DE69631540D1 - Materialien und methoden mit bezug zur identifizierung und sequenzierung des krebs-suszeptilitaetsgens brca2 und dessen anwendungen - Google Patents

Materialien und methoden mit bezug zur identifizierung und sequenzierung des krebs-suszeptilitaetsgens brca2 und dessen anwendungen

Info

Publication number
DE69631540D1
DE69631540D1 DE69631540T DE69631540T DE69631540D1 DE 69631540 D1 DE69631540 D1 DE 69631540D1 DE 69631540 T DE69631540 T DE 69631540T DE 69631540 T DE69631540 T DE 69631540T DE 69631540 D1 DE69631540 D1 DE 69631540D1
Authority
DE
Germany
Prior art keywords
brca2
cancer
sequencing
identification
susceptility
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Revoked
Application number
DE69631540T
Other languages
English (en)
Other versions
DE69631540T2 (de
Inventor
Phillip Andrew Futreal
Richard Francis Wooster
Alan Ashworth
Rudolf Stratton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Durham
Cancer Research Technology Ltd
Duke University
Original Assignee
University of Durham
Cancer Research Technology Ltd
Duke University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27267991&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69631540(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9523959.6A external-priority patent/GB9523959D0/en
Priority claimed from GBGB9525555.0A external-priority patent/GB9525555D0/en
Priority claimed from GBGB9617961.9A external-priority patent/GB9617961D0/en
Application filed by University of Durham, Cancer Research Technology Ltd, Duke University filed Critical University of Durham
Publication of DE69631540D1 publication Critical patent/DE69631540D1/de
Application granted granted Critical
Publication of DE69631540T2 publication Critical patent/DE69631540T2/de
Anticipated expiration legal-status Critical
Revoked legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
DE69631540T 1995-11-23 1996-11-25 Materialien und methoden mit bezug zur identifizierung und sequenzierung des krebs-suszeptilitaetsgens brca2 und dessen anwendungen Revoked DE69631540T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GBGB9523959.6A GB9523959D0 (en) 1995-11-23 1995-11-23 Materials and methods relating to the diagnosis and prophylactic and therapeutic treatment of cancer
GB9523959 1995-11-23
GBGB9525555.0A GB9525555D0 (en) 1995-12-14 1995-12-14 Materials and methods relating to the diagnosis and prophylactic and therapeutic treatment of cancer
GB9525555 1995-12-14
GBGB9617961.9A GB9617961D0 (en) 1996-08-28 1996-08-28 Materials and methods relating to the diagnosis and prophylactic and therapeuti treatment of cancer
GB9617961 1996-08-28
PCT/GB1996/002904 WO1997019110A1 (en) 1995-11-23 1996-11-25 Materials and methods relating to the identification and sequencing of the brca2 cancer susceptibility gene and uses thereof

Publications (2)

Publication Number Publication Date
DE69631540D1 true DE69631540D1 (de) 2004-03-18
DE69631540T2 DE69631540T2 (de) 2005-01-27

Family

ID=27267991

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69631540T Revoked DE69631540T2 (de) 1995-11-23 1996-11-25 Materialien und methoden mit bezug zur identifizierung und sequenzierung des krebs-suszeptilitaetsgens brca2 und dessen anwendungen

Country Status (10)

Country Link
US (1) US6045997A (de)
EP (1) EP0858467B1 (de)
JP (1) JP2001507563A (de)
AT (1) ATE259378T1 (de)
AU (1) AU707636C (de)
CA (1) CA2238010A1 (de)
DE (1) DE69631540T2 (de)
DK (1) DK0858467T3 (de)
ES (1) ES2217328T3 (de)
WO (1) WO1997019110A1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
IL124620A0 (en) * 1995-12-18 1998-12-06 Myriad Genetics Inc Chromosome 13-linked breast cancer susceptibility gene
AU773601B2 (en) * 1995-12-18 2004-05-27 Endorecherche Inc. Chromosome 13-linked breast cancer susceptibility gene
US5837492A (en) 1995-12-18 1998-11-17 Myriad Genetics, Inc. Chromosome 13-linked breast cancer susceptibility gene
US6838256B2 (en) 1996-02-12 2005-01-04 Gene Logic Inc. Coding sequences of the human BRCA1 gene
US20030022184A1 (en) * 1996-02-12 2003-01-30 Oncormed. Inc. Coding sequences of the human BRCA1 gene
EP0972078B1 (de) * 1997-03-20 2005-06-01 Affymetrix, Inc. (a California Corporation) Iterative resequenzierung
EP2275575A3 (de) * 1997-08-15 2012-07-11 Gene Logic Inc. Menschliche BRCA2-Gen-kodierende Sequenzhaplotypen
US20090269814A1 (en) * 1998-05-22 2009-10-29 Murphy Patricia D Method of Analyzing a BRCA2 Gene in a Human Subject
US20140302494A9 (en) * 1997-08-15 2014-10-09 Myriad Genetics, Incorporated Method of analyzing a brca2 gene in a human subject
US6207370B1 (en) 1997-09-02 2001-03-27 Sequenom, Inc. Diagnostics based on mass spectrometric detection of translated target polypeptides
US6492109B1 (en) 1997-09-23 2002-12-10 Gene Logic, Inc. Susceptibility mutation 6495delGC of BRCA2
US6686163B2 (en) 1998-05-06 2004-02-03 Gene Logic Inc. Coding sequence haplotype of the human BRCA1 gene
US6562958B1 (en) * 1998-06-09 2003-05-13 Genome Therapeutics Corporation Nucleic acid and amino acid sequences relating to Acinetobacter baumannii for diagnostics and therapeutics
US20030180789A1 (en) * 1998-12-30 2003-09-25 Dale Roderic M.K. Arrays with modified oligonucleotide and polynucleotide compositions
US6087112A (en) * 1998-12-30 2000-07-11 Oligos Etc. Inc. Arrays with modified oligonucleotide and polynucleotide compositions
MXPA01008605A (es) * 1999-02-24 2003-06-24 Juan Saus Proteina de enlace del antigeno goodpasture.
AU784861B2 (en) 1999-10-21 2006-07-06 Case Western Reserve University Gene expression profiling of inflammatory bowel disease
AT409381B (de) * 2000-03-03 2002-07-25 Gloessl Josef Dr Xylosyltransferase-gen
US6727353B2 (en) * 2000-04-14 2004-04-27 Icagen, Inc. Nucleic acid encoding Kv10.1, a voltage-gated potassium channel from human brain
EP1370684B1 (de) 2000-06-15 2008-05-28 Novartis Vaccines and Diagnostics, Inc. Polynukleotide zur bestimmung von kolonkrebs
WO2002004628A2 (en) * 2000-07-06 2002-01-17 Genvec, Inc. Method of identifying a binding partner of a gene product
EP1299950B1 (de) 2000-07-13 2008-05-21 CT-Concept Technologie AG Verfahren und vorrichtung zur zustandsabhängigen regelung des transienten verhaltens von leistungshalbleiterschaltern
US20030175749A1 (en) * 2001-12-08 2003-09-18 Jong-Yoon Chun Annealing control primer and its uses
WO2003104429A2 (en) * 2002-06-10 2003-12-18 Idec Pharmaceuticals Corporation Genes overexpressed by ovarian cancer and their use in developing novel therapeutics
US7461048B2 (en) * 2003-07-21 2008-12-02 Aureon Laboratories, Inc. Systems and methods for treating, diagnosing and predicting the occurrence of a medical condition
US8759089B2 (en) * 2007-02-06 2014-06-24 Geneprotech, Inc. Methods and systems for high homologous recombination (“HR”) targeting efficiency
US7892823B2 (en) * 2007-02-06 2011-02-22 Geneprotech, Inc. Methods and systems for high homologous recombination (“HR”) targeting efficiency
US20130058979A1 (en) * 2009-11-30 2013-03-07 Agency For Science, Technology And Research Treatment and prevention of cancers associated with intracellular oncoproteins by antibody therapy or vaccination
CN106460060B (zh) 2014-04-04 2020-02-11 中美冠科生物技术（太仓）有限公司 Hnf4g-rspo2融合基因及其在癌症治疗中的用途
US11773449B2 (en) 2017-09-01 2023-10-03 The Hospital For Sick Children Profiling and treatment of hypermutant cancer
CN116179710B (zh) * 2023-03-14 2023-11-24 成都诺森医学检验有限公司 基于高通量测序平台的brca1/2基因突变检测的引物组、文库构建与环化方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0393502B1 (de) * 1989-04-19 1995-12-27 F. Hoffmann-La Roche Ag Auflösbare Interferon-gamma-Rezeptoren sowie Verfahren zu deren Herstellung
US5464758A (en) * 1993-06-14 1995-11-07 Gossen; Manfred Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters
WO1995019369A1 (en) * 1994-01-14 1995-07-20 Vanderbilt University Method for detection and treatment of breast cancer
WO1995019360A1 (fr) * 1994-01-14 1995-07-20 Taisho Pahrmaceutical Co., Ltd. Derive de thiazoline

Also Published As

Publication number Publication date
AU707636C (en) 2003-01-16
WO1997019110A1 (en) 1997-05-29
AU707636B2 (en) 1999-07-15
AU7635096A (en) 1997-06-11
CA2238010A1 (en) 1997-05-29
ATE259378T1 (de) 2004-02-15
EP0858467B1 (de) 2004-02-11
DE69631540T2 (de) 2005-01-27
JP2001507563A (ja) 2001-06-12
US6045997A (en) 2000-04-04
ES2217328T3 (es) 2004-11-01
EP0858467A1 (de) 1998-08-19
DK0858467T3 (da) 2004-06-14

Similar Documents

Publication Publication Date Title
DE69631540D1 (de) Materialien und methoden mit bezug zur identifizierung und sequenzierung des krebs-suszeptilitaetsgens brca2 und dessen anwendungen
EP0796913A3 (de) GDP-Dissoziation stimulierendes Protein, gehirnspezifisches Nucleosomfügungsprotein, Skelettmuskel-spezifisches Ubiquitin-Conjugationsenzym, Zellproliferationsprotein, Phosphatidylinositolkinase, Nel verwandte Proteine
DK1005540T3 (da) IKK-beta-proteiner, nukleinsyrer og fremgangsmåder
ATE280226T1 (de) Genetische marker für brust und eierstockkrebs
SI0917571T1 (en) Agouti-related gene
ATE418563T1 (de) Nik proteine, nukleinsäure sowie verfahren
ATE468394T1 (de) Vermischen von heterologen dns-sequenzen
WO1999053061A3 (en) Tumor associated nucleic acids and uses therefor
DE69634912D1 (de) Intrazellulare domäne des her-2/neu proteins, für die prevention oder behandlung von bösartigen tumoren
DE69707985D1 (de) Kodierende sequenzen des menschlichen brca1-gens
ATE209684T1 (de) Dna-sequenzen für matrix-metallproteasen, ihre herstellung und verwendung
DE69933998D1 (de) Verbindungen und verfahren für therapie und diagnose von lungenkrebs
DE3650266D1 (de) DNS-Sequenzen, rekombinante DNS-Moleküle und Verfahren zur Herstellung von "mullerian inhibiting substance"-ähnlichen Polypeptiden.
NZ279963A (en) Human tissue inhibitor of metalloproteinase-4 (timp-4) and dna (rna) encoding polypeptide which may be derived from atcc 75946
WO1999053040A3 (de) Menschliche nukleinsäuresequenzen aus ovartumorgewebe
EE200100472A (et) Polüpeptiid, antikehad, lahustuv polüpeptiid, polü- või oligonukleotiid ja meetod diferentsiaalseltekspresseerunud DNA järjestuste spetsiifiliseks identifitseerimiseks
HUP9800377A1 (hu) Új növekedési faktor és ezt kódoló génszekvencia
ATE295878T1 (de) Kabeljau-spezifische urazil-dna glykosilase, dafür kodierendes gen, selbiges gen beinhaltende, rekombinante dna oder operative teile davon, ein verfahren zur herstellung des proteins und die anwendung des protein oder der operativen teile zur überwachung und kontrolle der pcr
EP1005539A4 (de) Ikk-alpha proteine, nukleinsäuren und verfahren
EP1100815A4 (de) Von protease typ ii spaltbares peptid
WO2004076614A3 (de) Humane nukleinsäuresequenzen aus prostatakarzinomen
HK1052026A1 (en) Human enzymes of the metalloprotease family
DE69931759D1 (de) Methode zur erstellung von genexpressionsprofilen
EP0960128A4 (de) In Krebszellen überexprimiertes Genprodukt
WO2005049818A3 (en) Genes encoding human deubiquitinating enzymes

Legal Events

Date Code Title Description
8363 Opposition against the patent
8331 Complete revocation