DE69615684D1 - Rekombinante temperaturempfindliche influenza-virus mutanten - Google Patents
Rekombinante temperaturempfindliche influenza-virus mutantenInfo
- Publication number
- DE69615684D1 DE69615684D1 DE69615684T DE69615684T DE69615684D1 DE 69615684 D1 DE69615684 D1 DE 69615684D1 DE 69615684 T DE69615684 T DE 69615684T DE 69615684 T DE69615684 T DE 69615684T DE 69615684 D1 DE69615684 D1 DE 69615684D1
- Authority
- DE
- Germany
- Prior art keywords
- influenza virus
- temperature sensitive
- virus mutants
- sensitive influenza
- recombinant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 241000712461 unidentified influenza virus Species 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- General Engineering & Computer Science (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/462,388 US5690937A (en) | 1995-06-05 | 1995-06-05 | Temperature sensitive clustered changed-to-alanine mutants of influenza virus PB2 gene |
PCT/US1996/008441 WO1996039179A1 (en) | 1995-06-05 | 1996-06-03 | Novel recombinant temperature sensitive mutants of influenza |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69615684D1 true DE69615684D1 (de) | 2001-11-08 |
DE69615684T2 DE69615684T2 (de) | 2002-07-11 |
Family
ID=23836264
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69615684T Expired - Fee Related DE69615684T2 (de) | 1995-06-05 | 1996-06-03 | Rekombinante temperaturempfindliche influenza-virus mutanten |
Country Status (8)
Country | Link |
---|---|
US (1) | US5690937A (de) |
EP (1) | EP0835132B1 (de) |
JP (1) | JP3545418B2 (de) |
KR (1) | KR19990022335A (de) |
AU (1) | AU701020B2 (de) |
CA (2) | CA2423891A1 (de) |
DE (1) | DE69615684T2 (de) |
WO (1) | WO1996039179A1 (de) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0704533A1 (de) * | 1994-09-30 | 1996-04-03 | Bayer Ag | Abgeschwächtes Impfvirus, Verfahren zur dessen Herstellung und Arzneimittel die es enthalten |
US7157089B1 (en) * | 1996-11-26 | 2007-01-02 | Stressgen Biotechnologies Corporation | Immune responses using compositions containing stress proteins |
CA2238659C (en) * | 1997-05-26 | 2010-12-14 | Akzo Nobel N.V. | Recombinant birnavirus vaccine |
US6482414B1 (en) | 1998-08-13 | 2002-11-19 | The University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Cold-adapted equine influenza viruses |
US6579528B1 (en) * | 1998-08-13 | 2003-06-17 | The University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Cold-adapted equine influenza viruses |
US6177082B1 (en) | 1998-08-13 | 2001-01-23 | The University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Cold-adapted equine influenza viruses |
US8715940B2 (en) | 1999-04-06 | 2014-05-06 | Wisconsin Alumni Research Foundation | Method of making recombinant influenza virus |
DE60125736D1 (de) * | 2000-04-03 | 2007-02-15 | Univ Pittsburgh | Zusammensetzungen, die kälteangepasste pferdeinfluenzaviren enthaltende, für die behandlung von bestehende virusinfektionen des atmungssystems |
AU2003231083A1 (en) | 2002-04-26 | 2003-11-10 | Medimmune, Llc | Multi plasmid system for the production of influenza virus |
US7465456B2 (en) | 2002-04-26 | 2008-12-16 | Medimmune, Llc | Multi plasmid system for the production of influenza virus |
WO2005018539A2 (en) | 2003-06-16 | 2005-03-03 | Medimmune Vaccines, Inc. | Influenza hemagglutinin and neuraminidase variants |
DE602004027537D1 (de) | 2003-12-23 | 2010-07-15 | Medimmune Inc | |
DK1748790T3 (en) | 2004-05-24 | 2015-10-19 | Medimmune Llc | Multiplasmidsystem for the production of influenza |
CA2822895A1 (en) | 2004-05-25 | 2005-12-08 | Medimmune, Llc | Influenza hemagglutinin and neuraminidase variants |
JP5414178B2 (ja) | 2004-12-23 | 2014-02-12 | メディミューン,エルエルシー | ウイルス増殖用の非腫瘍形成性mdck細胞株 |
ES2527503T3 (es) | 2005-03-08 | 2015-01-26 | Medimmune, Llc | Virus influenza reordenantes |
US7790434B2 (en) * | 2005-06-21 | 2010-09-07 | Medimmune, Llc | Methods and compositions for expressing negative-sense viral RNA in canine cells |
BRPI0612268A2 (pt) * | 2005-06-21 | 2009-01-27 | Medimmune Vaccines Inc | Ácido nucleico isolado, vetor de expressço, mÉtodos para produzir um rna genâmico da influenza, para produzir um vÍrus da influenza recombinante, para gerar um vÍrus de rna segmentado de filamento negativo recombinante nas cÉlulas caninas cultivadas e para gerar partÍculas virais da influenza infecciosa em cÉlulas caninas cultivadas, cÉlula, e, vÍrus |
EP2614836A3 (de) * | 2005-10-17 | 2013-10-23 | MedImmune, LLC | Schnell wachsender reassortanter Influenza-A-Virus |
WO2007124327A2 (en) | 2006-04-19 | 2007-11-01 | Medimmune Llc. | Methods and compositions for expressing negative-sense viral rna in canine cells |
WO2008133701A1 (en) * | 2006-07-21 | 2008-11-06 | Medimmune, Llc. | Methods and compositions for increasing replication capacity of an influenza virus |
CN104278014A (zh) * | 2006-08-09 | 2015-01-14 | 米迪缪尼有限公司 | 流感血凝素和神经氨酸酶变体 |
CN101627113B (zh) | 2006-09-15 | 2013-04-24 | 米迪缪尼有限公司 | 支持病毒生长到高效价的mdck细胞系和采用该细胞系的生物反应器方法 |
EP2674486A1 (de) | 2007-06-18 | 2013-12-18 | MedImmune, LLC | Influenza-B-Viren mit Veränderungen im Hämagglutininpolypeptid |
CA2730408A1 (en) | 2008-07-11 | 2010-01-14 | Chin-Fen Yang | Influenza hemagglutinin and neuraminidase variants |
EP2396033B1 (de) | 2009-02-12 | 2016-09-28 | MedImmune, LLC | Influenza-hämagglutinin- und neuraminidase-varianten |
EP2694645A1 (de) | 2011-04-08 | 2014-02-12 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Verfahren zur erhöhung der replikationskapazität eines influenzavirus in kultivierten zellen |
WO2012156476A2 (en) | 2011-05-16 | 2012-11-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for screening substances capable of modulating the replication of an influenza virus |
AU2018314269B2 (en) * | 2017-08-11 | 2022-12-08 | University Of Kentucky Research Foundation | Anti-neurodegenerative therapeutic, method of manufacture, and use |
CN110468109B (zh) * | 2019-07-26 | 2020-12-15 | 军事科学院军事医学研究院军事兽医研究所 | 一种h3n2亚型犬流感病毒鼠适应强毒株及其应用 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU7838194A (en) * | 1993-09-20 | 1995-04-10 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Method for generating influenza a viruses bearing attenuating mutations in internal protein genes |
-
1995
- 1995-06-05 US US08/462,388 patent/US5690937A/en not_active Expired - Fee Related
-
1996
- 1996-06-03 CA CA002423891A patent/CA2423891A1/en not_active Abandoned
- 1996-06-03 DE DE69615684T patent/DE69615684T2/de not_active Expired - Fee Related
- 1996-06-03 KR KR1019970708815A patent/KR19990022335A/ko not_active Application Discontinuation
- 1996-06-03 AU AU59706/96A patent/AU701020B2/en not_active Ceased
- 1996-06-03 WO PCT/US1996/008441 patent/WO1996039179A1/en not_active Application Discontinuation
- 1996-06-03 CA CA002223579A patent/CA2223579C/en not_active Expired - Fee Related
- 1996-06-03 EP EP96917006A patent/EP0835132B1/de not_active Expired - Lifetime
- 1996-06-03 JP JP50104397A patent/JP3545418B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JPH11507510A (ja) | 1999-07-06 |
EP0835132A4 (de) | 1999-09-01 |
US5690937A (en) | 1997-11-25 |
AU5970696A (en) | 1996-12-24 |
CA2423891A1 (en) | 1996-12-12 |
DE69615684T2 (de) | 2002-07-11 |
EP0835132B1 (de) | 2001-10-04 |
CA2223579A1 (en) | 1996-12-12 |
CA2223579C (en) | 2003-05-20 |
JP3545418B2 (ja) | 2004-07-21 |
WO1996039179A1 (en) | 1996-12-12 |
KR19990022335A (ko) | 1999-03-25 |
EP0835132A1 (de) | 1998-04-15 |
AU701020B2 (en) | 1999-01-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |