DE69523301T2 - Ein narkotikum enthaltende aerosolformulierung - Google Patents

Ein narkotikum enthaltende aerosolformulierung

Info

Publication number
DE69523301T2
DE69523301T2 DE69523301T DE69523301T DE69523301T2 DE 69523301 T2 DE69523301 T2 DE 69523301T2 DE 69523301 T DE69523301 T DE 69523301T DE 69523301 T DE69523301 T DE 69523301T DE 69523301 T2 DE69523301 T2 DE 69523301T2
Authority
DE
Germany
Prior art keywords
narcotic
aerosol formulation
aerosol
formulation
narcotic aerosol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69523301T
Other languages
English (en)
Other versions
DE69523301D1 (de
Inventor
Stephan J Farr
Anthony M Rowe
Reid Rubsamen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aradigm Corp
Original Assignee
Aradigm Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aradigm Corp filed Critical Aradigm Corp
Publication of DE69523301D1 publication Critical patent/DE69523301D1/de
Application granted granted Critical
Publication of DE69523301T2 publication Critical patent/DE69523301T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
DE69523301T 1994-05-13 1995-05-10 Ein narkotikum enthaltende aerosolformulierung Expired - Fee Related DE69523301T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24222394A 1994-05-13 1994-05-13
PCT/US1995/005798 WO1995031182A1 (en) 1994-05-13 1995-05-10 Narcotic containing aerosol formulation

Publications (2)

Publication Number Publication Date
DE69523301D1 DE69523301D1 (de) 2001-11-22
DE69523301T2 true DE69523301T2 (de) 2002-07-04

Family

ID=22913932

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69523301T Expired - Fee Related DE69523301T2 (de) 1994-05-13 1995-05-10 Ein narkotikum enthaltende aerosolformulierung

Country Status (7)

Country Link
US (1) US5910301A (de)
EP (1) EP0759744B1 (de)
JP (1) JP3911290B2 (de)
AU (1) AU700162B2 (de)
CA (1) CA2189351C (de)
DE (1) DE69523301T2 (de)
WO (1) WO1995031182A1 (de)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5874481A (en) * 1995-06-07 1999-02-23 Alliance Pharmaceutical Corp. Fluorochemical solutions for the delivery of lipophilic pharmaceutical agents
US5955098A (en) * 1996-04-12 1999-09-21 Flemington Pharmaceutical Corp. Buccal non polar spray or capsule
JP2000512649A (ja) * 1996-06-27 2000-09-26 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 徐放性スフェンタニル組成物
GB9707934D0 (en) * 1997-04-18 1997-06-04 Danbiosyst Uk Improved delivery of drugs to mucosal surfaces
GB2326334A (en) † 1997-06-13 1998-12-23 Chiesi Farma Spa Pharmaceutical aerosol compositions
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US20030185761A1 (en) * 1997-10-01 2003-10-02 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating pain
US20040136914A1 (en) * 1997-10-01 2004-07-15 Dugger Harry A. Buccal, polar and non-polar spray containing ondansetron
US20030077227A1 (en) * 1997-10-01 2003-04-24 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the central nervous system
US7632517B2 (en) * 1997-10-01 2009-12-15 Novadel Pharma Inc. Buccal, polar and non-polar spray containing zolpidem
US20030077229A1 (en) * 1997-10-01 2003-04-24 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing cardiovascular or renal drugs
US20030082107A1 (en) * 1997-10-01 2003-05-01 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating an infectious disease or cancer
US6858018B1 (en) * 1998-09-28 2005-02-22 Vyteris, Inc. Iontophoretic devices
WO2000047203A1 (en) * 1999-02-12 2000-08-17 Mqs, Inc. Formulation and system for intra-oral delivery of pharmaceutical agents
US6541021B1 (en) * 1999-03-18 2003-04-01 Durect Corporation Devices and methods for pain management
AU4341401A (en) * 2000-03-10 2001-09-24 Durect Corp Opioid formulations
US7074803B2 (en) * 2001-03-02 2006-07-11 Durect Corporation Opioid formulations
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
CA2382133C (en) 2000-05-10 2010-11-23 Alliance Pharmaceutical Corporation Phospholipid-based powders for drug delivery
US20020000225A1 (en) 2000-06-02 2002-01-03 Carlos Schuler Lockout mechanism for aerosol drug delivery devices
US20030190290A1 (en) * 2000-06-22 2003-10-09 Calvin Ross Pharmaceutical compositions
CN100346788C (zh) * 2000-07-31 2007-11-07 尼科梅德丹麦有限公司 用于鼻内给药的芬太尼组合物
US20020106407A1 (en) * 2000-12-11 2002-08-08 Dennis Coleman Method and apparatus for treating breakthrough pain
US6455028B1 (en) 2001-04-23 2002-09-24 Pharmascience Ipratropium formulation for pulmonary inhalation
US7905230B2 (en) * 2001-05-09 2011-03-15 Novartis Ag Metered dose inhaler with lockout
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
US20030138508A1 (en) * 2001-12-18 2003-07-24 Novack Gary D. Method for administering an analgesic
US6737042B2 (en) 2001-05-24 2004-05-18 Alexza Molecular Delivery Corporation Delivery of drug esters through an inhalation route
US7766013B2 (en) 2001-06-05 2010-08-03 Alexza Pharmaceuticals, Inc. Aerosol generating method and device
US7458374B2 (en) 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
US7645442B2 (en) 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
DE10141650C1 (de) 2001-08-24 2002-11-28 Lohmann Therapie Syst Lts Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen
US7854230B2 (en) * 2001-10-22 2010-12-21 O.R. Solutions, Inc. Heated medical instrument stand with surgical drape and method of detecting fluid and leaks in the stand tray
SI1458360T1 (sl) 2001-12-19 2011-08-31 Novartis Ag Pulmonalno dajanje aminoglikozidov
US7666876B2 (en) * 2002-03-19 2010-02-23 Vernalis (R&D) Limited Buprenorphine formulations for intranasal delivery
US7118010B2 (en) 2002-05-10 2006-10-10 Oriel Therapeutics, Inc. Apparatus, systems and related methods for dispensing and /or evaluating dry powders
US6889690B2 (en) * 2002-05-10 2005-05-10 Oriel Therapeutics, Inc. Dry powder inhalers, related blister devices, and associated methods of dispensing dry powder substances and fabricating blister packages
US7677411B2 (en) * 2002-05-10 2010-03-16 Oriel Therapeutics, Inc. Apparatus, systems and related methods for processing, dispensing and/or evaluatingl dry powders
US6985798B2 (en) 2002-05-10 2006-01-10 Oriel Therapeutics, Inc. Dry powder dose filling systems and related methods
EP1534366B1 (de) * 2002-06-27 2014-01-08 Oriel Therapeutics, Inc. Füllsystem für trockenpulverdosierung und relevante verfahren
US20040102476A1 (en) * 2002-11-25 2004-05-27 Chan Tai Wah High concentration formulations of opioids and opioid derivatives
US20040105818A1 (en) 2002-11-26 2004-06-03 Alexza Molecular Delivery Corporation Diuretic aerosols and methods of making and using them
US7913688B2 (en) 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
GB0300531D0 (en) 2003-01-10 2003-02-12 West Pharm Serv Drug Res Ltd Pharmaceutical compositions
US7648982B2 (en) * 2003-02-28 2010-01-19 Ym Biosciences Inc. Opioid delivery system
US7648981B2 (en) * 2003-02-28 2010-01-19 Ym Biosciences Inc. Opioid delivery system
ES2325834T3 (es) * 2003-02-28 2009-09-21 Ym Biosciences Inc. Sistema de administracion de opioides.
WO2005082369A1 (en) * 2003-02-28 2005-09-09 Delex Therapeutics Inc. Opioid delivery system
US20060062812A1 (en) * 2003-03-11 2006-03-23 Calvin Ross Novel compositions
EP1625333A1 (de) 2003-05-21 2006-02-15 Alexza Pharmaceuticals, Inc. Unabhängige heizeinheit und diese benutzende medikamentenabgabevorrichtung
US7451761B2 (en) * 2003-10-27 2008-11-18 Oriel Therapeutics, Inc. Dry powder inhalers, related blister package indexing and opening mechanisms, and associated methods of dispensing dry powder substances
US7377277B2 (en) * 2003-10-27 2008-05-27 Oriel Therapeutics, Inc. Blister packages with frames and associated methods of fabricating dry powder drug containment systems
US7540286B2 (en) 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
US20090032427A1 (en) * 2005-09-29 2009-02-05 Nektar Therapeutics Receptacles and Kits, Such as for Dry Powder Packaging
WO2007123955A2 (en) * 2006-04-19 2007-11-01 Novadel Pharma Inc. Stable hydroalcoholic oral spray formulations and methods
ES2594867T3 (es) 2007-03-09 2016-12-23 Alexza Pharmaceuticals, Inc. Unidad de calentamiento para usar en un dispositivo de administración de fármaco
WO2008141264A1 (en) * 2007-05-10 2008-11-20 Novadel Pharma Inc. Anti-insomnia compositions and methods
EP2247330B1 (de) 2008-02-07 2017-09-20 The University of Washington Ringförmige aerosolvorrichtung
US20130142868A1 (en) * 2010-08-20 2013-06-06 University Of Washington Circumferential Aerosol Device for Delivering Drugs to Olfactory Epithelium and Brain
BR112013022249B8 (pt) 2011-03-03 2022-10-25 Impel Neuropharma Inc Dispositivo de distribuição de droga nasal
BR112013028572B8 (pt) 2011-05-09 2022-10-25 Impel Neuropharma Inc Bocais para distribuição de droga nasal
EP2991713B1 (de) 2013-04-28 2019-06-19 Impel Neuropharma Inc. Medizinischer einzeldosisbehälter
JP6753927B2 (ja) 2015-09-10 2020-09-09 インペル ニューロファーマ インコーポレイテッド 直列形経鼻送達デバイス
EP3713628A4 (de) 2017-11-21 2021-08-18 Impel Neuropharma Inc. Intranasale vorrichtung mit tauchrohr
JP2021503988A (ja) 2017-11-21 2021-02-15 インペル ニューロファーマ インコーポレイテッド インレットインターフェースを用いた鼻腔内装置
CN111836615A (zh) 2018-01-05 2020-10-27 英倍尔药业股份有限公司 通过精密鼻装置的奥氮平的鼻内递送
ES2937440T3 (es) 2018-01-05 2023-03-28 Impel Pharmaceuticals Inc Administración intranasal de dihidroergotamina mediante un dispositivo olfativo de precisión
KR20210034047A (ko) 2018-07-19 2021-03-29 임펠 뉴로파마 인코포레이티드 파킨슨 병 치료를 위한 레보도파 및 도파 데카르복실라아제 저해제의 기도 전달
EA202191856A1 (ru) 2019-01-03 2021-09-02 Импел Ньюрофарма, Инк. Устройство для назальной доставки лекарственных средств
US11135379B2 (en) 2019-02-15 2021-10-05 Bn Intellectual Properties, Inc. Method of delivering pharmaceutical products
EP3969085A4 (de) 2019-05-17 2023-06-21 Impel Pharmaceuticals Inc. Einwegvorrichtung zur nasalen verabreichung
US11147780B2 (en) 2020-02-24 2021-10-19 Algia Pharma, Llc Multidrug pain management package

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3812854A (en) * 1972-10-20 1974-05-28 A Michaels Ultrasonic nebulizer
GB8501015D0 (en) * 1985-01-16 1985-02-20 Riker Laboratories Inc Drug
DE3602370A1 (de) * 1986-01-27 1987-08-06 Chrubasik Sigrun Verwendung von analgetica durch inhalation
US5225183A (en) * 1988-12-06 1993-07-06 Riker Laboratories, Inc. Medicinal aerosol formulations
GB8900267D0 (en) * 1989-01-06 1989-03-08 Riker Laboratories Inc Narcotic analgesic formulations and apparatus containing same
US5439670A (en) * 1989-11-28 1995-08-08 Riker Laboratories, Inc. Medicinal aerosol formulations
SG45171A1 (en) * 1990-03-21 1998-01-16 Boehringer Ingelheim Int Atomising devices and methods
US5230884A (en) * 1990-09-11 1993-07-27 University Of Wales College Of Cardiff Aerosol formulations including proteins and peptides solubilized in reverse micelles and process for making the aerosol formulations
DE69127756T2 (de) * 1990-12-05 1998-02-05 Gen Hospital Corp Verwendung von no zur behandlung oder prävention der bronchokonstriktion
GB9109064D0 (en) * 1991-04-26 1991-06-12 Dunne Miller Weston Ltd Dispensing device
US5674471A (en) * 1991-12-12 1997-10-07 Glaxo Group Limited Aerosol formulations containing P134a and salbutamol
WO1994016755A1 (en) * 1993-01-29 1994-08-04 Miris Medical Corporation Intrapulmonary delivery of narcotics
US5589156A (en) * 1994-05-02 1996-12-31 Henry; Richard A. Prilocaine and hydrofluourocarbon aerosol preparations
US5653961A (en) * 1995-03-31 1997-08-05 Minnesota Mining And Manufacturing Company Butixocort aerosol formulations in hydrofluorocarbon propellant

Also Published As

Publication number Publication date
JPH10503753A (ja) 1998-04-07
CA2189351A1 (en) 1995-11-23
AU2478695A (en) 1995-12-05
EP0759744A1 (de) 1997-03-05
JP3911290B2 (ja) 2007-05-09
DE69523301D1 (de) 2001-11-22
US5910301A (en) 1999-06-08
EP0759744A4 (de) 1997-10-29
EP0759744B1 (de) 2001-10-17
CA2189351C (en) 2008-12-30
AU700162B2 (en) 1998-12-24
WO1995031182A1 (en) 1995-11-23

Similar Documents

Publication Publication Date Title
DE69523301T2 (de) Ein narkotikum enthaltende aerosolformulierung
DE69413387D1 (de) Aerosol-abgabevorrichtung
DE69418907D1 (de) Ausgabevorrichtung
BR9504547A (pt) Dispensador
NO960323D0 (no) En container
DE69514679D1 (de) Bandspender
DE69502111T2 (de) Aerosolabgabevorrichtung
NO954675L (no) Beleggblanding
DE69600409T2 (de) Aerosol-Behälter
DE69510301D1 (de) Ein Flächenbelag
BR9508317A (pt) Dispensador
DE69513407T2 (de) Ein materialspender
DE9411522U1 (de) Dosierer
FI950864A0 (fi) Jakelulaite
DE19681702T1 (de) Zweikomponenten-Aerosol-Dose
DE69500501T2 (de) Ausgabevorrichtung
FI945565A0 (fi) Käsiohjain
MD351F1 (ro) Generator aerosol
DE9408604U1 (de) Aerosolgenerator
FI945132A0 (fi) Takograf
IT234842Y1 (it) Distributore polveri a 3 movimenti
AU126153S (en) A nail
KR960010273U (ko) 스틱커로 처리된 우표
KR970026834U (ko) 한무제 신침
DE9418639U1 (de) Spraydosen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee