DE68929167D1 - Genexpressions-Elemente und Herstellung von chimären Maus-Mensch-Antikörpern - Google Patents
Genexpressions-Elemente und Herstellung von chimären Maus-Mensch-AntikörpernInfo
- Publication number
- DE68929167D1 DE68929167D1 DE68929167T DE68929167T DE68929167D1 DE 68929167 D1 DE68929167 D1 DE 68929167D1 DE 68929167 T DE68929167 T DE 68929167T DE 68929167 T DE68929167 T DE 68929167T DE 68929167 D1 DE68929167 D1 DE 68929167D1
- Authority
- DE
- Germany
- Prior art keywords
- production
- gene expression
- expression elements
- human antibodies
- chimeric mouse
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
- C07K16/462—Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/034—Fusion polypeptide containing a localisation/targetting motif containing a motif for targeting to the periplasmic space of Gram negative bacteria as a soluble protein, i.e. signal sequence should be cleaved
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24062488A | 1988-09-06 | 1988-09-06 | |
US24174488A | 1988-09-08 | 1988-09-08 | |
US24373988A | 1988-09-13 | 1988-09-13 | |
US25300288A | 1988-10-04 | 1988-10-04 | |
US36764189A | 1989-06-19 | 1989-06-19 | |
US38276889A | 1989-07-21 | 1989-07-21 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE68929167D1 true DE68929167D1 (de) | 2000-04-13 |
DE68929167T2 DE68929167T2 (de) | 2000-11-16 |
Family
ID=27559300
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE68929167T Expired - Fee Related DE68929167T2 (de) | 1988-09-06 | 1989-09-06 | Genexpressions-Elemente und Herstellung von chimären Maus-Mensch-Antikörpern |
Country Status (9)
Country | Link |
---|---|
US (1) | US6461824B1 (de) |
EP (2) | EP0967277A3 (de) |
AT (1) | ATE190355T1 (de) |
AU (1) | AU643189B2 (de) |
CA (1) | CA1341351C (de) |
DE (1) | DE68929167T2 (de) |
ES (1) | ES2146572T3 (de) |
GR (1) | GR3033630T3 (de) |
WO (1) | WO1990002569A1 (de) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990002569A1 (en) | 1988-09-06 | 1990-03-22 | International Genetic Engineering, Inc. | Production of chimeric mouse-human antibodies with specificity to human tumor antigens |
US5576184A (en) * | 1988-09-06 | 1996-11-19 | Xoma Corporation | Production of chimeric mouse-human antibodies with specificity to human tumor antigens |
IL89490A0 (en) * | 1988-11-17 | 1989-09-10 | Hybritech Inc | Chimeric antibodies directed against metal chelates |
US6291159B1 (en) | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for producing polymers having a preselected activity |
US6291158B1 (en) | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for tapping the immunological repertoire |
AU627591B2 (en) * | 1989-06-19 | 1992-08-27 | Xoma Corporation | Chimeric mouse-human km10 antibody with specificity to a human tumor cell antigen |
US5580774A (en) * | 1989-07-31 | 1996-12-03 | Eli Lilly And Company | Chimeric antibodies directed against a human glycoprotein antigen |
AU662311B2 (en) * | 1991-02-05 | 1995-08-31 | Novartis Ag | Recombinant antibodies specific for a growth factor receptor |
US20050196400A1 (en) * | 1991-05-06 | 2005-09-08 | Xoma Technology Ltd. | Production of chimeric mouse-human antibodies with specificity to human tumor antigens |
US5621083A (en) | 1991-11-04 | 1997-04-15 | Xoma Corporation | Immunotoxins comprising ribosome-inactivating proteins |
US5837491A (en) * | 1991-11-04 | 1998-11-17 | Xoma Corporation | Polynucleotides encoding gelonin sequences |
US6146850A (en) | 1991-11-04 | 2000-11-14 | Xoma Corporation | Proteins encoding gelonin sequences |
US6143522A (en) * | 1995-12-08 | 2000-11-07 | University Technologies International, Inc. | Methods of modulating apoptosis |
US6747133B1 (en) | 1995-12-08 | 2004-06-08 | University Technologies International Inc. | Antibodies against the tumor suppressor gene ING1 |
US6117633A (en) * | 1995-12-08 | 2000-09-12 | University Technologies International Inc. | DNA sequence encoding the tumor suppressor gene ING1 |
US6037121A (en) * | 1995-12-08 | 2000-03-14 | University Technologies International Inc. | DNA sequence encoding a tumor suppressor gene |
US20030035798A1 (en) | 2000-08-16 | 2003-02-20 | Fang Fang | Humanized antibodies |
EP1578917A4 (de) | 2001-07-19 | 2008-01-23 | Perlan Therapeutics Inc | Multimere proteine und verfahren zu deren herstellung und verwendung |
AU2003211342A1 (en) * | 2002-03-01 | 2003-09-16 | Japan Envirochemicals, Ltd. | Proteins capable of binding to environmental hormones and process for producing the same |
US20050009097A1 (en) * | 2003-03-31 | 2005-01-13 | Better Marc D. | Human engineered antibodies to Ep-CAM |
US20050138692A1 (en) * | 2003-06-02 | 2005-06-23 | Biotechnology Foundation, Inc. | Production of cancer-specific antibodies in plants |
US20060040354A1 (en) * | 2004-07-20 | 2006-02-23 | O'keefe Theresa L | Novel polyadenylation signal for use in expression vectors |
US8211648B2 (en) | 2005-07-22 | 2012-07-03 | Kalobios Pharmaceuticals, Inc. | Secretion of antibodies without signal peptides from bacteria |
PE20140196A1 (es) | 2007-08-09 | 2014-03-19 | Boehringer Ingelheim Int | Anticuerpos anti-cd37 |
CA2712605C (en) * | 2008-02-01 | 2017-02-07 | Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Health | Monoclonal antibodies for ebola and marburg viruses |
US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
RU2724663C2 (ru) | 2010-02-08 | 2020-06-25 | Ридженерон Фармасьютикалз, Инк. | Мышь с общей легкой цепью |
RU2664232C2 (ru) | 2011-08-05 | 2018-08-15 | Регенерон Фармасьютикалз, Инк. | Мыши с гуманизированной универсальной легкой цепью |
WO2013171287A1 (en) | 2012-05-16 | 2013-11-21 | Boehringer Ingelheim International Gmbh | Combination of cd37 antibodies with ice (ifosfamide, carboplatin, etoposide) |
SG11201407644UA (en) * | 2012-06-05 | 2014-12-30 | Regeneron Pharma | Methods for making fully human bispecific antibodies using a common light chain |
RU2016141307A (ru) | 2014-03-21 | 2018-04-24 | Регенерон Фармасьютикалз, Инк. | Отличные от человека животные, которые вырабатывают однодоменные связывающие белки |
WO2016149678A1 (en) | 2015-03-19 | 2016-09-22 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
AU2018221172A1 (en) | 2017-02-17 | 2019-09-05 | Adimab, Llc | Monoclonal antibodies and cocktails for treatment of Ebola infections |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4612282A (en) * | 1981-12-15 | 1986-09-16 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Monoclonal antibodies reactive with human breast cancer |
US4818709A (en) | 1983-01-21 | 1989-04-04 | Primus Frederick J | CEA-family antigens, Anti-CEA antibodies and CEA immunoassay |
GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
JPS60224492A (ja) * | 1984-04-24 | 1985-11-08 | Yuu Honshiyo | 異種遺伝子の結合法 |
EP0173494A3 (de) * | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimäre Rezeptoren durch Verbindung und Expression von DNS |
JPS61167699A (ja) * | 1985-01-19 | 1986-07-29 | Green Cross Corp:The | モノクロ−ナル抗体 |
DE3689123T2 (de) * | 1985-11-01 | 1994-03-03 | Xoma Corp | Modulare einheit von antikörpergenen, daraus hergestellte antikörper und verwendung. |
CA1341281C (en) | 1986-07-09 | 2001-08-07 | Hubert J.P. Schoemaker | Immunotherapy of tumor with monoclonal antibody against the 17-1a antigen |
IE872455L (en) * | 1986-09-12 | 1988-03-12 | Lanstrase Ltd | Improved recombinant expression |
IL84285A (en) * | 1986-10-27 | 1993-03-15 | Int Genetic Engineering | Chimeric antibody with specificity to human tumor antigen |
IL85035A0 (en) * | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
US4816282A (en) * | 1987-09-30 | 1989-03-28 | Lonza Inc. | Moisture-stabilized foods having improved shelf life |
CA1340221C (en) | 1988-01-29 | 1998-12-15 | Thomas Frank Bumol | Vectors, compounds and method for expression of a human adenocarcinoma antigen |
US4975369A (en) | 1988-04-21 | 1990-12-04 | Eli Lilly And Company | Recombinant and chimeric KS1/4 antibodies directed against a human adenocarcinoma antigen |
WO1990002569A1 (en) | 1988-09-06 | 1990-03-22 | International Genetic Engineering, Inc. | Production of chimeric mouse-human antibodies with specificity to human tumor antigens |
US5576184A (en) | 1988-09-06 | 1996-11-19 | Xoma Corporation | Production of chimeric mouse-human antibodies with specificity to human tumor antigens |
WO1990003799A1 (en) | 1988-10-12 | 1990-04-19 | Centocor, Inc. | Radiotherapeutic immunoconjugates labeled with iodine-125 |
WO1993008298A1 (en) | 1991-10-18 | 1993-04-29 | The Wistar Institute Of Anatomy And Biology | Soluble variants of type i membrane proteins, and methods of using them |
-
1989
- 1989-09-06 WO PCT/US1989/003852 patent/WO1990002569A1/en unknown
- 1989-09-06 AT AT89309048T patent/ATE190355T1/de not_active IP Right Cessation
- 1989-09-06 EP EP99202598A patent/EP0967277A3/de not_active Withdrawn
- 1989-09-06 AU AU44021/89A patent/AU643189B2/en not_active Ceased
- 1989-09-06 CA CA000610388A patent/CA1341351C/en not_active Expired - Fee Related
- 1989-09-06 DE DE68929167T patent/DE68929167T2/de not_active Expired - Fee Related
- 1989-09-06 ES ES89309048T patent/ES2146572T3/es not_active Expired - Lifetime
- 1989-09-06 EP EP89309048A patent/EP0364096B1/de not_active Expired - Lifetime
-
1995
- 1995-06-06 US US08/467,142 patent/US6461824B1/en not_active Expired - Fee Related
-
2000
- 2000-06-07 GR GR20000401317T patent/GR3033630T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
GR3033630T3 (en) | 2000-10-31 |
US6461824B1 (en) | 2002-10-08 |
EP0364096A2 (de) | 1990-04-18 |
EP0364096B1 (de) | 2000-03-08 |
EP0967277A3 (de) | 2003-10-15 |
WO1990002569A1 (en) | 1990-03-22 |
CA1341351C (en) | 2002-03-26 |
EP0967277A2 (de) | 1999-12-29 |
DE68929167T2 (de) | 2000-11-16 |
EP0364096A3 (de) | 1992-08-05 |
ES2146572T3 (es) | 2000-08-16 |
ATE190355T1 (de) | 2000-03-15 |
AU4402189A (en) | 1990-04-02 |
AU643189B2 (en) | 1993-11-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE190355T1 (de) | Genexpressions-elemente und herstellung von chimären maus-mensch-antikörpern | |
ZA878044B (en) | Chimeric antibody with specificity to human tumor antigen | |
ATE112802T1 (de) | Herstellung von funktionellen menschlichen urokinasepolypeptiden. | |
DE3751922D1 (de) | Herstellung und Verwendung von IL-6 | |
DK69890D0 (da) | Monoklonale antistoffer, der er reaktive med cachetin | |
ATE195323T1 (de) | Anti-lymphotoxin-antikörper, herstellung und verwendung | |
ATE188486T1 (de) | Modifizierte polypeptide mit erhoehter biologischer aktivitaet | |
NO166943C (no) | Analogifremgangsmaate for fremstilling av enzymresistente immunomodulerende peptider. | |
GB2301363A (en) | Human phosphodiesterase type ivc and its production and use | |
DE69334211D1 (de) | Multidrug resistenz gen | |
DE3581400D1 (de) | Maus/mensch-hybridoma mit erzeugung von antiviralen menschlichen antikoerpern, deren herstellung und antivirale menschliche monoklonale antikoerper. | |
EP0404003A3 (de) | Chimäre Maus-Mensch-KM10-Antikörper, spezifisch für ein menschliches Tumorzellen-Antigen | |
ES2061566T3 (es) | Anticuerpos monoclonales contra la proteina e7 del papilomavirus humano tipo 16, procedimiento para su preparacion, asi como su empleo. | |
SU572590A1 (ru) | Струйный усилитель |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |