DE69410198D1 - Cyclohexanderivate als Kaliumkanalaktivatoren - Google Patents

Cyclohexanderivate als Kaliumkanalaktivatoren

Info

Publication number
DE69410198D1
DE69410198D1 DE69410198T DE69410198T DE69410198D1 DE 69410198 D1 DE69410198 D1 DE 69410198D1 DE 69410198 T DE69410198 T DE 69410198T DE 69410198 T DE69410198 T DE 69410198T DE 69410198 D1 DE69410198 D1 DE 69410198D1
Authority
DE
Germany
Prior art keywords
potassium channel
channel activators
cyclohexane derivatives
chem
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69410198T
Other languages
English (en)
Other versions
DE69410198T2 (de
Inventor
Yasuhiro Kabasawa
Fumihiro Ozaki
Keiji Ishibashi
Takashi Hasegawa
Hitoshi Oinuma
Manabu Shirato
Katsuhiro Moriya
Toshiaki Ogawa
Satoshi Katayama
Shigeru Souda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai R&D Management Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of DE69410198D1 publication Critical patent/DE69410198D1/de
Application granted granted Critical
Publication of DE69410198T2 publication Critical patent/DE69410198T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
DE69410198T 1993-09-21 1994-09-14 Cyclohexanderivate als Kaliumkanalaktivatoren Expired - Lifetime DE69410198T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP23453893 1993-09-21

Publications (2)

Publication Number Publication Date
DE69410198D1 true DE69410198D1 (de) 1998-06-18
DE69410198T2 DE69410198T2 (de) 1999-03-11

Family

ID=16972600

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69410198T Expired - Lifetime DE69410198T2 (de) 1993-09-21 1994-09-14 Cyclohexanderivate als Kaliumkanalaktivatoren

Country Status (14)

Country Link
US (2) US5478839A (de)
EP (1) EP0644182B1 (de)
KR (1) KR0149066B1 (de)
CN (1) CN1100031C (de)
AT (1) ATE166046T1 (de)
AU (1) AU686642B2 (de)
CA (1) CA2131749A1 (de)
DE (1) DE69410198T2 (de)
FI (1) FI107155B (de)
HU (1) HU221198B1 (de)
NO (1) NO302234B1 (de)
NZ (1) NZ264480A (de)
RU (1) RU2129113C1 (de)
ZA (1) ZA947146B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2594799A (en) 1998-02-11 1999-08-30 Du Pont Pharmaceuticals Company Novel cyclic sulfonamide derivatives as metalloproteinase inhibitors
JP4838537B2 (ja) * 2005-05-25 2011-12-14 株式会社 資生堂 不全角化抑制剤、毛穴縮小剤又は肌荒れ防止・改善剤及び皮膚外用組成物
EP2089389A2 (de) 2006-11-01 2009-08-19 Bristol-Myers Squibb Company Heterocyclische verbindungen als modulatoren der glucocorticoidrezeptor,- ap1- und/oder nf-kappa-b-aktivität

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4200640A (en) * 1976-04-02 1980-04-29 Chugai Seiyaku Kabushiki Kaisha Nitric ester of N-(2-hydroxyethyl)nicotinamide and pharmaceutical use
GB9000342D0 (en) * 1990-01-08 1990-03-07 May & Baker Ltd New compositions of matter
GB9002879D0 (en) * 1990-02-08 1990-04-04 May & Baker Ltd New compositions of matter
EP0609442A4 (de) * 1991-10-14 1995-02-08 Eisai Co Ltd Thioformamidderivate.

Also Published As

Publication number Publication date
ATE166046T1 (de) 1998-05-15
HUT68036A (en) 1995-05-29
FI944207A (fi) 1995-03-22
KR950008446A (ko) 1995-04-17
AU7169694A (en) 1995-04-06
DE69410198T2 (de) 1999-03-11
RU2129113C1 (ru) 1999-04-20
NO943472L (no) 1995-03-22
CN1106380A (zh) 1995-08-09
US5478839A (en) 1995-12-26
HU9402702D0 (en) 1994-12-28
NZ264480A (en) 1995-07-26
KR0149066B1 (ko) 1998-10-15
CA2131749A1 (en) 1995-03-22
NO302234B1 (no) 1998-02-09
CN1100031C (zh) 2003-01-29
HU221198B1 (en) 2002-08-28
NO943472D0 (no) 1994-09-19
AU686642B2 (en) 1998-02-12
US5605907A (en) 1997-02-25
EP0644182A1 (de) 1995-03-22
FI107155B (fi) 2001-06-15
FI944207A0 (fi) 1994-09-12
ZA947146B (en) 1996-03-15
RU94033470A (ru) 1996-08-10
EP0644182B1 (de) 1998-05-13

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Legal Events

Date Code Title Description
8332 No legal effect for de
8370 Indication related to discontinuation of the patent is to be deleted
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: EISAI R&D MANAGEMENT CO., LTD., TOKYO, JP