MX9708032A - Derivados de indol-3-carbonilo e indol 3-sulfonilo como antagonistas del factor activador de plaqueta. - Google Patents
Derivados de indol-3-carbonilo e indol 3-sulfonilo como antagonistas del factor activador de plaqueta.Info
- Publication number
- MX9708032A MX9708032A MX9708032A MX9708032A MX9708032A MX 9708032 A MX9708032 A MX 9708032A MX 9708032 A MX9708032 A MX 9708032A MX 9708032 A MX9708032 A MX 9708032A MX 9708032 A MX9708032 A MX 9708032A
- Authority
- MX
- Mexico
- Prior art keywords
- indole
- carbonyl
- activating factor
- platelet activating
- factor antagonists
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 2
- -1 Indole-3-carbonyl Chemical class 0.000 title 2
- HVAUUPRFYPCOCA-AREMUKBSSA-N 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCOC[C@@H](OC(C)=O)COP([O-])(=O)OCC[N+](C)(C)C HVAUUPRFYPCOCA-AREMUKBSSA-N 0.000 title 1
- 108010003541 Platelet Activating Factor Proteins 0.000 title 1
- 208000009144 Pure autonomic failure Diseases 0.000 abstract 2
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 abstract 1
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 abstract 1
- 208000025865 Ulcer Diseases 0.000 abstract 1
- 208000038016 acute inflammation Diseases 0.000 abstract 1
- 230000006022 acute inflammation Effects 0.000 abstract 1
- 230000000172 allergic effect Effects 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 208000010668 atopic eczema Diseases 0.000 abstract 1
- 230000024245 cell differentiation Effects 0.000 abstract 1
- 230000007969 cellular immunity Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000003111 delayed effect Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000001605 fetal effect Effects 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 210000004072 lung Anatomy 0.000 abstract 1
- 230000035800 maturation Effects 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 230000032696 parturition Effects 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000035939 shock Effects 0.000 abstract 1
- 208000017520 skin disease Diseases 0.000 abstract 1
- 230000036269 ulceration Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente invencion proporciona compuestos de la Formula I, y las sales farmacéuticamente aceptables de los mismos, que son potentes antagonistas del factor activador de plaquetas, y son utiles en el tratamiento de desordenes relacionados con el factor activador de plaquetas, incluyendo asma, choque, síndrome de insuficiencia respiratoria, inflamacion aguda, rechazo de organo trasplantado, ulceracion gastrointestinal, enfermedades alérgicas de la piel, inmunidad celular demora, parturicion, maduracion de pulmon fetal, y diferenciacion celular.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/424,911 US5567711A (en) | 1995-04-19 | 1995-04-19 | Indole-3-carbonyl and indole-3-sulfonyl derivatives as platelet activating factor antagonists |
| US08424911 | 1995-04-19 | ||
| PCT/US1996/004010 WO1996033196A1 (en) | 1995-04-19 | 1996-03-25 | Indole-3-carbonyl and indole-3-sulfonyl derivatives as platelet activating factor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX9708032A true MX9708032A (es) | 1997-11-29 |
| MXPA97008032A MXPA97008032A (es) | 1998-07-03 |
Family
ID=
Also Published As
| Publication number | Publication date |
|---|---|
| DK0821685T3 (da) | 2002-01-21 |
| JPH11503758A (ja) | 1999-03-30 |
| PT821685E (pt) | 2002-03-28 |
| CA2218020A1 (en) | 1996-10-24 |
| IL117723A (en) | 2000-07-26 |
| EP0821685B1 (en) | 2001-10-04 |
| AU5429596A (en) | 1996-11-07 |
| US5567711A (en) | 1996-10-22 |
| ATE206425T1 (de) | 2001-10-15 |
| EP0821685A1 (en) | 1998-02-04 |
| US5643922A (en) | 1997-07-01 |
| IL117723A0 (en) | 1996-07-23 |
| AU705237B2 (en) | 1999-05-20 |
| KR19990007863A (ko) | 1999-01-25 |
| US5654305A (en) | 1997-08-05 |
| WO1996033196A1 (en) | 1996-10-24 |
| DE69615676D1 (de) | 2001-11-08 |
| DE69615676T2 (de) | 2002-07-11 |
| ES2164240T3 (es) | 2002-02-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration | ||
| MM | Annulment or lapse due to non-payment of fees |