DE69623786T2 - Mch2, EINE APOPTOTISCHE CYSTEIN-PROTEASE, ZUSAMMENSETZUNGEN FÜR IHRE PRÄPARATION UND METHODEN FÜR IHRE VERWENDUNG - Google Patents

Mch2, EINE APOPTOTISCHE CYSTEIN-PROTEASE, ZUSAMMENSETZUNGEN FÜR IHRE PRÄPARATION UND METHODEN FÜR IHRE VERWENDUNG

Info

Publication number
DE69623786T2
DE69623786T2 DE69623786T DE69623786T DE69623786T2 DE 69623786 T2 DE69623786 T2 DE 69623786T2 DE 69623786 T DE69623786 T DE 69623786T DE 69623786 T DE69623786 T DE 69623786T DE 69623786 T2 DE69623786 T2 DE 69623786T2
Authority
DE
Germany
Prior art keywords
mch2
disclosed
alpha
beta
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69623786T
Other languages
English (en)
Other versions
DE69623786D1 (de
Inventor
Gerald Litwack
S Alnemri
Teresa Fernandez-Alnemri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Thomas Jefferson University
Original Assignee
Thomas Jefferson University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomas Jefferson University filed Critical Thomas Jefferson University
Application granted granted Critical
Publication of DE69623786D1 publication Critical patent/DE69623786D1/de
Publication of DE69623786T2 publication Critical patent/DE69623786T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • C12N9/6475—Interleukin 1-beta convertase-like enzymes (3.4.22.10; 3.4.22.36; 3.4.22.63)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Detergent Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69623786T 1995-05-18 1996-05-16 Mch2, EINE APOPTOTISCHE CYSTEIN-PROTEASE, ZUSAMMENSETZUNGEN FÜR IHRE PRÄPARATION UND METHODEN FÜR IHRE VERWENDUNG Expired - Lifetime DE69623786T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/446,925 US5672500A (en) 1995-05-18 1995-05-18 Mch2, an apoptotic cysteine protease, and compositions for making and methods of using the same
PCT/US1996/007010 WO1996036698A1 (en) 1995-05-18 1996-05-16 Mch2, AN APOPTOTIC CYSTEINE PROTEASE, AND COMPOSITIONS FOR MAKING AND METHODS OF USING THE SAME

Publications (2)

Publication Number Publication Date
DE69623786D1 DE69623786D1 (de) 2002-10-24
DE69623786T2 true DE69623786T2 (de) 2003-05-15

Family

ID=23774339

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69623786T Expired - Lifetime DE69623786T2 (de) 1995-05-18 1996-05-16 Mch2, EINE APOPTOTISCHE CYSTEIN-PROTEASE, ZUSAMMENSETZUNGEN FÜR IHRE PRÄPARATION UND METHODEN FÜR IHRE VERWENDUNG

Country Status (8)

Country Link
US (4) US5672500A (de)
EP (1) EP0842267B1 (de)
JP (1) JPH11505705A (de)
AT (1) ATE224443T1 (de)
CA (1) CA2221409C (de)
DE (1) DE69623786T2 (de)
ES (1) ES2183960T3 (de)
WO (1) WO1996036698A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6060238A (en) * 1995-02-13 2000-05-09 The Regents Of The University Of Michigan Method and composition for regulating apoptosis
US6015665A (en) * 1995-02-13 2000-01-18 The Regents Of The University Of Michigan Method and composition for regulating apoptosis
US7097972B1 (en) 1995-02-13 2006-08-29 Regents Of The University Of Michigan Method and composition for regulating apoptosis
US7807783B1 (en) 1995-04-03 2010-10-05 The Regents Of The University Of Michigan Methods and compositions for regulating FAS-associated apoptosis
US6747138B1 (en) 1995-04-03 2004-06-08 Regents Of The University Of Michigan Methods and compositions for regulating Fas-associated apoptosis
US5672500A (en) * 1995-05-18 1997-09-30 Thomas Jefferson University Mch2, an apoptotic cysteine protease, and compositions for making and methods of using the same
US6635738B2 (en) * 1996-03-04 2003-10-21 The Trustees Of Columbia University In The City Of New York Compounds which prevent neuronal cell death and uses thereof
US6558900B2 (en) * 1996-07-12 2003-05-06 Emory University Regulation of apoptosis and in vitro model for studies thereof
JP4777489B2 (ja) * 1997-03-31 2011-09-21 ザ チルドレンズ メディカル センター コーポレーション アポトーシス性酵素を不活性化するためのニトロシル化
US6455296B2 (en) * 1997-05-29 2002-09-24 Thomas Jefferson University Apoptotic protease Mch6, nucleic acids encoding same and methods of use
US6270980B1 (en) * 1997-06-05 2001-08-07 Idun Pharmaceuticals, Inc. Rapid methods for identifying modifiers of cellular apoptosis activity
CN1300828A (zh) * 1999-12-22 2001-06-27 上海博德基因开发有限公司 一种新的多肽－半胱氨酸蛋白酶10和编码这种多肽的多核苷酸
US6566135B1 (en) * 2000-10-04 2003-05-20 Isis Pharmaceuticals, Inc. Antisense modulation of caspase 6 expression
DE10241152A1 (de) * 2002-09-05 2004-03-18 GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) Tubulysin-Biosynthese-Gene
US7410765B2 (en) * 2004-11-17 2008-08-12 The Regents Of The University Of California System for protease mediated protein expression
WO2009117539A2 (en) * 2008-03-19 2009-09-24 Abbott Laboratories Bioluminescent construct

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4873191A (en) * 1981-06-12 1989-10-10 Ohio University Genetic transformation of zygotes
US4736866A (en) * 1984-06-22 1988-04-12 President And Fellows Of Harvard College Transgenic non-human mammals
US5108921A (en) * 1989-04-03 1992-04-28 Purdue Research Foundation Method for enhanced transmembrane transport of exogenous molecules
ATE522621T1 (de) * 1993-04-05 2011-09-15 Univ Utah Res Found Diagnose und behandlung von williams syndrom
US5672500A (en) * 1995-05-18 1997-09-30 Thomas Jefferson University Mch2, an apoptotic cysteine protease, and compositions for making and methods of using the same

Also Published As

Publication number Publication date
EP0842267A1 (de) 1998-05-20
EP0842267A4 (de) 2000-04-26
US5958720A (en) 1999-09-28
ES2183960T3 (es) 2003-04-01
US6359127B1 (en) 2002-03-19
US5985640A (en) 1999-11-16
JPH11505705A (ja) 1999-05-25
ATE224443T1 (de) 2002-10-15
CA2221409C (en) 2011-07-26
WO1996036698A1 (en) 1996-11-21
DE69623786D1 (de) 2002-10-24
US5672500A (en) 1997-09-30
CA2221409A1 (en) 1996-11-21
EP0842267B1 (de) 2002-09-18

Similar Documents

Publication Publication Date Title
DE69623786T2 (de) Mch2, EINE APOPTOTISCHE CYSTEIN-PROTEASE, ZUSAMMENSETZUNGEN FÜR IHRE PRÄPARATION UND METHODEN FÜR IHRE VERWENDUNG
McKeehan et al. Purification and partial characterization of the aminoacyl transfer ribonucleic acid binding enzyme from rabbit reticulocytes
Wold et al. Identification of cellular proteins required for simian virus 40 DNA replication
YU8997A (sh) Prečišćen protein koji ima serinsku proteaznu inhibitorsku aktivnost i farmaceutski preparat koji ga sadrži
KR960705850A (ko) 사람 쿠니즈형 프로테아제 저해인자(human kunitz-type protease inhibitors)
ATE79138T1 (de) Typenspezifische papillomavirus-dns-sequenzen und peptide.
ES2259190T3 (es) Composiciones y metodos para la biosintesis de taxol.
MX9708427A (es) Serpina derivada de pancreas.
DE69226636D1 (de) Stabilisierte enzyme
Lee et al. RNA annealing activity is intrinsically associated with U2AF
KR970707162A (ko) II종 포스포리파제 A2 저해작용을 갖는 신규한 모노클로날 항체 및 그 일부를 포함하는 단백질(Novel monoclonal antibody having inhibitory effect on type II phospholipase A2 and protein containing a part of the same)
CA2281955A1 (en) Ikb kinase, subunits thereof, and methods of using same
FI961202A (fi) Grb3-3-geeni, sen variantteja ja niiden käyttöjä
ATE464320T1 (de) Ntb-a, ein oberflächenmolekül impliziert in der aktivität natürlicher killerzellen (nk)
BR9811412A (pt) Variante de enzima subtilase tendo melhorado desempenho de lavagem em detergentes, sequência de dna isolada, vetor de expressão, célula hospedeira microbiana, processos para produzir uma variante e para identificar uma variante de protease, composição, e, uso de uma variante de subtilase
WO1997014797A3 (en) Cystatin m, a novel cysteine proteinase inhibitor
Hiltkel et al. Structure/function analysis of human cystatin SN and comparison of the cysteine proteinase inhibitory profiles of human cystatins C and SN
AR013801A1 (es) Nuevas moleculas de acido nucleico aislada, una proteina de epoxido hidrolasa de artropodo hematofago aislada, una formulacion de proteinas deepoxido hidrolasa de pulga, una composicion terapeutica que reduce la infestacion de ectoparasitos hematofagos; uso de dicha composicion para la
DE69510782D1 (de) DNA, WELCHE FÜR DEN VORLÄUFER DES INTERLEUKIN-1 BETA KONVERTIERENDEN ENZYMS KODIERT (ICE rel-II)
ATE213773T1 (de) In apoptosis beteiligte cysteine protease cmh-1 und dns-sequenzen dafür
ZA962707B (en) New inhibitor of the erythrina caffra type and its use to purity serine proteases.
Maier et al. Generation of starting points for microsequencing with a protease specific for the amino side of aspartyl residues
WO2000064464A8 (en) NUCLEIC ACIDS AND PROTEINS OF A RAT GANGLIOSIDE GM1-SPECIFIC αl→2FUCOSYLTRANSFERASE AND USES THEREOF
MXPA04006975A (es) Gen humano de la proteasa desubiquitinante del cromosoma 7 y su ortologo murino.
BR9810643A (pt) Genes e proteìnas de telomerase de vertebrado, eutilização dos mesmos

Legal Events

Date Code Title Description
8364 No opposition during term of opposition