DE69425745D1 - Verfahren und zusammensetzungen zur behandlung der thrombose - Google Patents

Verfahren und zusammensetzungen zur behandlung der thrombose

Info

Publication number
DE69425745D1
DE69425745D1 DE69425745T DE69425745T DE69425745D1 DE 69425745 D1 DE69425745 D1 DE 69425745D1 DE 69425745 T DE69425745 T DE 69425745T DE 69425745 T DE69425745 T DE 69425745T DE 69425745 D1 DE69425745 D1 DE 69425745D1
Authority
DE
Germany
Prior art keywords
peptides
amino acid
contain
hydrophobic amino
rgd
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69425745T
Other languages
English (en)
Other versions
DE69425745T2 (de
Inventor
D Pierschbacher
Soan Cheng
S Craig
F Tschopp
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanford Burnham Prebys Medical Discovery Institute
La Jolla Cancer Research Foundation
Original Assignee
Sanford Burnham Prebys Medical Discovery Institute
La Jolla Cancer Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanford Burnham Prebys Medical Discovery Institute, La Jolla Cancer Research Foundation filed Critical Sanford Burnham Prebys Medical Discovery Institute
Application granted granted Critical
Publication of DE69425745D1 publication Critical patent/DE69425745D1/de
Publication of DE69425745T2 publication Critical patent/DE69425745T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70546—Integrin superfamily
    • C07K14/70557—Integrin beta3-subunit-containing molecules, e.g. CD41, CD51, CD61
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69425745T 1993-06-18 1994-06-17 Verfahren und zusammensetzungen zur behandlung der thrombose Expired - Lifetime DE69425745T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7944193A 1993-06-18 1993-06-18
US17106893A 1993-12-20 1993-12-20
PCT/US1994/006913 WO1995000544A1 (en) 1993-06-18 1994-06-17 Method and composition for treating thrombosis

Publications (2)

Publication Number Publication Date
DE69425745D1 true DE69425745D1 (de) 2000-10-05
DE69425745T2 DE69425745T2 (de) 2001-04-19

Family

ID=26762011

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69425745T Expired - Lifetime DE69425745T2 (de) 1993-06-18 1994-06-17 Verfahren und zusammensetzungen zur behandlung der thrombose

Country Status (7)

Country Link
EP (1) EP0705274B1 (de)
JP (1) JPH09501910A (de)
AT (1) ATE195949T1 (de)
AU (1) AU7112794A (de)
CA (1) CA2165332A1 (de)
DE (1) DE69425745T2 (de)
WO (1) WO1995000544A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
US5770565A (en) * 1994-04-13 1998-06-23 La Jolla Cancer Research Center Peptides for reducing or inhibiting bone resorption
EP0727225A3 (de) * 1995-02-14 1997-01-15 Sonus Pharma Inc Zusammensetzungen und Verfahren zur Herstellung von gerichteter Ultraschallabbildung
US5858972A (en) * 1996-01-11 1999-01-12 La Jolla Cancer Research Foundation Antithrombotic agents and methods of use
US6235877B1 (en) 1999-08-04 2001-05-22 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Peptido-mimetic compounds containing RGD sequence useful as integrin inhibitors
US20070243632A1 (en) 2003-07-08 2007-10-18 Coller Barry S Methods for measuring platelet reactivity of patients that have received drug eluting stents
US7790362B2 (en) 2003-07-08 2010-09-07 Accumetrics, Inc. Controlled platelet activation to monitor therapy of ADP antagonists
US7595169B2 (en) * 2005-04-27 2009-09-29 Accumetrics, Inc. Method for determining percent platelet aggregation
CA2623565A1 (en) 2005-09-28 2007-04-05 Biovascular, Inc. Methods and compositions for blocking platelet and cell adhesion, cell migration and inflammation
US20070231258A1 (en) * 2006-03-31 2007-10-04 Karyon Ctt Ltd. Peptide conjugates
GB2453589A (en) * 2007-10-12 2009-04-15 King S College London Protease inhibition

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZW6189A1 (en) * 1988-05-09 1990-05-09 Smithkline Beckman Corp Anti-aggregatory peptides
US5318899A (en) * 1989-06-16 1994-06-07 Cor Therapeutics, Inc. Platelet aggregation inhibitors
EP0527798B1 (de) * 1990-04-06 1997-07-16 La Jolla Cancer Research Foundation Verfahren und verbindung zur behandlung von thrombose
US5192746A (en) * 1990-07-09 1993-03-09 Tanabe Seiyaku Co., Ltd. Cyclic cell adhesion modulation compounds

Also Published As

Publication number Publication date
EP0705274A1 (de) 1996-04-10
DE69425745T2 (de) 2001-04-19
AU7112794A (en) 1995-01-17
WO1995000544A1 (en) 1995-01-05
EP0705274B1 (de) 2000-08-30
JPH09501910A (ja) 1997-02-25
CA2165332A1 (en) 1995-01-05
ATE195949T1 (de) 2000-09-15

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Legal Events

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