DE69523629D1 - 6-[triazolyl[3-(trifluoromethyl)phenyl]methyl]-2-chinolinone und - chinolinonethione - Google Patents

6-[triazolyl[3-(trifluoromethyl)phenyl]methyl]-2-chinolinone und - chinolinonethione

Info

Publication number
DE69523629D1
DE69523629D1 DE69523629T DE69523629T DE69523629D1 DE 69523629 D1 DE69523629 D1 DE 69523629D1 DE 69523629 T DE69523629 T DE 69523629T DE 69523629 T DE69523629 T DE 69523629T DE 69523629 D1 DE69523629 D1 DE 69523629D1
Authority
DE
Germany
Prior art keywords
chinolinonethione
quinolinone
triazolyl
trifluoromethyl
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69523629T
Other languages
English (en)
Other versions
DE69523629T2 (de
Inventor
Gaston Venet
Jean-Pierre Mabire
Charles Sanz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Application granted granted Critical
Publication of DE69523629D1 publication Critical patent/DE69523629D1/de
Publication of DE69523629T2 publication Critical patent/DE69523629T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69523629T 1994-12-28 1995-12-21 6-[triazolyl[3-(trifluoromethyl)phenyl]methyl]-2-chinolinone und - chinolinonethione Expired - Fee Related DE69523629T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP94203773 1994-12-28
PCT/EP1995/005173 WO1996020200A1 (en) 1994-12-28 1995-12-21 6-[triazolyl[3-(trifluoromethyl)phenyl]methyl]-2-quinolinones and -quinolinethiones

Publications (2)

Publication Number Publication Date
DE69523629D1 true DE69523629D1 (de) 2001-12-06
DE69523629T2 DE69523629T2 (de) 2002-07-18

Family

ID=8217501

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69523629T Expired - Fee Related DE69523629T2 (de) 1994-12-28 1995-12-21 6-[triazolyl[3-(trifluoromethyl)phenyl]methyl]-2-chinolinone und - chinolinonethione

Country Status (25)

Country Link
US (1) US5922734A (de)
EP (1) EP0800524B1 (de)
JP (1) JPH10511654A (de)
CN (1) CN1085668C (de)
AR (1) AR002264A1 (de)
AT (1) ATE207924T1 (de)
AU (1) AU698199B2 (de)
BR (1) BR9510504A (de)
CA (1) CA2207268A1 (de)
DE (1) DE69523629T2 (de)
DK (1) DK0800524T3 (de)
ES (1) ES2166838T3 (de)
FI (1) FI972794A (de)
HR (1) HRP950616A2 (de)
IL (1) IL116577A (de)
MY (1) MY131690A (de)
NO (1) NO311220B1 (de)
NZ (1) NZ298789A (de)
PL (1) PL182956B1 (de)
PT (1) PT800524E (de)
RU (1) RU2165419C2 (de)
TR (1) TR199501688A2 (de)
TW (1) TW316902B (de)
WO (1) WO1996020200A1 (de)
ZA (1) ZA9510989B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW591030B (en) * 1997-03-10 2004-06-11 Janssen Pharmaceutica Nv Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles
US6420555B1 (en) 1998-06-16 2002-07-16 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Imidazolyl derivatives
DK1097150T3 (da) * 1998-06-16 2004-07-26 Sod Conseils Rech Applic Imidazolylderivater
EP1420015A1 (de) * 1999-06-11 2004-05-19 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Imidazol-Derivate
ATE434615T1 (de) * 2000-11-21 2009-07-15 Janssen Pharmaceutica Nv Farnesyltransferase hemmende benzoheterocyclische derivate
US20040044032A1 (en) * 2000-11-28 2004-03-04 End David William Farnesyl protein transfer inhibitors for the treatment of inflammatory bowel disease
DE60117847T2 (de) * 2000-12-27 2006-11-16 Janssen Pharmaceutica N.V. Farnesyltransferase hemmende, in der 4-stellung substituierte chinolin- und chinazolinderivate
ES2263684T3 (es) * 2000-12-27 2006-12-16 Janssen Pharmaceutica N.V. Derivados de 4-heterociclil-quinolina y -quinazolina que inhiben la farnesil transferasa.
US8232402B2 (en) * 2008-03-12 2012-07-31 Link Medicine Corporation Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4792561A (en) * 1986-05-29 1988-12-20 Syntex (U.S.A.) Inc. Carbostyril derivatives as combined thromboxane synthetase and cyclic-AMP phosphodiesterase inhibitors
US4859684A (en) * 1986-09-15 1989-08-22 Janssen Pharmaceutica N.V. (1H-imidazol-1-ylmethyl) substituted benzimidazole derivatives and use thereof in treating androgen dependent disorders
NZ221729A (en) * 1986-09-15 1989-07-27 Janssen Pharmaceutica Nv Imidazolyl methyl-substituted benzimidazole derivatives and pharmaceutical compositions
GB8827822D0 (en) * 1988-11-29 1988-12-29 Janssen Pharmaceutica Nv (1h-azol-1-ylmethyl)substituted quinoline derivatives
US5157046A (en) * 1988-11-29 1992-10-20 Janssen Pharmaceutica N.V. Method of treating epithelial disorders
US5185346A (en) * 1988-11-29 1993-02-09 Hanssen Pharmaceutica (1H-azol-1-ylmethyl)substituted quinoline derivatives
CA2002864C (en) * 1988-11-29 1999-11-16 Eddy J. E. Freyne (1h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives
CA2002859C (en) * 1988-11-29 1998-12-29 Jean P. F. Van Wauwe Method of treating epithelial disorders

Also Published As

Publication number Publication date
TW316902B (de) 1997-10-01
PT800524E (pt) 2002-04-29
TR199501688A2 (tr) 1996-07-21
BR9510504A (pt) 1999-06-01
ATE207924T1 (de) 2001-11-15
CN1085668C (zh) 2002-05-29
AR002264A1 (es) 1998-03-11
WO1996020200A1 (en) 1996-07-04
NO311220B1 (no) 2001-10-29
DK0800524T3 (da) 2002-03-25
PL182956B1 (pl) 2002-05-31
ZA9510989B (en) 1997-06-27
RU2165419C2 (ru) 2001-04-20
AU698199B2 (en) 1998-10-29
DE69523629T2 (de) 2002-07-18
ES2166838T3 (es) 2002-05-01
PL321041A1 (en) 1997-11-24
US5922734A (en) 1999-07-13
EP0800524A1 (de) 1997-10-15
NZ298789A (en) 1999-07-29
JPH10511654A (ja) 1998-11-10
AU4436296A (en) 1996-07-19
NO973029L (no) 1997-06-27
MX9704667A (es) 1997-09-30
CA2207268A1 (en) 1996-07-04
FI972794A0 (fi) 1997-06-27
EP0800524B1 (de) 2001-10-31
MY131690A (en) 2007-08-30
FI972794A (fi) 1997-06-27
CN1171789A (zh) 1998-01-28
IL116577A (en) 2000-02-29
HRP950616A2 (en) 1997-10-31
NO973029D0 (no) 1997-06-27
IL116577A0 (en) 1996-03-31

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee