DE69423899T2 - Pseudo-oder nicht peptidartige bradykinin rezeptor antagoniste - Google Patents

Pseudo-oder nicht peptidartige bradykinin rezeptor antagoniste

Info

Publication number
DE69423899T2
DE69423899T2 DE69423899T DE69423899T DE69423899T2 DE 69423899 T2 DE69423899 T2 DE 69423899T2 DE 69423899 T DE69423899 T DE 69423899T DE 69423899 T DE69423899 T DE 69423899T DE 69423899 T2 DE69423899 T2 DE 69423899T2
Authority
DE
Germany
Prior art keywords
bradykinin
peptidal
pseudo
bradykinin receptor
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69423899T
Other languages
English (en)
Other versions
DE69423899D1 (de
Inventor
James Kyle
Joseph Mavunkel
Zhijian Lu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scios LLC
Original Assignee
Scios LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/118,981 external-priority patent/US5444048A/en
Priority claimed from US08/281,904 external-priority patent/US5686565A/en
Priority claimed from US08/281,907 external-priority patent/US5541286A/en
Application filed by Scios LLC filed Critical Scios LLC
Publication of DE69423899D1 publication Critical patent/DE69423899D1/de
Application granted granted Critical
Publication of DE69423899T2 publication Critical patent/DE69423899T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/18—Kallidins; Bradykinins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69423899T 1993-09-09 1994-09-09 Pseudo-oder nicht peptidartige bradykinin rezeptor antagoniste Expired - Lifetime DE69423899T2 (de)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US11855893A 1993-09-09 1993-09-09
US11934193A 1993-09-09 1993-09-09
US08/118,981 US5444048A (en) 1992-10-08 1993-09-09 Bradykinin antagonist pseudopeptide derivatives of olefinic aminoalkanoic acids
US08/118,550 US5552383A (en) 1992-10-08 1993-09-09 Bradykinin antagonist pseudopeptide derivatives of aminoalkanoic acids and related olefins
US28190894A 1994-07-28 1994-07-28
US28190694A 1994-07-28 1994-07-28
US08/281,904 US5686565A (en) 1992-10-08 1994-07-28 Bradykinin antagonist pseudopeptide derivatives of aminoalkanoic acids and related olefins
US08/281,907 US5541286A (en) 1992-10-08 1994-07-28 Bradykinin antagonist pseudopeptide derivatives of olefinic aminoalkanoic acids
PCT/US1994/010128 WO1995007294A1 (en) 1993-09-09 1994-09-09 Pseudo- and non-peptide bradykinin receptor antagonists

Publications (2)

Publication Number Publication Date
DE69423899D1 DE69423899D1 (de) 2000-05-11
DE69423899T2 true DE69423899T2 (de) 2000-11-09

Family

ID=27574846

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69423899T Expired - Lifetime DE69423899T2 (de) 1993-09-09 1994-09-09 Pseudo-oder nicht peptidartige bradykinin rezeptor antagoniste

Country Status (7)

Country Link
EP (1) EP0716661B1 (de)
JP (1) JPH11500100A (de)
AT (1) ATE191486T1 (de)
CA (1) CA2171446C (de)
DE (1) DE69423899T2 (de)
ES (1) ES2148347T3 (de)
WO (1) WO1995007294A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0813544B1 (de) * 1994-03-09 2004-10-27 Cortech, Inc. Bradykinin-antagonist peptide mit n-substituierten glycinen
FR2746647B1 (fr) * 1996-03-27 1998-05-15 Oreal Composition apaisante comprenant un extrait d'iridacee
DE69601765T2 (de) * 1995-09-07 1999-07-08 Oreal Extrakt von Iridaceen und Zusammensetzungen, die ihn enthalten
FR2739553B1 (fr) * 1995-10-06 1998-01-02 Oreal Utilisation d'antagonistes de la bradykinine pour stimuler ou induire la pousse des cheveux et/ou stopper leur chute
DE19612067A1 (de) * 1996-03-27 1997-10-02 Hoechst Ag Verwendung von Bradykinin-Antagonisten zur Herstellung von Arzneimitteln zur Behandlung von chronisch fibrogenetischen Lebererkrankungen und akuten Lebererkrankungen
DE19642289A1 (de) * 1996-10-14 1998-04-16 Hoechst Ag Verwendung von Bradykinin-Antagonisten zur Herstellung von Arzneimitteln zur Behandlung und Prävention der Alzheimer'schen Krankheit
FR2756566B1 (fr) * 1996-12-04 1999-01-08 Fournier Ind & Sante Peptides agonistes du recepteur b2 de la bradykinine, procede de preparation et utilisation en therapeutique
AU8811401A (en) * 2000-09-25 2002-04-02 Toray Industries Spiro compounds and adhesion molecule inhibitors containing the same as the active ingredient
AU2003268512A1 (en) 2002-09-09 2004-03-29 Janssen Pharmaceutica N.V. Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
PL1725553T3 (pl) 2004-03-11 2008-10-31 Idorsia Pharmaceuticals Ltd Pochodne tetrahydropirydoindolu
EP1740171B1 (de) 2004-03-11 2010-06-09 Actelion Pharmaceuticals Ltd. Indol-1-yl-essigsäurederivate
AU2005276640A1 (en) 2004-08-26 2006-03-02 Actelion Pharmaceuticals Ltd. 2-sulfanyl-benzoimidazol-1-yl-acetic acid derivatives as CRTH2 antagonists
EP2061765B1 (de) * 2006-09-01 2014-10-22 Senhwa Biosciences, Inc. Serin-Threonin-Proteinkinase- und PARP-Modulatoren
CA2670858C (en) 2006-11-28 2015-01-13 Janssen Pharmaceutica N.V. Salts of 3-(3-amino-2-(r)-hydroxy-propyl)-1-(4-fluoro-phenyl)-8-(8-methyl-naphthalen-1-ylmethyl)-1,3,8-triaza-spiro[4.5]decan-4-one
EP2150552B1 (de) 2007-04-09 2013-01-02 Janssen Pharmaceutica NV 1,3,8-trisubstituierte-1,3,8-triaza-spiro[4.5]decan-4-on derivate als liganden des orl-1 rezeptors zur behandlung von angst und depression
CN104387382A (zh) 2008-03-24 2015-03-04 梅迪维新技术公司 吡啶并[3,4-b]吲哚和应用方法
EP2480079A4 (de) * 2009-09-23 2015-04-08 Medivation Technologies Inc Pyrido-(3,4-b-)indole und verwendungsverfahren dafür
KR20230038457A (ko) 2020-06-10 2023-03-20 알리고스 테라퓨틱스 인코포레이티드 코로나바이러스, 피코르나바이러스 및 노로바이러스 감염을 치료하기 위한 항바이러스 화합물
PE20240775A1 (es) 2021-07-09 2024-04-17 Aligos Therapeutics Inc Compuestos antivirales

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989009230A1 (en) * 1988-03-25 1989-10-05 Administrators Of The Tulane Educational Fund Therapeutic peptides
AU1873992A (en) * 1991-04-19 1992-11-17 Nova Technology Limited Partnership Bradykinin antagonist peptides
US5521158A (en) * 1992-10-08 1996-05-28 Scios Nova Inc. Pseudopeptide bradykinin receptor antagonists

Also Published As

Publication number Publication date
EP0716661A1 (de) 1996-06-19
DE69423899D1 (de) 2000-05-11
EP0716661B1 (de) 2000-04-05
ATE191486T1 (de) 2000-04-15
JPH11500100A (ja) 1999-01-06
CA2171446A1 (en) 1995-03-16
CA2171446C (en) 2004-11-23
WO1995007294A1 (en) 1995-03-16
ES2148347T3 (es) 2000-10-16

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: SCIOS INC., SUNNYVALE, CALIF., US

8364 No opposition during term of opposition