DE69617469D1 - Behandlung von multipler sklerose - Google Patents

Behandlung von multipler sklerose

Info

Publication number
DE69617469D1
DE69617469D1 DE69617469T DE69617469T DE69617469D1 DE 69617469 D1 DE69617469 D1 DE 69617469D1 DE 69617469 T DE69617469 T DE 69617469T DE 69617469 T DE69617469 T DE 69617469T DE 69617469 D1 DE69617469 D1 DE 69617469D1
Authority
DE
Germany
Prior art keywords
multiple sclerosis
treatment
symptoms
patient
vitamin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69617469T
Other languages
English (en)
Other versions
DE69617469T2 (de
Inventor
F Deluca
E Hayes
T Cantorna
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Publication of DE69617469D1 publication Critical patent/DE69617469D1/de
Application granted granted Critical
Publication of DE69617469T2 publication Critical patent/DE69617469T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/592—9,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
DE69617469T 1996-02-13 1996-09-05 Behandlung von multipler sklerose Expired - Lifetime DE69617469T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/600,913 US5716946A (en) 1996-02-13 1996-02-13 Multiple sclerosis treatment
PCT/US1996/014253 WO1997029740A1 (en) 1996-02-13 1996-09-05 Multiple sclerosis treatment

Publications (2)

Publication Number Publication Date
DE69617469D1 true DE69617469D1 (de) 2002-01-10
DE69617469T2 DE69617469T2 (de) 2002-07-18

Family

ID=24405578

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69617469T Expired - Lifetime DE69617469T2 (de) 1996-02-13 1996-09-05 Behandlung von multipler sklerose

Country Status (12)

Country Link
US (1) US5716946A (de)
EP (1) EP0880350B1 (de)
JP (1) JP3701687B2 (de)
KR (1) KR100347657B1 (de)
AT (1) ATE209483T1 (de)
AU (1) AU6915396A (de)
CA (1) CA2245661C (de)
DE (1) DE69617469T2 (de)
DK (1) DK0880350T3 (de)
ES (1) ES2164916T3 (de)
PT (1) PT880350E (de)
WO (1) WO1997029740A1 (de)

Families Citing this family (34)

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US6242434B1 (en) 1997-08-08 2001-06-05 Bone Care International, Inc. 24-hydroxyvitamin D, analogs and uses thereof
US20020183288A1 (en) * 1995-04-03 2002-12-05 Bone Care International, Inc. Method for treating and preventing hyperparathyroidism
US20040043971A1 (en) * 1995-04-03 2004-03-04 Bone Care International, Inc. Method of treating and preventing hyperparathyroidism with active vitamin D analogs
US7048906B2 (en) 1995-05-17 2006-05-23 Cedars-Sinai Medical Center Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions
US6861053B1 (en) 1999-08-11 2005-03-01 Cedars-Sinai Medical Center Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth
EP1011683A4 (de) * 1997-05-22 2003-06-11 Cephalon Inc Vitamin d analoge und der wirkung auf neuronen
CA2333256A1 (en) 1998-05-29 1999-12-02 Bone Care International, Inc. Method for making hydroxy-25-ene-vitamin d compounds
US5972917A (en) * 1998-05-29 1999-10-26 Bone Care Int Inc 1 α-hydroxy-25-ene-vitamin D, analogs and uses thereof
US6800287B2 (en) 1998-09-25 2004-10-05 Yeda Research And Development Co., Ltd. Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use
US6479474B2 (en) * 1999-07-08 2002-11-12 Wisconsin Alumni Research Foundation Dietary calcium as a supplement to vitamin D compound treatment of multiple sclerosis
AU6730600A (en) * 1999-08-27 2001-03-26 Chugai Seiyaku Kabushiki Kaisha Vitamin d derivatives having substituents at the 2alpha-position
US6358939B1 (en) 1999-12-21 2002-03-19 Northern Lights Pharmaceuticals, Llc Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease
US6989377B2 (en) 1999-12-21 2006-01-24 Wisconsin Alumni Research Foundation Treating vitamin D responsive diseases
US7012086B1 (en) 2000-06-30 2006-03-14 The Foundation For Innovative Therapies, Inc. Treatment of retrovirus induced derangements with niacin compounds
US20050175585A1 (en) * 2001-06-11 2005-08-11 Transition Therapeutics Inc. Combination therapies using vitamin B12 and interferon for treatment of viral proliferative and inflammatory disesases
CA2487038A1 (en) * 2001-06-11 2002-12-19 Transition Therapeutics Inc. Combination therapies using vitamin b12 and therapeutic agents for treatment of viral, proliferative and inflammatory diseases
US7658926B2 (en) * 2001-09-14 2010-02-09 Opexa Pharmaceuticals, Inc. Autologous T-cell vaccines materials and methods
PT1459065E (pt) * 2001-12-04 2010-10-11 Teva Pharma Processos para a medição da potência do acetato de glatirâmero
ES2614603T3 (es) * 2002-02-20 2017-06-01 Emisphere Technologies, Inc. Procedimiento de administración de moléculas GLP-1
EP1546719B1 (de) * 2002-08-08 2015-04-01 Baylor College Of Medicine Isolierung und identifizierung von t-zellen
US7566696B2 (en) * 2002-09-05 2009-07-28 Wisconsin Alumni Research Foundation Use of calcitonin and calcitonin-like peptides to treat and prevent multiple sclerosis
AU2003284246A1 (en) * 2002-10-16 2004-05-04 Samuel F. Hunter Method for treatment of demyelinating central nervous system disease using gm-csf
WO2004062620A2 (en) * 2003-01-13 2004-07-29 Cedars-Sinai Medical Center Paricalcitol as a chemotherapeutic agent
EP1603530A1 (de) * 2003-03-04 2005-12-14 Teva Pharmaceutical Industries Limited Kombinationstherapie mit glatirameracetat und alphacalcidol zur behandlung von multipler sklerose
US7094775B2 (en) * 2004-06-30 2006-08-22 Bone Care International, Llc Method of treating breast cancer using a combination of vitamin D analogues and other agents
US20060003950A1 (en) * 2004-06-30 2006-01-05 Bone Care International, Inc. Method of treating prostatic diseases using a combination of vitamin D analogues and other agents
WO2006032053A2 (en) * 2004-09-14 2006-03-23 Teva Pharmaceutical Industries, Ltd. Methods of treating symptoms of multiple sclerosis using vitamin d and related compounds
MX2007009735A (es) * 2005-02-14 2007-09-21 Wisconsin Alumni Res Found Uso de calcitonina y peptidos tipo calcitonina para tratar y prevenir esclerosis multiple.
US20100003228A1 (en) * 2006-05-05 2010-01-07 Willimas Jim C T-cell vaccine
WO2009097614A1 (en) * 2008-02-01 2009-08-06 Wisconsin Alumni Research Foundation Methods of treating multiple sclerosis by administering pulse dose calcitrol
US20140296190A1 (en) * 2013-03-27 2014-10-02 Dsm Ip Assets B.V. Marketing the use of 25-hydroxyvitamin d3 to enhance cognition
JP7166923B2 (ja) 2016-02-05 2022-11-08 オリオニス バイオサイエンシズ ビーブイ 標的療法剤およびその使用
WO2018141964A1 (en) 2017-02-06 2018-08-09 Orionis Biosciences Nv Targeted chimeric proteins and uses thereof
WO2018144999A1 (en) 2017-02-06 2018-08-09 Orionis Biosciences, Inc. Targeted engineered interferon and uses thereof

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4279826A (en) * 1980-09-22 1981-07-21 Wisconsin Alumni Research Foundation 23,25-Dihydroxyvitamin D3
US4307025A (en) * 1981-02-17 1981-12-22 Wisconsin Alumni Research Foundation 1α, 25-dihydroxy-2β-fluorovitamin D3
US4448721A (en) * 1982-09-20 1984-05-15 Wisconsin Alumni Research Foundation Hydroxyvitamin D2 compounds and process for preparing same
US5036061A (en) * 1983-05-09 1991-07-30 Deluca Hector F Process for the preparation of 1 alpha,25-dihydroxylated vitamin D2 and related compounds
US4502991A (en) * 1983-08-18 1985-03-05 Wisconsin Alumni Research Foundation 23,23-Difluoro-1α,25-dihydroxy-vitamin D3
US4500460A (en) * 1983-08-18 1985-02-19 Wisconsin Alumni Research Foundation 23,23-Difluoro-25-hydroxy-vitamin D3 and process for preparing same
US4769181A (en) * 1983-11-07 1988-09-06 Wisconsin Alumni Research Foundation 1,25-dihydroxyvitamin D2 compounds
US4505906A (en) * 1984-01-30 1985-03-19 Wisconsin Alumni Research Foundation Hydroxyvitamin D2 isomers
US4588528A (en) * 1984-05-31 1986-05-13 Wisconsin Alumni Research Foundation 1,24-dihydroxy-Δ22 -vitamin D3 and process for preparing same
US4594192A (en) * 1985-03-20 1986-06-10 Wisconsin Alumni Research Foundation 2α-fluorovitamin D3
US4619920A (en) * 1985-09-16 1986-10-28 Wisconsin Alumni Research Foundation 26,26,26,27,27-pentafluoro-1α-hydroxy-27-methoxyvitamin D3
JPS63104926A (ja) * 1986-10-21 1988-05-10 Teijin Ltd 老年性痴呆症治療又は予防剤
CA1333616C (en) * 1989-03-09 1994-12-20 Hector F. Deluca 19-nor-vitamin d compounds
US4973584A (en) * 1989-03-09 1990-11-27 Deluca Hector F Novel 1α-hydroxyvitamin D2 epimer and derivatives
US5030772A (en) * 1990-02-14 1991-07-09 Deluca Hector F Process for preparing vitamin D2 compounds and the corresponding 1 α-hydroxylated derivatives
US5260290A (en) * 1990-02-14 1993-11-09 Wisconsin Alumni Research Foundation Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives
JP2845342B2 (ja) * 1990-04-28 1999-01-13 大正製薬株式会社 ビタミンｄ▲下３▼誘導体含有固形製剤組成物
US5260199A (en) * 1991-07-30 1993-11-09 Wisconsin Alumni Research Foundation Method of producing 1,25-dihydroxyvitamin D3 receptor protein
IL104201A0 (en) * 1991-12-26 1993-05-13 Wisconsin Alumni Res Found 26,27-dimethylene-1 alpha-25-dihydroxyvitamin d2 and its 24-epimer and pharmaceutical compositions containing them
AU666529B2 (en) * 1992-04-24 1996-02-15 Wisconsin Alumni Research Foundation Method of treating osteoporosis with 1 alpha, 24 (R)-dihydroxy-22 (E)-dehydro-vitamin D3
TW272187B (de) * 1992-05-20 1996-03-11 Hoffmann La Roche
US5371249A (en) * 1993-05-11 1994-12-06 Wisconsin Alumni Research Foundation Iodo vitamin D3 compounds and method for preparing same
US5380720A (en) * 1993-05-11 1995-01-10 Wisconsin Alumni Research Foundation Iodo vitamin D3 compounds and method for preparing same
RU2153491C2 (ru) * 1993-07-09 2000-07-27 Лаборатуар Терамекс С.А. Аналоги витамина d, соединения, способы их получения и фармацевтическая композиция
US5373004A (en) * 1993-11-24 1994-12-13 Wisconsin Alumni Research Foundation 26,28-methylene-1α, 25-dihydroxyvitamin D2 compounds
US5471382A (en) * 1994-01-10 1995-11-28 Informed Access Systems, Inc. Medical network management system and process

Also Published As

Publication number Publication date
KR100347657B1 (ko) 2002-11-25
ATE209483T1 (de) 2001-12-15
JP3701687B2 (ja) 2005-10-05
WO1997029740A1 (en) 1997-08-21
AU6915396A (en) 1997-09-02
CA2245661A1 (en) 1997-08-21
KR19990082492A (ko) 1999-11-25
CA2245661C (en) 2004-02-03
US5716946A (en) 1998-02-10
PT880350E (pt) 2002-04-29
ES2164916T3 (es) 2002-03-01
EP0880350A1 (de) 1998-12-02
EP0880350B1 (de) 2001-11-28
DK0880350T3 (da) 2002-03-25
JPH11510819A (ja) 1999-09-21
DE69617469T2 (de) 2002-07-18

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Legal Events

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