DE69332921D1 - Hemmung des Tumorzellwachstums durch Verabreichung von B7-transfizierten Zellen - Google Patents

Hemmung des Tumorzellwachstums durch Verabreichung von B7-transfizierten Zellen

Info

Publication number
DE69332921D1
DE69332921D1 DE69332921T DE69332921T DE69332921D1 DE 69332921 D1 DE69332921 D1 DE 69332921D1 DE 69332921 T DE69332921 T DE 69332921T DE 69332921 T DE69332921 T DE 69332921T DE 69332921 D1 DE69332921 D1 DE 69332921D1
Authority
DE
Germany
Prior art keywords
tumor cells
tumor cell
cell growth
inhibition
administration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69332921T
Other languages
English (en)
Other versions
DE69332921T2 (de
Inventor
Lieping Chen
Ingegerd Hellstroem
Karl Erik Hellstroem
Jeffrey A Ledbetter
Peter S Linsley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of DE69332921D1 publication Critical patent/DE69332921D1/de
Publication of DE69332921T2 publication Critical patent/DE69332921T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5156—Animal cells expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Compounds Of Unknown Constitution (AREA)
DE69332921T 1992-10-02 1993-10-01 Hemmung des Tumorzellwachstums durch Verabreichung von B7-transfizierten Zellen Expired - Lifetime DE69332921T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US95612392A 1992-10-02 1992-10-02
US956123 1992-10-02
US610293A 1993-01-15 1993-01-15
US6102 1993-01-15

Publications (2)

Publication Number Publication Date
DE69332921D1 true DE69332921D1 (de) 2003-06-05
DE69332921T2 DE69332921T2 (de) 2004-05-19

Family

ID=26675186

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69332921T Expired - Lifetime DE69332921T2 (de) 1992-10-02 1993-10-01 Hemmung des Tumorzellwachstums durch Verabreichung von B7-transfizierten Zellen

Country Status (11)

Country Link
US (1) US6183734B1 (de)
EP (1) EP0600591B1 (de)
JP (1) JP3837169B2 (de)
AT (1) ATE239073T1 (de)
AU (1) AU662450B2 (de)
CA (1) CA2107537C (de)
DE (1) DE69332921T2 (de)
DK (1) DK0600591T3 (de)
ES (1) ES2197147T3 (de)
MX (1) MX9306147A (de)
PT (1) PT600591E (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5056137A (en) * 1989-09-27 1991-10-08 Sills Richard R Method and apparatus for encoding and decoding signals
US5858776A (en) * 1993-11-03 1999-01-12 Repligen Corporation Tumor cells with increased immunogenicity and uses therefor
JPH10512242A (ja) * 1994-12-30 1998-11-24 カイロン コーポレイション 組み合わせ遺伝子送達ビヒクル
EP0733373A3 (de) * 1995-03-23 1999-04-28 Bristol-Myers Squibb Company Zusammensetzung und Verfahren zur Erhöhung der Tumorzellenimmunogenität durch Verabreichung von B7-CD2-transfizierten Zellen
WO1996034952A1 (de) * 1995-05-04 1996-11-07 Boehringer Ingelheim International Gmbh Expression von tap und lmp in tumorzellen
DE19516040A1 (de) * 1995-05-04 1996-11-07 Boehringer Ingelheim Int Expression TAP und LMP in Tumorzellen
SE9604581D0 (sv) * 1996-12-12 1996-12-12 Karolinska Innovations Ab An agent against cancer and virus infections
US7235653B2 (en) 1996-12-31 2007-06-26 Isis Pharmaceuticals, Inc. Oligonucleotide compositions and methods for the modulation of the expression of B7 protein
US6077833A (en) * 1996-12-31 2000-06-20 Isis Pharmaceuticals, Inc. Oligonucleotide compositions and methods for the modulation of the expression of B7 protein
US6319906B1 (en) 1996-12-31 2001-11-20 Isis Pharmaceuticals Oligonucleotide compositions and methods for the modulation of the expression of B7 protein
US6682741B1 (en) * 1998-06-10 2004-01-27 The United States Of America As Represented By The Department Of Health And Human Services β2 microglobulin fusion proteins and high affinity variants
AUPQ755300A0 (en) * 2000-05-17 2000-06-08 Monash University Immune potentiating compositions
US20040136972A1 (en) * 2001-09-07 2004-07-15 Yeda Research And Development Co. Ltd. Methods of treating disease by transplantation of developing allogeneic or xenogeneic organs or tissues
US7780993B2 (en) * 2001-09-07 2010-08-24 Yeda Research And Development Co. Ltd. Therapeutic transplantation using developing, human or porcine, renal or hepatic, grafts
US20030096016A1 (en) * 2001-09-07 2003-05-22 Yeda Research And Development Co. Ltd. Methods of kidney transplantation utilizing developing nephric tissue
CA2485098A1 (en) * 2002-05-02 2003-11-13 University Of Connecticut Health Center Use of heat shock proteins to enhance efficacy of antibody therapeutics
IL165425A0 (en) * 2004-11-28 2006-01-15 Yeda Res & Dev Methods of treating disease by transplantation of developing allogeneic or xenogeneic organs or tissues
US20050090440A1 (en) * 2003-04-28 2005-04-28 Krissansen Geoffrey W. Tumour treating combinations, compositions and methods
CA2463464A1 (en) * 2003-04-28 2004-10-28 Auckland Uniservices Limited Methods of treatment and compositions therefor
US7960355B2 (en) 2003-05-23 2011-06-14 Isis Pharmaceuticals, Inc. Compositions and methods for the modulation of the expression of B7 protein
US7897582B2 (en) 2003-05-23 2011-03-01 Isis Pharmaceuticals, Inc. Oligonucleotide compositions and methods for the modulation of the expression of B7 protein

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992000092A1 (en) * 1990-07-02 1992-01-09 Bristol-Myers Squibb Company Ligand for cd28 receptor on b cells and methods

Also Published As

Publication number Publication date
DE69332921T2 (de) 2004-05-19
AU4877293A (en) 1994-04-14
CA2107537C (en) 2007-01-30
AU662450B2 (en) 1995-08-31
EP0600591A2 (de) 1994-06-08
JP3837169B2 (ja) 2006-10-25
ES2197147T3 (es) 2004-01-01
DK0600591T3 (da) 2003-08-25
ATE239073T1 (de) 2003-05-15
CA2107537A1 (en) 1994-04-03
EP0600591A3 (de) 1995-03-01
US6183734B1 (en) 2001-02-06
MX9306147A (es) 1994-06-30
PT600591E (pt) 2003-09-30
EP0600591B1 (de) 2003-05-02
JPH0769928A (ja) 1995-03-14

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