KR900011477A - 항-트립타아제 항체 및 이것을 사용한 후천성 면역결핍증 치료용 조성물 - Google Patents
항-트립타아제 항체 및 이것을 사용한 후천성 면역결핍증 치료용 조성물 Download PDFInfo
- Publication number
- KR900011477A KR900011477A KR1019900000339A KR900000339A KR900011477A KR 900011477 A KR900011477 A KR 900011477A KR 1019900000339 A KR1019900000339 A KR 1019900000339A KR 900000339 A KR900000339 A KR 900000339A KR 900011477 A KR900011477 A KR 900011477A
- Authority
- KR
- South Korea
- Prior art keywords
- antitryptase
- tryptase
- antibody
- igg
- molecular weight
- Prior art date
Links
- 208000030507 AIDS Diseases 0.000 title claims 4
- 102000001400 Tryptase Human genes 0.000 claims 7
- 108060005989 Tryptase Proteins 0.000 claims 7
- 239000012634 fragment Substances 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 229940023041 peptide vaccine Drugs 0.000 claims 3
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 108091005804 Peptidases Proteins 0.000 claims 1
- 239000004365 Protease Substances 0.000 claims 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8135—Kazal type inhibitors, e.g. pancreatic secretory inhibitor, ovomucoid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (12)
- 트립타아제 또는 그의 항원 결합 부위를 함유하는 단편과 특이적으로 반응할수 있는 항트립타아제 항체.
- 제1항에 있어서, 상기 트립타아제가, 각각의 분자량이 약 35,000인 4개의 소단위로 구성되는 약 140,000의 분자량을 갖는 트립신 형 프로테아제인 항트립타아제 항체.
- 제1항에 있어서, 상기 항트립타아제 항체가 항트립타아제 IgG인 항트립타아제 항체
- 제1항에 있어서, 상기 단편이 항 트립타아제 IgG의 F(ab')2또는 Fab 단편인 항트립타아제 항체.
- 유효 성분으로서 트립타아제 또는 그의 항원 결합 부위를 함유하는 단편과 특이하게 반응할 수 있는 항트립타아제 항체와 제약상 허용되는 담체로 구성되는 제약조성물.
- 제5항에 있어서, AIDS 치료용인 제약 조성물.
- 제5항에 있어서, 상기 항트립타아제 항체가 항트립타아제 IgG인 제약조성물.
- 제5항에 있어서, 상기 단편이 항트립타아제 IgG의 F(ab′)2또는 Fab인 제약 조성물.
- 트립타아제 또는 그의 항원 결합 부위를 함유하는 단편과 특이적으로 반응 할 수 있는 항트립타아제 항체를 치료학상 유료량으로 포유류에 투여하는 것으로 되는 AIDS 치료법.
- 트립타아제로 되는 AIDS에 대한 펩티드 백신.
- 제10항에 있어서, 상기 트립타아제가, 각각의 분자량이 약 35,000인 4개의 소단위를 구성된 분자량 140.000의 트립신형 트립타아제인 펩티드 백신.
- 제10항에 있어서, 상기 백신이 추가로 보조제를 함유하는 펩티드 백신.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1-6985 | 1989-01-13 | ||
JP698589 | 1989-01-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR900011477A true KR900011477A (ko) | 1990-08-01 |
Family
ID=11653460
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019900000339A KR900011477A (ko) | 1989-01-13 | 1990-01-12 | 항-트립타아제 항체 및 이것을 사용한 후천성 면역결핍증 치료용 조성물 |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP0379295A3 (ko) |
KR (1) | KR900011477A (ko) |
CA (1) | CA2007238A1 (ko) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2025630A1 (en) * | 1989-09-22 | 1991-03-23 | Nobuhiko Katunuma | Human tryptase-like protein |
US5594116A (en) * | 1995-11-08 | 1997-01-14 | Promega Corporation | Tryptase polyclonal antibody and purification method for use in human tryptase immunoassay |
US5861264A (en) * | 1996-05-21 | 1999-01-19 | Axys Pharmaceuticals, Inc. | Anti-tryptase detection as a diagnostic for inflammatory diseases |
AU3985197A (en) * | 1997-08-18 | 1999-03-08 | Arris Pharmaceutical Corporation | Anti-tryptase detection as a diagnostic for inflammatory diseases |
WO2006010492A1 (en) * | 2004-07-28 | 2006-02-02 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with tryptase 1 (tps1) |
JP6995127B2 (ja) * | 2017-02-10 | 2022-02-04 | ジェネンテック, インコーポレイテッド | 抗トリプターゼ抗体、その組成物、及びその使用 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2007083A1 (en) * | 1989-01-09 | 1990-07-09 | Nobuhiko Katunuma | Pharmaceutical use of trypstatin |
-
1990
- 1990-01-05 CA CA002007238A patent/CA2007238A1/en not_active Abandoned
- 1990-01-09 EP EP19900300248 patent/EP0379295A3/en not_active Withdrawn
- 1990-01-12 KR KR1019900000339A patent/KR900011477A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CA2007238A1 (en) | 1990-07-13 |
EP0379295A3 (en) | 1990-12-19 |
EP0379295A2 (en) | 1990-07-25 |
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WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |