DE69614105T2 - Lagerstabile hämoglobinlösungen - Google Patents

Lagerstabile hämoglobinlösungen

Info

Publication number
DE69614105T2
DE69614105T2 DE69614105T DE69614105T DE69614105T2 DE 69614105 T2 DE69614105 T2 DE 69614105T2 DE 69614105 T DE69614105 T DE 69614105T DE 69614105 T DE69614105 T DE 69614105T DE 69614105 T2 DE69614105 T2 DE 69614105T2
Authority
DE
Germany
Prior art keywords
hemoglobin solutions
storage
solutions
storage stable
stable hemoglobin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69614105T
Other languages
English (en)
Other versions
DE69614105D1 (de
Inventor
A Kerwin
L Looker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter Biotech Technology SARL
Original Assignee
Baxter Biotech Technology SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Biotech Technology SARL filed Critical Baxter Biotech Technology SARL
Publication of DE69614105D1 publication Critical patent/DE69614105D1/de
Application granted granted Critical
Publication of DE69614105T2 publication Critical patent/DE69614105T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
DE69614105T 1995-05-02 1996-05-01 Lagerstabile hämoglobinlösungen Expired - Lifetime DE69614105T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/433,896 US5929031A (en) 1995-05-02 1995-05-02 Storage stable hemoglobin solutions
PCT/US1996/006080 WO1996034889A1 (en) 1995-05-02 1996-05-01 Storage stable hemoglobin solutions

Publications (2)

Publication Number Publication Date
DE69614105D1 DE69614105D1 (de) 2001-08-30
DE69614105T2 true DE69614105T2 (de) 2002-03-21

Family

ID=23721974

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69614105T Expired - Lifetime DE69614105T2 (de) 1995-05-02 1996-05-01 Lagerstabile hämoglobinlösungen

Country Status (7)

Country Link
US (1) US5929031A (de)
EP (1) EP0826004B1 (de)
JP (1) JPH11507016A (de)
AT (1) ATE203546T1 (de)
CA (1) CA2216382A1 (de)
DE (1) DE69614105T2 (de)
WO (1) WO1996034889A1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6242417B1 (en) * 1994-03-08 2001-06-05 Somatogen, Inc. Stabilized compositions containing hemoglobin
US6271351B1 (en) 1995-03-23 2001-08-07 Biopure Corporation Method for preserving a hemoglobin blood substitute
US6610832B1 (en) 1995-03-23 2003-08-26 Biopure Corporation Preserving a hemoglobin blood substitute with a transparent overwrap
US6288027B1 (en) 1995-03-23 2001-09-11 Biopure Corporation Preserving a hemoglobin blood substitute with a transparent overwrap
US6018035A (en) * 1997-07-21 2000-01-25 Baxter International Inc. Reagents for isotropic size enhancement of a peptide, protein, nucleotide or other substrate
US5981710A (en) * 1997-07-21 1999-11-09 Baxter International, Inc. Therapeutic hemoglobin composition having isotropically increased size
US6204254B1 (en) 1997-09-12 2001-03-20 Baxter International, Inc. Biocompatible surfaces and a method for their preparation
DE60022751T2 (de) * 1999-07-01 2006-07-13 Sysmex Corp. Mittel zur stabilisierung von hämoglobinen
JP3466516B2 (ja) 1999-09-07 2003-11-10 科学技術振興事業団 安定保存可能な酸素輸液剤
US6894150B1 (en) 1999-10-01 2005-05-17 Ross Walden Tye Non-pyrogenic, endotoxin-free, stroma-free tetrameric hemoglobin
US7449339B2 (en) * 1999-11-23 2008-11-11 Nir Diagnostics Inc. Spectroscopic method and apparatus for total hemoglobin measurement
US6949384B2 (en) * 2001-12-21 2005-09-27 Spectromedical Inc. Method for monitoring degradation of Hb-based blood substitutes
FR2809624B1 (fr) * 2000-05-31 2002-08-02 Centre Nat Rech Scient Utilisation comme substitut sanguin d'une hemoglobine extracellulaire de poids moleculaire eleve
US6974447B2 (en) * 2001-04-17 2005-12-13 Baxter International Inc. High gas barrier receptacle and closure assembly
WO2002085111A1 (en) * 2001-04-18 2002-10-31 Northfield Laboratories Flexible container system for storage of stabilized hemoglobin solutions
WO2003059162A1 (en) * 2002-01-15 2003-07-24 Broad Of Regents, The University Of Texas System Methods and compositions to reduce scattering of light during therapeutic and diagnostic imaging procedures
WO2003072143A1 (en) * 2002-02-27 2003-09-04 Pharmain, Ltd. Compositions for delivery of therapeutics and other materials, and methods of making and using the same
US7635463B2 (en) * 2002-02-27 2009-12-22 Pharmain Corporation Compositions for delivery of therapeutics and other materials
JP2006502116A (ja) * 2002-07-12 2006-01-19 メダレックス， インク． タンパク質の酸化分解を防ぐ方法及び組成物
US7223604B1 (en) * 2002-09-27 2007-05-29 Science & Technology Corporation @ Unm Methods and kits for the detection of erythrocytes
MXPA05007885A (es) * 2003-01-29 2005-09-21 Northfield Lab Soluciones de hemoglobina polimerizada que tienen cantidad reducida de tetramero y metodo para prepararlas.
WO2005112977A2 (en) * 2004-04-23 2005-12-01 Pharmain, Ltd. Compositions for treatment with glucagon-like peptide, and methods of making and using the same
JP2006164312A (ja) * 2004-12-02 2006-06-22 Hitachi Ltd 半導体装置およびそれを用いた磁気記録再生装置
WO2006096774A2 (en) * 2005-03-07 2006-09-14 Sangart, Inc. Composition and methods for delivering carbon monoxide (co) and nitric ozide (no) co to tissue using heme proteins as carriers
US20090004159A1 (en) * 2006-01-24 2009-01-01 The Board Of Trustees Of The University Of Illinoi Polymerized Hemoglobin Media and Its Use in Isolation and Transplantation of Islet Cells
WO2008021577A2 (en) * 2006-01-24 2008-02-21 The Board Of Trustees Of The University Of Illinois Polymerized hemoglobin media and its use in isolation and transplantation of islet cells
US7504377B2 (en) * 2006-10-23 2009-03-17 Ikor, Inc. Nitric oxide-blocked cross-linked tetrameric hemoglobin
US7494974B2 (en) * 2006-10-24 2009-02-24 Ikor, Inc. Carboxymethylated cross-linked tetrameric hemoglobin
JP2008195656A (ja) * 2007-02-14 2008-08-28 Nipro Corp 人工酸素運搬体製剤
US8609815B2 (en) 2010-09-02 2013-12-17 Sangart, Inc. Methods for preparing stable deoxygenated PEG-hemoglobin conjugate solutions comprising an antioxidant
CA2860158A1 (en) * 2011-01-07 2012-07-12 Somerset Group Enterprises, Inc. Modular extracorporeal systems and methods for treating blood-borne diseases
US9375525B2 (en) 2012-01-09 2016-06-28 Somerset Group Enterprises, Inc. Modular extracorporeal systems and methods for treating blood-borne diseases
US9763889B2 (en) * 2015-06-29 2017-09-19 Billion King International Ltd. Oral delivery system for hemoglobin based oxygen carriers
US10052290B2 (en) * 2016-02-04 2018-08-21 Billion King International Ltd. Enteric-coated hemoglobin multiparticulate for oral delivery of hemoglobin based oxygen carriers
EP4133285A1 (de) * 2020-04-09 2023-02-15 Institut National de la Santé et de la Recherche Médicale (INSERM) Verfahren und zusammensetzungen zur bestimmung der qualität von einheiten roter blutkörperchen

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3144705C2 (de) * 1981-11-11 1983-12-08 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Verfahren zur Herstellung eines lagerstabilen, vernetzten Hämoglobinpräparates mit hoher Sauerstoff-Transportkapazität, sowie das nach diesem Verfahren hergestellte Hämoglobinpräparat
US4727027A (en) * 1983-05-02 1988-02-23 Diamond Scientific Co. Photochemical decontamination treatment of whole blood or blood components
US4861867A (en) * 1988-02-03 1989-08-29 Baxter International, Inc. Purified hemoglobin solutions and method for making same
US5234903A (en) * 1989-11-22 1993-08-10 Enzon, Inc. Chemically modified hemoglobin as an effective, stable non-immunogenic red blood cell substitute
US5352773A (en) * 1990-08-06 1994-10-04 Baxter International Inc. Stable hemoglobin based composition and method to store same
JP2709419B2 (ja) * 1990-08-06 1998-02-04 バクスター、インターナショナル、インコーポレイテッド 安定なヘモグロビンに基づく組成物及びその貯蔵方法
WO1992008478A1 (en) * 1990-11-20 1992-05-29 Enzon, Inc. Method of enhancing long-term storage stability of hemoglobin products
SE9301581D0 (sv) * 1993-05-07 1993-05-07 Kabi Pharmacia Ab Protein formulation

Also Published As

Publication number Publication date
AU708264B2 (en) 1999-07-29
ATE203546T1 (de) 2001-08-15
AU5852096A (en) 1996-11-21
WO1996034889A1 (en) 1996-11-07
US5929031A (en) 1999-07-27
EP0826004B1 (de) 2001-07-25
CA2216382A1 (en) 1996-11-07
DE69614105D1 (de) 2001-08-30
JPH11507016A (ja) 1999-06-22
EP0826004A1 (de) 1998-03-04

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