DE69333929D1 - Konjugate von alginat und bioaktiven mitteln - Google Patents
Konjugate von alginat und bioaktiven mittelnInfo
- Publication number
- DE69333929D1 DE69333929D1 DE69333929T DE69333929T DE69333929D1 DE 69333929 D1 DE69333929 D1 DE 69333929D1 DE 69333929 T DE69333929 T DE 69333929T DE 69333929 T DE69333929 T DE 69333929T DE 69333929 D1 DE69333929 D1 DE 69333929D1
- Authority
- DE
- Germany
- Prior art keywords
- conjugates
- alginate
- bioactive agents
- bioactive
- agents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0084—Guluromannuronans, e.g. alginic acid, i.e. D-mannuronic acid and D-guluronic acid units linked with alternating alpha- and beta-1,4-glycosidic bonds; Derivatives thereof, e.g. alginates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9220294 | 1992-09-25 | ||
GB9220294A GB2270920B (en) | 1992-09-25 | 1992-09-25 | Alginate-bioactive agent conjugates |
PCT/GB1993/001999 WO1994007536A2 (en) | 1992-09-25 | 1993-09-23 | Alginate-bioactive agent conjugates |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69333929D1 true DE69333929D1 (de) | 2006-01-12 |
DE69333929T2 DE69333929T2 (de) | 2006-08-10 |
Family
ID=10722516
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69333929T Expired - Fee Related DE69333929T2 (de) | 1992-09-25 | 1993-09-23 | Konjugate von alginat und bioaktiven mitteln |
Country Status (7)
Country | Link |
---|---|
US (1) | US5622718A (de) |
EP (2) | EP0662002B1 (de) |
JP (1) | JPH08502053A (de) |
CA (1) | CA2145502A1 (de) |
DE (1) | DE69333929T2 (de) |
GB (1) | GB2270920B (de) |
WO (1) | WO1994007536A2 (de) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2270920B (en) * | 1992-09-25 | 1997-04-02 | Univ Keele | Alginate-bioactive agent conjugates |
TR199701410T1 (xx) * | 1995-05-23 | 1998-03-21 | Smithkline Beecham Plc | Bir ilaca tatland�rma eklenmesiyle haz�rlanan kimya bile�i�i. |
FR2750864B1 (fr) * | 1996-07-10 | 1999-04-16 | Oreal | Utilisation d'un polyholoside dans une composition destinee a stimuler les defenses immunitaires, et composition le comprenant |
ATE413415T1 (de) | 1996-09-19 | 2008-11-15 | Univ Michigan | Polymere enthaltend polysaccharide wie alginate oder modifizierte alginate |
EP1806367A3 (de) * | 1996-09-19 | 2007-11-28 | The Regents Of The University Of Michigan | Polysaccharide wie Alginate oder modifizierte Alginate enthaltende Polymere |
WO1998047496A2 (en) * | 1997-04-18 | 1998-10-29 | Access Pharmaceuticals, Inc. | Polymer-platinum compounds |
US5965118A (en) * | 1997-04-18 | 1999-10-12 | Access Pharmaceuticals, Inc. | Polymer-platinum compounds |
US5939453A (en) * | 1998-06-04 | 1999-08-17 | Advanced Polymer Systems, Inc. | PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers |
DE19836960A1 (de) * | 1998-08-14 | 2000-02-17 | Ulrich Zimmermann | Verfahren zur Gewinnung hochgereinigter Alginate |
AU6419899A (en) * | 1998-10-09 | 2000-05-01 | Regents Of The University Of Michigan, The | Hydrogels and water soluble polymeric carriers for drug delivery |
WO2001017515A1 (en) * | 1999-09-03 | 2001-03-15 | School Of Pharmacy, University Of London | Degradable polymers |
WO2002020663A2 (en) * | 2000-09-06 | 2002-03-14 | Ap Pharma, Inc. | Degradable polyacetal polymers |
MXPA03003401A (es) * | 2000-10-16 | 2004-06-30 | Neopharm Inc | Formulacion liposomica de mitoxantrona. |
DE10112825A1 (de) | 2001-03-16 | 2002-10-02 | Fresenius Kabi De Gmbh | HESylierung von Wirkstoffen in wässriger Lösung |
DE10129369C1 (de) * | 2001-06-21 | 2003-03-06 | Fresenius Kabi De Gmbh | Wasserlösliches, einen Aminozucker aufweisendes Antibiotikum in Form eines Pol ysaccharid-Konjugats |
DE10209821A1 (de) * | 2002-03-06 | 2003-09-25 | Biotechnologie Ges Mittelhesse | Kopplung von Proteinen an ein modifiziertes Polysaccharid |
DE10209822A1 (de) * | 2002-03-06 | 2003-09-25 | Biotechnologie Ges Mittelhesse | Kopplung niedermolekularer Substanzen an ein modifiziertes Polysaccharid |
DE10242076A1 (de) * | 2002-09-11 | 2004-03-25 | Fresenius Kabi Deutschland Gmbh | HAS-Allergen-Konjugate |
CA2495242A1 (en) * | 2002-09-11 | 2004-03-25 | Fresenius Kabi Deutschland Gmbh | Hasylated polypeptides, especially hasylated erythropoietin |
AU2003273413A1 (en) * | 2002-10-08 | 2004-05-04 | Fresenius Kabi Deutschland Gmbh | Pharmaceutically active oligosaccharide conjugates |
US20080274948A1 (en) * | 2003-08-08 | 2008-11-06 | Fresenius Kabi Deutschland Gmbh | Conjugates of Hydroxyalkyl Starch and G-Csf |
US20080206182A1 (en) * | 2003-08-08 | 2008-08-28 | Fresenius Kabi Deutschland Gmbh | Conjugates of a Polymer and a Protein Linked by an Oxime Group |
WO2005014655A2 (en) * | 2003-08-08 | 2005-02-17 | Fresenius Kabi Deutschland Gmbh | Conjugates of hydroxyalkyl starch and a protein |
WO2005092928A1 (en) * | 2004-03-11 | 2005-10-06 | Fresenius Kabi Deutschland Gmbh | Conjugates of hydroxyalkyl starch and a protein, prepared by reductive amination |
EP1758608A2 (de) * | 2004-03-11 | 2007-03-07 | Fresenius Kabi Deutschland GmbH | Konjugate von hydroxyalkylstärke und erythropoetin |
EP1824459A1 (de) * | 2004-12-17 | 2007-08-29 | Medipol S.A. | Hydrophile teilchen auf basis von kationischen chitosan-derivaten |
EP2992902A1 (de) | 2004-12-27 | 2016-03-09 | Silence Therapeutics GmbH | Mit peg beschichtete lipid-komplexe und ihre anwendung |
US20100062973A1 (en) * | 2005-03-11 | 2010-03-11 | Fresenius Kabi Deutschland Gmbh | Production of bioactive glycoproteins from inactive starting material |
US20060235084A1 (en) * | 2005-03-31 | 2006-10-19 | Jorge Heller | PEG-polyacetal diblock and triblock copolymers and pharmaceutical compositions |
US7456213B2 (en) * | 2005-03-31 | 2008-11-25 | A.P. Pharma, Inc. | PEG-poly(ortho ester) graft copolymers and pharmaceutical compositions |
US7767656B2 (en) * | 2005-04-25 | 2010-08-03 | Molly S Shoichet | Blends of temperature sensitive and anionic polymers for drug delivery |
EP1762250A1 (de) * | 2005-09-12 | 2007-03-14 | Fresenius Kabi Deutschland GmbH | Konjugate welche durch chemische Ligation zwischen Hydroxyalkylstärken und aktiven Substanzen mit Bildung eines Thiazolidin-Ringes entstehen |
JP2009534342A (ja) * | 2006-04-20 | 2009-09-24 | サイレンス・セラピューティクス・アーゲー | 血管内皮に特異的に送達するためのリポプレックス処方剤 |
US20090060943A1 (en) * | 2007-08-31 | 2009-03-05 | O'mara Brendan Joseph | Syndrome X Composition and Method of Lowering Blood Pressure and Glycemic Index |
EP2070950A1 (de) * | 2007-12-14 | 2009-06-17 | Fresenius Kabi Deutschland GmbH | Hydroxyalkylstärkederivate und deren Herstellungsverfahren |
EP2070951A1 (de) * | 2007-12-14 | 2009-06-17 | Fresenius Kabi Deutschland GmbH | Verfahren zur Herstellung eines Hydroxyalkylstärkederivats mit zwei Linkern |
WO2011072399A1 (en) | 2009-12-18 | 2011-06-23 | The Governing Council Of The University Of Toronto | Injectable polymer composition for use as a cell delivery vehicle |
WO2012167223A1 (en) * | 2011-06-02 | 2012-12-06 | Massachusetts Institute Of Technology | Modified alginates for cell encapsulation and cell therapy |
WO2013082149A1 (en) * | 2011-11-28 | 2013-06-06 | Case Western Reserve University | Polysaccharide therapeutic conjugates |
US10471118B2 (en) | 2014-05-30 | 2019-11-12 | Case Western Reserve University | Retinylamine derivitives for treatment of ocular disorders |
US11129845B2 (en) | 2014-06-18 | 2021-09-28 | Case Western Reserve University | Compositions and methods for the delivery of nucleic acids |
US10426735B2 (en) | 2014-08-01 | 2019-10-01 | Massachusetts Institute Of Technology | Modified alginates for anti-fibrotic materials and applications |
US10925980B2 (en) | 2014-08-04 | 2021-02-23 | Case Western Reserve University | Molecular probes and methods of use |
EP3302445A1 (de) * | 2015-06-03 | 2018-04-11 | Ewos Innovation AS | Orales freisetzungssystem für bioaktive wirkstoffe |
US11407786B2 (en) | 2015-06-18 | 2022-08-09 | Case Western Reserve University | Compositions and methods for the delivery of nucleic acids |
US10376592B2 (en) | 2015-06-29 | 2019-08-13 | University of Pittsburgh—of the Commonwealth System of Higher Education | Stapled acid-sensitive endosome disrupting alginates |
FI3528830T3 (fi) * | 2016-10-21 | 2023-01-13 | Polymyksiini-alginaattioligomeerikonjugaatteja | |
GB2555391B (en) * | 2016-10-21 | 2019-06-26 | Algipharma As | Bacitracin-alginate oligomer conjugates |
US11318231B2 (en) | 2017-11-06 | 2022-05-03 | Massachusetts Institute Of Technology | Anti-inflammatory coatings to improve biocompatibility of neurological implants |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3833729A (en) * | 1961-04-24 | 1974-09-03 | Purdue Frederick Co | Novel pyrazolidone derivatives in pharmaceutical compositions and methods |
US3320236A (en) * | 1963-03-07 | 1967-05-16 | Miles Lab | Reaction products of polymeric dialdehyde polysaccharides with p-aminosalicylates |
GB1174854A (en) * | 1967-07-07 | 1969-12-17 | Miles Lab | New Biologically Active Conjugates |
US4003792A (en) * | 1967-07-01 | 1977-01-18 | Miles Laboratories, Inc. | Conjugates of acid polysaccharides and complex organic substances |
CH594367A5 (de) * | 1974-05-17 | 1978-01-13 | Brenner Beat Max | |
US4631190A (en) * | 1981-06-26 | 1986-12-23 | Shen Wei C | Acidity-sensitive spacer molecule to control the release of pharmaceuticals from molecular carriers |
GB8500209D0 (en) * | 1985-01-04 | 1985-02-13 | Ceskoslovenska Akademie Ved | Synthetic polymeric drugs |
IL84252A (en) * | 1987-10-23 | 1994-02-27 | Yissum Res Dev Co | Phospholipase inhibiting compositions |
US5013669A (en) * | 1988-06-01 | 1991-05-07 | Smithkline Diagnostics, Inc. | Mass producible biologically active solid phase devices |
US5183503A (en) * | 1992-05-13 | 1993-02-02 | Greenberg Allen A | Method of shaker molding and composition therefor |
ZA936692B (en) * | 1992-09-12 | 1994-04-29 | Dott Ltd Comp | Physiologically active peptide composition |
GB2270920B (en) * | 1992-09-25 | 1997-04-02 | Univ Keele | Alginate-bioactive agent conjugates |
-
1992
- 1992-09-25 GB GB9220294A patent/GB2270920B/en not_active Expired - Fee Related
-
1993
- 1993-09-23 JP JP6508814A patent/JPH08502053A/ja active Pending
- 1993-09-23 DE DE69333929T patent/DE69333929T2/de not_active Expired - Fee Related
- 1993-09-23 EP EP93920995A patent/EP0662002B1/de not_active Expired - Lifetime
- 1993-09-23 EP EP99201853A patent/EP0947202A3/de not_active Withdrawn
- 1993-09-23 WO PCT/GB1993/001999 patent/WO1994007536A2/en active IP Right Grant
- 1993-09-23 CA CA002145502A patent/CA2145502A1/en not_active Abandoned
- 1993-09-23 US US08/406,876 patent/US5622718A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
GB2270920B (en) | 1997-04-02 |
EP0662002B1 (de) | 2005-12-07 |
EP0947202A2 (de) | 1999-10-06 |
WO1994007536A2 (en) | 1994-04-14 |
WO1994007536A3 (en) | 1994-07-21 |
GB2270920A (en) | 1994-03-30 |
DE69333929T2 (de) | 2006-08-10 |
EP0662002A1 (de) | 1995-07-12 |
EP0947202A3 (de) | 2000-07-12 |
JPH08502053A (ja) | 1996-03-05 |
CA2145502A1 (en) | 1994-04-14 |
GB9220294D0 (en) | 1992-11-11 |
US5622718A (en) | 1997-04-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |