DE69412551D1 - Isolierung und Struktur von Spongistatin 5, 7, 8 und 9 und deren Verwendung als Antitumor-Mittel - Google Patents
Isolierung und Struktur von Spongistatin 5, 7, 8 und 9 und deren Verwendung als Antitumor-MittelInfo
- Publication number
- DE69412551D1 DE69412551D1 DE69412551T DE69412551T DE69412551D1 DE 69412551 D1 DE69412551 D1 DE 69412551D1 DE 69412551 T DE69412551 T DE 69412551T DE 69412551 T DE69412551 T DE 69412551T DE 69412551 D1 DE69412551 D1 DE 69412551D1
- Authority
- DE
- Germany
- Prior art keywords
- spongistatin
- isolation
- found
- human cancer
- tumor agents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- JOEPUFOWFXWEDN-UHFFFAOYSA-N Spongistatin 5 Natural products C1C(=O)C(C)C(C2C)OCC2=CC(O2)CC(C)(O)CC2(O2)CC(O)CC2CC(=O)OC(C(C(CC(=C)CC(O)C=CC(Cl)=C)O2)O)C(C)C2C(O)C(O2)(O)CC(O)C(C)C2CCCC=CC(O2)CC(O)CC22CC(OC)CC1O2 JOEPUFOWFXWEDN-UHFFFAOYSA-N 0.000 title abstract 3
- BTCJGYMVVGSTDN-UHFFFAOYSA-N Spongistatin 7 Natural products C1C(=O)C(C)C(C2C)OCC2=CC(O2)CC(C)(O)CC2(O2)CC(O)CC2CC(=O)OC(C(C(CC(=C)CC(O)C=CC=C)O2)O)C(C)C2C(O)C(O2)(O)CC(O)C(C)C2CCCC=CC(O2)CC(O)CC22CC(OC)CC1O2 BTCJGYMVVGSTDN-UHFFFAOYSA-N 0.000 title abstract 3
- GLMCWICCTJHQKE-UHFFFAOYSA-N Spongistatin 9 Natural products C1C(=O)C(C)C(C2C)OCC2=CC(O2)CC(C)(O)CC2(O2)CC(OC(C)=O)CC2CC(=O)OC(C(C(CC(=C)CC(O)C=CC(Cl)=C)O2)O)C(C)C2C(O)C(O2)(O)CC(O)C(C)C2CCCC=CC(O2)CC(O)CC22CC(OC)CC1O2 GLMCWICCTJHQKE-UHFFFAOYSA-N 0.000 title abstract 2
- WYJXOZQMHBISBD-UHFFFAOYSA-N spongistatin 8 Natural products C1C(=O)C(C)C(C2C)OCC2=CC(O2)CC(C)(O)CC2(O2)CC(OC(C)=O)CC2CC(=O)OC(C(C(CC(=C)CC(O)C=CC=C)O2)O)C(C)C2C(O)C(O2)(O)CC(O)C(C)C2CCCC=CC(O2)CC(O)CC22CC(OC)CC1O2 WYJXOZQMHBISBD-UHFFFAOYSA-N 0.000 title abstract 2
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 238000002955 isolation Methods 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 241001465805 Nymphalidae Species 0.000 abstract 1
- 241000243142 Porifera Species 0.000 abstract 1
- 241000796716 Spirastrella Species 0.000 abstract 1
- 241000520664 Spongia Species 0.000 abstract 1
- 239000003966 growth inhibitor Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- ICXJVZHDZFXYQC-UHFFFAOYSA-N spongistatin 1 Natural products OC1C(O2)(O)CC(O)C(C)C2CCCC=CC(O2)CC(O)CC2(O2)CC(OC)CC2CC(=O)C(C)C(OC(C)=O)C(C)C(=C)CC(O2)CC(C)(O)CC2(O2)CC(OC(C)=O)CC2CC(=O)OC2C(O)C(CC(=C)CC(O)C=CC(Cl)=C)OC1C2C ICXJVZHDZFXYQC-UHFFFAOYSA-N 0.000 abstract 1
- HAOCRCFHEPRQOY-JKTUOYIXSA-N spongistatin-1 Chemical compound C([C@@H]1C[C@@H](C[C@@]2(C[C@@H](O)C[C@@H](C2)\C=C/CCC[C@@H]2[C@H](C)[C@@H](O)C[C@](O2)(O)[C@H]2O)O1)OC)C(=O)[C@@H](C)[C@@H](OC(C)=O)[C@H](C)C(=C)C[C@H](O1)C[C@](C)(O)C[C@@]1(O1)C[C@@H](OC(C)=O)C[C@@H]1CC(=O)O[C@H]1[C@H](O)[C@@H](CC(=C)C(C)[C@H](O)\C=C\C(Cl)=C)O[C@@H]2[C@@H]1C HAOCRCFHEPRQOY-JKTUOYIXSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/086,664 US5393897A (en) | 1993-07-02 | 1993-07-02 | Isolation and structure of spongistatins 5,7,8 and 9 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69412551D1 true DE69412551D1 (de) | 1998-09-24 |
| DE69412551T2 DE69412551T2 (de) | 1999-02-04 |
Family
ID=22200068
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69412551T Expired - Fee Related DE69412551T2 (de) | 1993-07-02 | 1994-06-30 | Isolierung und Struktur von Spongistatin 5, 7, 8 und 9 und deren Verwendung als Antitumor-Mittel |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5393897A (de) |
| EP (1) | EP0634414B1 (de) |
| JP (1) | JP3430322B2 (de) |
| AT (1) | ATE169919T1 (de) |
| CA (1) | CA2126910C (de) |
| DE (1) | DE69412551T2 (de) |
| DK (1) | DK0634414T3 (de) |
| ES (1) | ES2123714T3 (de) |
| MX (1) | MX9404999A (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997048278A1 (en) * | 1996-06-18 | 1997-12-24 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of The Arizona State University | Antifungal activity of the spongistatins |
| US5883120A (en) * | 1997-06-16 | 1999-03-16 | Arizona Board Of Regents, A Body Corporate, Acting On Behalf Of Arizona State University | Antifungal activity of the spongistatins |
| US5952376A (en) * | 1997-11-07 | 1999-09-14 | The Trustees Of The University Of Pennsylvania | Trienyl compounds |
| US6521661B1 (en) | 2000-07-20 | 2003-02-18 | Harbor Branch Oceanographic Institution, Inc. | Cyclic peroxides as novel antifungal agents |
| US20040235889A1 (en) * | 2001-05-02 | 2004-11-25 | Miao-Kun Sun | Carbonic anhydrase activator for enhancing learning and memory |
| US20050065205A1 (en) * | 2002-03-07 | 2005-03-24 | Daniel Alkon | Methods for Alzheimer's disease treatment and cognitive enhance |
| US6825229B2 (en) | 2002-03-07 | 2004-11-30 | Blanchette Rockefeller Neurosciences Institute | Methods for Alzheimer's Disease treatment and cognitive enhancement |
| US20080004332A1 (en) * | 2002-03-07 | 2008-01-03 | Alkon Daniel L | Methods for alzheimer's disease treatment and cognitive enhancement |
| TW200538181A (en) * | 2004-05-18 | 2005-12-01 | Brni Neurosciences Inst | Treatment of depressive disorders |
| WO2007016202A1 (en) | 2005-07-29 | 2007-02-08 | Blanchette Rockefeller Neurosciences Institute | Use of a pkc activator, alone or combined with a pkc inhibitor to enhance long term memory |
| CA2659242C (en) | 2006-07-28 | 2015-08-11 | Blanchette Rockefeller Neurosciences Institute | Methods of stimulating cellular growth, synaptic remodeling and consolidation of long-term memory |
| CA2873179A1 (en) | 2007-02-09 | 2008-08-21 | Blanchette Rockefeller Neurosciences Institute | Use of bryostatins and neristatins in the treatment of cognitive impairment due to head trauma |
| CA2864550C (en) | 2007-02-09 | 2018-07-10 | Blanchette Rockefeller Neurosciences Institute | Therapeutic effects of bryostatins, bryologs, and other related substances on ischemia/stroke-induced memory impairment and brain injury |
| US9053844B2 (en) * | 2009-09-09 | 2015-06-09 | Littelfuse, Inc. | Geometric configuration or alignment of protective material in a gap structure for electrical devices |
| WO2012006516A2 (en) | 2010-07-08 | 2012-01-12 | Alkon Daniel L | Dag-type and indirect protein kinase c activators and anticoagulant for the treatment of stroke |
| JP6062362B2 (ja) | 2010-08-19 | 2017-01-18 | ブランシェット・ロックフェラー・ニューロサイエンスィズ・インスティテュート | Ｐｋｃ活性化剤を使用した、異常な樹状突起棘に関連した認知障害の治療 |
| JP6422778B2 (ja) | 2011-11-13 | 2018-11-14 | ブランシェット・ロックフェラー・ニューロサイエンスィズ・インスティテュート | Ｐｋｃアクチベーターおよびその組合せ |
| WO2016130969A1 (en) | 2015-02-13 | 2016-08-18 | George Robert Pettit | Silstatin compounds |
| CA2985625A1 (en) | 2015-05-11 | 2016-11-17 | Alkon, Daniel L. | Treatment of neurodegenerative conditions using pkc activators after determining the presence of the apoe4 allele |
| US11629167B2 (en) | 2017-11-09 | 2023-04-18 | Arizona Board Of Regents On Behalf Of Arizona State University | Betulastatin compounds |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4164584A (en) * | 1977-10-25 | 1979-08-14 | Research Corporation | Anti-leukemic trichothecene epoxides |
| US4560774A (en) * | 1982-11-17 | 1985-12-24 | Arizona State University | Macrocyclic lactones |
| US4996229A (en) * | 1985-06-06 | 1991-02-26 | University Of Hawaii | Scytophycins |
| ATE51003T1 (de) * | 1985-09-13 | 1990-03-15 | Biotechnolog Forschung Gmbh | Makrozyklische antibiotika. |
| US4833257A (en) * | 1986-07-28 | 1989-05-23 | Arizona Board Of Regents | Compositions of matter and methods of using same |
| US4940726A (en) * | 1989-04-26 | 1990-07-10 | Arizona Board Of Regents | Cell growth inhibitory macrocyclic lactones denominated Combretastatin D-1 and Combretastatin D-2 |
| US5436400A (en) * | 1993-01-19 | 1995-07-25 | Arizona Board Of Regents | Isolation and structure of spongistatin 1 |
| US5328929A (en) * | 1993-07-02 | 1994-07-12 | Arizona Board Of Regents | Isolation and structure of spongistatin 2, spongistatin 3, spongistatin 4 and spongistatin 6 |
-
1993
- 1993-07-02 US US08/086,664 patent/US5393897A/en not_active Expired - Lifetime
-
1994
- 1994-06-28 CA CA002126910A patent/CA2126910C/en not_active Expired - Fee Related
- 1994-06-29 JP JP18173594A patent/JP3430322B2/ja not_active Expired - Fee Related
- 1994-06-30 ES ES94304809T patent/ES2123714T3/es not_active Expired - Lifetime
- 1994-06-30 EP EP94304809A patent/EP0634414B1/de not_active Expired - Lifetime
- 1994-06-30 DE DE69412551T patent/DE69412551T2/de not_active Expired - Fee Related
- 1994-06-30 MX MX9404999A patent/MX9404999A/es unknown
- 1994-06-30 AT AT94304809T patent/ATE169919T1/de not_active IP Right Cessation
- 1994-06-30 DK DK94304809T patent/DK0634414T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| ES2123714T3 (es) | 1999-01-16 |
| US5393897A (en) | 1995-02-28 |
| EP0634414B1 (de) | 1998-08-19 |
| DE69412551T2 (de) | 1999-02-04 |
| DK0634414T3 (da) | 1999-05-25 |
| JPH07157428A (ja) | 1995-06-20 |
| MX9404999A (es) | 1995-01-31 |
| CA2126910C (en) | 2001-07-17 |
| CA2126910A1 (en) | 1995-01-03 |
| JP3430322B2 (ja) | 2003-07-28 |
| EP0634414A1 (de) | 1995-01-18 |
| ATE169919T1 (de) | 1998-09-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69412551T2 (de) | Isolierung und Struktur von Spongistatin 5, 7, 8 und 9 und deren Verwendung als Antitumor-Mittel | |
| GB2301363A (en) | Human phosphodiesterase type ivc and its production and use | |
| JPS57500830A (de) | ||
| DE68929167D1 (de) | Genexpressions-Elemente und Herstellung von chimären Maus-Mensch-Antikörpern | |
| BR9507229A (pt) | Amilase composição detergente aditivo detergente uso de um detergente e de uma amilase construç~o de dna vetor de expressão recombinante célula e processo para produzir amilase | |
| ATE50763T1 (de) | Tetralin-derivate, ihre herstellung und verwendung. | |
| DE69001458D1 (de) | Mit einer benzotriazolgruppe substituierte diorganopolysiloxane enthaltende kosmetika sowie deren verwendung zum schutz von haut und haaren. | |
| ATE279516T1 (de) | Menschliche neuronale nikotin-acetylcholin- rezeptor-verbindungen und methoden ihres einsatzes | |
| DK0451611T3 (da) | Human hæmatopoietisk stamcelle | |
| Chen | Factors influencing methane fermentation of micro-algae | |
| EP0718858A3 (de) | Verwendung von organischen Materialien hoher nichtionischer Ladungsträgerbeweglichkeit | |
| WO1998037185A3 (en) | Vectors for controlled gene expression | |
| EA200100264A1 (ru) | Ангиоцидин: адгезионный рецептор опухолей клетки, специфический для cys-ser-val-thr-cys-gly | |
| ATE63111T1 (de) | Substituierte oximether, ihre verwendung als bioregulatoren zur senkung des endogenen ethylenspiegels in pflanzen. | |
| CA2126911A1 (en) | Isolation and structure of spongistatin 2, spongistatin 3, spongistatin 4 and spongistatin 6 | |
| ATE64393T1 (de) | Monosulfactame. | |
| DE69410492T2 (de) | Isolierung und Struktur von Spongistatin 1 und dessen Verwendung als Antitumor-Mittel | |
| ATE236983T1 (de) | Durch zelldichte stimulierte protein-tyrosin- phosphatasen | |
| PT942978E (pt) | Metodos para produzir o complexos promotor da anafase | |
| DE69033725T2 (de) | Erhöhung der naphthalindioxygenase-wirkung während der mikrobiellen indigoherstellung | |
| DE3484422D1 (de) | Verfahren zur herstellung von indanyl-derivaten und deren verwendung. | |
| ATE452643T1 (de) | Herstellung eines biologischen faktors und schaffung einer immunologisch vorteilhaften umgebung unter verwendung genetisch veränderter sertolizellen | |
| ATE139779T1 (de) | Asymmetrische hydrierung von furoimidazol- derivate | |
| DE69400022D1 (de) | Doppeldunkelfeld-Anfärbeverfahren; Proben, erhalten durch das Verfahren und Verwendung von Enzymmarkern in Doppeldunkelfeldfärbungen. | |
| ATE71671T1 (de) | Methylenchloridzusammensetzung und deren verwendung zum entfetten von metallen. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |