KR910006478A - 인체 트립타제 유사 단백질 - Google Patents

인체 트립타제 유사 단백질 Download PDF

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Publication number
KR910006478A
KR910006478A KR1019900014991A KR900014991A KR910006478A KR 910006478 A KR910006478 A KR 910006478A KR 1019900014991 A KR1019900014991 A KR 1019900014991A KR 900014991 A KR900014991 A KR 900014991A KR 910006478 A KR910006478 A KR 910006478A
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South Korea
Prior art keywords
protein
human
tryptase
human tryptase
kda
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KR1019900014991A
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English (en)
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노부히꼬 가뜨누마
마꼬또 요시모또
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다이쇼 세이야꾸 가부시끼가이샤
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Publication of KR910006478A publication Critical patent/KR910006478A/ko

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4826—Trypsin (3.4.21.4) Chymotrypsin (3.4.21.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

내용 없음

Description

인체 트립타제 유사 단백질
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 인체 트립타제 유사 단백질을 1%아가로오스 겔로 전기영동을 행하여 얻은 결과를 나타냄.
제2도는 인체 트립타제 유사 단백질을 환원 조건하에서 SDS-폴리아크릴아미드 겔로 전기영동을 행하여 얻은 결과 및 웨스턴 블롯 분석결과를 나타냄.
제3도는 인체 트립타제 유사 단백질의 최적 pH조건을 나타내는 그래프임.

Claims (7)

  1. 항쥐 트립타제 항체와 특이하게 결합할 수 있고, 인체 T세포로부터 얻어지는 약 35±3 KDa의 서브유니트 2개 및 약 30±2 KDa의 서브유니트 4개를 포함하는 것을 특징으로 하는 인체 트립타제 유사 단백질.
  2. 제1항에 있어서, 트립신 유사 활성 및 키모트립신 유사 활성을 갖는 것을 특징으로 하는 인체 트립신 유사 단백질.
  3. 제1 또는 2항에 있어서, 인체 급성 임파아구성 백혈구 세포주 MOLT-4로부터 얻어지는 것을 특징으로 하는 인체 트립타제 유사 단백질.
  4. 제1항에 기재된 인체 트립타제 유사 단백질의 약 35±3 KDa의 서브유니트 또는 약 30±2 KDa의 서브유니트.
  5. 인체 트립타제 유사 단백질 또는 그의 항원 결합 부위를 함유하는 단편과 특이하게 결합할 수 있는 항인체 트립타제 유사 단백질 항체.
  6. 유효성분으로서 항인체 트립타제 유사 단백질 항체 또는 그의 항원 결합 부위를 함유하는 단편과, 제약상 허용되는 담체로 이루어지는 후천성 면역 결핍증 치료용 조성물.
  7. 제1항에 기재된 인체 트립타제 유사 단백질로 이루어지는 후천성 면역 결핍증용 백신.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900014991A 1989-09-22 1990-09-21 인체 트립타제 유사 단백질 KR910006478A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP24789389 1989-09-22
JP1-247893 1989-09-22

Publications (1)

Publication Number Publication Date
KR910006478A true KR910006478A (ko) 1991-04-29

Family

ID=17170146

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900014991A KR910006478A (ko) 1989-09-22 1990-09-21 인체 트립타제 유사 단백질

Country Status (4)

Country Link
EP (1) EP0419292A1 (ko)
JP (1) JPH03175983A (ko)
KR (1) KR910006478A (ko)
CA (1) CA2025630A1 (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5861264A (en) * 1996-05-21 1999-01-19 Axys Pharmaceuticals, Inc. Anti-tryptase detection as a diagnostic for inflammatory diseases
EP0890646A3 (en) * 1997-06-10 2001-07-18 Smithkline Beecham Plc HE2NW40 Serine Protease
AU3985197A (en) * 1997-08-18 1999-03-08 Arris Pharmaceutical Corporation Anti-tryptase detection as a diagnostic for inflammatory diseases
WO2001012788A2 (en) * 1999-08-18 2001-02-22 Zymogenetics, Inc. Tryptase-like polypeptide ztryp1
US6514741B1 (en) 1999-08-18 2003-02-04 Zymogenetics, Inc. Tryptase-like polypeptide ztryp1
JP6995127B2 (ja) 2017-02-10 2022-02-04 ジェネンテック， インコーポレイテッド 抗トリプターゼ抗体、その組成物、及びその使用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2007238A1 (en) * 1989-01-13 1990-07-13 Nobuhiko Katunuma Anti-tryptase antibody and composition for treatment of aids using the same

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Publication number Publication date
EP0419292A1 (en) 1991-03-27
CA2025630A1 (en) 1991-03-23
JPH03175983A (ja) 1991-07-31

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