DE69632728D1 - 1,4-disubstituierte piperidinderivate - Google Patents

1,4-disubstituierte piperidinderivate

Info

Publication number
DE69632728D1
DE69632728D1 DE69632728T DE69632728T DE69632728D1 DE 69632728 D1 DE69632728 D1 DE 69632728D1 DE 69632728 T DE69632728 T DE 69632728T DE 69632728 T DE69632728 T DE 69632728T DE 69632728 D1 DE69632728 D1 DE 69632728D1
Authority
DE
Germany
Prior art keywords
group
diseases
digestive
disubstituted
urination
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69632728T
Other languages
English (en)
Other versions
DE69632728T2 (de
Inventor
Yoshimi Tsuchiya
Takashi Nomoto
Hirokazu Ohsawa
Kumiko Kawakami
Kenji Ohwaki
Masaru Nishikibe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSD KK
Original Assignee
Banyu Phamaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Phamaceutical Co Ltd filed Critical Banyu Phamaceutical Co Ltd
Publication of DE69632728D1 publication Critical patent/DE69632728D1/de
Application granted granted Critical
Publication of DE69632728T2 publication Critical patent/DE69632728T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69632728T 1995-04-28 1996-04-25 1,4-disubstituierte piperidinderivate Expired - Lifetime DE69632728T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP12982795 1995-04-28
JP12982795 1995-04-28
PCT/JP1996/001128 WO1996033973A1 (fr) 1995-04-28 1996-04-25 Derives disubstitues en position 1,4 de piperidine

Publications (2)

Publication Number Publication Date
DE69632728D1 true DE69632728D1 (de) 2004-07-22
DE69632728T2 DE69632728T2 (de) 2004-10-14

Family

ID=15019212

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69632728T Expired - Lifetime DE69632728T2 (de) 1995-04-28 1996-04-25 1,4-disubstituierte piperidinderivate

Country Status (8)

Country Link
US (1) US5750540A (de)
EP (1) EP0823423B1 (de)
KR (1) KR19990008109A (de)
AT (1) ATE269305T1 (de)
AU (1) AU700837B2 (de)
CA (1) CA2218479C (de)
DE (1) DE69632728T2 (de)
WO (1) WO1996033973A1 (de)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2179574A1 (en) * 1995-06-26 1996-12-27 Tomomi Okada Substituted piperidine derivative and medicine comprising the same
AU7145996A (en) * 1995-10-13 1997-04-30 Banyu Pharmaceutical Co., Ltd. Substituted heteroaromatic derivatives
AU2793197A (en) * 1996-05-31 1998-01-05 Banyu Pharmaceutical Co., Ltd. 1,4-disubstituted piperidine derivatives
PE92198A1 (es) * 1996-08-01 1999-01-09 Banyu Pharma Co Ltd Derivados de 1,4-piperidina disustituida que contienen fluor
NZ336202A (en) * 1996-11-11 2000-10-27 Christian R Noe Pure enantiomer aryl-cycloalkyl-hydroxycarboxylic acid esters and use in treating smooth muscle spasms and respiritory diseases
KR19990037220A (ko) * 1997-10-31 1999-05-25 타이도 나오카타 아릴아세트산 아미드 유도체 또는 그 염 및 이를 함유하는 의약
KR20010043032A (ko) * 1998-04-28 2001-05-25 도모따께 다께시 1-[(1-치환-4-피페리디닐)메틸]-4-피페리딘 유도체, 그의제조방법, 그것을 함유하는의약조성물 및 이 화합물의중간체
US6180823B1 (en) 1998-11-06 2001-01-30 Sepracor Inc. Stereoselective process for alkyl phenylglycolic acids
DE19933926A1 (de) * 1999-07-20 2001-01-25 Boehringer Ingelheim Pharma Biphenylderivate, ihre Herstellung und ihre Verwendung als Arzneimittel
US6809108B1 (en) 1999-07-23 2004-10-26 Banyu Pharmaceutical Co., Ltd. Amide derivatives
US6403818B1 (en) 2000-02-28 2002-06-11 Eisai Co., Ltd. Process for producing α-hydroxy-carbonyl compound
US6846835B2 (en) * 2000-07-11 2005-01-25 Banyu Pharmaceutical Co., Ltd. Ester derivatives
CA2472711C (en) 2002-01-18 2012-03-20 Yamanouchi Pharmaceutical Co., Ltd. 2-acylaminothiazole derivative or salt thereof
US7084153B2 (en) 2002-04-12 2006-08-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments comprising steroids and a novel anticholinergic
DE10216429A1 (de) * 2002-04-12 2003-10-23 Boehringer Ingelheim Pharma Arzneimittel enthaltend Steroide und ein neues Anticholinergikum
MXPA05000434A (es) * 2002-07-08 2005-04-19 Ranbaxy Lab Ltd Derivados de hexano [3.1.0] azabiciclo 3,6-disustituido utiles como antagonistas de receptor muscarinico.
WO2004014853A1 (en) 2002-07-31 2004-02-19 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists
EP1545508A4 (de) 2002-08-09 2009-11-25 Ranbaxy Lab Ltd 3,6-disubstituierte azabicyclo ¬3.1.0 hexan-derivate als muscarinische rezeptor-antagonisten
EP1534675B1 (de) 2002-08-23 2009-02-25 Ranbaxy Laboratories, Ltd. Fluor- und sulfonylaminohaltige, 3,6-disubstituierte azabicyclo¬3.1.0 hexanderivate als muscarinrezeptorantagonisten
TW200800953A (en) * 2002-10-30 2008-01-01 Theravance Inc Intermediates for preparing substituted 4-amino-1-(pyridylmethyl) piperidine
EP1572648B1 (de) 2002-12-10 2008-07-09 Ranbaxy Laboratories, Ltd. 3,6-disubstituierte azabicyclo ¬3.1.0 -hexanderivative als antagonisten des muscarinrezeptors
AU2002347552A1 (en) 2002-12-23 2004-07-14 Ranbaxy Laboratories Limited 1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists
ATE386738T1 (de) 2002-12-23 2008-03-15 Ranbaxy Lab Ltd Flavaxat-derivate als muscarin-rezeptor antagonisten
US7488748B2 (en) * 2003-01-28 2009-02-10 Ranbaxy Laboratories Limited 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists
AU2003205964A1 (en) * 2003-02-07 2004-08-30 Ranbaxy Laboratories Limited Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
WO2004089898A1 (en) * 2003-04-09 2004-10-21 Ranbaxy Laboratories Limited Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
ATE362364T1 (de) 2003-04-10 2007-06-15 Ranbaxy Lab Ltd Substituierte azabicyclo hexane derivate als muscarin rezeptor antagonisten
WO2004089899A1 (en) 2003-04-10 2004-10-21 Ranbaxy Laboratories Limited Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
CN100436414C (zh) * 2003-04-11 2008-11-26 兰贝克赛实验室有限公司 作为毒蕈碱受体拮抗剂的氮杂双环衍生物
TW200510298A (en) * 2003-06-13 2005-03-16 Theravance Inc Substituted pyrrolidine and related compounds
AR044851A1 (es) * 2003-06-24 2005-10-05 Novartis Ag Compuestos heterociclicos, antagonistas del receptor m3 muscarinico
WO2005007645A1 (en) * 2003-07-11 2005-01-27 Theravance, Inc. Substituted 4-amino-1-benzylpiperidine compounds
WO2005082253A1 (en) * 2004-02-20 2005-09-09 Philips Intellectual Property & Standards Gmbh Drug application during a ct scan
US7250414B2 (en) * 2004-03-11 2007-07-31 Theravance, Inc. Diphenylmethyl compounds useful as muscarinic receptor antagonists
EP1725525A1 (de) * 2004-03-11 2006-11-29 Theravance, Inc. Als muscarinrezeptorantagonisten geeignete diphenylmethylverbindungen
TW200540154A (en) * 2004-06-10 2005-12-16 Theravance Inc Crystalline form of a substituted pyrrolidine compound
US20070014819A1 (en) * 2005-07-13 2007-01-18 Weckteck Biotechnology Company Limited Method of emulsifying phytosterol by natural saponin,emulsion prepared thereby and water dispersible phytosterol powder product
CA2626612A1 (en) 2005-10-19 2007-04-26 Ranbaxy Laboratories Limited Pharmaceutical compositions of muscarinic receptor antagonists
KR20080074166A (ko) * 2005-11-08 2008-08-12 아스테라스 세이야쿠 가부시키가이샤 혈소판감소증을 치료하는 조성물 및 방법
EP1968980A1 (de) * 2005-12-30 2008-09-17 Ranbaxy Laboratories, Ltd. Muscarin-rezeptor-antagonisten
ES2452032T3 (es) * 2006-08-08 2014-03-31 Akarx, Inc. Composiciones y métodos para aumentar los niveles de plaquetas de la sangre en humanos
PL2283006T3 (pl) * 2008-04-24 2015-08-31 F2G Ltd Pirolowe środki przeciwgrzybicze
US8263623B2 (en) 2008-07-11 2012-09-11 Pfizer Inc. Triazol derivatives useful for the treatment of diseases
EP2464352A1 (de) * 2009-08-14 2012-06-20 Eisai Inc. Verwendung von e5501 zur anregung der thrombozytenproduktion
EP2632903A4 (de) * 2010-10-28 2014-11-26 Viamet Pharmaceuticals Inc Metalloenzymhemmerverbindungen
RU2016152499A (ru) 2014-05-30 2018-07-04 Драг Дискавери Ресеч Сентэ Новые соединения в качестве противотуберкулезных препаратов
CN111096967B (zh) 2014-11-21 2023-03-10 F2G有限公司 抗真菌剂
GB201609222D0 (en) 2016-05-25 2016-07-06 F2G Ltd Pharmaceutical formulation
US11819503B2 (en) 2019-04-23 2023-11-21 F2G Ltd Method of treating coccidioides infection

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4022787A (en) * 1975-07-18 1977-05-10 Carter-Wallace, Inc. Anticholinergic ester and salts thereof
US4721722A (en) * 1985-07-12 1988-01-26 United Pharmaceuticals, Inc. Anti-spasmodic agents containing quaternary nitrogen
IT1231238B (it) * 1987-09-21 1991-11-26 Angeli Inst Spa Derivati ammidinici
US4843074A (en) * 1988-05-17 1989-06-27 Marion Laboratories, Inc. 1-azabicyclo[2.2.2]octan-3-yl 2-aryl-3-azacyclo-2-hydroxypropionates and their quaternary salts
US5482940A (en) * 1988-05-24 1996-01-09 American Home Products Corporation Use of aryl- and heteroaryl piperazinyl carboxamides in the treatment of various central nervous system disorders
US5066680A (en) * 1989-02-14 1991-11-19 Fujisawa Pharmaceutical Co., Ltd. Novel substituted-acetamide compound and a process for the preparation thereof
JP3026845B2 (ja) * 1991-02-20 2000-03-27 日清製粉株式会社 ピペリジン誘導体
GB9202443D0 (en) * 1992-02-05 1992-03-18 Fujisawa Pharmaceutical Co A novel substituted-acetamide compound and a process for the preparation thereof
CA2179574A1 (en) * 1995-06-26 1996-12-27 Tomomi Okada Substituted piperidine derivative and medicine comprising the same

Also Published As

Publication number Publication date
ATE269305T1 (de) 2004-07-15
CA2218479C (en) 2008-01-15
DE69632728T2 (de) 2004-10-14
KR19990008109A (ko) 1999-01-25
AU700837B2 (en) 1999-01-14
EP0823423A4 (de) 1998-09-02
CA2218479A1 (en) 1996-10-31
AU5513996A (en) 1996-11-18
EP0823423B1 (de) 2004-06-16
EP0823423A1 (de) 1998-02-11
WO1996033973A1 (fr) 1996-10-31
US5750540A (en) 1998-05-12

Similar Documents

Publication Publication Date Title
DE69632728D1 (de) 1,4-disubstituierte piperidinderivate
ATE205490T1 (de) Substituierte heteroaromatische derivate
NO973027L (no) Nye kinuklidinderivater og medisinsk preparat
NO303778B1 (no) Sulfonamid-derivat eller sulfonester-derivat, middel og preparat omfattende et slikt derivat, anvendelse derav samt mellomprodukt
NO944911L (no) Ikke-peptid-takykininreseptorantagonister
NO942452D0 (no) Amid- og ureaderivater med antihyperkolesteremisk aktivitet, deres fremstilling og terapeutiske anvendelser
DE69203797D1 (de) Amidino-Verbindungen, ihre Herstellung und Verwendung als Arzneimittel.
ATE109484T1 (de) Thienopyridin -derivative und diese enthaltende arzneimittel.
NO944915D0 (no) Öking av trambomodulinekspresjon
NO20014119D0 (no) Medikament inneholdende et sulfopyranosylacylglycerolderivat
ES2129123T3 (es) Nuevo derivado de bisoxadiazolidina.
DE69617226T2 (de) Piperidinderivate.
HU9600621D0 (en) Imidazolidinone derivative, acid-addition salt thereof, and remedy for senile dementia
AU650079B2 (en) 1,3-dioxolane derivatives as cholesterol-lowering agents
GR3022450T3 (en) Piperidine derivatives with antihistaminic and antileukohienic activity.
DE69300318T2 (de) Flavonderivate.
ATE257826T1 (de) Benzimidazolderivate und sie enthaltende medikamente

Legal Events

Date Code Title Description
8364 No opposition during term of opposition