DE69403463D1 - Verfahren zur herstellung von wirkstoff enthaltenden teilchen durch extrusion und lyophilisation - Google Patents

Verfahren zur herstellung von wirkstoff enthaltenden teilchen durch extrusion und lyophilisation

Info

Publication number
DE69403463D1
DE69403463D1 DE69403463T DE69403463T DE69403463D1 DE 69403463 D1 DE69403463 D1 DE 69403463D1 DE 69403463 T DE69403463 T DE 69403463T DE 69403463 T DE69403463 T DE 69403463T DE 69403463 D1 DE69403463 D1 DE 69403463D1
Authority
DE
Germany
Prior art keywords
particles
extrusion
lyophilisation
active substance
containing active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69403463T
Other languages
English (en)
Other versions
DE69403463T2 (de
Inventor
Thanh-Tam Nguyen
Joeelle Jacquot-Leyder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cephalon France SAS
Original Assignee
Laboratoire L Lafon SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoire L Lafon SA filed Critical Laboratoire L Lafon SA
Publication of DE69403463D1 publication Critical patent/DE69403463D1/de
Application granted granted Critical
Publication of DE69403463T2 publication Critical patent/DE69403463T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/20—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by expressing the material, e.g. through sieves and fragmenting the extruded length
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25C—PRODUCING, WORKING OR HANDLING ICE
    • F25C1/00—Producing ice

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Mechanical Engineering (AREA)
  • Thermal Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Preparation (AREA)
  • Drying Of Solid Materials (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
  • Extrusion Moulding Of Plastics Or The Like (AREA)
  • Formation And Processing Of Food Products (AREA)
  • Seeds, Soups, And Other Foods (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Beans For Foods Or Fodder (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Noodles (AREA)
DE69403463T 1993-03-23 1994-03-15 Verfahren zur herstellung von wirkstoff enthaltenden teilchen durch extrusion und lyophilisation Expired - Lifetime DE69403463T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9303316A FR2702968B1 (fr) 1993-03-23 1993-03-23 Procédé de préparation de particules renfermant un ingrédient actif par extrusion et lyophilisation .
PCT/FR1994/000281 WO1994021371A1 (fr) 1993-03-23 1994-03-15 Procede de preparation de particules renfermant un ingredient actif par extrusion et lyophilisation

Publications (2)

Publication Number Publication Date
DE69403463D1 true DE69403463D1 (de) 1997-07-03
DE69403463T2 DE69403463T2 (de) 1998-01-15

Family

ID=9445245

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69403463T Expired - Lifetime DE69403463T2 (de) 1993-03-23 1994-03-15 Verfahren zur herstellung von wirkstoff enthaltenden teilchen durch extrusion und lyophilisation

Country Status (10)

Country Link
EP (1) EP0690747B1 (de)
JP (1) JP3601825B2 (de)
AT (1) ATE153562T1 (de)
CA (1) CA2156915C (de)
DE (1) DE69403463T2 (de)
DK (1) DK0690747T3 (de)
ES (1) ES2105663T3 (de)
FR (1) FR2702968B1 (de)
GR (1) GR3024243T3 (de)
WO (1) WO1994021371A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5618845A (en) * 1994-10-06 1997-04-08 Cephalon, Inc. Acetamide derivative having defined particle size
AU729586B2 (en) * 1994-10-06 2001-02-08 Cephalon, Inc. Modafinil having defined particle size
DE19750679B4 (de) * 1997-11-15 2004-10-21 Institut für Lebensmittelwissenschaft, Lehrstuhl für Lebensmittelverfahrenstechnik Verfahren zum Erzeugen von kaltgesprühten, verfestigten, lagerstabilen und rieselfähigen Mikrokapselsystemen sowie deren Verwendung
DE19848849A1 (de) * 1998-10-22 2000-04-27 Knoll Ag Verfahren zur Herstellung von festen, sphärischen Formen, enthaltend eine biologisch aktive Substanz
GB9908014D0 (en) 1999-04-08 1999-06-02 Scherer Corp R P Pharmaceutical compositions
SE9903236D0 (sv) * 1999-09-10 1999-09-10 Astra Ab Method to obtain microparticles
JP4997683B2 (ja) * 2000-09-25 2012-08-08 日本新薬株式会社 医薬固体分散体の製法
ES2317943T3 (es) * 2000-10-11 2009-05-01 Cephalon, Inc. Composiciones que comprenden compuestos de modafinilo.
HU229409B1 (en) * 2000-10-11 2013-12-30 Cephalon Compositions comprising modafinil compounds
US20040115277A1 (en) * 2000-12-13 2004-06-17 Thomas Kissel Microparticles with an improved release profile and method for the production thereof
US7141555B2 (en) * 2000-12-19 2006-11-28 Cephalon, Inc. Modafinil compound and cyclodextrin mixtures
US7704975B2 (en) 2000-12-19 2010-04-27 Cephalon, Inc. Modafinil compound and cyclodextrin mixtures
AUPR272901A0 (en) * 2001-01-25 2001-02-22 Gainful Plan Limited Method of preparing biological materials and preparations produced using same
IL158959A (en) * 2001-05-25 2010-06-30 Cephalon Inc Solid pharmaceutical formulations comprising modafinil
EP1275377B1 (de) 2001-07-11 2003-06-18 Apr Applied Pharma Research S.A. Fettlösliche Substanzen enthaltende Granulate und Verfahren zu ihrer Herstellung
US7229644B2 (en) * 2002-05-23 2007-06-12 Cephalon, Inc. Pharmaceutical formulations of modafinil
US20040048931A1 (en) 2002-07-12 2004-03-11 Craig Heacock Modafinil pharmaceutical compositions
US20080044468A1 (en) * 2002-07-25 2008-02-21 Romi Barat Singh Processes For The Preparation Of Oral Dosage Formulations Of Modafinil
US20040116532A1 (en) 2002-09-13 2004-06-17 Craig Heacock Pharmaceutical formulations of modafinil
JP2006518754A (ja) 2003-02-24 2006-08-17 マリンクロッド・インコーポレイテッド ベンズヒドリルチオアセトアミドの改良製法
EP1582221A1 (de) 2004-03-31 2005-10-05 Chiesi S.A. Orale Pharmazeutische zusammensetzung zur Geschmacksmaskierung
FR2889910B1 (fr) * 2005-08-25 2012-02-10 Virbac Sa Produit pour la preparation d'aliments supplementes pour animaux
EP2061587A1 (de) * 2007-04-26 2009-05-27 Sigmoid Pharma Limited Herstellung mehrerer minikapseln
EP2238973A1 (de) 2009-04-07 2010-10-13 Cephalon France Lyophilisierte Präparate von Proteasominhibitoren

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2403078A1 (fr) * 1977-09-19 1979-04-13 Lafon Labor Nouveau procede de preparation de formes pharmaceutiques, cosmetiques ou de diagnostic
US4230687A (en) * 1978-05-30 1980-10-28 Griffith Laboratories U.S.A., Inc. Encapsulation of active agents as microdispersions in homogeneous natural polymeric matrices
FR2539626B2 (fr) * 1983-01-25 1985-06-21 Lafon Labor Nouveau procede de preparation de formes galeniques utiles notamment en therapeutique, dietetique, cosmetique et diagnostic, et formes obtenues selon ce procede
FR2581541B1 (fr) * 1985-05-09 1988-05-20 Rhone Poulenc Sante Nouvelles compositions pharmaceutiques permettant la liberation prolongee d'un principe actif et leur procede de preparation
FR2657257B1 (fr) * 1990-01-19 1994-09-02 Rhone Poulenc Sante Procede de preparation de medicaments sous forme de perles.

Also Published As

Publication number Publication date
JPH08507940A (ja) 1996-08-27
CA2156915C (fr) 2005-01-11
EP0690747B1 (de) 1997-05-28
GR3024243T3 (en) 1997-10-31
ATE153562T1 (de) 1997-06-15
CA2156915A1 (fr) 1994-09-29
FR2702968A1 (fr) 1994-09-30
DE69403463T2 (de) 1998-01-15
FR2702968B1 (fr) 1995-06-23
EP0690747A1 (de) 1996-01-10
WO1994021371A1 (fr) 1994-09-29
ES2105663T3 (es) 1997-10-16
DK0690747T3 (da) 1997-12-22
JP3601825B2 (ja) 2004-12-15

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