (sv) 1995-05-05
KR19990008290A (ko) 1999-01-25
AU702637B2 (en) 1999-02-25
IL118136A0 (en) 1996-09-12
CN1189840A (zh) 1998-08-05
PT824548E (pt) 2005-04-29
EP0824548A1 (de) 1998-02-25
CA2219943C (en) 2010-10-12
EP0824548B1 (de) 2004-12-08

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: CRUCELL SWEDEN AB, SOLNA, SE

8381 Inventor (new situation)

Inventor name: HOLMGREN, JAN, S-421 74 VAESTRA FROELUNDA, SE

Inventor name: LEBENS, MICHAEL RICHARD, 413 22 GOETEBORG, SE