DE69532033D1 - Für ein fibroblasten-aktivierungsprotein kodierende nukleinsäure und verwendungen dafür - Google Patents
Für ein fibroblasten-aktivierungsprotein kodierende nukleinsäure und verwendungen dafürInfo
- Publication number
- DE69532033D1 DE69532033D1 DE69532033T DE69532033T DE69532033D1 DE 69532033 D1 DE69532033 D1 DE 69532033D1 DE 69532033 T DE69532033 T DE 69532033T DE 69532033 T DE69532033 T DE 69532033T DE 69532033 D1 DE69532033 D1 DE 69532033D1
- Authority
- DE
- Germany
- Prior art keywords
- nucleic acid
- fibroblaste
- activation protein
- encoding nucleic
- protein encoding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000039446 nucleic acids Human genes 0.000 title abstract 2
- 108020004707 nucleic acids Proteins 0.000 title abstract 2
- 150000007523 nucleic acids Chemical class 0.000 title abstract 2
- 230000004913 activation Effects 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 102100023832 Prolyl endopeptidase FAP Human genes 0.000 abstract 2
- 108010072257 fibroblast activation protein alpha Proteins 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70517—CD8
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US230491 | 1994-04-20 | ||
US08/230,491 US5587299A (en) | 1994-04-20 | 1994-04-20 | Isolated nucleic acid molecule coding for fibroblast activation protein alpha and uses thereof |
PCT/US1995/004860 WO1995029233A1 (en) | 1994-04-20 | 1995-04-19 | ISOLATED NUCLEIC ACID MOLECULE CODING FOR FIBROBLAST ACTIVATION PROTEIN α AND USES THEREOF |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69532033D1 true DE69532033D1 (de) | 2003-12-04 |
DE69532033T2 DE69532033T2 (de) | 2004-07-08 |
Family
ID=22865438
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69532033T Expired - Lifetime DE69532033T2 (de) | 1994-04-20 | 1995-04-19 | Für ein fibroblasten-aktivierungsprotein kodierende nukleinsäure und verwendungen dafür |
Country Status (7)
Country | Link |
---|---|
US (1) | US5587299A (de) |
EP (1) | EP0763105B1 (de) |
JP (1) | JPH10504443A (de) |
AT (1) | ATE253113T1 (de) |
AU (1) | AU685273B2 (de) |
DE (1) | DE69532033T2 (de) |
WO (1) | WO1995029233A1 (de) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5767242A (en) * | 1994-04-20 | 1998-06-16 | Boehringer Ingelheim Int'l Gmbh | Isolated dimeric fibroblast activation protein alpha, and uses thereof |
US6979697B1 (en) * | 1998-08-21 | 2005-12-27 | Point Therapeutics, Inc. | Regulation of substrate activity |
US6890904B1 (en) | 1999-05-25 | 2005-05-10 | Point Therapeutics, Inc. | Anti-tumor agents |
AU2001256325A1 (en) * | 2000-03-17 | 2001-09-24 | Boehringer Ingelheim Pharma Kg | Human and humanized fap-alpha-specific antibodies |
EP1534331B1 (de) * | 2002-06-21 | 2014-10-29 | Johns Hopkins University School of Medicine | Membran-assoziierte tumorendothel-marker |
JP2006507352A (ja) * | 2002-07-09 | 2006-03-02 | ポイント セラピューティクス, インコーポレイテッド | イソロイシンのボロプロリン化合物に関する方法および組成物 |
JP2004173695A (ja) * | 2002-11-25 | 2004-06-24 | F Hoffmann La Roche Ag | Dpp−ivの結晶構造およびその使用方法 |
US7309774B2 (en) * | 2003-02-07 | 2007-12-18 | The Board Of Regents Of The University Of Oklahoma | Antiplasmin cleaving enzyme |
US20080057491A1 (en) * | 2003-02-07 | 2008-03-06 | Mckee Patrick A | Substrates and inhibitors of antiplasmin cleaving enzyme and methods of use |
EP1812458A2 (de) * | 2004-10-27 | 2007-08-01 | Wen-Tien Chen | Verfahren und zusammensetzungen zur desaktivierung von seprase |
WO2007111657A2 (en) | 2005-12-14 | 2007-10-04 | Ludwig Institute For Cancer Research | Method for diagnosing rheumatoid arthritis via assaying myofibroblast-like synoviocytes for fibroblast activation protein |
US8933201B2 (en) | 2006-06-07 | 2015-01-13 | The Board Of Regents Of The University Of Oklahoma | Substrates and inhibitors of antiplasmin cleaving enzyme and fibroblast activation protein and methods of use |
WO2011040973A2 (en) | 2009-10-02 | 2011-04-07 | Ludwig Institute For Cancer Research Ltd. | Tnf-immunoconjugates with fibroblast activation protein antibodies and methods and uses thereof |
WO2011040972A1 (en) | 2009-10-02 | 2011-04-07 | Ludwig Institute For Cancer Research Ltd. | Anti-fibroblast activation protein antibodies and methods and uses thereof |
CN103267852B (zh) * | 2013-05-15 | 2015-03-25 | 中国医学科学院北京协和医院 | 成纤维激活蛋白α在制备胰腺癌预后试剂盒中的用途 |
EP3503918B1 (de) | 2016-08-29 | 2020-09-30 | Psioxus Therapeutics Limited | Adenovirus mit bispezifischem t-zell-engager (bite) |
GB201713765D0 (en) | 2017-08-28 | 2017-10-11 | Psioxus Therapeutics Ltd | Modified adenovirus |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989008114A1 (en) * | 1988-02-25 | 1989-09-08 | The General Hospital Corporation | Rapid immunoselection cloning method |
CA2075259A1 (en) * | 1991-08-26 | 1993-02-27 | Junsheng Sang | Expression cloning method |
WO1993005804A1 (en) * | 1991-09-18 | 1993-04-01 | Sloan-Kettering Institute For Cancer Research | Activated stromal fibroblast-specific antibody, f19 and methods of using the same |
-
1994
- 1994-04-20 US US08/230,491 patent/US5587299A/en not_active Expired - Lifetime
-
1995
- 1995-04-19 JP JP7527758A patent/JPH10504443A/ja active Pending
- 1995-04-19 EP EP95917601A patent/EP0763105B1/de not_active Expired - Lifetime
- 1995-04-19 AT AT95917601T patent/ATE253113T1/de active
- 1995-04-19 WO PCT/US1995/004860 patent/WO1995029233A1/en active IP Right Grant
- 1995-04-19 AU AU23594/95A patent/AU685273B2/en not_active Ceased
- 1995-04-19 DE DE69532033T patent/DE69532033T2/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0763105A1 (de) | 1997-03-19 |
AU2359495A (en) | 1995-11-16 |
EP0763105B1 (de) | 2003-10-29 |
ATE253113T1 (de) | 2003-11-15 |
EP0763105A4 (de) | 1999-10-27 |
US5587299A (en) | 1996-12-24 |
AU685273B2 (en) | 1998-01-15 |
WO1995029233A1 (en) | 1995-11-02 |
DE69532033T2 (de) | 2004-07-08 |
JPH10504443A (ja) | 1998-05-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8327 | Change in the person/name/address of the patent owner |
Owner name: MEMORIAL SLOAN-KETTERING CANCER CENTER, NEW YORK, |
|
8364 | No opposition during term of opposition |