DE69403333T2 - Vorrichtungen zum übertragen von flüssigkeiten - Google Patents
Vorrichtungen zum übertragen von flüssigkeitenInfo
- Publication number
- DE69403333T2 DE69403333T2 DE69403333T DE69403333T DE69403333T2 DE 69403333 T2 DE69403333 T2 DE 69403333T2 DE 69403333 T DE69403333 T DE 69403333T DE 69403333 T DE69403333 T DE 69403333T DE 69403333 T2 DE69403333 T2 DE 69403333T2
- Authority
- DE
- Germany
- Prior art keywords
- channel
- flow
- channels
- site
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000007788 liquid Substances 0.000 title claims description 48
- 239000012530 fluid Substances 0.000 claims description 32
- 239000002699 waste material Substances 0.000 claims description 30
- 239000000126 substance Substances 0.000 claims description 15
- 239000003153 chemical reaction reagent Substances 0.000 claims description 14
- 239000011148 porous material Substances 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 12
- 230000009471 action Effects 0.000 claims description 9
- 239000012528 membrane Substances 0.000 claims description 9
- 238000012546 transfer Methods 0.000 claims description 8
- 238000000926 separation method Methods 0.000 claims description 7
- 238000011144 upstream manufacturing Methods 0.000 claims description 5
- 230000000007 visual effect Effects 0.000 claims description 3
- 230000032258 transport Effects 0.000 claims description 2
- 238000003556 assay Methods 0.000 claims 1
- 239000000523 sample Substances 0.000 description 73
- 238000004458 analytical method Methods 0.000 description 43
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 14
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 14
- 210000002966 serum Anatomy 0.000 description 11
- 235000012000 cholesterol Nutrition 0.000 description 6
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- 239000004816 latex Substances 0.000 description 5
- 229920000126 latex Polymers 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- 239000000427 antigen Substances 0.000 description 4
- 102000036639 antigens Human genes 0.000 description 4
- 108091007433 antigens Proteins 0.000 description 4
- 239000000758 substrate Substances 0.000 description 4
- 210000002700 urine Anatomy 0.000 description 4
- 108010089254 Cholesterol oxidase Proteins 0.000 description 3
- 108010055297 Sterol Esterase Proteins 0.000 description 3
- 102000000019 Sterol Esterase Human genes 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 238000002405 diagnostic procedure Methods 0.000 description 3
- 210000003743 erythrocyte Anatomy 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 229920006395 saturated elastomer Polymers 0.000 description 3
- 239000012491 analyte Substances 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 230000002452 interceptive effect Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000008620 Cholesterol Assay Methods 0.000 description 1
- 101100216185 Oryza sativa subsp. japonica AP25 gene Proteins 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 238000010256 biochemical assay Methods 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 238000005094 computer simulation Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 210000004180 plasmocyte Anatomy 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0605—Metering of fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0621—Control of the sequence of chambers filled or emptied
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Sampling And Sample Adjustment (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939307319A GB9307319D0 (en) | 1993-04-07 | 1993-04-07 | Liquid transfer devices |
| PCT/GB1994/000708 WO1994022579A1 (en) | 1993-04-07 | 1994-03-31 | Liquid transfer devices |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69403333D1 DE69403333D1 (de) | 1997-06-26 |
| DE69403333T2 true DE69403333T2 (de) | 1997-08-28 |
Family
ID=10733541
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69403333T Expired - Fee Related DE69403333T2 (de) | 1993-04-07 | 1994-03-31 | Vorrichtungen zum übertragen von flüssigkeiten |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5618494A (OSRAM) |
| EP (1) | EP0693000B1 (OSRAM) |
| JP (1) | JPH08509060A (OSRAM) |
| CN (1) | CN1120820A (OSRAM) |
| AU (1) | AU6383294A (OSRAM) |
| CA (1) | CA2158766A1 (OSRAM) |
| DE (1) | DE69403333T2 (OSRAM) |
| GB (2) | GB9307319D0 (OSRAM) |
| TW (1) | TW267993B (OSRAM) |
| WO (1) | WO1994022579A1 (OSRAM) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9324310D0 (en) * | 1993-11-26 | 1994-01-12 | Univ Birmingham | Liquid transfer device |
| BR9710052A (pt) * | 1996-06-28 | 2000-01-11 | Caliper Techn Corp | Sistema microfluido com compensação para polarização eletroforética, eletropipetador, processos para introduzir materiais a partir de uma série de fontes em um sistema microfluido, para distribuir de maneira controlável uma corrente de fluido e para transportar amostras de fluido, sistema de amostragem, emprego de um substrato, emprego de um sistema microfluido, e, substrato. |
| JP4171075B2 (ja) * | 1997-04-25 | 2008-10-22 | カリパー・ライフ・サイエンシズ・インコーポレーテッド | 改良されたチャネル幾何学的形状を組み込む微小流体装置 |
