DE69433534D1 - Verfahren zur herstellung von makrozyklischen agentien und ihren chelaten und konjugaten - Google Patents

Verfahren zur herstellung von makrozyklischen agentien und ihren chelaten und konjugaten

Info

Publication number
DE69433534D1
DE69433534D1 DE69433534T DE69433534T DE69433534D1 DE 69433534 D1 DE69433534 D1 DE 69433534D1 DE 69433534 T DE69433534 T DE 69433534T DE 69433534 T DE69433534 T DE 69433534T DE 69433534 D1 DE69433534 D1 DE 69433534D1
Authority
DE
Germany
Prior art keywords
chelating agent
conjugate
chelates
conjugates
agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69433534T
Other languages
English (en)
Other versions
DE69433534T2 (de
Inventor
Chi-Lin Cheng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dow Chemical Co
Original Assignee
Dow Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Chemical Co filed Critical Dow Chemical Co
Publication of DE69433534D1 publication Critical patent/DE69433534D1/de
Application granted granted Critical
Publication of DE69433534T2 publication Critical patent/DE69433534T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3046—Stomach, Intestines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
DE69433534T 1994-09-07 1994-09-07 Verfahren zur herstellung von makrozyklischen agentien und ihren chelaten und konjugaten Expired - Lifetime DE69433534T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1994/010304 WO1996007435A1 (en) 1994-09-07 1994-09-07 Process for preparing macrocyclic chelating agents and formation of chelates and conjugates thereof

Publications (2)

Publication Number Publication Date
DE69433534D1 true DE69433534D1 (de) 2004-03-11
DE69433534T2 DE69433534T2 (de) 2004-07-08

Family

ID=22242968

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69433534T Expired - Lifetime DE69433534T2 (de) 1994-09-07 1994-09-07 Verfahren zur herstellung von makrozyklischen agentien und ihren chelaten und konjugaten

Country Status (7)

Country Link
EP (1) EP0783326B1 (de)
JP (1) JPH10505357A (de)
KR (1) KR100367264B1 (de)
AT (1) ATE258806T1 (de)
AU (1) AU698763B2 (de)
DE (1) DE69433534T2 (de)
WO (1) WO1996007435A1 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7225820B2 (ja) 2019-01-21 2023-02-21 株式会社アイシン 車両用開閉体制御装置

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5006643A (en) * 1987-06-24 1991-04-09 The Dow Chemical Company Process for preparing isothiocyanato functionalized metal complexes
EP0353450B1 (de) * 1988-06-24 1995-03-29 The Dow Chemical Company Macrocyclische bifunktionelle Chelatbildner, Komplexe davon und ihre konjugierten Antikörper
GB9115287D0 (en) * 1991-07-15 1991-08-28 Antibioticos Spa Process for the preparation of cephalosporins intermediates
SG52470A1 (en) * 1992-04-13 1998-09-28 Dow Chemical Co Process for preparing macrocyclic chelating agents and formation of chelates and conjugates thereof

Also Published As

Publication number Publication date
WO1996007435A1 (en) 1996-03-14
JPH10505357A (ja) 1998-05-26
AU7833994A (en) 1996-03-27
ATE258806T1 (de) 2004-02-15
KR970706024A (ko) 1997-11-03
EP0783326A1 (de) 1997-07-16
AU698763B2 (en) 1998-11-05
EP0783326B1 (de) 2004-02-04
KR100367264B1 (ko) 2003-03-15
DE69433534T2 (de) 2004-07-08

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Legal Events

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8364 No opposition during term of opposition