DE69410359T2 - Benzospiroalken-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen - Google Patents
Benzospiroalken-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische ZusammensetzungenInfo
- Publication number
- DE69410359T2 DE69410359T2 DE69410359T DE69410359T DE69410359T2 DE 69410359 T2 DE69410359 T2 DE 69410359T2 DE 69410359 T DE69410359 T DE 69410359T DE 69410359 T DE69410359 T DE 69410359T DE 69410359 T2 DE69410359 T2 DE 69410359T2
- Authority
- DE
- Germany
- Prior art keywords
- branched
- linear
- group
- unsubstituted
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9308861A FR2709306B1 (fr) | 1993-07-20 | 1993-07-20 | Nouveaux dérivés de benzospiroalcène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69410359D1 DE69410359D1 (de) | 1998-06-25 |
DE69410359T2 true DE69410359T2 (de) | 1999-01-07 |
Family
ID=9449388
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69410359T Expired - Fee Related DE69410359T2 (de) | 1993-07-20 | 1994-07-06 | Benzospiroalken-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen |
Country Status (14)
Country | Link |
---|---|
US (1) | US5436261A (ja) |
EP (1) | EP0635497B1 (ja) |
JP (1) | JP3105138B2 (ja) |
AT (1) | ATE166345T1 (ja) |
AU (1) | AU674080B2 (ja) |
CA (1) | CA2128359C (ja) |
CY (1) | CY2158B1 (ja) |
DE (1) | DE69410359T2 (ja) |
DK (1) | DK0635497T3 (ja) |
ES (1) | ES2119106T3 (ja) |
FR (1) | FR2709306B1 (ja) |
HK (1) | HK1009648A1 (ja) |
NZ (1) | NZ264050A (ja) |
ZA (1) | ZA945337B (ja) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2707981B1 (fr) * | 1993-07-20 | 1995-09-01 | Adir | Nouveaux dérivés de benzospiroalcène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
US6156783A (en) * | 1996-04-30 | 2000-12-05 | Smithkline Beecham P.L.C. | Spiroazabicyclic compounds, processes for their preparation, and their pharmaceutical use |
FR2787450B1 (fr) * | 1998-12-18 | 2001-01-26 | Adir | Nouveaux derives spiroimidazoliniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US7288559B2 (en) * | 2003-03-14 | 2007-10-30 | Merck + Co, Inc. | Carboxamide spirohydantoin CGRP receptor antagonists |
US7115767B2 (en) * | 2003-07-18 | 2006-10-03 | Abbott Laboratories | Tetraline derivatives as ghrelin receptor modulators |
CA2629454A1 (en) | 2005-11-18 | 2007-05-31 | Merck & Co., Inc. | Bicyclic spirohydantoin cgrp receptor antagonists |
JP2009515971A (ja) | 2005-11-18 | 2009-04-16 | メルク エンド カムパニー インコーポレーテッド | スピロヒダントインアリールcgrp受容体アンタゴニスト |
JP2009515973A (ja) * | 2005-11-18 | 2009-04-16 | メルク エンド カムパニー インコーポレーテッド | スピロラクタム三環式cgrp受容体アンタゴニスト |
US7851464B2 (en) * | 2005-11-18 | 2010-12-14 | Merck Sharp & Dohme Corp. | Spirolactam aryl CGRP receptor antagonists |
EP1951051B1 (en) | 2005-11-18 | 2012-10-03 | Merck Sharp & Dohme Corp. | Spirohydantoin tricyclic cgrp receptor antagonists |
EP1954268B1 (en) * | 2005-11-18 | 2012-09-26 | Merck Sharp & Dohme Corp. | Spirolactam bicyclic cgrp receptor antagonists |
TW201026691A (en) | 2008-10-07 | 2010-07-16 | Schering Corp | Biaryl spiroaminooxazoline analogues as alpha2C adrenergic receptor modulators |
US20130079271A1 (en) * | 2009-10-01 | 2013-03-28 | Kevin D. McCormick | Reversed biaryl spiroaminooxazoline analogues as alpha2c adrenergic receptor modulators |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2716648A (en) * | 1955-08-30 | Hydantoin derivatives | ||
US3532744A (en) * | 1967-07-28 | 1970-10-06 | American Home Prod | 1- and 2-amino substituted indane and tetralene carboxylic acids |
-
1993
- 1993-07-20 FR FR9308861A patent/FR2709306B1/fr not_active Expired - Fee Related
-
1994
- 1994-07-06 ES ES94401549T patent/ES2119106T3/es not_active Expired - Lifetime
- 1994-07-06 AT AT94401549T patent/ATE166345T1/de not_active IP Right Cessation
- 1994-07-06 DK DK94401549T patent/DK0635497T3/da active
- 1994-07-06 EP EP94401549A patent/EP0635497B1/fr not_active Expired - Lifetime
- 1994-07-06 DE DE69410359T patent/DE69410359T2/de not_active Expired - Fee Related
- 1994-07-18 AU AU67550/94A patent/AU674080B2/en not_active Ceased
- 1994-07-19 US US08/276,918 patent/US5436261A/en not_active Expired - Fee Related
- 1994-07-19 CA CA002128359A patent/CA2128359C/fr not_active Expired - Fee Related
- 1994-07-20 ZA ZA945337A patent/ZA945337B/xx unknown
- 1994-07-20 JP JP06198901A patent/JP3105138B2/ja not_active Expired - Fee Related
- 1994-07-20 NZ NZ264050A patent/NZ264050A/en unknown
-
1998
- 1998-09-04 HK HK98110471A patent/HK1009648A1/xx not_active IP Right Cessation
-
1999
- 1999-11-19 CY CY9900039A patent/CY2158B1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CY2158B1 (en) | 2002-08-23 |
CA2128359A1 (fr) | 1995-01-21 |
HK1009648A1 (en) | 1999-06-04 |
JPH07304753A (ja) | 1995-11-21 |
CA2128359C (fr) | 2002-03-19 |
AU6755094A (en) | 1995-02-02 |
AU674080B2 (en) | 1996-12-05 |
DK0635497T3 (da) | 1999-03-08 |
NZ264050A (en) | 1995-07-26 |
EP0635497A3 (fr) | 1995-02-22 |
ATE166345T1 (de) | 1998-06-15 |
FR2709306A1 (fr) | 1995-03-03 |
EP0635497B1 (fr) | 1998-05-20 |
ZA945337B (en) | 1995-03-01 |
EP0635497A2 (fr) | 1995-01-25 |
ES2119106T3 (es) | 1998-10-01 |
JP3105138B2 (ja) | 2000-10-30 |
US5436261A (en) | 1995-07-25 |
DE69410359D1 (de) | 1998-06-25 |
FR2709306B1 (fr) | 1995-10-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: LES LABORATOIRES SERVIER, NEUILLY SUR SEINE, FR |
|
8339 | Ceased/non-payment of the annual fee |