| GB9709821D0 (en) * | 1997-05-15 | 1997-07-09 | Clinical Diagnostic Chemicals | Allergy assay |
| US6379620B1 (en) | 1998-11-16 | 2002-04-30 | Barry M. Tydings | Assaying device and method for in field urinalysis |
| US20020019059A1 (en) * | 1999-01-28 | 2002-02-14 | Calvin Y.H. Chow | Devices, systems and methods for time domain multiplexing of reagents |
| GB2353093B (en) * | 1999-08-13 | 2003-09-17 | Glaxo Group Ltd | Apparatus for liquid sample handling |
| US6805838B2 (en) * | 2002-03-04 | 2004-10-19 | Barry M. Tydings | Assaying device and method for in field urinalysis |
| US20090047673A1 (en) * | 2006-08-22 | 2009-02-19 | Cary Robert B | Miniaturized lateral flow device for rapid and sensitive detection of proteins or nucleic acids |
| US8980561B1 (en) | 2006-08-22 | 2015-03-17 | Los Alamos National Security, Llc. | Nucleic acid detection system and method for detecting influenza |
| WO2009137055A1 (en) * | 2008-05-05 | 2009-11-12 | Los Alamos National Security, Llc | Nanocrystal-based lateral flow microarrays and low-voltage signal detection systems |
| JP2011522521A (ja) * | 2008-05-05 | 2011-08-04 | ロスアラモス ナショナル セキュリティ，エルエルシー | 高度に単純化された側方流動ベースの核酸サンプル調製および受動的流体流動制御 |
| US20120288961A1 (en) * | 2009-12-22 | 2012-11-15 | University Of Washington | Capillarity-based devices for performing chemical processes and associated systems and methods |
| PT2699698T (pt) | 2011-04-20 | 2017-04-11 | Mesa Biotech Inc | Reação de amplificação oscilante para ácidos nucleicos |
| US9528987B2 (en) | 2011-06-23 | 2016-12-27 | University Of Washington | Reagent patterning in capillarity-based analyzers and associated systems and methods |
| KR101283638B1 (ko) * | 2012-09-26 | 2013-07-08 | 주식회사 디브이씨 | 물체를 만난 유체의 흐름 관찰장치 |
| US9724689B2 (en) * | 2012-11-20 | 2017-08-08 | Detectachem Llc | Colorimetric test system designed to control flow of simultaneously released chemicals to a target area |
| WO2014116756A1 (en) | 2013-01-22 | 2014-07-31 | University Of Washington Through Its Center For Commercialization | Sequential delivery of fluid volumes and associated devices, systems and methods |
| EP3286546B1 (en) | 2015-04-24 | 2023-07-19 | Mesa Biotech, Inc. | Fluidic test cassette |
| WO2024211341A2 (en) * | 2023-04-03 | 2024-10-10 | Burst Diagnostics Llc | Chemiluminescence microfluidic immunoassay device and methods of use thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4323536A (en) * | 1980-02-06 | 1982-04-06 | Eastman Kodak Company | Multi-analyte test device |
| CA1292176C (en) * | 1985-09-18 | 1991-11-19 | Joel M. Blatt | Volume metering capillary gap device for applying a liquid sample onto a reactive surface |
| US4918025A (en) * | 1987-03-03 | 1990-04-17 | Pb Diagnostic Systems, Inc. | Self contained immunoassay element |
| US5275785A (en) * | 1987-10-30 | 1994-01-04 | Unilever Patent Holdings B.V. | Test device for detecting an analyte in a liquid sample |
| GB8725458D0 (en) * | 1987-10-30 | 1987-12-02 | Unilever Plc | Chemical testing |
| GB2216283A (en) * | 1988-03-30 | 1989-10-04 | Alroy & Stanley Associates Inc | Spectacles with extractable temples |
| IE940110L (en) * | 1989-03-23 | 1990-09-23 | Bunce Roger A | Liquid transfer devices |
| US5242606A (en) * | 1990-06-04 | 1993-09-07 | Abaxis, Incorporated | Sample metering port for analytical rotor having overflow chamber |
| GB9123922D0 (en) * | 1991-11-11 | 1992-01-02 | Bunce Roger A | Liquid transfer devices |
| GB9123903D0 (en) * | 1991-11-11 | 1992-01-02 | Bunce Roger A | Liquid transfer assay devices |
| US5223219A (en) * | 1992-04-10 | 1993-06-29 | Biotrack, Inc. | Analytical cartridge and system for detecting analytes in liquid samples |
-
1993
- 1993-04-07 GB GB939307319A patent/GB9307319D0/en active Pending
-
1994
- 1994-03-31 JP JP6521857A patent/JPH08509060A/ja active Pending
- 1994-03-31 US US08/325,348 patent/US5618494A/en not_active Expired - Fee Related
- 1994-03-31 AU AU63832/94A patent/AU6383294A/en not_active Abandoned
- 1994-03-31 GB GB9406449A patent/GB2276940B/en not_active Revoked
- 1994-03-31 CN CN94191715A patent/CN1120820A/zh active Pending
- 1994-03-31 DE DE69403333T patent/DE69403333T2/de not_active Expired - Fee Related
- 1994-03-31 WO PCT/GB1994/000708 patent/WO1994022579A1/en not_active Ceased
- 1994-03-31 CA CA002158766A patent/CA2158766A1/en not_active Abandoned
- 1994-03-31 EP EP94911275A patent/EP0693000B1/en not_active Expired - Lifetime
- 1994-04-07 TW TW083103018A patent/TW267993B/zh active
Also Published As
| Publication number | Publication date |
|---|---|
| EP0693000A1 (en) | 1996-01-24 |
| DE69403333D1 (de) | 1997-06-26 |
| CA2158766A1 (en) | 1994-10-13 |
| GB2276940B (en) | 1997-01-22 |
| CN1120820A (zh) | 1996-04-17 |
| WO1994022579A1 (en) | 1994-10-13 |
| TW267993B (OSRAM) | 1996-01-11 |
| GB9307319D0 (en) | 1993-06-02 |
| GB9406449D0 (en) | 1994-05-25 |
| EP0693000B1 (en) | 1997-05-21 |
| JPH08509060A (ja) | 1996-09-24 |
| US5618494A (en) | 1997-04-08 |
| AU6383294A (en) | 1994-10-24 |
| GB2276940A (en) | 1994-10-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: BTG INTERNATIONAL LTD., LONDON, GB |
|
| 8339 | Ceased/non-payment of the annual fee |