DE69126871D1 - Verfahren und verbindung zur behandlung von thrombose - Google Patents

Verfahren und verbindung zur behandlung von thrombose

Info

Publication number
DE69126871D1
DE69126871D1 DE69126871T DE69126871T DE69126871D1 DE 69126871 D1 DE69126871 D1 DE 69126871D1 DE 69126871 T DE69126871 T DE 69126871T DE 69126871 T DE69126871 T DE 69126871T DE 69126871 D1 DE69126871 D1 DE 69126871D1
Authority
DE
Germany
Prior art keywords
peptides
contain
rgd
adjacent
provides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69126871T
Other languages
English (en)
Other versions
DE69126871T2 (de
Inventor
Michael Pierschbacher
David Lukeman
Soan Cheng
William Craig
Juerg Tschopp
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanford Burnham Prebys Medical Discovery Institute
Original Assignee
Sanford Burnham Prebys Medical Discovery Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanford Burnham Prebys Medical Discovery Institute filed Critical Sanford Burnham Prebys Medical Discovery Institute
Publication of DE69126871D1 publication Critical patent/DE69126871D1/de
Application granted granted Critical
Publication of DE69126871T2 publication Critical patent/DE69126871T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70546—Integrin superfamily
    • C07K14/70557—Integrin beta3-subunit-containing molecules, e.g. CD41, CD51, CD61
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Secondary Cells (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Wire Bonding (AREA)
  • Control Of El Displays (AREA)
  • Driving Mechanisms And Operating Circuits Of Arc-Extinguishing High-Tension Switches (AREA)
DE69126871T 1990-04-06 1991-04-05 Verfahren und verbindung zur behandlung von thrombose Expired - Fee Related DE69126871T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50644490A 1990-04-06 1990-04-06
PCT/US1991/002356 WO1991015515A1 (en) 1990-04-06 1991-04-05 Method and composition for treating thrombosis

Publications (2)

Publication Number Publication Date
DE69126871D1 true DE69126871D1 (de) 1997-08-21
DE69126871T2 DE69126871T2 (de) 1998-03-12

Family

ID=24014617

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69126871T Expired - Fee Related DE69126871T2 (de) 1990-04-06 1991-04-05 Verfahren und verbindung zur behandlung von thrombose

Country Status (12)

Country Link
US (2) US6013625A (de)
EP (2) EP0749979A3 (de)
JP (1) JPH05509294A (de)
AT (1) ATE155482T1 (de)
AU (2) AU660926B2 (de)
CA (1) CA2079606A1 (de)
DE (1) DE69126871T2 (de)
DK (1) DK0527798T3 (de)
ES (1) ES2104702T3 (de)
FI (1) FI924472A0 (de)
GR (1) GR3024996T3 (de)
WO (1) WO1991015515A1 (de)

