ATE279516T1 - Menschliche neuronale nikotin-acetylcholin- rezeptor-verbindungen und methoden ihres einsatzes - Google Patents
Menschliche neuronale nikotin-acetylcholin- rezeptor-verbindungen und methoden ihres einsatzesInfo
- Publication number
- ATE279516T1 ATE279516T1 AT94912758T AT94912758T ATE279516T1 AT E279516 T1 ATE279516 T1 AT E279516T1 AT 94912758 T AT94912758 T AT 94912758T AT 94912758 T AT94912758 T AT 94912758T AT E279516 T1 ATE279516 T1 AT E279516T1
- Authority
- AT
- Austria
- Prior art keywords
- subunits
- alpha
- methods
- acetylcholine receptor
- human neuronal
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2803193A | 1993-03-08 | 1993-03-08 | |
PCT/US1994/002447 WO1994020617A2 (en) | 1993-03-08 | 1994-03-08 | Human neuronal nicotinic acetylcholine receptor compositions and methods employing same |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE279516T1 true ATE279516T1 (de) | 2004-10-15 |
Family
ID=21841175
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT94912758T ATE279516T1 (de) | 1993-03-08 | 1994-03-08 | Menschliche neuronale nikotin-acetylcholin- rezeptor-verbindungen und methoden ihres einsatzes |
Country Status (10)
Country | Link |
---|---|
US (5) | US5837489A (de) |
EP (2) | EP0688361B1 (de) |
JP (2) | JP3628691B2 (de) |
AT (1) | ATE279516T1 (de) |
AU (1) | AU694424B2 (de) |
CA (1) | CA2155330C (de) |
DE (1) | DE69434067T2 (de) |
ES (1) | ES2229216T3 (de) |
GB (1) | GB2286397B (de) |
WO (1) | WO1994020617A2 (de) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6936457B1 (en) * | 1990-04-03 | 2005-08-30 | Merck & Co., Inc. | DNA ENCODING HUMAN α AND β SUBUNITS OF NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR, CELLS TRANSFORMED THEREWITH, AND RECOMBINANT CELL LINE EXPRESSING A HUMAN α AND β SUBUNIT OF NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR |
CA2155330C (en) | 1993-03-08 | 2002-01-29 | Kathryn J. Elliott | Human neuronal nicotinic acetylcholine receptor compositions and methods employing same |
US6485967B1 (en) * | 1995-06-07 | 2002-11-26 | Merck & Co., Inc. | Human neuronal nicotinic acetylcholine receptor α6 and β3 nucleic acid |
CA2279669A1 (en) * | 1995-12-15 | 1997-06-16 | Enzo Therapeutics, Inc. | Property effecting and/or property exhibiting constructs for the expression of non-native nucleic acid processing components for therapeutic and diagnostic uses |
US6323000B2 (en) | 1996-12-20 | 2001-11-27 | Clark A. Briggs | Variant human α7 acetylcholine receptor subunit, and methods of production and uses thereof |
CA2293254A1 (en) * | 1997-06-13 | 1998-12-23 | Allelix Biopharmaceuticals Inc. | Assay methods and compositions useful for measuring receptor ligand binding |
US6875606B1 (en) * | 1997-10-23 | 2005-04-05 | The United States Of America As Represented By The Department Of Veterans Affairs | Human α-7 nicotinic receptor promoter |
US6632823B1 (en) | 1997-12-22 | 2003-10-14 | Merck & Co., Inc. | Substituted pyridine compounds useful as modulators of acetylcholine receptors |
EP0953637A3 (de) * | 1998-03-24 | 2001-04-25 | Smithkline Beecham Plc | Acetylcholine Receptor |
US6252132B1 (en) * | 1998-11-02 | 2001-06-26 | Institut Pasteur | Mutant mouse containing a knockout mutation in DNA encoding an endogenous alpha 4 subunit of nicotinic acetylcholine receptor |
JP2003501022A (ja) | 1999-05-27 | 2003-01-14 | ファルマシア・アンド・アップジョン・カンパニー | イオンチャネルコンダクタンスを測定するための方法およびその組成物 |
US6693172B1 (en) | 1999-05-27 | 2004-02-17 | Pharmacia And Upjohn Company | Double mutant alpha-7 nicotinic acetylcholine receptor |
GB9913248D0 (en) * | 1999-06-09 | 1999-08-04 | Babraham Inst | Recombinant nematode nicotinic receptor and uses |
US20030096411A1 (en) * | 1999-12-07 | 2003-05-22 | George Michalopoulos | Novel long-term three-dimensional tissue culture system |
US6737270B1 (en) | 1999-12-07 | 2004-05-18 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Long-term three dimensional tissue culture system |
DE19959582A1 (de) * | 1999-12-10 | 2001-06-13 | Bayer Ag | Nukleinsäuren, die für neue Acetylcholinrezeptor-beta-Untereinheiten von Insekten kodieren |
AU4432901A (en) * | 2000-03-29 | 2001-10-08 | Synaptica Limited | Alpha 7 nicotinic receptor screening assays |
WO2002016358A2 (en) | 2000-08-18 | 2002-02-28 | Pharmacia & Upjohn Company | Quinuclidine-substituted aryl moieties for treatment of disease (nicotinic acetylcholine receptor ligands) |
US6486172B2 (en) | 2000-08-18 | 2002-11-26 | Pharmacia & Upjohn Company | Quinuclidine-substituted aryl compounds for treatment of disease |
US6492385B2 (en) | 2000-08-18 | 2002-12-10 | Pharmacia & Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease |
US6500840B2 (en) | 2000-08-21 | 2002-12-31 | Pharmacia & Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease |
AU2001284646A1 (en) | 2000-08-21 | 2002-03-04 | Pharmacia And Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease |
US20040023876A1 (en) * | 2000-10-31 | 2004-02-05 | Yonghong Xiao | Regulation of human serotonin receptor precursor |
PE20021019A1 (es) | 2001-04-19 | 2002-11-13 | Upjohn Co | Grupos azabiciclicos sustituidos |
AU2002324842C9 (en) * | 2001-08-31 | 2008-07-10 | Agensys, Inc. | 205P1B5 in treatment and detection of cancer |
WO2003023014A2 (en) * | 2001-09-12 | 2003-03-20 | Pharmacia & Upjohn Company | Human ion channels |
US7229779B2 (en) | 2001-09-18 | 2007-06-12 | Abbott Laboratories | Variant human α7 acetylcholine receptor subunit, and methods of production and use thereof |
US20060126682A1 (en) * | 2001-10-08 | 2006-06-15 | Geola Technologies Ltd. | Pulsed multiple colour laser system |
WO2003095976A2 (en) * | 2002-05-09 | 2003-11-20 | Memory Pharmaceuticals Corporation | Qm-7 and qt-6 cells transfected with mutant cell surface expressed channel receptors and assays using the transfected cells |
US7176198B2 (en) * | 2002-08-01 | 2007-02-13 | Pfizer Inc. | 1H-pyrazole and 1H-pyrrole-azabicyclic compounds for the treatment of disease |
US20040151729A1 (en) * | 2002-10-28 | 2004-08-05 | George Michalopoulos | Novel long-term three-dimensional culture system |
EP1592710A2 (de) * | 2003-02-14 | 2005-11-09 | Memory Pharmaceutical Corporation | Makak alpha-7 nikotin-acetylcholin-rezeptor und verfahren zu dessen anwendung |
US7576878B2 (en) * | 2003-04-03 | 2009-08-18 | Hewlett-Packard Development Company, L.P. | Enhanced management of raster image processing resources |
WO2005030145A2 (en) * | 2003-09-24 | 2005-04-07 | Targacept, Inc. | Composition and pharmacology of novel alpha-6-containing nicotinic acetylcholine receptors |
WO2005085416A1 (ja) * | 2004-03-04 | 2005-09-15 | Riken | 糸状菌特異的抗菌剤のスクリーニング方法及びそのためのキット |
US7482752B2 (en) * | 2005-01-20 | 2009-01-27 | Lg Electronics Inc. | Plasma display panel with electrode pairs at display and non-display regions, each pair having a different separation gap on each region |
WO2006091672A2 (en) * | 2005-02-23 | 2006-08-31 | Dow Agrosciences Llc | Novel assays utilizing nicotinic acetylcholine receptor subunits |
US7879913B2 (en) * | 2005-06-28 | 2011-02-01 | Catholic Healthcare West | Iptakalim hydrochloride for decreasing nicotine use |
US20190275171A1 (en) * | 2016-09-23 | 2019-09-12 | Ionis Pharmaceuticals, Inc. | Gene therapy and targeted delivery of conjugated compounds |
JP2021503960A (ja) * | 2017-11-27 | 2021-02-15 | コーダ バイオセラピューティクス, インコーポレイテッド | 神経疾患のための組成物および方法 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4703008A (en) * | 1983-12-13 | 1987-10-27 | Kiren-Amgen, Inc. | DNA sequences encoding erythropoietin |
US4855231A (en) * | 1984-10-30 | 1989-08-08 | Phillips Petroleum Company | Regulatory region for heterologous gene expression in yeast |
US4837148A (en) * | 1984-10-30 | 1989-06-06 | Phillips Petroleum Company | Autonomous replication sequences for yeast strains of the genus pichia |
US4882279A (en) * | 1985-10-25 | 1989-11-21 | Phillips Petroleum Company | Site selective genomic modification of yeast of the genus pichia |
US4859609A (en) * | 1986-04-30 | 1989-08-22 | Genentech, Inc. | Novel receptors for efficient determination of ligands and their antagonists or agonists |
US5071773A (en) * | 1986-10-24 | 1991-12-10 | The Salk Institute For Biological Studies | Hormone receptor-related bioassays |
US5024939A (en) * | 1987-07-09 | 1991-06-18 | Genentech, Inc. | Transient expression system for producing recombinant protein |
US4929555A (en) * | 1987-10-19 | 1990-05-29 | Phillips Petroleum Company | Pichia transformation |
US4981784A (en) * | 1987-12-02 | 1991-01-01 | The Salk Institute For Biological Studies | Retinoic acid receptor method |
CA1341554C (en) * | 1988-03-18 | 2007-10-09 | The Salk Institute For Biological Studies | Neuronal nicotinic acetylcholine receptor compositions and assay |
US5449606A (en) * | 1988-03-18 | 1995-09-12 | The Salk Institute For Biological Studies | DNA encoding neuronal nicotinic acetylcholine receptor compositions containing the beta 4 subunit |
US5386025A (en) * | 1990-02-20 | 1995-01-31 | The Salk Institute Biotechnology/Industrial Associates | Calcium channel compositions and methods |
ATE139542T1 (de) * | 1988-04-04 | 1996-07-15 | Salk Inst Biotech Ind | Calciumkanal-zusammensetzungen und verfahren |
EP0463064B1 (de) * | 1989-03-14 | 1999-07-21 | The Salk Institute For Biological Studies | Neuronale nikotinacetylcholinrezeptorzusammensetzungen enthaltend die beta-4 subeinheit |
JPH05504254A (ja) * | 1989-10-25 | 1993-07-08 | ザ ソーク インスティテュート フォア バイオロジカル スタディーズ | レセプター感染アッセイ |
US5091518A (en) * | 1989-11-16 | 1992-02-25 | The Salk Institute For Biological Studies | Beta retinoic acid response elements compositions and assays |
US5369028A (en) * | 1990-04-03 | 1994-11-29 | The Salk Institute Biotechnology/Industrial Associates, Inc. | DNA and mRNA encoding human neuronal nicotinic acetylcholine receptor compositions and cells transformed with same |
US5401629A (en) * | 1990-08-07 | 1995-03-28 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Assay methods and compositions useful for measuring the transduction of an intracellular signal |
CA2155330C (en) | 1993-03-08 | 2002-01-29 | Kathryn J. Elliott | Human neuronal nicotinic acetylcholine receptor compositions and methods employing same |
AU1091595A (en) | 1993-11-08 | 1995-05-29 | Salk Institute Biotechnology/Industrial Associates, Inc., The | Human neuronal nicotinic acetylcholine receptor compositions and methods employing same |
-
1994
- 1994-03-08 CA CA002155330A patent/CA2155330C/en not_active Expired - Fee Related
- 1994-03-08 AU AU65173/94A patent/AU694424B2/en not_active Ceased
- 1994-03-08 EP EP94912758A patent/EP0688361B1/de not_active Expired - Lifetime
- 1994-03-08 GB GB9503688A patent/GB2286397B/en not_active Expired - Fee Related
- 1994-03-08 EP EP04077712A patent/EP1508614A1/de not_active Withdrawn
- 1994-03-08 JP JP52024094A patent/JP3628691B2/ja not_active Expired - Fee Related
- 1994-03-08 AT AT94912758T patent/ATE279516T1/de not_active IP Right Cessation
- 1994-03-08 DE DE69434067T patent/DE69434067T2/de not_active Expired - Fee Related
- 1994-03-08 WO PCT/US1994/002447 patent/WO1994020617A2/en active IP Right Grant
- 1994-03-08 ES ES94912758T patent/ES2229216T3/es not_active Expired - Lifetime
-
1995
- 1995-06-05 US US08/466,589 patent/US5837489A/en not_active Expired - Fee Related
- 1995-06-05 US US08/467,574 patent/US6022704A/en not_active Expired - Fee Related
-
1996
- 1996-07-16 US US08/700,636 patent/US5910582A/en not_active Expired - Fee Related
-
1998
- 1998-12-21 US US09/217,345 patent/US6303753B1/en not_active Expired - Fee Related
-
2001
- 2001-06-27 US US09/892,985 patent/US6664375B2/en not_active Expired - Fee Related
-
2004
- 2004-02-05 JP JP2004029558A patent/JP2004194667A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CA2155330A1 (en) | 1994-09-15 |
US6022704A (en) | 2000-02-08 |
WO1994020617A2 (en) | 1994-09-15 |
GB2286397A (en) | 1995-08-16 |
DE69434067D1 (de) | 2004-11-18 |
US6303753B1 (en) | 2001-10-16 |
WO1994020617A3 (en) | 1994-10-27 |
GB9503688D0 (en) | 1995-04-12 |
JPH08507441A (ja) | 1996-08-13 |
AU6517394A (en) | 1994-09-26 |
JP2004194667A (ja) | 2004-07-15 |
GB2286397C (en) | 1997-09-10 |
JP3628691B2 (ja) | 2005-03-16 |
ES2229216T3 (es) | 2005-04-16 |
EP0688361A1 (de) | 1995-12-27 |
US5837489A (en) | 1998-11-17 |
EP0688361B1 (de) | 2004-10-13 |
EP1508614A1 (de) | 2005-02-23 |
US5910582A (en) | 1999-06-08 |
US6664375B2 (en) | 2003-12-16 |
US20020111463A1 (en) | 2002-08-15 |
CA2155330C (en) | 2002-01-29 |
AU694424B2 (en) | 1998-07-23 |
GB2286397B (en) | 1997-09-10 |
DE69434067T2 (de) | 2006-03-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |