DE69422275T2 - Chemopräventive verbindungen, verfahren zur herstellung und anwendungen - Google Patents

Chemopräventive verbindungen, verfahren zur herstellung und anwendungen

Info

Publication number
DE69422275T2
DE69422275T2 DE69422275T DE69422275T DE69422275T2 DE 69422275 T2 DE69422275 T2 DE 69422275T2 DE 69422275 T DE69422275 T DE 69422275T DE 69422275 T DE69422275 T DE 69422275T DE 69422275 T2 DE69422275 T2 DE 69422275T2
Authority
DE
Germany
Prior art keywords
chemopreventive
connections
applications
production method
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69422275T
Other languages
English (en)
Other versions
DE69422275D1 (de
Inventor
Nak Doo Kim
Jong Wook Lee
Sang Geon Kim
Young Ro Choi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of DE69422275D1 publication Critical patent/DE69422275D1/de
Application granted granted Critical
Publication of DE69422275T2 publication Critical patent/DE69422275T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/18—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69422275T 1993-10-21 1994-10-21 Chemopräventive verbindungen, verfahren zur herstellung und anwendungen Expired - Fee Related DE69422275T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1019930021876A KR0138005B1 (ko) 1993-10-21 1993-10-21 신규의 화학적 보호제(chemopreventive agent)및 그의 제조방법
PCT/KR1994/000144 WO1995011236A1 (en) 1993-10-21 1994-10-21 New chemopreventive compounds and a preparation method and use thereof

Publications (2)

Publication Number Publication Date
DE69422275D1 DE69422275D1 (de) 2000-01-27
DE69422275T2 true DE69422275T2 (de) 2000-08-10

Family

ID=19366274

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69422275T Expired - Fee Related DE69422275T2 (de) 1993-10-21 1994-10-21 Chemopräventive verbindungen, verfahren zur herstellung und anwendungen

Country Status (7)

Country Link
US (1) US5658913A (de)
EP (1) EP0674628B1 (de)
JP (1) JP2670384B2 (de)
KR (1) KR0138005B1 (de)
CN (1) CN1043887C (de)
DE (1) DE69422275T2 (de)
WO (1) WO1995011236A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0157105B1 (ko) * 1995-10-14 1998-11-16 김태훈 화학적 발암억제제
JP2003506084A (ja) * 1999-08-05 2003-02-18 メルク エンド カムパニー インコーポレーテッド ヒトシトクロムｐ４５０３ａ４およびヒトシトクロムｐ４５０２ｃ９に対するモノクローナル抗体
US7078045B2 (en) * 2000-03-02 2006-07-18 Sang-Geon Kim Pharmaceutical composition for treatment and prevention of liver fibrosis and cirrhosis
NZ521710A (en) * 2000-04-07 2004-06-25 Sang Geon Kim Prophylactic and therapeutic use of oltipraz as an antifibrotic and anticirrhotic agent in the liver and pharmaceutical composition containing oltipraz
GB0008689D0 (en) * 2000-04-07 2000-05-31 Nokia Networks Oy A method and system for processing signals
KR20030067935A (ko) * 2002-02-09 2003-08-19 김상건 올티프라즈를 포함하는 간경화(간경변증) 치료를 위한 간 조직 재생용 제약 조성물
US7001619B2 (en) * 2002-03-27 2006-02-21 Council Of Scientific And Industrial Research Hepatocurative effect of emblica officinalis against CYP 450 bio-activation hepatotoxicity of drugs
US7498331B2 (en) * 2003-11-06 2009-03-03 United States Of America As Represented By The Secretary Of The Army Arthropod repellent pharmacophore models, compounds identified as fitting the pharmacophore models, and methods of making and using thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3931166A (en) * 1972-04-13 1976-01-06 Firmenich & Cie Certain 2,5-dimethyl-3-thiopyrazines
CA1001631A (en) * 1972-05-05 1976-12-14 Merck Sharp And Dohme (I.A.) Corp. 2-(3-substituted amino-2-hydroxy-propoxy)-3-substituted pyrazines and method for preparation
US4085109A (en) * 1974-06-24 1978-04-18 Firmenich & Cie Pyridine sulfur flavoring agents
US3989713A (en) * 1974-07-24 1976-11-02 Firmenich & Cie Pyrrylmethylthio flavoring agents
GB1549829A (en) * 1976-05-26 1979-08-08 Farmaceutici Italia 10'-methoxy-1',6'-dimethylergoline-8'-beta-methyl-amino(or thio)-pyrazines

Also Published As

Publication number Publication date
DE69422275D1 (de) 2000-01-27
JP2670384B2 (ja) 1997-10-29
CN1115981A (zh) 1996-01-31
KR0138005B1 (ko) 1998-05-15
EP0674628B1 (de) 1999-12-22
WO1995011236A1 (en) 1995-04-27
US5658913A (en) 1997-08-19
CN1043887C (zh) 1999-06-30
JPH08503972A (ja) 1996-04-30
KR950010897A (ko) 1995-05-15
EP0674628A1 (de) 1995-10-04

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee