DE69512416D1 - Fibrinogenkonzentrate aus blutplasma, verfahren und anlage für ihre herstellung - Google Patents

Fibrinogenkonzentrate aus blutplasma, verfahren und anlage für ihre herstellung

Info

Publication number
DE69512416D1
DE69512416D1 DE69512416T DE69512416T DE69512416D1 DE 69512416 D1 DE69512416 D1 DE 69512416D1 DE 69512416 T DE69512416 T DE 69512416T DE 69512416 T DE69512416 T DE 69512416T DE 69512416 D1 DE69512416 D1 DE 69512416D1
Authority
DE
Germany
Prior art keywords
pct
fibrinogen
fibrinogen concentrate
plant
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69512416T
Other languages
English (en)
Other versions
DE69512416T2 (de
DE69512416T3 (de
Inventor
Ruth Laub
Wael Luc De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CROIX ROUGE DE BELGIQUE BRUESS
Original Assignee
CROIX ROUGE DE BELGIQUE BRUESS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8218658&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69512416(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by CROIX ROUGE DE BELGIQUE BRUESS filed Critical CROIX ROUGE DE BELGIQUE BRUESS
Publication of DE69512416D1 publication Critical patent/DE69512416D1/de
Publication of DE69512416T2 publication Critical patent/DE69512416T2/de
Application granted granted Critical
Publication of DE69512416T3 publication Critical patent/DE69512416T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
    • A61L2/0088—Liquid substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0028—Polypeptides; Proteins; Degradation products thereof
    • A61L26/0042—Fibrin; Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Materials Engineering (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • External Artificial Organs (AREA)
DE69512416T 1994-07-14 1995-07-14 Fibrinogenkonzentrate aus blutplasma, verfahren und anlage für ihre herstellung Expired - Lifetime DE69512416T3 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP94870121 1994-07-14
EP94870121 1994-07-14
EP95927599A EP0771324B2 (de) 1994-07-14 1995-07-14 Fibrinogenkonzentrate aus blutplasma, verfahren und anlage für ihre herstellung
PCT/BE1995/000069 WO1996002571A1 (fr) 1994-07-14 1995-07-14 Concentre de fibrinogene issu de plasma sanguin, procede et installation pour sa preparation

Publications (3)

Publication Number Publication Date
DE69512416D1 true DE69512416D1 (de) 1999-10-28
DE69512416T2 DE69512416T2 (de) 2000-02-17
DE69512416T3 DE69512416T3 (de) 2011-12-15

Family

ID=8218658

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69512416T Expired - Lifetime DE69512416T3 (de) 1994-07-14 1995-07-14 Fibrinogenkonzentrate aus blutplasma, verfahren und anlage für ihre herstellung

Country Status (9)

Country Link
US (1) US5834420A (de)
EP (1) EP0771324B2 (de)
JP (1) JP4211894B2 (de)
AT (1) ATE184884T1 (de)
CA (1) CA2195127C (de)
DE (1) DE69512416T3 (de)
ES (1) ES2139227T5 (de)
IL (1) IL122665A (de)
WO (1) WO1996002571A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0771324B2 (de) * 1994-07-14 2011-02-09 CAF-DCF Département Central de Fractionnement de la Croix Rouge S.C.R.L. Fibrinogenkonzentrate aus blutplasma, verfahren und anlage für ihre herstellung
ATE367830T1 (de) * 1995-07-14 2007-08-15 Caf Dcf Cvba Scrl Vorrichtung zur inaktivierung von viralen kontaminationen in blutprodukten
ES2262340T3 (es) * 1998-09-24 2006-11-16 Pharming Intellectual Property Bv Purificacion del fibrinogeno de la leche mediante el uso de cromatografia de intercambio cationico.
ES2267289T3 (es) * 1998-09-24 2007-03-01 Pharming Intellectual Property Bv Purificacion de fibrinogeno a partir de fluidos mediante precipitacion y cromatografia de interaccion hidrofoba.
FR2785206B1 (fr) * 1998-10-14 2001-01-19 Fond Jean Dausset Ceph Dispositif de centrifugation pour automate de laboratoire
US6946140B1 (en) * 1999-02-09 2005-09-20 The Research Foundation Of State University Of New York Methods and compositions for enhancing fibroblast migration
CA2394797A1 (en) 1999-12-20 2001-06-28 Tsuyoshi Takahashi Process for producing virus-free plasma protein composition by porous membrane treatment, virus-free plasma protein composition and method of removing viruses
CA2395431C (en) * 1999-12-23 2010-08-17 Csl Limited Separation of fibrinogen from plasma proteases
US20030086817A1 (en) * 2001-11-06 2003-05-08 Horton Isaac B. Blood purification system
WO2003070285A1 (en) * 2002-02-19 2003-08-28 Resolution Chemicals Limited Solvent-based sterilisation of pharmaceuticals
AU2004216476B2 (en) 2003-02-27 2009-01-08 Takeda Pharmaceutical Company Limited Method for the validatable inactivation of pathogens in a biological fluid by irradiation
US20050124038A1 (en) * 2003-07-14 2005-06-09 Pharmacia Corporation Transfection of cartilage and matrices thereof in vitro
EP2338441B1 (de) 2003-12-11 2013-01-23 Isto Technologies Inc. Teilchenförmiges Knorpelsystem
ATE553186T1 (de) * 2004-02-20 2012-04-15 Isto Technologies Inc Bandscheibenreparatur und verfahren dafür
DE102004009400A1 (de) 2004-02-24 2005-09-08 Zlb Behring Gmbh Fibrinogen Reinigung
CN101005859B (zh) * 2004-06-29 2012-08-15 利莱恩斯生命科学有限公司 灭病毒生物液体的制备方法
FR2887883B1 (fr) 2005-06-29 2007-08-31 Lab Francais Du Fractionnement Procede de separation des proteines fibrinogene, facteur xiii et colle biologique d'une fraction plasmatique solubilisee et de preparation de concentres lyophilises desdites proteines
CN101977635A (zh) * 2008-03-28 2011-02-16 医疗器械研究基金会 通过溶剂/去污剂处理对生物流体进行病毒灭活的方法
US9371355B2 (en) 2010-09-20 2016-06-21 Octapharma Ag Process for production of fibrinogen
US20140287044A1 (en) * 2011-03-04 2014-09-25 Rare Antibody Antigen Supply, Inc. Fibrin sealant (fibringluraas) consisting of a kit of lyophilized or frozen high concentrate fribinogen
RU2663792C2 (ru) * 2012-03-13 2018-08-09 Октафарма Аг Способ очистки фибриногена, продукт фибриногена и средство для очистки или производства продукта фибриногена
CH706420A1 (fr) * 2012-04-19 2013-10-31 Valerie Soulie Procédé d'inactivation virale d'un fluide biologique, dispositif et récipient pour la mise en œuvre d'un tel procédé.
US20140154233A1 (en) * 2012-12-05 2014-06-05 Csl Limited Method of purifying therapeutic proteins
US10188965B2 (en) 2012-12-05 2019-01-29 Csl Behring Gmbh Hydrophobic charge induction chromatographic depletion of a protein from a solution
IL231230A0 (en) 2014-02-27 2014-08-31 Omrix Biopharmaceuticals Ltd Fibrinogen preparation
US9932388B2 (en) 2014-11-13 2018-04-03 Hemarus Therapeutics Limited Chromatographic process for producing high purity fibrinogen and thrombin
CA3161383A1 (en) * 2019-12-10 2021-06-17 Vera OTT Method for manufacturing a fibrinogen preparation
CN111518197B (zh) * 2020-03-30 2024-01-05 哈尔滨派斯菲科生物制药有限公司 一种纤维蛋白原的生产方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5598196A (en) * 1979-01-16 1980-07-25 Meito Sangyo Kk Fractionation of fibrinogen or its constituents and their use
DE2916711A1 (de) * 1979-04-25 1980-11-06 Behringwerke Ag Blutgerinnungsfaktoren und verfahren zu ihrer herstellung
US4481189A (en) † 1982-04-14 1984-11-06 New York Blood Center Inc. Process for preparing sterilized plasma and plasma derivatives
US4540573A (en) * 1983-07-14 1985-09-10 New York Blood Center, Inc. Undenatured virus-free biologically active protein derivatives
GB8505882D0 (en) * 1985-03-07 1985-04-11 Central Blood Lab Authority Purification of blood coagulation factor viii
DE3734923C1 (de) * 1987-10-15 1989-01-26 Biotest Pharma Gmbh Verfahren zur Herstellung einer sterilen Plasmaproteinloesung,die Fibrinogen und den Gerinnungsfaktor XIII enthaelt
FR2632309B1 (fr) † 1988-06-07 1990-08-24 Lille Transfusion Sanguine Procede de purification par voie chromatographique de proteines, notamment de facteur viii, et les produits obtenus
ES2057191T5 (es) † 1989-01-13 2003-05-01 Mitsubishi Pharma Corp Metodo de produccion para una composicion que contiene proteinas.
DE69229272T2 (de) * 1991-09-05 2000-02-03 Baxter International Inc., Deerfield Topischer fibrinogenkomplex
FR2686883B1 (fr) * 1992-02-04 1994-05-13 Aquitaine Develop Transf Sanguin Procede de fabrication de fibrinogene de tres haute purete, fibrinogene de tres haute purete obtenu ainsi qu'une composition pharmaceutique le contenant.
EP0771324B2 (de) * 1994-07-14 2011-02-09 CAF-DCF Département Central de Fractionnement de la Croix Rouge S.C.R.L. Fibrinogenkonzentrate aus blutplasma, verfahren und anlage für ihre herstellung

Also Published As

Publication number Publication date
CA2195127C (en) 2007-06-19
EP0771324A1 (de) 1997-05-07
IL122665A0 (en) 1998-08-16
JP4211894B2 (ja) 2009-01-21
US5834420A (en) 1998-11-10
WO1996002571A1 (fr) 1996-02-01
IL122665A (en) 2001-08-26
CA2195127A1 (en) 1996-02-01
EP0771324B2 (de) 2011-02-09
DE69512416T2 (de) 2000-02-17
DE69512416T3 (de) 2011-12-15
JPH10506607A (ja) 1998-06-30
ATE184884T1 (de) 1999-10-15
EP0771324B1 (de) 1999-09-22
ES2139227T3 (es) 2000-02-01
ES2139227T5 (es) 2011-05-04

Similar Documents

Publication Publication Date Title
DE69512416D1 (de) Fibrinogenkonzentrate aus blutplasma, verfahren und anlage für ihre herstellung
AU643101B2 (en) Process for removing hydrogen cyanide and ammonia from aqueous solutions
ATE174009T1 (de) Verfahren zur entfernung von chlorat- und bromatverbindungen aus wasser durch katalytische reduktion
DE60014047D1 (de) Verfahren zur reinigung von milchsäure auf industrieller basis
ATE235506T1 (de) Behandlung einer proteinlösung mit a1/fe und anschliesende membrankonzentration
DE69518901D1 (de) Verfahren zur Herstellung von Xylitol
DE60114048D1 (de) Verfahren zur aufreinigung von maltose
ATE79266T1 (de) Verfahren zur herstellung vom antihaemophilfaktor (ahf) durch kaeltefaellung und zur verbesserung der loeslichkeit des hergestellten ahf-produktes.
HUP0302530A2 (hu) Eljárás 2-nitro-4-metilszulfonil-benzoesav tisztítására
DE69010442D1 (de) Reinigung von 1,1-Dichlor-1-fluorethan.
ES2068000T3 (es) Separacion de metales de peroxiacidos o peroxisales acuosos.
DE69602062D1 (de) Verfahren zur reinigung von diacetylrhein
DE69122960D1 (de) Verfahren und zubereitungen für die behandlung von verletzungen
DE50110986D1 (de) Verfahren zur Reinigung von Kerzenfiltern und Membrananlagen
ATE173236T1 (de) Nitratrückgewinnungsanlage
NZ516235A (en) Method for purification of proteins
ATE296156T1 (de) Verfahren zur reinigung und wiederverwendung von abfallgelantine
ATE73820T1 (de) Verfahren zur herstellung eines hochgereinigten antihaemophilie-faktors.
KR890002412A (ko) 높은 pH에서의 중성 아미노산 회수
DE60118380D1 (de) Neue poröse schwefelschwamm-eisenverbindung, verfahren zu ihrer herstellung und verfahren zur entschwefelung von erdgas mit der verbindung
KR930006151A (ko) 지렁이로부터 프로테아제를 분리 정제하는 방법
MY118332A (en) Process for the production of an aqueous solution of a tertiary amine oxide.
ES2105969A1 (es) Procedimiento para la recuperacion de acido sulfurico a partir de corrientes residuales de sulfurico de mediana concentracion contaminadas con materia organica.
MX9701863A (es) Proceso para la recuperacion de acido citrico.
EP0913386A4 (de)

Legal Events

Date Code Title Description
8363 Opposition against the patent
8366 Restricted maintained after opposition proceedings