DE69615676D1 - Indol-3-carbonyl und indol-3-sulfony derivate als antagonisten des plättchen aktivierenden faktors - Google Patents

Indol-3-carbonyl und indol-3-sulfony derivate als antagonisten des plättchen aktivierenden faktors

Info

Publication number
DE69615676D1
DE69615676D1 DE69615676T DE69615676T DE69615676D1 DE 69615676 D1 DE69615676 D1 DE 69615676D1 DE 69615676 T DE69615676 T DE 69615676T DE 69615676 T DE69615676 T DE 69615676T DE 69615676 D1 DE69615676 D1 DE 69615676D1
Authority
DE
Germany
Prior art keywords
indol
antagonists
sulfony
carbonyl
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69615676T
Other languages
English (en)
Other versions
DE69615676T2 (de
Inventor
S Sheppard
K Davidson
B Summers
M Carrera
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of DE69615676D1 publication Critical patent/DE69615676D1/de
Publication of DE69615676T2 publication Critical patent/DE69615676T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Indole Compounds (AREA)
DE69615676T 1995-04-19 1996-03-25 Indol-3-carbonyl und indol-3-sulfony derivate als antagonisten des plättchen aktivierenden faktors Expired - Fee Related DE69615676T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/424,911 US5567711A (en) 1995-04-19 1995-04-19 Indole-3-carbonyl and indole-3-sulfonyl derivatives as platelet activating factor antagonists
PCT/US1996/004010 WO1996033196A1 (en) 1995-04-19 1996-03-25 Indole-3-carbonyl and indole-3-sulfonyl derivatives as platelet activating factor antagonists

Publications (2)

Publication Number Publication Date
DE69615676D1 true DE69615676D1 (de) 2001-11-08
DE69615676T2 DE69615676T2 (de) 2002-07-11

Family

ID=23684396

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69615676T Expired - Fee Related DE69615676T2 (de) 1995-04-19 1996-03-25 Indol-3-carbonyl und indol-3-sulfony derivate als antagonisten des plättchen aktivierenden faktors

Country Status (13)

Country Link
US (3) US5567711A (de)
EP (1) EP0821685B1 (de)
JP (1) JPH11503758A (de)
KR (1) KR19990007863A (de)
AT (1) ATE206425T1 (de)
AU (1) AU705237B2 (de)
CA (1) CA2218020A1 (de)
DE (1) DE69615676T2 (de)
DK (1) DK0821685T3 (de)
ES (1) ES2164240T3 (de)
IL (1) IL117723A (de)
PT (1) PT821685E (de)
WO (1) WO1996033196A1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0777656B1 (de) * 1994-08-26 2004-04-14 Auckland Division Cancer Society Of New Zealand (Incorporated) Neue auf dna gerichtete alkylierungsmittel
US6630496B1 (en) 1996-08-26 2003-10-07 Genetics Institute Llc Inhibitors of phospholipase enzymes
ES2288807T1 (es) 1998-02-02 2008-02-01 Trustees Of Tufts College Uso de inhibidores de dipeptidasa para regular el metabolismo de la glucosa.
US6916841B2 (en) * 1998-02-25 2005-07-12 Genetics Institute, Llc Inhibitors of phospholipase enzymes
US6828344B1 (en) 1998-02-25 2004-12-07 Genetics Institute, Llc Inhibitors of phospholipase enzymes
US6500853B1 (en) 1998-02-28 2002-12-31 Genetics Institute, Llc Inhibitors of phospholipase enzymes
DE19815026A1 (de) * 1998-04-03 1999-10-07 Hoechst Schering Agrevo Gmbh Substituierte Piperidine, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel und Fungizide
CA2340100A1 (en) 1998-08-11 2000-02-24 Daiichi Pharmaceutical Co., Ltd. Novel sulfonyl derivatives
EP1156045A4 (de) * 1999-01-28 2002-04-17 Nippon Shinyaku Co Ltd Amid-derivate und drogen-zusammensetzungen
DE10000739A1 (de) * 2000-01-11 2001-07-12 Merck Patent Gmbh Piperidin- und Piperazinderivate
WO2001058869A2 (en) * 2000-02-11 2001-08-16 Bristol-Myers Squibb Company Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators in treating respiratory and non-respiratory diseases
CA2432642A1 (en) * 2000-12-21 2002-08-08 Subhash P. Khanapure Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use
PT1474425E (pt) * 2002-01-07 2006-09-29 Eisai Co Ltd Desazapurinas e sua utilizacao
TW200307542A (en) * 2002-05-30 2003-12-16 Astrazeneca Ab Novel compounds
SE0201635D0 (sv) * 2002-05-30 2002-05-30 Astrazeneca Ab Novel compounds
SE0202241D0 (sv) * 2002-07-17 2002-07-17 Astrazeneca Ab Novel Compounds
TW200401641A (en) * 2002-07-18 2004-02-01 Wyeth Corp 1-Heterocyclylalkyl-3-sulfonylindole or-indazole derivatives as 5-hydroxytryptamine-6 ligands
DE10253426B4 (de) * 2002-11-15 2005-09-22 Elbion Ag Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phosphodiesterase 4 und Verfahren zu deren Herstellung
SE0301569D0 (sv) * 2003-05-27 2003-05-27 Astrazeneca Ab Novel compounds
SE0302232D0 (sv) * 2003-08-18 2003-08-18 Astrazeneca Ab Novel Compounds
US7157471B2 (en) 2003-08-25 2007-01-02 Boehringer Ingelheim International Gmbh Haloalkyl- and piperidine-substituted benzimidazole-derivatives
WO2005019203A1 (en) * 2003-08-25 2005-03-03 Boehringer Ingelheim International Gmbh Haloalkyl- and piperidine-substituted benzimidazole-derivatives
US7504401B2 (en) * 2003-08-29 2009-03-17 Locus Pharmaceuticals, Inc. Anti-cancer agents and uses thereof
SE0303180D0 (sv) * 2003-11-26 2003-11-26 Astrazeneca Ab Novel compounds
US7723360B2 (en) * 2004-08-06 2010-05-25 Boehringer Ingelheim International Gmbh Alkyl-and piperidine-substituted benzimidazole derivatives
GB0500604D0 (en) * 2005-01-13 2005-02-16 Astrazeneca Ab Novel process
MY150958A (en) * 2005-06-16 2014-03-31 Astrazeneca Ab Compounds for the treatment of multi-drug resistant bacterial infections
EP1917255A2 (de) * 2005-07-29 2008-05-07 F. Hoffmann-Roche AG Indol-3-yl-carbonyl-piperidin- und piperazin-derivate
US7645752B2 (en) * 2006-01-13 2010-01-12 Wyeth Llc Sulfonyl substituted 1H-indoles as ligands for the 5-hydroxytryptamine receptors
CN101454284A (zh) * 2006-05-26 2009-06-10 阿斯利康(瑞典)有限公司 联芳基或芳基-杂芳基取代的吲哚类化合物
US20080280891A1 (en) * 2006-06-27 2008-11-13 Locus Pharmaceuticals, Inc. Anti-cancer agents and uses thereof
EP3552664A1 (de) 2011-05-12 2019-10-16 Proteostasis Therapeutics, Inc. Proteostase-regulatoren
EP2968285A4 (de) * 2013-03-13 2016-12-21 Flatley Discovery Lab Verbindungen und verfahren zur behandlung von zystischer fibrose
KR102129842B1 (ko) 2013-10-02 2020-07-06 주식회사 대웅제약 술포닐인돌 유도체 및 이의 제조방법
WO2015073528A1 (en) 2013-11-12 2015-05-21 Proteostasis Therapeutics, Inc. Proteasome activity enhancing compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT98673B (pt) * 1990-08-15 1999-01-29 British Bio Technology Processo para a preparacao de compostos que sao antagonistas do factor de activacao de plaquetas por exemplo derivados de benzimidazole e de seus intermediarios
GB9102997D0 (en) * 1991-02-13 1991-03-27 Pfizer Ltd Therapeutic agents
GB9107398D0 (en) * 1991-04-09 1991-05-22 British Bio Technology Compounds
IL102494A0 (en) * 1991-07-17 1993-01-14 Abbott Lab Platelet activating factor antagonists
GB9200245D0 (en) * 1992-01-07 1992-02-26 British Bio Technology Compounds
US5486525A (en) * 1993-12-16 1996-01-23 Abbott Laboratories Platelet activating factor antagonists: imidazopyridine indoles

Also Published As

Publication number Publication date
CA2218020A1 (en) 1996-10-24
DK0821685T3 (da) 2002-01-21
IL117723A (en) 2000-07-26
JPH11503758A (ja) 1999-03-30
EP0821685B1 (de) 2001-10-04
ATE206425T1 (de) 2001-10-15
MX9708032A (es) 1997-11-29
US5643922A (en) 1997-07-01
ES2164240T3 (es) 2002-02-16
IL117723A0 (en) 1996-07-23
AU705237B2 (en) 1999-05-20
AU5429596A (en) 1996-11-07
DE69615676T2 (de) 2002-07-11
US5567711A (en) 1996-10-22
WO1996033196A1 (en) 1996-10-24
US5654305A (en) 1997-08-05
KR19990007863A (ko) 1999-01-25
PT821685E (pt) 2002-03-28
EP0821685A1 (de) 1998-02-04

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee