DE69524774T2 - Beta-carbolin-derivate als melatonin-agonisten, ihre herstellungsverfahren und verwendung als arzneimittel - Google Patents

Beta-carbolin-derivate als melatonin-agonisten, ihre herstellungsverfahren und verwendung als arzneimittel

Info

Publication number
DE69524774T2
DE69524774T2 DE69524774T DE69524774T DE69524774T2 DE 69524774 T2 DE69524774 T2 DE 69524774T2 DE 69524774 T DE69524774 T DE 69524774T DE 69524774 T DE69524774 T DE 69524774T DE 69524774 T2 DE69524774 T2 DE 69524774T2
Authority
DE
Germany
Prior art keywords
melatonine
agonists
production process
medicinal products
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69524774T
Other languages
German (de)
English (en)
Other versions
DE69524774D1 (de
Inventor
Jean-Bernard Fourtillan
Marianne Fourtillan
Jean-Claude Jacquesy
Marie-Paule Jouannetaud
Bruno Violeau
Omar Karam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Macef SAS
Original Assignee
LABORATOIRES BESINS INTERNATIONAL PARIS
Macef SAS
Laboratoires Besins International SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LABORATOIRES BESINS INTERNATIONAL PARIS, Macef SAS, Laboratoires Besins International SAS filed Critical LABORATOIRES BESINS INTERNATIONAL PARIS
Application granted granted Critical
Publication of DE69524774D1 publication Critical patent/DE69524774D1/de
Publication of DE69524774T2 publication Critical patent/DE69524774T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Anesthesiology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
DE69524774T 1994-09-14 1995-09-14 Beta-carbolin-derivate als melatonin-agonisten, ihre herstellungsverfahren und verwendung als arzneimittel Expired - Lifetime DE69524774T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9410964A FR2724384B1 (fr) 1994-09-14 1994-09-14 Nouveaux derives de la 3,4-dihydro beta-carboline agonistes de la melatonine, leur procede de preparation et leur utilisation a titre de medicament
PCT/FR1995/001179 WO1996008490A1 (fr) 1994-09-14 1995-09-14 NOUVEAUX DERIVES DE β-CARBOLINE ET D'ANALOGUES A STRUCTURE NAPHTALENIQUE AGONISTES DE LA MELATONINE, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION A TITRE DE MEDICAMENT

Publications (2)

Publication Number Publication Date
DE69524774D1 DE69524774D1 (de) 2002-01-31
DE69524774T2 true DE69524774T2 (de) 2002-09-19

Family

ID=9466929

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69524774T Expired - Lifetime DE69524774T2 (de) 1994-09-14 1995-09-14 Beta-carbolin-derivate als melatonin-agonisten, ihre herstellungsverfahren und verwendung als arzneimittel

Country Status (13)

Country Link
US (1) US6048868A (da)
EP (1) EP0781281B1 (da)
JP (1) JP4051712B2 (da)
CN (1) CN1046514C (da)
AT (1) ATE211138T1 (da)
AU (1) AU3475595A (da)
DE (1) DE69524774T2 (da)
DK (1) DK0781281T3 (da)
ES (1) ES2169147T3 (da)
FR (1) FR2724384B1 (da)
PT (1) PT781281E (da)
WO (1) WO1996008490A1 (da)
ZA (1) ZA961898B (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2724384B1 (fr) * 1994-09-14 1999-04-16 Cemaf Nouveaux derives de la 3,4-dihydro beta-carboline agonistes de la melatonine, leur procede de preparation et leur utilisation a titre de medicament
FR2754262B1 (fr) * 1996-10-08 1998-10-30 Synthelabo Derives de 1h-pyrido[3,4-b]indole-4-carboxamide, leur preparation et leur application en therapeutique
FR2765581B1 (fr) * 1997-07-03 1999-08-06 Synthelabo Derives de 3-aryl-1,9-dihydro-2h-pyrido[2,3-b]indol-2-one, leur preparation et leur application en therapeutique
FR2765582B1 (fr) * 1997-07-03 1999-08-06 Synthelabo Derives de 3-alkyl-1,9-dihydro-2h-pyrido[2,3-b]indol-2-one leur preparation et leur application en therapeutique
ES2174632T3 (es) * 1998-03-17 2002-11-01 Macef Derivados de beta-carbolina hipnotica, procedimiento para su preparacion y su utilizacion como productos medicinales.
FR2792937B1 (fr) 1999-04-27 2001-08-10 Cemaf NOUVEAUX DERIVES DE PYRROLO-(3,4-b) QUINOLEINE, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION A TITRE DE MEDICAMENT
UA74826C2 (en) * 2000-05-17 2006-02-15 Ortho Mcneil Pharm Inc ?-carboline derivatives as phosphodiesterase inhibitors
FR2824829B1 (fr) * 2001-05-16 2005-06-03 Macef Nouveaux derives de dihydroimidazo [5,1-a]-beta-carboline, leur procede de preparation et leur application a titre de medicament
WO2003078448A1 (en) 2002-03-13 2003-09-25 Signum Biosciences, Inc. Modulation of protein methylation and phosphoprotein phosphate
US7872133B2 (en) * 2003-06-23 2011-01-18 Ono Pharmaceutical Co., Ltd. Tricyclic heterocycle compound
US7767689B2 (en) * 2004-03-15 2010-08-03 Ptc Therapeutics, Inc. Carboline derivatives useful in the treatment of cancer
CN1980672B (zh) 2004-03-15 2011-05-04 Ptc医疗公司 用于抑制血管生成的咔啉衍生物
US8076353B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Inhibition of VEGF translation
US8076352B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Administration of carboline derivatives useful in the treatment of cancer and other diseases
PT1829874E (pt) 2004-12-22 2014-04-10 Ono Pharmaceutical Co Composto tricíclico e sua utilização
WO2006084033A1 (en) * 2005-02-03 2006-08-10 Signum Biosciences, Inc. Compositions and methods for enhancing cognitive function
US7923041B2 (en) 2005-02-03 2011-04-12 Signum Biosciences, Inc. Compositions and methods for enhancing cognitive function
FR2898358B1 (fr) * 2006-03-08 2008-05-30 Macef Sa Association d'un antagoniste du recepteur 5ht2 et d'activateur du recepteur 5ht2 par modulation allosterique et leurs utilisations comme produits medicaux
FR2908768A1 (fr) * 2006-06-19 2008-05-23 Fourtillan Snc DERIVES DE 3H,11H-OXAZOLO (3',4':1,2)PYRIDO(3,4-b)INDOLE ET LEUR UTILISATION EN THERAPEUTIQUE
FR2904973A1 (fr) * 2006-08-18 2008-02-22 Fourtillan Snc Derives de 1-methylidene-pyrido[3,4-b]indole et leur utilisation en therapeutique.
FR2912405A1 (fr) * 2007-02-08 2008-08-15 Fourtillan Snc Derives des imidazo[1',5':1,6]pyrido[3,4-b]indoles et leur utilisation en therapeutique
FR2912747A1 (fr) * 2007-02-19 2008-08-22 Fourtillan Snc Derives des 1-(1-hydoxy-3-oxo-propen-1-yl)-1,2,3,3a,8,8a-hexahydro- pyrrolo[2,3-b)indoles et leur utilisation en therapeutique
WO2008103470A2 (en) 2007-02-21 2008-08-28 Trustees Of Columbia University In The City Of New York Oncogenic-ras-signal dependent lethal compounds
FR2916200A1 (fr) * 2007-05-18 2008-11-21 Fourtillan Snc Nouveaux derives des 1,2,3,4,6,7,12,12a-octahydro pyrazino[1',2':1,6]pyrido[3,4-b]indoles, leur preparation et leur utilisation en therapeutique
CA2758424C (en) 2008-04-21 2018-03-06 Signum Biosciences, Inc. Tryptamine derivatives as pp2a methylation modulators
CA2975985A1 (fr) 2015-02-04 2016-08-11 Soeur Josefa Menendez Systeme therapeutique transdermique contenant de la valentonine et son utilisation comme medicament
FI130627B (en) * 2021-03-31 2023-12-18 Equinorm Ltd NEW HETEROCYCLIC COMPOUNDS AND THEIR USE

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3395E (fr) * 1904-03-23 1904-10-27 Georges Felix Coffignon Cordon métallique
ES273769A1 (es) * 1961-01-18 1962-06-01 Geigy Ag J R Procedimiento para la preparaciën de nuevos derivados de amidas de acido beta-carbolin-carboxilico
FR1524953A (fr) * 1962-03-26 1968-05-17 Konink Pharmaceutische Fabrike Procédé de préparation des dérivés de la quinolizine
FR3395M (fr) * 1963-07-30 1965-06-28 Roussel Uclaf Nouveau médicament notamment pour le traitement des états neurodépressifs et des psychoses d'anxiété.
GB1055203A (en) * 1964-09-16 1967-01-18 Ici Ltd -ß-carboline derivatives, a process for their manufacture, and compositions containing them
US3718657A (en) * 1970-12-03 1973-02-27 Abbott Lab Certain-2-substituted-1,2,3,4-tetrahydro-beta or gamma carbolines
US4336260A (en) * 1977-12-08 1982-06-22 The Dow Chemical Company Method and compositions using 1-aryl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid for treating depression
DK72180A (da) * 1979-04-10 1980-10-11 Ciba Geigy Ag Fremgangsmaade til fremstilling af diazatricycler samt salte deraf
FR2455044A1 (fr) * 1979-04-26 1980-11-21 Synthelabo Pyrido-indoles et leur application en therapeutique
DE3621413A1 (de) * 1986-06-26 1988-01-07 Boehringer Ingelheim Kg Verwendung carbocyclisch und heterocyclisch annelierter dihydropyridine als cardioprotektive mittel sowie neue heterocyclisch und carbocyclisch anellierte dihydropyridine, verfahren zu deren herstellung und zwischenstufen fuer deren herstellung
US5283343A (en) * 1987-08-17 1994-02-01 Whitby Research, Inc. 2-aryl substituted N-acetyltryptamines and process of preparing such
US5093352A (en) * 1988-11-14 1992-03-03 Whitby Research, Inc. Antidepressant agents
FR2663935A1 (fr) * 1990-06-27 1992-01-03 Adir Nouveaux 1,2,3,4,5,6-hexahydroazepino [4,5-b] indoles et 1,2,3,4-tetrahydrobethacarbolines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
DE4104257A1 (de) * 1991-02-13 1992-08-20 Boehringer Ingelheim Kg Verwendung von anellierten tetrahydropyridinessigsaeurederivaten fuer die behandlung neurologischer erkrankungen
US5206377A (en) * 1991-12-05 1993-04-27 Whitby Research, Inc. Compounds useful as antiproliferative agents
FR2724384B1 (fr) * 1994-09-14 1999-04-16 Cemaf Nouveaux derives de la 3,4-dihydro beta-carboline agonistes de la melatonine, leur procede de preparation et leur utilisation a titre de medicament

Also Published As

Publication number Publication date
WO1996008490A1 (fr) 1996-03-21
CN1046514C (zh) 1999-11-17
DK0781281T3 (da) 2002-04-15
JPH10505606A (ja) 1998-06-02
DE69524774D1 (de) 2002-01-31
ATE211138T1 (de) 2002-01-15
FR2724384A1 (fr) 1996-03-15
ES2169147T3 (es) 2002-07-01
CN1161039A (zh) 1997-10-01
EP0781281B1 (fr) 2001-12-19
JP4051712B2 (ja) 2008-02-27
ZA961898B (en) 1996-09-17
PT781281E (pt) 2002-08-30
FR2724384B1 (fr) 1999-04-16
EP0781281A1 (fr) 1997-07-02
AU3475595A (en) 1996-03-29
US6048868A (en) 2000-04-11

Similar Documents

Publication Publication Date Title
DE69524774T2 (de) Beta-carbolin-derivate als melatonin-agonisten, ihre herstellungsverfahren und verwendung als arzneimittel
PL322015A1 (en) Derivatives of hydroxylamine useful as compounds enhancing production of accompanying molecular protein and ethod of obtaining them
DE69231522D1 (de) 1-substituierte-4-amino-1h-imidazo 4,5-c chinoline, zwischenprodukte und arzneimittel
DK0705265T3 (da) Hidtil ukendte kemiske forbindelse med PDE IV-inhiberende aktivitet
DE59409094D1 (de) Neue pyrazincarboxamidderivate, ihre herstellung und ihre verwendung in arzneimitteln
FI946073A (fi) Vitamiini D-sarjan, 20-asemassa modifioituja johdannaisia, menetelmä tällaisten johdannaisten valmistamiseksi, menetelmässä käytettäviä välituotteita, mainittuja johdannaisia sisältäviä farmaseuttisia valmisteita ja johdannaisten käyttö lääkeaineiden valmistamiseen
DE69715439T2 (de) Pyridylalkan-säureamide als cytostatika und immunosupressive arzneimittel
HUT51269A (en) Process for producing benzimidazole derivatives and pharmaceutical compositions comprising same
IL94278A0 (en) 2-saccharine derivatives,their preparation and pharmaceutical compositions containing them
DE69528710D1 (de) 2-substituierte 1,2,5-thiadiazolidin-3-on-1,1-dioxiden, zusammensetzung und deren verwendung
YU131891A (sh) Derivati acetamida, postupak za njihovo dobijanje i farmaceutski preparati koji ih sadrže
DE69623819D1 (de) Furan- und thiophencarbothioamid derivate, deren herstellung und deren verwendung als inhibitoren der replikation von hiv-1 und hiv-1 mutanten
DE3770726D1 (de) Decahydrochinolinderivate, verfahren zu ihrer herstellung und zwischenprodukte davon, ihre verwendung als arzneimittel und ihre pharmazeutischen zusammensetzungen.
DE59810359D1 (de) Benzoxazin- und benzothiazin-derivate und deren verwendung in arzneimitteln
DE59507967D1 (de) Dioxo-thiopyrano-pyridin-carbonsäure-derivate und ihre verwendung als arzneimittel
DE69517768D1 (de) IMIDAZOLYLALKYLDERIVATE VON IMIDAZO [5,1-c][1,4]BENZOXAZIN-1-ON UND IHRE VERWENDUNG ALS ARZNEIMITTEL
ATE147742T1 (de) 8-alpha-acylamino-ergoline, ihre herstellung und verwendung als arzneimittel
BG101328A (en) New derivatives of imidazoloquinaxalon with heterocyclic substituents, their preparation and use
TR199900013T2 (xx) Yeni bile�ikler.
DE3880348D1 (de) N-substituierte alpha-mercaptomethylbenzenpropanamid-derivate, ihre herstellung, ihre verwendung als arzneimittel und diese enthaltende zusammensetzungen.
SE9901079D0 (sv) Novel compounds
ATE334675T1 (de) Arzneimittel enthaltend substituierte 2,5- diaminomethyl-1h-pyrrole
DE50212538D1 (de) Substituierte 5,6,6a,11b-tetrahydro-7-oxa-5-aza-benzoäcüfluoren-6-carbonsäurederivate als nmda-antagonisten
ATE150026T1 (de) Benzo(f>chinoxalindionderivative, deren herstellung und verwendung in arzneimitteln
DE69903024D1 (de) Thiocolchicosid-derivate, ihre herstellung und verwendung als arzneimittel

Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: MACEF, BORDEAUX, FR LABORATOIRES BESINS INTERNATIO