DE69626276T2 - Tetronsäurederivate zur behandlung von hiv- und anderen retroviruserkrankungen - Google Patents

Tetronsäurederivate zur behandlung von hiv- und anderen retroviruserkrankungen

Info

Publication number
DE69626276T2
DE69626276T2 DE69626276T DE69626276T DE69626276T2 DE 69626276 T2 DE69626276 T2 DE 69626276T2 DE 69626276 T DE69626276 T DE 69626276T DE 69626276 T DE69626276 T DE 69626276T DE 69626276 T2 DE69626276 T2 DE 69626276T2
Authority
DE
Germany
Prior art keywords
acid derivatives
pct
treating hiv
tetronic acid
retrovirus diseases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69626276T
Other languages
English (en)
Other versions
DE69626276D1 (de
Inventor
Robert A Chrusciel
Linda Louise Maggiora
Suvit Thaisrivongs
James Michael Tustin
Clark William Smith
Ruben Tommasi
Paul Adrian Aristoff
Harvey Irving Skulnick
W Jeffrey Howe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Pharmacia and Upjohn Co
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co, Upjohn Co filed Critical Pharmacia and Upjohn Co
Application granted granted Critical
Publication of DE69626276D1 publication Critical patent/DE69626276D1/de
Publication of DE69626276T2 publication Critical patent/DE69626276T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/60—Two oxygen atoms, e.g. succinic anhydride
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69626276T 1995-03-20 1996-03-07 Tetronsäurederivate zur behandlung von hiv- und anderen retroviruserkrankungen Expired - Fee Related DE69626276T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40732295A 1995-03-20 1995-03-20
PCT/US1996/002680 WO1996029333A1 (en) 1995-03-20 1996-03-07 Substituted tetronic acids useful for treating hiv and other retroviruses

Publications (2)

Publication Number Publication Date
DE69626276D1 DE69626276D1 (de) 2003-03-27
DE69626276T2 true DE69626276T2 (de) 2003-11-13

Family

ID=23611540

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69626276T Expired - Fee Related DE69626276T2 (de) 1995-03-20 1996-03-07 Tetronsäurederivate zur behandlung von hiv- und anderen retroviruserkrankungen

Country Status (11)

Country Link
US (1) US6060600A (de)
EP (1) EP0817786B1 (de)
JP (1) JPH11503416A (de)
AT (1) ATE232867T1 (de)
AU (1) AU5417696A (de)
DE (1) DE69626276T2 (de)
DK (1) DK0817786T3 (de)
ES (1) ES2191095T3 (de)
PT (1) PT817786E (de)
SI (1) SI0817786T1 (de)
WO (1) WO1996029333A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9603097D0 (en) * 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline compounds
JP3726684B2 (ja) * 2001-01-11 2005-12-14 株式会社Ｋｄｄｉ研究所 動画像データ転送における輻輳を回避する通信システム
DE102006039912A1 (de) * 2006-08-25 2008-03-20 Bayer Healthcare Ag Substituierte Spirotetronsäuren und ihre Verwendung
DE102006059319A1 (de) * 2006-12-15 2008-06-19 Bayer Healthcare Ag Substituierte Aminofuranone und ihre Verwendung

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA852614B (en) * 1985-05-17 1986-10-09 Takeda Chemical Industries, Ltd. Ascorbic acid ethers and their production
JP2515556B2 (ja) * 1986-08-29 1996-07-10 武田薬品工業株式会社 ヒドロキシブテノライド誘導体およびその製造法
DE68901024D1 (de) * 1988-10-20 1992-04-23 Shionogi & Co Gegen anaerobe bakterien wirksame antibiotika, ihre produktion und enterobakter-staemme, die sie produzieren.
JP3156006B2 (ja) * 1990-07-30 2001-04-16 武田薬品工業株式会社 テトロン酸誘導体、その製造法及び用途
EP0480624A1 (de) * 1990-10-11 1992-04-15 Merck & Co. Inc. HIV Protease Hemmstoffe
WO1993004055A2 (en) * 1991-08-27 1993-03-04 The Upjohn Company Compounds used for the inhibition of hiv-protease
DE69226487T2 (de) * 1991-09-26 1999-02-18 Nippon Zoki Pharmaceutical Co Verwendung von Furanonderivaten zur Vorbeugung oder Behandlung von Autoimmunkrankheiten
ZA938019B (en) * 1992-11-13 1995-04-28 Upjohn Co Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating HIV and other retroviruses
IL108459A0 (en) * 1993-02-05 1994-04-12 Opjohn Company 4-Hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl [B] pyran-2-ones useful for treating infections due to hiv and other retroviruses
US5977169A (en) * 1993-09-17 1999-11-02 Chrusciel; Robert A. Substituted tetronic acids useful for treating HIV and other retroviruses

Also Published As

Publication number Publication date
PT817786E (pt) 2003-06-30
ES2191095T3 (es) 2003-09-01
AU5417696A (en) 1996-10-08
SI0817786T1 (en) 2003-08-31
US6060600A (en) 2000-05-09
DE69626276D1 (de) 2003-03-27
JPH11503416A (ja) 1999-03-26
ATE232867T1 (de) 2003-03-15
EP0817786B1 (de) 2003-02-19
EP0817786A1 (de) 1998-01-14
WO1996029333A1 (en) 1996-09-26
DK0817786T3 (da) 2003-05-26

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee