DE69432190D1 - Papamycinderivate - Google Patents
PapamycinderivateInfo
- Publication number
- DE69432190D1 DE69432190D1 DE69432190T DE69432190T DE69432190D1 DE 69432190 D1 DE69432190 D1 DE 69432190D1 DE 69432190 T DE69432190 T DE 69432190T DE 69432190 T DE69432190 T DE 69432190T DE 69432190 D1 DE69432190 D1 DE 69432190D1
- Authority
- DE
- Germany
- Prior art keywords
- papamycinderivate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/200,265 US5362735A (en) | 1994-02-23 | 1994-02-23 | Rapamycin derivatives |
PCT/US1994/008726 WO1995022972A1 (en) | 1994-02-23 | 1994-08-02 | Rapamycin derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69432190D1 true DE69432190D1 (de) | 2003-04-03 |
DE69432190T2 DE69432190T2 (de) | 2003-11-27 |
Family
ID=22740995
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69432190T Expired - Fee Related DE69432190T2 (de) | 1994-02-23 | 1994-08-02 | Papamycinderivate |
Country Status (5)
Country | Link |
---|---|
US (1) | US5362735A (de) |
EP (1) | EP0754040B1 (de) |
JP (1) | JPH10500661A (de) |
DE (1) | DE69432190T2 (de) |
WO (1) | WO1995022972A1 (de) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5336499A (en) * | 1992-01-10 | 1994-08-09 | Antelman Technologies, Ltd. | Molecular crystal device for pharmaceuticals |
US6187757B1 (en) * | 1995-06-07 | 2001-02-13 | Ariad Pharmaceuticals, Inc. | Regulation of biological events using novel compounds |
EP0937082A2 (de) | 1996-07-12 | 1999-08-25 | Ariad Pharmaceuticals, Inc. | Nicht immunhemmende antifungale rapaloge |
US7067526B1 (en) | 1999-08-24 | 2006-06-27 | Ariad Gene Therapeutics, Inc. | 28-epirapalogs |
CA2383451A1 (en) * | 1999-08-24 | 2001-03-01 | Ariad Gene Therapeutics, Inc. | 28-epirapalogs |
AU2748701A (en) | 1999-10-29 | 2001-06-06 | Kosan Biosciences, Inc. | Rapamycin analogs |
WO2004014222A2 (en) * | 2002-08-12 | 2004-02-19 | The Regents Of The University Of Michigan | Diagnosis and treatment of tuberous sclerosis |
AU2003293529A1 (en) | 2002-12-16 | 2004-07-29 | Nitromed, Inc. | Nitrosated and nitrosylated rapamycin compounds, compositions and methods of use |
ATE457716T1 (de) | 2002-12-30 | 2010-03-15 | Angiotech Int Ag | Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung |
EP1648454A1 (de) * | 2003-07-25 | 2006-04-26 | Wyeth | Lyophilisierte formulierung von cci-779 |
CA2571710A1 (en) | 2004-06-24 | 2006-11-02 | Nicholas Valiante | Small molecule immunopotentiators and assays for their detection |
US20060189551A1 (en) * | 2004-10-04 | 2006-08-24 | Duke University | Combination therapies for fungal pathogens |
US8021849B2 (en) * | 2004-11-05 | 2011-09-20 | Siemens Healthcare Diagnostics Inc. | Methods and kits for the determination of sirolimus in a sample |
US7189582B2 (en) * | 2005-04-27 | 2007-03-13 | Dade Behring Inc. | Compositions and methods for detection of sirolimus |
US20080207671A1 (en) * | 2006-07-31 | 2008-08-28 | The Regents Of The University Of Michigan | Diagnosis and treatment of diseases arising from defects in the tuberous sclerosis pathway |
WO2008083169A2 (en) | 2006-12-26 | 2008-07-10 | The Johns Hopkins University | Compositions and methods for the treatment of immunologic disorders |
JP2011502954A (ja) | 2006-12-27 | 2011-01-27 | ザ ジョンズ ホプキンス ユニバーシティー | 免疫応答を刺激する組成物および方法 |
US7989173B2 (en) | 2006-12-27 | 2011-08-02 | The Johns Hopkins University | Detection and diagnosis of inflammatory disorders |
US20080188461A1 (en) * | 2007-02-01 | 2008-08-07 | Regents Of The University Of Michigan | Compositions and methods for detecting, preventing and treating seizures and seizure related disorders |
US8945505B2 (en) | 2007-02-02 | 2015-02-03 | Panaphix, Inc. | Use of arsenic compounds for treatment of pain and inflammation |
WO2009089549A1 (en) * | 2008-01-11 | 2009-07-16 | Massachusetts Eye & Ear Infirmary | Conditional-stop dimerizable caspase transgenic animals |
EP2473523A2 (de) | 2009-08-31 | 2012-07-11 | Amplimmune, Inc. | Verfahren und zusammensetzungen zur hemmung von transplantatabstossung |
CA2772411C (en) * | 2009-09-10 | 2017-08-22 | Kominox, Inc. | Cancer stem cell-targeted and drug resistant cancer therapy |
US20110150856A1 (en) | 2009-12-21 | 2011-06-23 | Sarah Bacus | Compositions and methods for treatment of vitiligo |
US20110150798A1 (en) * | 2009-12-21 | 2011-06-23 | Sarah Bacus | Compositions and methods for increasing cellular far and bleaching skin |
CA2822746A1 (en) * | 2009-12-21 | 2011-06-30 | Sarah Bacus | Compositions and methods for treatment of vitiligo |
EP2589383A1 (de) | 2011-11-06 | 2013-05-08 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin | FKBP-subtypspezifisches Rapamycin-Analogon zur Verwendung bei der Behandlung von Erkrankungen |
EP2836234B1 (de) | 2012-04-12 | 2019-06-12 | Yale University | Vehikel zur kontrollierten abgabe verschiedener pharmazeutischer substanzen |
MX2015007846A (es) | 2012-12-19 | 2016-04-28 | Amplimmune Inc | Anticuerpos anti-b7-h4 humana y sus usos. |
EP2997373A1 (de) | 2013-05-17 | 2016-03-23 | MedImmune, LLC | Rezeptoren für b7-h4 |
CN105283553B (zh) | 2013-06-11 | 2021-06-25 | 克隆技术实验室有限公司 | 蛋白质富集的微泡及其制备和使用方法 |
ES2957882T3 (es) | 2015-09-04 | 2024-01-29 | Univ Yale | Nanocomposiciones de ácidos biliares poliméricos dirigidas al páncreas y al colon |
WO2017173453A1 (en) | 2016-04-01 | 2017-10-05 | The Brigham And Women's Hospital, Inc. | Stimuli-responsive nanoparticles for biomedical applications |
AU2019265632A1 (en) | 2018-05-09 | 2021-01-07 | Yale University | Particles for spatiotemporal release of agents |
US20210115378A1 (en) | 2018-05-09 | 2021-04-22 | Yale University | Compositions and systems for ex vivo cell modulation and methods of use thereof |
LT3813946T (lt) | 2018-06-15 | 2024-07-10 | Janssen Pharmaceutica Nv | Rapamicino analogai ir jų panaudojimas |
EP4069223A4 (de) | 2019-12-05 | 2023-12-20 | Janssen Pharmaceutica NV | Rapamycinanaloga und verwendungen davon |
CN116600789A (zh) | 2020-06-19 | 2023-08-15 | 耶鲁大学 | 用于诱导耐受性的聚合胆汁酸酯纳米颗粒 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4650803A (en) * | 1985-12-06 | 1987-03-17 | University Of Kansas | Prodrugs of rapamycin |
US5023264A (en) * | 1990-07-16 | 1991-06-11 | American Home Products Corporation | Rapamycin oximes |
US5023263A (en) * | 1990-08-09 | 1991-06-11 | American Home Products Corporation | 42-oxorapamycin |
US5023262A (en) * | 1990-08-14 | 1991-06-11 | American Home Products Corporation | Hydrogenated rapamycin derivatives |
US5102876A (en) * | 1991-05-07 | 1992-04-07 | American Home Products Corporation | Reduction products of rapamycin |
ZA935112B (en) * | 1992-07-17 | 1994-02-08 | Smithkline Beecham Corp | Rapamycin derivatives |
-
1994
- 1994-02-23 US US08/200,265 patent/US5362735A/en not_active Expired - Fee Related
- 1994-08-02 DE DE69432190T patent/DE69432190T2/de not_active Expired - Fee Related
- 1994-08-02 WO PCT/US1994/008726 patent/WO1995022972A1/en active IP Right Grant
- 1994-08-02 EP EP94924550A patent/EP0754040B1/de not_active Expired - Lifetime
- 1994-08-02 JP JP7522321A patent/JPH10500661A/ja not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
JPH10500661A (ja) | 1998-01-20 |
EP0754040B1 (de) | 2003-02-26 |
EP0754040A1 (de) | 1997-01-22 |
US5362735A (en) | 1994-11-08 |
WO1995022972A1 (en) | 1995-08-31 |
DE69432190T2 (de) | 2003-11-27 |
EP0754040A4 (de) | 1997-07-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |