DE69423899D1 - Pseudo-oder nicht peptidartige bradykinin rezeptor antagoniste - Google Patents

Pseudo-oder nicht peptidartige bradykinin rezeptor antagoniste

Info

Publication number
DE69423899D1
DE69423899D1 DE69423899T DE69423899T DE69423899D1 DE 69423899 D1 DE69423899 D1 DE 69423899D1 DE 69423899 T DE69423899 T DE 69423899T DE 69423899 T DE69423899 T DE 69423899T DE 69423899 D1 DE69423899 D1 DE 69423899D1
Authority
DE
Germany
Prior art keywords
bradykinin
peptidal
pseudo
bradykinin receptor
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69423899T
Other languages
English (en)
Other versions
DE69423899T2 (de
Inventor
James Kyle
Joseph Mavunkel
Zhijian Lu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scios LLC
Original Assignee
Scios LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/118,550 external-priority patent/US5552383A/en
Priority claimed from US08/281,904 external-priority patent/US5686565A/en
Priority claimed from US08/281,907 external-priority patent/US5541286A/en
Application filed by Scios LLC filed Critical Scios LLC
Publication of DE69423899D1 publication Critical patent/DE69423899D1/de
Application granted granted Critical
Publication of DE69423899T2 publication Critical patent/DE69423899T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/18—Kallidins; Bradykinins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69423899T 1993-09-09 1994-09-09 Pseudo-oder nicht peptidartige bradykinin rezeptor antagoniste Expired - Lifetime DE69423899T2 (de)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US11934193A 1993-09-09 1993-09-09
US11855893A 1993-09-09 1993-09-09
US08/118,550 US5552383A (en) 1992-10-08 1993-09-09 Bradykinin antagonist pseudopeptide derivatives of aminoalkanoic acids and related olefins
US08/118,981 US5444048A (en) 1992-10-08 1993-09-09 Bradykinin antagonist pseudopeptide derivatives of olefinic aminoalkanoic acids
US28190894A 1994-07-28 1994-07-28
US28190694A 1994-07-28 1994-07-28
US08/281,904 US5686565A (en) 1992-10-08 1994-07-28 Bradykinin antagonist pseudopeptide derivatives of aminoalkanoic acids and related olefins
US08/281,907 US5541286A (en) 1992-10-08 1994-07-28 Bradykinin antagonist pseudopeptide derivatives of olefinic aminoalkanoic acids
PCT/US1994/010128 WO1995007294A1 (en) 1993-09-09 1994-09-09 Pseudo- and non-peptide bradykinin receptor antagonists

Publications (2)

Publication Number Publication Date
DE69423899D1 true DE69423899D1 (de) 2000-05-11
DE69423899T2 DE69423899T2 (de) 2000-11-09

Family

ID=27574846

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69423899T Expired - Lifetime DE69423899T2 (de) 1993-09-09 1994-09-09 Pseudo-oder nicht peptidartige bradykinin rezeptor antagoniste

Country Status (7)

Country Link
EP (1) EP0716661B1 (de)
JP (1) JPH11500100A (de)
AT (1) ATE191486T1 (de)
CA (1) CA2171446C (de)
DE (1) DE69423899T2 (de)
ES (1) ES2148347T3 (de)
WO (1) WO1995007294A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE280777T1 (de) * 1994-03-09 2004-11-15 Cortech Inc Bradykinin-antagonist peptide mit n- substituierten glycinen
PL186769B1 (pl) * 1995-09-07 2004-02-27 Oreal Zastosowanie wyciągu z Iridaceae i kompozycja zawierająca taki wyciąg
FR2746647B1 (fr) * 1996-03-27 1998-05-15 Oreal Composition apaisante comprenant un extrait d'iridacee
FR2739553B1 (fr) * 1995-10-06 1998-01-02 Oreal Utilisation d'antagonistes de la bradykinine pour stimuler ou induire la pousse des cheveux et/ou stopper leur chute
DE19612067A1 (de) * 1996-03-27 1997-10-02 Hoechst Ag Verwendung von Bradykinin-Antagonisten zur Herstellung von Arzneimitteln zur Behandlung von chronisch fibrogenetischen Lebererkrankungen und akuten Lebererkrankungen
DE19642289A1 (de) * 1996-10-14 1998-04-16 Hoechst Ag Verwendung von Bradykinin-Antagonisten zur Herstellung von Arzneimitteln zur Behandlung und Prävention der Alzheimer'schen Krankheit
FR2756566B1 (fr) 1996-12-04 1999-01-08 Fournier Ind & Sante Peptides agonistes du recepteur b2 de la bradykinine, procede de preparation et utilisation en therapeutique
CN1247577C (zh) * 2000-09-25 2006-03-29 东丽株式会社 螺环衍生物和以其作为有效成分的粘附分子抑制剂
MXPA05002622A (es) 2002-09-09 2005-09-08 Johnson & Johnson Derivados de 1,3,8,-triazaespiro [4.5]decan-4-ona sustituidos con hidroxialquilo utiles para el tratamiento de desordenes mediados por el receptor opioide huerfano.
RU2387652C2 (ru) 2004-03-11 2010-04-27 Актелион Фармасьютиклз Лтд Производные тетрагидропиридоиндола
KR101165863B1 (ko) 2004-03-11 2012-07-13 액테리온 파마슈티칼 리미티드 인돌-1-일-아세트산 유도체
WO2006021418A1 (en) 2004-08-26 2006-03-02 Actelion Pharmaceuticals Ltd 2-sulfanyl-benzoimidazol-1-yl-acetic acid derivatives as crth2 antagonists
ES2528316T3 (es) * 2006-09-01 2015-02-06 Senhwa Biosciences, Inc. Moduladores de la serina-treonina proteína quinasa y de PARP
US8703948B2 (en) 2006-11-28 2014-04-22 Janssen Pharmaceutica Nv Salts of 3-(3-amino-2-(R)-hydroxy-propyl)-1-(4-fluoro-phenyl)-8-(8-methyl-naphthalen-1-ylmethyl)-1,3,8-triaza-spiro[4.5]decan-4-one
CN101679430B (zh) 2007-04-09 2013-12-25 詹森药业有限公司 用于治疗焦虑和抑郁症的作为orl-1受体的配体的1,3,8-三取代-1,3,8-三氮杂-螺[4.5]癸-4-酮衍生物
BRPI0906244A2 (pt) 2008-03-24 2015-06-30 Medivation Technologies Inc Composto, composição farmacêutica, método para tratar um distúrbio cognitivo, psicótico, mediado por neurotransmissores ou um distúrbio neuronal em um indivíduo, uso de um composto e kit
JP5791611B2 (ja) * 2009-09-23 2015-10-07 メディベイション テクノロジーズ， インコーポレイテッド ピリド［３，４−ｂ］インドールおよび使用方法
EP4165037A1 (de) 2020-06-10 2023-04-19 Aligos Therapeutics, Inc. Antivirale verbindungen zur behandlung von coronavirus-, picornavirus- und norovirus-infektionen
WO2023283256A1 (en) 2021-07-09 2023-01-12 Aligos Therapeutics, Inc. Anti-viral compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989009230A1 (en) * 1988-03-25 1989-10-05 Administrators Of The Tulane Educational Fund Therapeutic peptides
AU1873992A (en) * 1991-04-19 1992-11-17 Nova Technology Limited Partnership Bradykinin antagonist peptides
US5521158A (en) * 1992-10-08 1996-05-28 Scios Nova Inc. Pseudopeptide bradykinin receptor antagonists

Also Published As

Publication number Publication date
JPH11500100A (ja) 1999-01-06
CA2171446A1 (en) 1995-03-16
CA2171446C (en) 2004-11-23
ES2148347T3 (es) 2000-10-16
DE69423899T2 (de) 2000-11-09
ATE191486T1 (de) 2000-04-15
EP0716661B1 (de) 2000-04-05
WO1995007294A1 (en) 1995-03-16
EP0716661A1 (de) 1996-06-19

Similar Documents

Publication Publication Date Title
DE69423899D1 (de) Pseudo-oder nicht peptidartige bradykinin rezeptor antagoniste
DK0610743T3 (da) Immunsuppressive aminoethylen-peptider
AU7581094A (en) Alkylsiloxanes as adjuvants for agriculture
AU9065891A (en) Novel renin inhibiting peptides
EE9800048A (et) Uudsed opioidpeptiidid
DE59600119D1 (de) Synergistisches Stabilisatorgemisch
DE59611198D1 (de) Synergistisches Stabilisatorgemisch
PT1237584E (pt) Conjugados de liga??o a receptor
CA2128784A1 (en) Large, latent complexes of tgf-beta2 and tgf-beta3
DE59207530D1 (de) Eintreibgerät für Heftmittel
NO934381D0 (no) Terapeutiske sammensetninger for osteoinduksjon
AU634280B2 (en) Anticoagulant peptides
DE59506591D1 (de) Peptide als therapeutikum für autoimmunerkrankungen
GR3021660T3 (en) Anticoagulant peptides
IL108509A0 (en) GnRH antagonist peptides
AU2280895A (en) Synthesis n-protected amino acids, especially n-boc-l-propargylglycine by zinc-mediated addition or organic halides to glycine cation equivalent
FI935060A0 (fi) Kompensaatiojärjestely
IL86722A (en) Guanidine-related compounds comprising a tetraphenylborate ion and their preparation
KR950016202U (ko) 양돈용 사료 공급기의 급수 밸브
KR950002175U (ko) 편향요크의 코마프리 보정편 이송장치
KR940025921U (ko) 체형개선용 팬티
KR950015491U (ko) 컨버젼스 컵 고정용 지그
KR940024010U (ko) 빗자루용 보조금구
KR950018371U (ko) 사료공급기용 개량호퍼
IT8741634A0 (it) Calzatura con mezzi elastici ausiliari di serraggio.

Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: SCIOS INC., SUNNYVALE, CALIF., US

8364 No opposition during term of opposition