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DE3855458T2 (de) * 1987-12-10 1996-12-05 Jolla Cancer Res Found Verfahren zur herstellung von conformationnell stabilisierten zelladhäsionspeptiden
US5827821A (en) * 1987-12-10 1998-10-27 The Burnham Institute Conformationally stabilized cell adhesion peptides
US5648330A (en) * 1990-04-06 1997-07-15 La Jolla Cancer Research Foundation Method and composition for treating vascular graft occlusion
ES2104702T3 (es) * 1990-04-06 1997-10-16 Jolla Cancer Res Found Metodo y composicion para el tratamiento de la trombosis.
US6521594B1 (en) * 1990-04-06 2003-02-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5612311A (en) * 1990-04-06 1997-03-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US6017877A (en) * 1990-04-06 2000-01-25 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5780303A (en) * 1990-04-06 1998-07-14 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5192746A (en) * 1990-07-09 1993-03-09 Tanabe Seiyaku Co., Ltd. Cyclic cell adhesion modulation compounds
EP0555328A1 (de) * 1990-11-02 1993-08-18 Genentech, Inc. Blutplättchenaggregationshemmstoffe
US6019958A (en) * 1991-02-08 2000-02-01 Diatide, Inc. Technetium-99m labeled peptides for imaging inflammation
DE69230525T2 (de) * 1991-02-08 2000-06-21 Diatide Inc Technetium-99m markierte Polypeptide zur Bildformung
US5645815A (en) 1991-02-08 1997-07-08 Diatide, Inc. Radiolabled compounds for thrombus imaging
US5736122A (en) * 1991-02-08 1998-04-07 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
US5561220A (en) * 1991-02-08 1996-10-01 Diatech, Inc. Technetium-99m labeled peptides for imaging inflammation
US6107459A (en) * 1991-02-08 2000-08-22 Diatide, Inc. Technetium-99m labeled peptides for diagnostic imaging
EP0578728B1 (de) * 1991-04-05 1998-07-01 Genentech, Inc. PLAETTCHENAGGREGATIONSINHIBITOREN MIT HOHER SPEZIFIZITAET ZUM GP IIbIIIa
US5674863A (en) * 1991-10-18 1997-10-07 Genentech, Inc. Nonpeptidyl integrin inhibitors having specificity for the GPIIb IIIa receptor
US5250679A (en) * 1991-10-18 1993-10-05 Genentech, Inc. Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor
US5227490A (en) * 1992-02-21 1993-07-13 Merck & Co., Inc. Fibrinogen receptor antagonists
UA43823C2 (uk) * 1992-07-06 2002-01-15 Мерк Патент Геселлшафт Міт Бесшренктер Хафтунг ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ ДЛЯ ІНГІБУВАННЯ ІНТЕГРИН <font face="Symbol">a</font><sub>V</sub><font face="Symbol">b</font><sub>3</sub>-ОПОСЕРЕДКОВАНОЇ КЛІТИННОЇ АДГЕЗІЇ КЛІТИН ССАВЦІВ, СПОСІБ ЛІКУВАННЯ ТА ПРОФІЛАКТИКИ ЗАХВОРЮВАННЯ, АСОЦІЙОВАНОГО З ПОРУШЕННЯМ АДГЕЗІЇ КЛІТИН, СПОСІБ БЛОКУВАННЯ ЗВ'ЯЗУВАННЯ ФІБРИНОГЕНОМ ІНТЕГРИНУ, КОМПОЗИЦІЯ ДЛЯ ЗАГОЄННЯ РАН
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US6488930B1 (en) * 1999-01-15 2002-12-03 Millennium Pharmaceuticals, Inc. Anti-CCR4 antibodies and methods of use therefor
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US6685914B1 (en) 1999-09-13 2004-02-03 Bristol-Myers Squibb Pharma Company Macrocyclic chelants for metallopharmaceuticals
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CN1184313C (zh) * 2000-07-26 2005-01-12 郑光会 衍生自黑眉蝮蛇的新型蛋白以及制备该蛋白的方法
WO2003034995A2 (en) 2001-10-22 2003-05-01 The Scripps Research Institute Integrin targeting compounds
JP4750360B2 (ja) 2001-10-22 2011-08-17 ザ スクリプス リサーチ インスティチュート 抗体ターゲッティング化合物
US8795672B2 (en) * 2003-02-14 2014-08-05 University Of Southern California Compositions and methods for cancer immunotherapy
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AU2005304771A1 (en) 2004-11-09 2006-05-18 University Of Southern California Targeted innate immunity
KR101373140B1 (ko) * 2005-03-03 2014-03-12 씨오브이엑스 테크놀로지스 아일랜드 리미티드 항-혈관형성 화합물
JP2009510105A (ja) 2005-09-28 2009-03-12 バイオバスキュラー インコーポレーティッド 血小板および細胞の接着、細胞移動、および炎症を阻止するための方法および組成物
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US20090098130A1 (en) * 2007-01-05 2009-04-16 Bradshaw Curt W Glucagon-like protein-1 receptor (glp-1r) agonist compounds
US8653632B2 (en) * 2007-03-28 2014-02-18 Medtronic Ats Medical Inc. System and method for conditioning implantable medical devices
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EP2335730A1 (de) 2009-12-18 2011-06-22 Deutsches Krebsforschungszentrum Fusionspolypeptide und ihre Verwendung zur Vorbeugung und Behandlung von Krebs
KR20130113493A (ko) 2011-01-03 2013-10-15 에프. 호프만-라 로슈 아게 항―ｄｉｇ 항체 및 펩티드에 접합되어 있는 디그옥시게닌의 복합체의 약학적 조성물

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Also Published As

Publication number Publication date
FI924472A (fi) 1992-10-05
DK0527798T3 (da) 1997-12-15
GR3024996T3 (en) 1998-01-30
AU660926B2 (en) 1995-07-13
CA2079606A1 (en) 1991-10-07
EP0527798A1 (de) 1993-02-24
EP0749979A2 (de) 1996-12-27
EP0749979A3 (de) 1998-03-11
AU7763191A (en) 1991-10-30
US6013625A (en) 2000-01-11
FI924472A0 (fi) 1992-10-05
WO1991015515A1 (en) 1991-10-17
ATE155482T1 (de) 1997-08-15
AU3424695A (en) 1996-03-14
JPH05509294A (ja) 1993-12-22
US6100236A (en) 2000-08-08
EP0527798B1 (de) 1997-07-16
ES2104702T3 (es) 1997-10-16
DE69126871T2 (de) 1998-03-12

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Legal Events

Date Code Title Description
8332 No legal effect for de
8370 Indication related to discontinuation of the patent is to be deleted
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee