DE69608457D1 - Verfahren zur identifizierung von mutationen durch ligation vom mehrfach oligonukleotidsonden - Google Patents

Verfahren zur identifizierung von mutationen durch ligation vom mehrfach oligonukleotidsonden

Info

Publication number
DE69608457D1
DE69608457D1 DE69608457T DE69608457T DE69608457D1 DE 69608457 D1 DE69608457 D1 DE 69608457D1 DE 69608457 T DE69608457 T DE 69608457T DE 69608457 T DE69608457 T DE 69608457T DE 69608457 D1 DE69608457 D1 DE 69608457D1
Authority
DE
Germany
Prior art keywords
ligation
oligonucleotide probe
identifying mutations
multiple oligonucleotide
mutations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69608457T
Other languages
English (en)
Inventor
D Yager
M Dunn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Visible Genetics Inc
Original Assignee
Visible Genetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Visible Genetics Inc filed Critical Visible Genetics Inc
Application granted granted Critical
Publication of DE69608457D1 publication Critical patent/DE69608457D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE69608457T 1995-08-30 1996-08-28 Verfahren zur identifizierung von mutationen durch ligation vom mehrfach oligonukleotidsonden Expired - Lifetime DE69608457D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US303895P 1995-08-30 1995-08-30
US08/590,503 US5888731A (en) 1995-08-30 1996-01-24 Method for identification of mutations using ligation of multiple oligonucleotide probes
PCT/US1996/014020 WO1997008344A2 (en) 1995-08-30 1996-08-28 Method for identification of mutations using ligation of multiple oligonucleotide probes

Publications (1)

Publication Number Publication Date
DE69608457D1 true DE69608457D1 (de) 2000-06-21

Family

ID=26671210

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69608457T Expired - Lifetime DE69608457D1 (de) 1995-08-30 1996-08-28 Verfahren zur identifizierung von mutationen durch ligation vom mehrfach oligonukleotidsonden

Country Status (7)

Country Link
US (2) US5888731A (de)
EP (1) EP0847449B1 (de)
JP (1) JPH11511327A (de)
AU (1) AU704962B2 (de)
CA (1) CA2227611A1 (de)
DE (1) DE69608457D1 (de)
WO (1) WO1997008344A2 (de)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6261808B1 (en) 1992-08-04 2001-07-17 Replicon, Inc. Amplification of nucleic acid molecules via circular replicons
WO1994003624A1 (en) * 1992-08-04 1994-02-17 Auerbach Jeffrey I Methods for the isothermal amplification of nucleic acid molecules
US5888731A (en) * 1995-08-30 1999-03-30 Visible Genetics Inc. Method for identification of mutations using ligation of multiple oligonucleotide probes
US6225056B1 (en) * 1996-09-13 2001-05-01 Laboratory Of Molecular Biophotonics Solid phases for target nucleic acid detection, process for production thereof, and method of target nucleic acid detection
CA2304258C (en) * 1998-07-24 2010-04-13 Lumigen, Inc. Methods of synthesizing polynucleotides by ligation of multiple oligomers
US5998175A (en) * 1998-07-24 1999-12-07 Lumigen, Inc. Methods of synthesizing and amplifying polynucleotides by ligation of multiple oligomers
DE69905832T2 (de) 1998-09-18 2004-02-05 Massachusetts Institute Of Technology, Cambridge Biologische Verwendungen von halbleitenden Nanokristallen
JP3313358B2 (ja) 1998-11-09 2002-08-12 栄研化学株式会社 核酸の合成方法
US7014994B1 (en) 1999-03-19 2006-03-21 Cornell Research Foundation,Inc. Coupled polymerase chain reaction-restriction-endonuclease digestion-ligase detection reaction process
US6692915B1 (en) 1999-07-22 2004-02-17 Girish N. Nallur Sequencing a polynucleotide on a generic chip
JP4721603B2 (ja) * 1999-11-08 2011-07-13 栄研化学株式会社 変異および／または多型の検出方法
EP1231281B1 (de) 1999-11-08 2006-02-01 Eiken Kagaku Kabushiki Kaisha Methode zum nachweis von variationen oder polymorphismen
EP1130113A1 (de) * 2000-02-15 2001-09-05 Johannes Petrus Schouten Amplifizierungsassay abhängig von multiplex Ligation
AU2001248352A1 (en) * 2000-03-15 2001-09-24 Epigenomics Ag Diagnosis of diseases associated with the cell cycle
US7129045B2 (en) * 2000-03-23 2006-10-31 Lumigen, Inc. Methods of detecting polynucleotide kinase and its use as a label
AU2001244677A1 (en) * 2000-04-07 2001-10-23 Eiken Kagaku Kabushiki Kaisha Method of amplifying nucleic acid by using double-stranded nucleic acid as template
US6368801B1 (en) 2000-04-12 2002-04-09 Molecular Staging, Inc. Detection and amplification of RNA using target-mediated ligation of DNA by RNA ligase
WO2002055149A2 (en) * 2000-10-20 2002-07-18 Photomedex Controlled dose delivery of ultraviolet light for treating skin disorders
FR2817963B1 (fr) * 2000-12-13 2004-08-06 Inst Optique Theorique Et Appl Dispositif d'imagerie par plasmon d'une surface metallique et procede d'utilisation du dispositif
WO2002048689A1 (fr) * 2000-12-13 2002-06-20 Institut D'optique Theorique Et Appliquee Procede de caracterisation d'une surface, et dispositif pour sa mise en oeuvre
US6479244B1 (en) * 2001-04-23 2002-11-12 Galileo Genomics Method for genotyping microsatellite DNA markers
AU2003303395A1 (en) * 2001-05-22 2004-07-22 Dahl, Gary, A. Target-dependent transcription using deletion mutants of n4 rna polymerase
US7256923B2 (en) * 2001-06-25 2007-08-14 University Of Washington Switchable window based on electrochromic polymers
US20110151438A9 (en) 2001-11-19 2011-06-23 Affymetrix, Inc. Methods of Analysis of Methylation
CA2467460A1 (en) * 2001-11-19 2003-05-30 Parallele Bioscience, Inc. Multiplex oligonucleotide addition and target amplification
US20030228906A1 (en) 2002-04-19 2003-12-11 Walker Jay S. Methods and apparatus for providing communications services at a gaming machine
US20040157238A1 (en) * 2002-09-20 2004-08-12 Quinn John J. Method for detection of multiple nucleic acid sequence variations
CN101061079A (zh) * 2002-11-22 2007-10-24 圣戈本陶瓷及塑料股份有限公司 氧化锆韧化的氧化铝esd安全陶瓷组合物、元件、及其制造方法
US9487823B2 (en) * 2002-12-20 2016-11-08 Qiagen Gmbh Nucleic acid amplification
GB0304371D0 (en) 2003-02-26 2003-04-02 Solexa Ltd DNA Sequence analysis
US8043834B2 (en) * 2003-03-31 2011-10-25 Qiagen Gmbh Universal reagents for rolling circle amplification and methods of use
WO2005017153A2 (en) * 2003-08-04 2005-02-24 Blue Heron Biotechnology, Inc. Methods for synthesis of defined polynucleotides
GB0320059D0 (en) * 2003-08-27 2003-10-01 Solexa Ltd A method of sequencing
US20050048498A1 (en) * 2003-08-29 2005-03-03 Applera Corporation Compositions, methods, and kits for assembling probes
US20050069895A1 (en) * 2003-08-29 2005-03-31 Applera Corporation Compositions, methods, and kits for fabricating coded molecular tags
US7198900B2 (en) * 2003-08-29 2007-04-03 Applera Corporation Multiplex detection compositions, methods, and kits
EP2208797A3 (de) 2004-03-01 2010-11-24 Applied Biosystems, LLC Verfahren, Zusammensetzungen und Kits für Polynukleotidamplifikation
US7700287B2 (en) * 2005-01-28 2010-04-20 Life Technologies Corporation Compositions and methods for terminating a sequencing reaction at a specific location in a target DNA template
US8309303B2 (en) * 2005-04-01 2012-11-13 Qiagen Gmbh Reverse transcription and amplification of RNA with simultaneous degradation of DNA
EP1762627A1 (de) 2005-09-09 2007-03-14 Qiagen GmbH Verfahren zur Aktivierung einer Nukleinsäure für eine Polymerase-Reaktion
DE102006020885A1 (de) * 2006-05-05 2007-11-08 Qiagen Gmbh Einführung von Sequenzelementen in Nukleinsäuren
US10174368B2 (en) 2009-09-10 2019-01-08 Centrillion Technology Holdings Corporation Methods and systems for sequencing long nucleic acids
US10072287B2 (en) 2009-09-10 2018-09-11 Centrillion Technology Holdings Corporation Methods of targeted sequencing
JP2013523178A (ja) * 2010-04-12 2013-06-17 レスポンス ジェネティクス，インコーポレイティド Ｋｒａｓプライマーおよびプローブ
ES2860945T3 (es) 2010-12-27 2021-10-05 Abbott Molecular Inc Cuantificación de muestras de títulos altos por PCR digital
AU2012278784B2 (en) * 2011-07-06 2015-12-24 The Johns Hopkins University Semi-digital ligation assay
JP6430253B2 (ja) * 2011-11-05 2018-11-28 プレジデント アンド フェローズ オブ ハーバード カレッジ 相互作用を検出および測定するための核酸ベースのリンカー
CN105531375B (zh) 2012-12-10 2020-03-03 分析生物科学有限公司 靶向基因组分析的方法
DE102013221402A1 (de) * 2013-10-22 2015-04-23 Siemens Aktiengesellschaft Verfahren zur Detektion und Quantifizierung von einer einzelsträngigen Ziel-Nukleinsäure
CN103898232B (zh) * 2014-04-18 2016-04-13 广州市康立明生物科技有限责任公司 一种检测低丰度分子改变的方法
US11198900B2 (en) 2014-12-06 2021-12-14 Children's Medical Center Corporation Nucleic acid-based linkers for detecting and measuring interactions
US11396650B2 (en) 2015-06-02 2022-07-26 Children's Medical Center Corporation Nucleic acid complexes for screening barcoded compounds
EP3889257A1 (de) 2015-11-11 2021-10-06 Resolution Bioscience, Inc. Hocheffiziente konstruktion von dna-bibliotheken
US11713483B2 (en) 2016-02-09 2023-08-01 Children's Medical Center Corporation Method for detection of analytes via polymer complexes
BR112019003704A2 (pt) 2016-08-25 2019-05-28 Resolution Bioscience Inc métodos para a detecção de alterações na cópia genômica em amostras de dna
WO2019100080A1 (en) 2017-11-20 2019-05-23 Children's Medical Center Corporation Force-controlled nanoswitch assays for single-molecule detection in complex biological fluids

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE53166B1 (en) * 1980-08-05 1988-08-03 Searle & Co Synthetic urogastrone gene,corresponding plasmid recombinants,transformed cells,production thereof and urogastrone expression
US4883750A (en) * 1984-12-13 1989-11-28 Applied Biosystems, Inc. Detection of specific sequences in nucleic acids
AU622426B2 (en) * 1987-12-11 1992-04-09 Abbott Laboratories Assay using template-dependent nucleic acid probe reorganization
US5093245A (en) * 1988-01-26 1992-03-03 Applied Biosystems Labeling by simultaneous ligation and restriction
US5132215A (en) * 1988-09-15 1992-07-21 Eastman Kodak Company Method of making double-stranded dna sequences
ES2089038T3 (es) * 1990-01-26 1996-10-01 Abbott Lab Procedimiento mejorado para amplificar acidos nucleicos blanco aplicable para la reaccion en cadena de polimerasa y ligasa.
US5427930A (en) * 1990-01-26 1995-06-27 Abbott Laboratories Amplification of target nucleic acids using gap filling ligase chain reaction
US5516663A (en) * 1990-01-26 1996-05-14 Abbott Laboratories Ligase chain reaction with endonuclease IV correction and contamination control
AU7762091A (en) * 1990-03-30 1991-10-30 City Of Hope Detection of minimal residual disease in lymphoid malignancies
US5042272A (en) * 1990-07-12 1991-08-27 Union Underwear Company Inc. Knitting machine fabric roll doffing apparatus
CA2052413C (en) * 1990-09-28 2004-07-13 Jeffrey L. Joseph Nucleotides sequences useful as type-specific probes, pcr primers and lcr probes for the amplifications and detection of human papilloma virus, and related kits and methods
WO1993020227A1 (en) * 1992-03-31 1993-10-14 Abbott Laboratories Method of multiplex ligase chain reaction
CA2133643A1 (en) * 1992-04-06 1993-10-14 Stanley R. Bouma Method and device for detection of nucleic acid or analyte using total internal reflectance
US5547843A (en) * 1992-07-17 1996-08-20 Associated Universities, Inc. Method for promoting specific alignment of short oligonucleotides on nucleic acids
CA2140331C (en) * 1992-08-03 2000-01-18 John J. Carrino Detecting and amplifying target nucleic acids using exonucleolytic activity
WO1994008047A1 (en) * 1992-09-25 1994-04-14 Abbott Laboratories Ligase chain reaction method for detecting small mutations
JPH08505531A (ja) * 1993-01-15 1996-06-18 ザ パブリック ヘルス リサーチ インスティチュート オブ ザ シティー オブ ニューヨーク インク Ｒｎａバイナリ・プローブとリボザイムリガーゼを用いたｒｎａ検定法
CA2160016C (en) * 1993-04-12 2008-06-03 Robert L. Letsinger Method of forming oligonucleotides
US5695933A (en) * 1993-05-28 1997-12-09 Massachusetts Institute Of Technology Direct detection of expanded nucleotide repeats in the human genome
US5650274A (en) * 1993-06-25 1997-07-22 Hitachi, Ltd. DNA analyzing method
WO1995011996A1 (en) * 1993-10-27 1995-05-04 Cornell Research Foundation, Inc. Detection assay for listeria and erwinia microorganisms
JP3738910B2 (ja) * 1994-04-04 2006-01-25 バイエル コーポレーション 特定の核酸配列を検出するためのハイブリダイゼーション−ライゲーション分析
US5866337A (en) * 1995-03-24 1999-02-02 The Trustees Of Columbia University In The City Of New York Method to detect mutations in a nucleic acid using a hybridization-ligation procedure
US5888731A (en) * 1995-08-30 1999-03-30 Visible Genetics Inc. Method for identification of mutations using ligation of multiple oligonucleotide probes

Also Published As

Publication number Publication date
WO1997008344A3 (en) 1997-08-14
US6025139A (en) 2000-02-15
EP0847449B1 (de) 2000-05-17
EP0847449A2 (de) 1998-06-17
CA2227611A1 (en) 1997-03-06
WO1997008344A2 (en) 1997-03-06
US5888731A (en) 1999-03-30
AU6908996A (en) 1997-03-19
AU704962B2 (en) 1999-05-13
JPH11511327A (ja) 1999-10-05

Similar Documents

Publication Publication Date Title
DE69608457D1 (de) Verfahren zur identifizierung von mutationen durch ligation vom mehrfach oligonukleotidsonden
DE69635150D1 (de) Verfahren und Vorrichtung zur Verwaltung von Reagenzien
DE59609524D1 (de) Verfahren zur Genexpressionsanalyse
DE69420547D1 (de) Wellenform-mischungsverfahren für system zur text-zu-sprache umsetzung
DE69931549D1 (de) Vorrichtung und Verfahren zur Interpolation von Bilddaten
DE69530277T2 (de) Verfahren zur auswahl von übertragungsvorzügen
DE69603255D1 (de) Verfahren zur modifizierung von oberflächen
DE69631677D1 (de) Verfahren zur positionsbestimmung von einem angerufenen teilnehmer
DE69619864T2 (de) Verfahren zur amplifizierung spezifischer nukleinsäuresequenzen
DE59605626D1 (de) Verfahren zur durchführung von kreuzkupplungsreaktionen
DE69515241D1 (de) Verfahren zur Emulsions-Polymerisation
DE69630686D1 (de) Verfahren zur echtheitsprüfung von münzen
DE69926451D1 (de) Verfahren und Vorrichtung zur Unterdrückung von Mehrkanalechos
DE59806044D1 (de) Verfahren zur ermittlung von segmentzeiten
DE59505524D1 (de) Verfahren zur carbonylierung von olefinen
DE69319752T2 (de) Verfahren zur identifizierung von analyten
DE69803138T2 (de) Verfahren und Vorrichtung zur Reinigung von Metallbändern
DE69814482D1 (de) Verfahren und Vorrichtung zur Darstellung von Oberflächen aus volumetrischen Daten
DE69501893T2 (de) Verfahren zur genetischen prüfung
DE69520508T2 (de) Verfahren zur verbesserung von durch radar erfassten daten
DE69601540T2 (de) Verfahren zur oxychlorierung
DE69512783T2 (de) Verfahren zur entfernung von gelösten metallkatalysatoren aus esterreaktionsprodukten
DE59702267D1 (de) Verfahren zur Reaktivierung von Platinmetall enthaltenden Katalysatorsystemen
DE69609963T2 (de) Verfahren zur iodierung
DE69534231D1 (de) Verfahren und Einrichtung zur Verwaltung von Mehrfachverbindungen

Legal Events

Date Code Title Description
8332 No legal effect for de