DE69535282D1 - Verwendung von bakteriellen enzymen z.b. heparinasen, chodroitinasen um wundheilungprozesse zu modulieren - Google Patents

Verwendung von bakteriellen enzymen z.b. heparinasen, chodroitinasen um wundheilungprozesse zu modulieren

Info

Publication number
DE69535282D1
DE69535282D1 DE69535282T DE69535282T DE69535282D1 DE 69535282 D1 DE69535282 D1 DE 69535282D1 DE 69535282 T DE69535282 T DE 69535282T DE 69535282 T DE69535282 T DE 69535282T DE 69535282 D1 DE69535282 D1 DE 69535282D1
Authority
DE
Germany
Prior art keywords
cell
heparinases
extracellular matrix
growth factors
heparan sulfate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69535282T
Other languages
English (en)
Other versions
DE69535282T2 (de
Inventor
Joseph Zimmermann
Israel Vlodavsky
Clark Bennett
Pamela Danagher
Richard Broughton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biomarin Pharmaceutical Inc
Original Assignee
Biomarin Pharmaceutical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomarin Pharmaceutical Inc filed Critical Biomarin Pharmaceutical Inc
Publication of DE69535282D1 publication Critical patent/DE69535282D1/de
Application granted granted Critical
Publication of DE69535282T2 publication Critical patent/DE69535282T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/51—Lyases (4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/825—Bacteria
DE69535282T 1994-07-08 1995-07-07 Verwendung von bakteriellen enzymen z.b. heparinasen, chodroitinasen um wundheilungprozesse zu modulieren Expired - Fee Related DE69535282T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US273109 1994-07-08
US08/273,109 US5997863A (en) 1994-07-08 1994-07-08 Attenuation of wound healing processes
PCT/US1995/008608 WO1996001648A1 (en) 1994-07-08 1995-07-07 Attenuation of wound healing processes

Publications (2)

Publication Number Publication Date
DE69535282D1 true DE69535282D1 (de) 2006-12-14
DE69535282T2 DE69535282T2 (de) 2007-05-24

Family

ID=23042598

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69535282T Expired - Fee Related DE69535282T2 (de) 1994-07-08 1995-07-07 Verwendung von bakteriellen enzymen z.b. heparinasen, chodroitinasen um wundheilungprozesse zu modulieren

Country Status (9)

Country Link
US (1) US5997863A (de)
EP (1) EP0769961B1 (de)
JP (1) JP4152433B2 (de)
AT (1) ATE344051T1 (de)
AU (1) AU707007B2 (de)
CA (1) CA2194370C (de)
DE (1) DE69535282T2 (de)
ES (1) ES2279514T3 (de)
WO (1) WO1996001648A1 (de)

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WO1997016556A1 (en) 1995-10-30 1997-05-09 Massachusetts Institute Of Technology Rationally designed polysaccharide lyases derived from heparinase i
GB2317182B (en) * 1996-09-11 2000-11-01 Johnson & Johnson Medical Sulfated polysaccharides and uses thereof in medical treatment
US6699672B1 (en) * 1997-09-02 2004-03-02 Insight Biopharmaceuticals Ltd. Heparanase specific molecular probes and their use research and medical applications
US20040213789A1 (en) * 1997-09-02 2004-10-28 Oron Yacoby-Zeevi Heparanase activity neutralizing anti-heparanase monoclonal antibody and other anti-heparanase antibodies
US20030161823A1 (en) * 1998-08-31 2003-08-28 Neta Ilan Therapeutic and cosmetic uses of heparanases
US20020088019A1 (en) * 1997-09-02 2002-07-04 Oron Yacoby-Zeevi Methods of and pharmaceutical compositions for improving implantation of embryos
US6177545B1 (en) * 1997-09-02 2001-01-23 Insight Strategy & Marketing Ltd. Heparanase specific molecular probes and their use in research and medical applications
US20010006630A1 (en) * 1997-09-02 2001-07-05 Oron Yacoby-Zeevi Introducing a biological material into a patient
WO1999046368A2 (en) * 1998-03-13 1999-09-16 Biomarin Pharmaceuticals Carbohydrate-modifying enzymes for burn and wound debridement and methods for treatment
US7056504B1 (en) 1998-08-27 2006-06-06 Massachusetts Institute Of Technology Rationally designed heparinases derived from heparinase I and II
WO2000012726A2 (en) 1998-08-27 2000-03-09 Massachusetts Institute Of Technology Rationally designed heparinases derived from heparinase i and ii
US20030217375A1 (en) * 1998-08-31 2003-11-20 Eyal Zcharia Transgenic animals expressing heparanase and uses thereof
EP1157118A4 (de) * 1999-03-01 2002-07-17 Insight Strategy & Marketing POLYNUKLEOTID, DAS FüR EIN POLYPEPTID MIT HEPARANASE-AKTIVäT KODIERT, UND DESSEN EXPRESSION IN GENETISCH VERäNDERTEN ZELLEN
CA2370539C (en) * 1999-04-23 2009-01-06 Massachusetts Institute Of Technology System and method for notating polymers
US6979563B1 (en) 1999-11-17 2005-12-27 Biomarin Enzymes, Inc. Attenuation of tumor growth, metastasis and angiogenesis
CA2414185A1 (en) * 1999-11-17 2001-05-25 Ibex Technologies, Inc. Attenuation of tumor growth, metastasis and angiogenesis by use of chondroitin sulfate degrading enzymes
WO2001038399A1 (fr) * 1999-11-24 2001-05-31 Seikagaku Corporation Procede de traitement des maladies des tissus superficiels
ES2527853T3 (es) * 2000-03-08 2015-01-30 Massachusetts Institute Of Technology Heparinasa III y sus usos
US7083937B2 (en) 2000-09-12 2006-08-01 Massachusetts Institute Of Technology Methods and products related to the analysis of polysaccarides
CA2423469A1 (en) 2000-10-18 2002-04-25 Massachusetts Institute Of Technology Methods and products related to pulmonary delivery of polysaccharides
WO2002091999A2 (en) * 2001-05-09 2002-11-21 Geron Corporation Treatment for wounds
IL160188A0 (en) * 2001-08-13 2004-07-25 Univ Florida Materials and methods to promote repair of nerve tissue
US6671189B2 (en) * 2001-11-09 2003-12-30 Minebea Co., Ltd. Power converter having primary and secondary side switches
GB0205022D0 (en) 2002-03-04 2002-04-17 Univ Cambridge Tech Materials and methods for the treatment of cns damage
US6974592B2 (en) * 2002-04-11 2005-12-13 Ocean Nutrition Canada Limited Encapsulated agglomeration of microcapsules and method for the preparation thereof
WO2004108069A2 (en) * 2002-05-04 2004-12-16 Acorda Therapeutics, Inc. Compositions and methods for promoting neuronal outgrowth
US6962699B2 (en) 2002-06-03 2005-11-08 Massachusetts Institute Of Technology Rationally designed polysaccharide lyases derived from chondroitinase B
US20060153827A1 (en) * 2002-08-15 2006-07-13 Gruskin Elliott A Chimeric protein
KR101175774B1 (ko) * 2002-11-04 2012-08-21 오션 뉴트리션 캐나다 리미티드 다중 쉘을 갖는 마이크로캡슐 및 이의 제조 방법
EP2460881B1 (de) 2003-05-16 2017-05-03 Acorda Therapeutics, Inc. Proteoglycan-abbauende Mutanten zur Behandlung des ZNS
US7959914B2 (en) 2003-05-16 2011-06-14 Acorda Therapeutics, Inc. Methods of reducing extravasation of inflammatory cells
ATE524067T1 (de) 2003-05-16 2011-09-15 Acorda Therapeutics Inc Zusammensetzungen und verfahren zur behandlung von zns-schäden
US20060269552A1 (en) * 2003-06-09 2006-11-30 Oron Yacoby-Zeevi Heparanase activity neutralizing anti-heparanase monclonal antibody and other anti-heparanase antibodies
WO2005074655A2 (en) * 2004-01-30 2005-08-18 Emory University Materials and method for promotion of nerve regeneration
EP1737954A2 (de) * 2004-03-10 2007-01-03 The Massachusetts Institute Of Technology Rekombinante chondroitinase abc i und verwendungen davon
WO2005112986A2 (en) * 2004-05-18 2005-12-01 Acorda Therapeutics, Inc. Purifying chondroitinase and stable formulations thereof
US8034450B2 (en) * 2005-01-21 2011-10-11 Ocean Nutrition Canada Limited Microcapsules and emulsions containing low bloom gelatin and methods of making and using thereof
US9968120B2 (en) 2006-05-17 2018-05-15 Dsm Nutritional Products Ag Homogenized formulations containing microcapsules and methods of making and using thereof
JP5189985B2 (ja) * 2005-09-26 2013-04-24 アコーダ セラピューティクス、インク． コンドロイチナーゼａｂｃｉ変異体を用いた組成物およびその使用方法
WO2007049361A1 (ja) * 2005-10-27 2007-05-03 Stelic Corp. 肝線維化抑制剤
US7767420B2 (en) * 2005-11-03 2010-08-03 Momenta Pharmaceuticals, Inc. Heparan sulfate glycosaminoglycan lyase and uses thereof
US7691613B2 (en) * 2006-11-03 2010-04-06 Momenta Pharmaceuticals, Inc. Glycosaminoglycan lyase IV and uses thereof
US7691612B2 (en) 2005-11-03 2010-04-06 Momenta Pharmaceuticals, Inc. Heparan sulfate glycosaminoglycan lyase and uses thereof
JP2009533490A (ja) * 2006-04-07 2009-09-17 オーシャン ニュートリッション カナダ リミテッド 低い界面張力を有する物質を含む乳濁液およびマイクロカプセル、ならびにそれらを作製および使用する方法
NZ596403A (en) * 2006-06-05 2013-02-22 Ocean Nutrition Canada Ltd Microcapsules with improved shells with wax in the outer shell
ES2473610T3 (es) 2006-10-10 2014-07-07 Acorda Therapeutics, Inc. Composiciones y métodos de uso de mutantes de condroitinasa ABCI
CN101641087B (zh) 2007-01-10 2013-08-21 加拿大海洋营养食品有限公司 素食的微胶囊
US20090286289A1 (en) * 2008-03-10 2009-11-19 Pang Danny Z Production of Hyaluronate Unsaturated Disaccharides and its Application
EP2756849B1 (de) * 2011-09-15 2016-03-16 Seikagaku Corporation Skelettmuskelregenerationsförderer
US9238090B1 (en) 2014-12-24 2016-01-19 Fettech, Llc Tissue-based compositions
CN109182321A (zh) * 2018-09-14 2019-01-11 深圳市长征生物科技有限公司 肝素黄杆菌肝素酶ⅰ的高效制备方法

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US4760131A (en) * 1986-04-23 1988-07-26 Collagen Corporation Wound-healing composition
US5169772A (en) * 1988-06-06 1992-12-08 Massachusetts Institute Of Technology Large scale method for purification of high purity heparinase from flavobacterium heparinum
WO1990006590A1 (en) * 1988-12-01 1990-06-14 Edward Bok Improved installation for transport and processing under a pulsating double-floating condition
US5116615A (en) * 1989-01-27 1992-05-26 Immunolytics, Inc. Method for treating benign prostatic hypertrophy
KR927003090A (ko) * 1989-08-23 1992-12-17 하다사 메디칼 오르가니제이션 헤파린효소를 포함하는 상처 치유 약제
US5242810A (en) * 1990-12-07 1993-09-07 Biogen, Inc. Bifunctional inhibitors of thrombin and platelet activation
US5262325A (en) * 1991-04-04 1993-11-16 Ibex Technologies, Inc. Method for the enzymatic neutralization of heparin
US5389539A (en) * 1992-11-30 1995-02-14 Massachusetts Institute Of Technology Purification of heparinase I, II, and III from Flavobacterium heparinum
AU1176595A (en) * 1993-11-12 1995-05-29 International Technology Management Associates, Ltd. Methods of repairing connective tissues
EP0726773A1 (de) * 1993-11-17 1996-08-21 Massachusetts Institute Of Technology Verfahren zur hemmung der angiogenese mittels heparinase

Also Published As

Publication number Publication date
JPH10506609A (ja) 1998-06-30
US5997863A (en) 1999-12-07
WO1996001648A1 (en) 1996-01-25
AU3094995A (en) 1996-02-09
ATE344051T1 (de) 2006-11-15
ES2279514T3 (es) 2007-08-16
EP0769961A1 (de) 1997-05-02
CA2194370C (en) 2001-02-27
EP0769961B1 (de) 2006-11-02
CA2194370A1 (en) 1996-01-25
JP4152433B2 (ja) 2008-09-17
AU707007B2 (en) 1999-07-01
DE69535282T2 (de) 2007-05-24

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee