DE69616523D1 - Verfahren zur baladung von lipidvesikeln - Google Patents

Verfahren zur baladung von lipidvesikeln

Info

Publication number
DE69616523D1
DE69616523D1 DE69616523T DE69616523T DE69616523D1 DE 69616523 D1 DE69616523 D1 DE 69616523D1 DE 69616523 T DE69616523 T DE 69616523T DE 69616523 T DE69616523 T DE 69616523T DE 69616523 D1 DE69616523 D1 DE 69616523D1
Authority
DE
Germany
Prior art keywords
methods
liposome formulations
preparation
stable
therapeutic agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69616523T
Other languages
English (en)
Other versions
DE69616523T2 (de
Inventor
Michael Hope
R Cullis
David Fenske
Kim Wong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of British Columbia
Original Assignee
University of British Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of British Columbia filed Critical University of British Columbia
Publication of DE69616523D1 publication Critical patent/DE69616523D1/de
Application granted granted Critical
Publication of DE69616523T2 publication Critical patent/DE69616523T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DE69616523T 1995-02-27 1996-02-27 Verfahren zur baladung von lipidvesikeln Expired - Lifetime DE69616523T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/399,692 US5800833A (en) 1995-02-27 1995-02-27 Method for loading lipid vesicles
PCT/CA1996/000120 WO1996026715A1 (en) 1995-02-27 1996-02-27 Method for loading lipid vesicles

Publications (2)

Publication Number Publication Date
DE69616523D1 true DE69616523D1 (de) 2001-12-06
DE69616523T2 DE69616523T2 (de) 2002-05-08

Family

ID=23580602

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69616523T Expired - Lifetime DE69616523T2 (de) 1995-02-27 1996-02-27 Verfahren zur baladung von lipidvesikeln

Country Status (7)

Country Link
US (2) US5800833A (de)
EP (1) EP0812186B1 (de)
AT (1) ATE207738T1 (de)
AU (1) AU4711296A (de)
CA (1) CA2213861C (de)
DE (1) DE69616523T2 (de)
WO (1) WO1996026715A1 (de)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5972379A (en) * 1995-02-14 1999-10-26 Sequus Pharmaceuticals, Inc. Liposome composition and method for administering a quinolone
US5837282A (en) * 1996-10-30 1998-11-17 University Of British Columbia Ionophore-mediated liposome loading
US7683044B2 (en) * 1999-03-25 2010-03-23 Center For Molecular Medicine And Immunology Sphingomyelin therapy of autoimmune disease
CA2368676C (en) * 1999-03-25 2010-09-07 Center For Molecular Medicine And Immunology Sphingomyelin containing preparation
US7311924B2 (en) * 1999-04-01 2007-12-25 Hana Biosciences, Inc. Compositions and methods for treating cancer
US7094423B1 (en) * 1999-07-15 2006-08-22 Inex Pharmaceuticals Corp. Methods for preparation of lipid-encapsulated therapeutic agents
WO2003018018A2 (en) * 2001-08-24 2003-03-06 Neopharm, Inc. Vinorelbine compositions and methods of use
JP2005525375A (ja) * 2002-03-05 2005-08-25 トランセイブ， インク． 生物活性物質をリポソーム又は脂質複合体内に封入する方法
US7718189B2 (en) 2002-10-29 2010-05-18 Transave, Inc. Sustained release of antiinfectives
ES2439727T3 (es) * 2002-10-29 2014-01-24 Insmed Incorporated Liberación sostenida de antiinfectantes
US7879351B2 (en) * 2002-10-29 2011-02-01 Transave, Inc. High delivery rates for lipid based drug formulations, and methods of treatment thereof
US20070031480A1 (en) * 2003-03-07 2007-02-08 Lawrence Mayer Enhanced delivery of sphingolipids
US20060198882A1 (en) * 2003-03-21 2006-09-07 Yechezkel Barenholz Stable liposomes or micelles comprising a sphinolipid and a peg-lipopolymer
WO2005002546A1 (en) * 2003-06-27 2005-01-13 Smithkline Beecham Corporation Stabilized topotecan liposomal composition and methods
US7915227B2 (en) * 2003-11-14 2011-03-29 Het Nederlands Kanker Instituut Pharmaceutical formulations employing short-chain sphingolipids and their use
US20050129753A1 (en) * 2003-11-14 2005-06-16 Gabizon Alberto A. Method for drug loading in liposomes
US8772013B2 (en) 2004-02-02 2014-07-08 Engeneic Molecular Delivery Pty Ltd Methods for targeted in vitro and in vivo drug delivery to mammalian cells via bacterially derived intact minicells
CN1925873B (zh) 2004-02-02 2011-02-09 恩杰内克分子递送有限公司 经细菌来源的完整微细胞在体外将药物靶向递送至哺乳动物细胞的组合物和方法
PT1744764E (pt) 2004-04-22 2012-08-30 Celator Pharmaceuticals Inc Formulações lipossómicas de agentes antraciclina e análogos de citidina
AU2011202665C1 (en) * 2004-05-03 2014-04-24 Ipsen Biopharm Ltd. Liposomes useful for drug delivery
US8658203B2 (en) 2004-05-03 2014-02-25 Merrimack Pharmaceuticals, Inc. Liposomes useful for drug delivery to the brain
DK1746976T3 (en) * 2004-05-03 2017-04-10 Merrimack Pharmaceuticals Inc LIPOSOMES SUITABLE FOR PHARMACEUTICAL SUPPLY
EP1796729A4 (de) 2004-10-06 2010-12-08 Bc Cancer Agency Liposome mit verbesserter arzneirückhaltung zur behandlung von krebs
CA2587470A1 (en) * 2004-11-15 2006-05-18 Yissum Research Development Company Of The Hebrew University Of Jerusale M Combination therapy associating preferably a ceramide with a cytotoxic drug
US7727537B2 (en) 2005-02-14 2010-06-01 Dpm Therapeutics Corp. Stabilized compositions for topical administration and methods of making same
DK1853303T3 (en) * 2005-02-14 2016-02-29 Dpm Therapeutics Corp STABILIZED COMPOSITIONS FOR TOPIC ADMINISTRATION AND PROCEDURES FOR PREPARING IT
US7838011B2 (en) 2005-02-14 2010-11-23 Pankaj Modi Stabilized protein compositions for topical administration and methods of making same
US20060280691A1 (en) * 2005-06-13 2006-12-14 University Of Alberta Spray freeze dried liposomal ciprofloxacin powder aerosol drug delivery
CA2838111C (en) 2005-12-08 2016-01-19 Insmed Incorporated Lipid-based compositions of antiinfectives for treating pulmonary infections and methods of use thereof
WO2007076117A2 (en) * 2005-12-22 2007-07-05 Celator Pharmaceuticals, Inc. Liposomal formulations comprising secondary and tertiary amines and methods for preparing thereof
ES2668554T3 (es) 2006-04-06 2018-05-18 Insmed Incorporated Métodos para la encapsulación liposomal inducida por coacervación y sus formulaciones
US20100196455A1 (en) * 2007-05-04 2010-08-05 Transave, Inc. Compositions of Multicationic Drugs for Reducing Interactions with Polyanionic Biomolecules and Methods of Use Thereof
US9333214B2 (en) 2007-05-07 2016-05-10 Insmed Incorporated Method for treating pulmonary disorders with liposomal amikacin formulations
US9114081B2 (en) 2007-05-07 2015-08-25 Insmed Incorporated Methods of treating pulmonary disorders with liposomal amikacin formulations
US9119783B2 (en) 2007-05-07 2015-09-01 Insmed Incorporated Method of treating pulmonary disorders with liposomal amikacin formulations
WO2009097011A1 (en) 2007-08-17 2009-08-06 Celator Pharmaceuticals, Inc. Improved platinum drug formulations
US9078812B2 (en) * 2007-12-06 2015-07-14 The Bay Zoltan Foundation For Applied Research Particulate drug carriers as desensitizing agents
US20090281054A1 (en) * 2008-05-06 2009-11-12 Venkata Reddy Compositions and methods comprising capuramycin analogues
CN102231978B (zh) 2008-10-07 2016-01-20 耶路撒冷希伯来大学伊森姆研究发展公司 包含包埋在聚合物基质中的脂质体的组合物和其使用方法
WO2013009928A1 (en) 2011-07-11 2013-01-17 Organic Medical Research Cannabinoid formulations
CN108743537B (zh) 2012-05-21 2021-06-11 英斯麦德公司 治疗肺部感染的系统
AU2013202947B2 (en) 2012-06-13 2016-06-02 Ipsen Biopharm Ltd. Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan
US9717724B2 (en) 2012-06-13 2017-08-01 Ipsen Biopharm Ltd. Methods for treating pancreatic cancer using combination therapies
CN104837483B (zh) 2012-11-20 2017-09-01 光谱医药公司 制备治疗用途的脂质体封装式长春新碱的改进方法
CN104884047A (zh) 2012-11-29 2015-09-02 英斯梅德股份有限公司 稳定的万古霉素制剂
DK3922241T3 (da) 2013-02-01 2023-12-04 Celator Pharmaceuticals Inc Fjernladning af svært vandopløselige lægemidler i liposomer
US9693958B2 (en) 2013-03-15 2017-07-04 Cureport, Inc. Methods and devices for preparation of lipid nanoparticles
SG11201608385YA (en) * 2014-04-10 2016-11-29 Suntory Holdings Ltd Method for masking bitterness of composition containing collagen peptide
MX2016014921A (es) 2014-05-15 2017-07-28 Insmed In Incorporated Metodos para tratar infecciones pulmonares micobacterianas no tuberculosas.
EP3177269A4 (de) 2014-08-04 2018-02-28 Zoneone Pharma, Inc. Fernladung von schwach wasserlöslichen medikamenten in lipidvesikel
US11318131B2 (en) 2015-05-18 2022-05-03 Ipsen Biopharm Ltd. Nanoliposomal irinotecan for use in treating small cell lung cancer
TWI678213B (zh) 2015-07-22 2019-12-01 美商史倍壯製藥公司 用於長春新鹼硫酸鹽脂質體注射之即可使用的調配物
PT3337467T (pt) 2015-08-20 2021-01-25 Ipsen Biopharm Ltd Terapia de combinação utilizando irinotecano lipossomal e um inibidor parp para tratamento do cancro
WO2017034957A1 (en) 2015-08-21 2017-03-02 Merrimack Pharmaceuticals, Inc. Methods for treating metastatic pancreatic cancer using combination therapies comprising liposomal irinotecan and oxaliplatin
AU2016340153B2 (en) 2015-10-16 2022-06-02 Ipsen Biopharm Ltd. Stabilizing camptothecin pharmaceutical compositions
WO2018083470A1 (en) 2016-11-02 2018-05-11 Ipsen Biopharm Ltd. Treating gastric cancer using combination therapies comprising liposomal irinotecan, oxaliplatin, 5-fluoruracil (and leucovorin)
US11571386B2 (en) 2018-03-30 2023-02-07 Insmed Incorporated Methods for continuous manufacture of liposomal drug products
AU2021292747A1 (en) 2020-06-18 2023-02-23 Akagera Medicines, Inc. Oxazolidinone compounds, liposome compositions comprising oxazolidinone compounds and methods of use thereof
MX2023001274A (es) 2020-07-28 2023-04-24 Jazz Pharmaceuticals Ireland Ltd Sintesis quiral de inhibidores de raf biciclicos fusionados.
JP2023535790A (ja) 2020-07-28 2023-08-21 ジャズ ファーマシューティカルズ アイルランド リミテッド 縮合二環式ｒａｆ阻害薬及びその使用方法
JP2023553343A (ja) 2020-11-25 2023-12-21 アカゲラ・メディスンズ，インコーポレイテッド 核酸を送達するための脂質ナノ粒子および関連する使用方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4086257A (en) * 1976-10-12 1978-04-25 Sears Barry D Phosphatidyl quaternary ammonium compounds
CH624011A5 (de) * 1977-08-05 1981-07-15 Battelle Memorial Institute
US4278689A (en) * 1978-07-11 1981-07-14 American Cyanamid Company 1,4-Bis(substituted-amino)-5,8-dihydroxy-anthraquinones and leuco bases thereof
US4197249A (en) * 1977-08-15 1980-04-08 American Cyanamid Company 1,4-Bis(substituted-amino)-5,8-dihydroxyanthraquinones and leuco bases thereof
US4588578A (en) * 1983-08-08 1986-05-13 The Liposome Company, Inc. Lipid vesicles prepared in a monophase
US4610868A (en) * 1984-03-20 1986-09-09 The Liposome Company, Inc. Lipid matrix carriers for use in drug delivery systems
DE3537761A1 (de) * 1985-10-24 1987-04-30 Bayer Ag Infusionsloesungen der 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7- (1-piperazinyl)-chinolin-3-carbonsaeure
DE3713672A1 (de) * 1987-04-24 1988-11-17 Bayer Ag Verfahren zur herstellung von parenteral verabreichbaren chinoloncarbonsaeuren
IL91664A (en) * 1988-09-28 1993-05-13 Yissum Res Dev Co Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release
WO1991009616A1 (en) * 1989-12-22 1991-07-11 Yale University Quinolone antibiotics encapsulated in lipid vesicles
AU660288B2 (en) * 1990-07-31 1995-06-22 Transave, Inc. Accumulation of amino acids and peptides into liposomes
AU654835B2 (en) * 1991-07-03 1994-11-24 Nexstar Pharmaceuticals, Inc. Loading technique for preparing drug containing liposomes
US5714163A (en) * 1994-06-27 1998-02-03 Nexstar Pharmaceuticals, Inc. Vinca alkaloid vesicles with enhanced efficacy and tumor targeting properties

Also Published As

Publication number Publication date
EP0812186A1 (de) 1997-12-17
CA2213861A1 (en) 1996-09-06
CA2213861C (en) 2001-04-17
AU4711296A (en) 1996-09-18
ATE207738T1 (de) 2001-11-15
EP0812186B1 (de) 2001-10-31
US5785987A (en) 1998-07-28
WO1996026715A1 (en) 1996-09-06
DE69616523T2 (de) 2002-05-08
US5800833A (en) 1998-09-01

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