DE69401684D1 - Acyl L-Carnitinester und diese enthaltende pharmazeutische Zusammensetzungen zur Behandlung von endotoxischem Schock - Google Patents

Acyl L-Carnitinester und diese enthaltende pharmazeutische Zusammensetzungen zur Behandlung von endotoxischem Schock

Info

Publication number
DE69401684D1
DE69401684D1 DE69401684T DE69401684T DE69401684D1 DE 69401684 D1 DE69401684 D1 DE 69401684D1 DE 69401684 T DE69401684 T DE 69401684T DE 69401684 T DE69401684 T DE 69401684T DE 69401684 D1 DE69401684 D1 DE 69401684D1
Authority
DE
Germany
Prior art keywords
treatment
pharmaceutical compositions
endotoxic shock
acyl
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69401684T
Other languages
English (en)
Other versions
DE69401684T2 (de
Inventor
Piero Foresta
Vito Ruggiero
Maria Ornella Tinti
Nazareno Scafetta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Application granted granted Critical
Publication of DE69401684D1 publication Critical patent/DE69401684D1/de
Publication of DE69401684T2 publication Critical patent/DE69401684T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69401684T 1993-07-14 1994-07-08 Acyl L-Carnitinester und diese enthaltende pharmazeutische Zusammensetzungen zur Behandlung von endotoxischem Schock Expired - Fee Related DE69401684T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITRM930468A IT1261828B (it) 1993-07-14 1993-07-14 Esteri di acil l-carnitine e composizioni farmaceutiche che li contengono per il trattamento dello shock endotossico.

Publications (2)

Publication Number Publication Date
DE69401684D1 true DE69401684D1 (de) 1997-03-20
DE69401684T2 DE69401684T2 (de) 1997-05-28

Family

ID=11401861

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69401684T Expired - Fee Related DE69401684T2 (de) 1993-07-14 1994-07-08 Acyl L-Carnitinester und diese enthaltende pharmazeutische Zusammensetzungen zur Behandlung von endotoxischem Schock

Country Status (10)

Country Link
US (2) US5625085A (de)
EP (1) EP0634392B1 (de)
JP (1) JP3940179B2 (de)
AT (1) ATE148689T1 (de)
DE (1) DE69401684T2 (de)
DK (1) DK0634392T3 (de)
ES (1) ES2098115T3 (de)
GR (1) GR3023306T3 (de)
HK (1) HK1005865A1 (de)
IT (1) IT1261828B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1261828B (it) * 1993-07-14 1996-06-03 Sigma Tau Ind Farmaceuti Esteri di acil l-carnitine e composizioni farmaceutiche che li contengono per il trattamento dello shock endotossico.
US5741816A (en) * 1994-06-20 1998-04-21 Tanabe Seiyaku Co., Ltd. Hair-growth agent
US20050232911A1 (en) * 2004-04-19 2005-10-20 Schreiber Brian D Prevention and treatment of metabolic abnormalities associated with excess intramyocellular lipid
US7777071B2 (en) * 2006-08-11 2010-08-17 Ssv Therapeutics, Inc. Production of carnitine conjugate intermediates
US20110015154A1 (en) * 2009-07-20 2011-01-20 Kellermann Gottfried H Supporting acetylcholine function
US20110098265A1 (en) * 2009-10-28 2011-04-28 Neuroscience, Inc. Methods for reducing cravings and impulses associated with addictive and compulsive behaviors
CN115141112A (zh) * 2022-06-25 2022-10-04 东北制药集团股份有限公司 一种乙酰左旋肉碱杂质、其制备及检测方法和用途

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1116037B (it) 1979-04-23 1986-02-10 Sigma Tau Ind Farmaceuti Esteri e ammidi di acil carnitine loro procedimenti di preparazione e loro uso terapeutico
IT1201481B (it) * 1985-10-08 1989-02-02 Prodotti Antibiotici Spa Pantotenil derivati
IT1184655B (it) * 1985-10-14 1987-10-28 Sigma Tau Ind Farmaceuti Imiego di acetil l-carnitina nel trattamento terapeutico degli stati di shock
IT1231751B (it) * 1989-04-12 1991-12-21 Sigma Tau Ind Farmaceuti Procedimento per la produzione di r(+) amminocarnitina e s(-) amminocarnitina
IT1240760B (it) 1990-02-12 1993-12-17 Sigma Tau Ind Farmaceuti Esteri di acil-l-carnitine con l'acido gamma-idrossibutirrico e composizioni farmaceutiche che li contengono per l'inibizione della degenerazione neuronale e nel trattamento del coma.
IT1242020B (it) * 1990-11-20 1994-02-02 Sigma Tau Ind Farmaceuti Ftalidilidene derivati della carnitina e di alcanoil carnitine e composizioni farmaceutiche che li contengono.
IT1248321B (it) * 1991-05-15 1995-01-05 Sigma Tau Ind Farmaceuti Uso di esteri di acil l-carnitine con l'acido gamma-idrossibutirrico per produrre composizioni farmaceutiche per il trattamento di epatopatie
IT1254136B (it) 1992-01-16 1995-09-08 Sigma Tau Ind Farmaceuti Esteri di acil carnitine con alcooli alifatici a lunga catena e composizioni farmaceutiche che li contengono, ad attivita' antimicotica.
IT1254135B (it) * 1992-01-16 1995-09-08 Sigma Tau Ind Farmaceuti Esteri di acil carnitine con alcooli alifatici a lunga catena e composizioni farmaceutiche che li contengono, ad attivita' antibatterica.
IT1258370B (it) * 1992-03-02 1996-02-26 Sigma Tau Ind Farmaceuti Esteri della l-carnitina e di acil l-carnitine dotati di attivita' miorilassante selettiva sull'apparato gastro-intestinale e composizioni farmaceutiche che li contengono.
IT1256705B (it) 1992-12-21 1995-12-12 Sigma Tau Ind Farmaceuti Procedimento per la preparazione di l-(-)-carnitina a partire da un prodotto di scarto avente opposta configurazione.
IT1261230B (it) 1993-04-08 1996-05-09 Sigma Tau Ind Farmaceuti Procedimento migliorato per la preparazione di l-(-)-carnitina a partire da suoi precursori aventi opposta configurazione.
IT1261828B (it) * 1993-07-14 1996-06-03 Sigma Tau Ind Farmaceuti Esteri di acil l-carnitine e composizioni farmaceutiche che li contengono per il trattamento dello shock endotossico.
IT1261489B (it) 1993-07-29 1996-05-23 Sigma Tau Ind Farmaceuti Procedimento per la produzione di r amminocarnitina e s amminocarnitina.

Also Published As

Publication number Publication date
DE69401684T2 (de) 1997-05-28
US6180667B1 (en) 2001-01-30
US5625085A (en) 1997-04-29
EP0634392B1 (de) 1997-02-05
ES2098115T3 (es) 1997-04-16
HK1005865A1 (en) 1999-01-29
JP3940179B2 (ja) 2007-07-04
DK0634392T3 (da) 1997-04-28
JPH0776561A (ja) 1995-03-20
GR3023306T3 (en) 1997-08-29
IT1261828B (it) 1996-06-03
ITRM930468A0 (it) 1993-07-14
ATE148689T1 (de) 1997-02-15
EP0634392A2 (de) 1995-01-18
EP0634392A3 (de) 1995-05-03
ITRM930468A1 (it) 1995-01-14

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee