DE69333992D1 - Verfahren zur herstellung eines sets von kombinatorischen polypeptidantigenen - Google Patents

Verfahren zur herstellung eines sets von kombinatorischen polypeptidantigenen

Info

Publication number
DE69333992D1
DE69333992D1 DE69333992T DE69333992T DE69333992D1 DE 69333992 D1 DE69333992 D1 DE 69333992D1 DE 69333992 T DE69333992 T DE 69333992T DE 69333992 T DE69333992 T DE 69333992T DE 69333992 D1 DE69333992 D1 DE 69333992D1
Authority
DE
Germany
Prior art keywords
polypeptide
antigenes
combinatory
preparing
variants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69333992T
Other languages
English (en)
Other versions
DE69333992T2 (de
Inventor
Roberto Crea
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CREAGEN Inc
Original Assignee
CREAGEN Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CREAGEN Inc filed Critical CREAGEN Inc
Application granted granted Critical
Publication of DE69333992D1 publication Critical patent/DE69333992D1/de
Publication of DE69333992T2 publication Critical patent/DE69333992T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE69333992T 1992-06-18 1993-06-18 Verfahren zur herstellung eines sets von kombinatorischen polypeptidantigenen Expired - Fee Related DE69333992T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US90012392A 1992-06-18 1992-06-18
US900123 1992-06-18
PCT/US1993/005899 WO1994000151A1 (en) 1992-06-18 1993-06-18 Combinatorial polypeptide antigens

Publications (2)

Publication Number Publication Date
DE69333992D1 true DE69333992D1 (de) 2006-05-04
DE69333992T2 DE69333992T2 (de) 2006-11-30

Family

ID=25412008

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69333992T Expired - Fee Related DE69333992T2 (de) 1992-06-18 1993-06-18 Verfahren zur herstellung eines sets von kombinatorischen polypeptidantigenen

Country Status (10)

Country Link
US (1) US6432675B1 (de)
EP (1) EP0728015B1 (de)
JP (2) JP3764476B2 (de)
AT (1) ATE319738T1 (de)
AU (1) AU678371B2 (de)
DE (1) DE69333992T2 (de)
DK (1) DK0728015T3 (de)
ES (1) ES2260754T3 (de)
PT (1) PT728015E (de)
WO (1) WO1994000151A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7118874B2 (en) 1998-10-09 2006-10-10 Variation Biotechnologies Inc. Immunogenic formulation and process for preparation thereof
JP4391827B2 (ja) * 2002-02-08 2009-12-24 バリエーション バイオテクノロジーズ インコーポレイティド 可変性ペプチドエピトープの免疫原性製剤及びその製造方法
ATE374255T1 (de) * 2002-04-17 2007-10-15 Bioren Inc Doping bei der walk-through-mutagenese
RU2237065C2 (ru) * 2002-10-03 2004-09-27 Государственный научный центр вирусологии и биотехнологии "Вектор" Иммуногенная библиотека химерных пептидов, мимикрирующая генетическое многообразие гипервариабельного района v3 белка оболочки gp120 вируса иммунодефицита человека
US8044185B2 (en) * 2005-09-06 2011-10-25 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Conformationally stabilized HIV envelope immunogens and triggering HIV-I envelope to reveal cryptic V3-loop epitopes
WO2007051036A2 (en) * 2005-10-26 2007-05-03 Protelix, Inc. Influenza combinatorial antigen vaccine
CA2637600A1 (en) 2006-01-17 2007-07-26 Health Research, Inc. Heteroduplex tracking assay
JP5247009B2 (ja) * 2006-06-16 2013-07-24 独立行政法人理化学研究所 配列抽出装置、配列抽出方法、プログラムおよび記録媒体
US20100093601A1 (en) * 2008-05-19 2010-04-15 Brett Tyler Compositions and methods to protect cells by blocking entry of pathogen proteins

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0255190A3 (de) 1986-08-01 1990-08-29 Repligen Corporation Rekombinante Polypeptide und ihre Verwendungen sowie Test für den AIDS-Virus
EP0311228A3 (de) 1987-10-09 1990-05-02 Repligen Corporation Rekombinante Polypeptide und ihre Verwendung einschliesslich Nachweisverfahren für AIDS-Virus
US5010175A (en) * 1988-05-02 1991-04-23 The Regents Of The University Of California General method for producing and selecting peptides with specific properties
EP1997891A1 (de) 1988-09-02 2008-12-03 Dyax Corporation Herstellung und Auswahl von Rekombinantproteinen mit verschiedenen Bindestellen
AU640619B2 (en) 1988-10-03 1993-09-02 Repligen Corporation Hiv proteins and peptides useful in the diagnosis, prophylaxis or therapy of aids
WO1990015078A1 (en) 1989-06-05 1990-12-13 Scott Charles F Jr HUMAN MONOCLONAL ANTIBODIES TO HIV-1MN gp 120
WO1991006575A1 (en) 1989-11-03 1991-05-16 Repligen Corporation Hiv-1 specific human monoclonal antibody
US5270170A (en) * 1991-10-16 1993-12-14 Affymax Technologies N.V. Peptide library and screening method

Also Published As

Publication number Publication date
WO1994000151A1 (en) 1994-01-06
ATE319738T1 (de) 2006-03-15
DE69333992T2 (de) 2006-11-30
EP0728015A4 (de) 1997-01-29
JPH07508520A (ja) 1995-09-21
AU678371B2 (en) 1997-05-29
JP3764476B2 (ja) 2006-04-05
JP2004121266A (ja) 2004-04-22
ES2260754T3 (es) 2006-11-01
DK0728015T3 (da) 2006-07-17
EP0728015A1 (de) 1996-08-28
PT728015E (pt) 2006-07-31
EP0728015B1 (de) 2006-03-08
AU4642893A (en) 1994-01-24
US6432675B1 (en) 2002-08-13

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee