DE69325451D1 - Verwendung von pyruvamid und ausgewählten pyruvyl-aminosäuren - Google Patents

Verwendung von pyruvamid und ausgewählten pyruvyl-aminosäuren

Info

Publication number
DE69325451D1
DE69325451D1 DE69325451T DE69325451T DE69325451D1 DE 69325451 D1 DE69325451 D1 DE 69325451D1 DE 69325451 T DE69325451 T DE 69325451T DE 69325451 T DE69325451 T DE 69325451T DE 69325451 D1 DE69325451 D1 DE 69325451D1
Authority
DE
Germany
Prior art keywords
pyruvamide
amino acids
pyruvyl
pyruvyl amino
acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69325451T
Other languages
English (en)
Other versions
DE69325451T2 (de
Inventor
Robert Miller
Nickki Parlet
Kent Cipollo
Madhup Dhaon
John Houbion
Edwin Lundell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
STANKO RONALD T PITTSBURGH PA US
Original Assignee
STANKO RONALD T PITTSBURGH PA US
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by STANKO RONALD T PITTSBURGH PA US filed Critical STANKO RONALD T PITTSBURGH PA US
Publication of DE69325451D1 publication Critical patent/DE69325451D1/de
Application granted granted Critical
Publication of DE69325451T2 publication Critical patent/DE69325451T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
DE69325451T 1992-04-16 1993-02-09 Verwendung von pyruvamid und ausgewählten pyruvyl-aminosäuren Expired - Fee Related DE69325451T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/868,891 US5256697A (en) 1992-04-16 1992-04-16 Method of administering pyruvate and methods of synthesizing pyruvate precursors
PCT/US1993/001134 WO1993021147A1 (en) 1992-04-16 1993-02-09 Method of administering pyruvate and methods of synthesizing pyruvate precursors

Publications (2)

Publication Number Publication Date
DE69325451D1 true DE69325451D1 (de) 1999-07-29
DE69325451T2 DE69325451T2 (de) 2000-01-20

Family

ID=25352516

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69325451T Expired - Fee Related DE69325451T2 (de) 1992-04-16 1993-02-09 Verwendung von pyruvamid und ausgewählten pyruvyl-aminosäuren

Country Status (9)

Country Link
US (4) US5256697A (de)
EP (1) EP0636117B1 (de)
JP (1) JPH082854B2 (de)
AU (1) AU3659993A (de)
CA (1) CA2130198A1 (de)
DE (1) DE69325451T2 (de)
ES (1) ES2135468T3 (de)
MX (1) MX9302191A (de)
WO (1) WO1993021147A1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5508308A (en) * 1992-04-16 1996-04-16 Abbott Laboratories Use of pyruvylglycine to treat ischemia/reperfusion injury following myocardial infarction
US5256697A (en) * 1992-04-16 1993-10-26 Abbott Laboratories Method of administering pyruvate and methods of synthesizing pyruvate precursors
US5670539A (en) * 1993-07-21 1997-09-23 New York State Office Of Mental Health Treatment of movement disorders using large neutral amino acids
US5612374A (en) * 1994-02-14 1997-03-18 Ronald T. Stanko Inhibiting growth of mammary adenocarcinoma
US5480909A (en) * 1994-08-08 1996-01-02 University Of Pittsburgh Medical Center Method for inhibiting generation of free-radicals
US5550166A (en) * 1995-03-17 1996-08-27 Ostlund; Richard E. Pinitol and derivatives thereof for the treatment of metabolic disorders
US6306828B1 (en) 1995-04-06 2001-10-23 Baxter International, Inc. Enantiomerically-enhanced nutritional energy substrates
US5801198A (en) * 1995-07-13 1998-09-01 University Of Pittsburgh Medical Center Retarding neutrophil infiltration ad morphologic reduction in ischemic bowel tissues
US5798388A (en) * 1996-09-06 1998-08-25 Cellular Sciences, Inc. Method and composition for treating mammalian diseases caused by inflammatory response
AU719332B2 (en) * 1995-09-19 2000-05-04 Cellular Sciences, Inc. Method and composition for treating mammalian diseases caused by inflammatory response
US5876916A (en) * 1996-03-18 1999-03-02 Case Western Reserve University Pyruvate compounds and methods for use thereof
US6086789A (en) * 1996-03-18 2000-07-11 Case Western Reserve University Medical uses of pyruvates
US5667962A (en) * 1996-03-18 1997-09-16 Case Western Reserve University Pyruvate thiolester for the prevention of reperfusion injury
US6008252A (en) * 1996-07-26 1999-12-28 Beale; Paxton K. Method for increasing muscle mass in a mammal
US5756469A (en) * 1996-07-26 1998-05-26 Beale; Paxton K. Composition of pyruvate and anti-cortisol compounds and method for increasing protein concentration in a mammal
US5716926A (en) * 1996-07-26 1998-02-10 Paxton K. Beale Composition of pyruvate and protein and method for increasing protein concentration in a mammal
US6417231B1 (en) 1996-12-23 2002-07-09 Frank L. Greenway Method and composition for delivering therapeutically effective amounts of pyruvate to a mammal
DE69838789T2 (de) * 1997-03-12 2008-10-30 Suzanne Cambridge de la Monte Verfahren zur behandlung oder prävention der alzheimerischen krankheit
US5886040A (en) * 1997-06-17 1999-03-23 Amt Labs, Inc. Creatine pyruvate salt with enhanced palatability
US20040058873A1 (en) * 1998-03-12 2004-03-25 Esmond Robert W. Method for treating or preventing Alzheimer's disease
WO2000071111A1 (en) 1999-05-20 2000-11-30 Humanetics Corporation Stimulating transport of glucose into animal tissue by the administration of pinitol
US6846842B2 (en) * 1999-10-07 2005-01-25 Beth Israel Deconess Medical Center, Inc. Pyruvate ester composition and method of use for resuscitation after events of ischemia and reperfusion
EP1372641A4 (de) 2001-03-05 2004-08-25 Stephen P Ernest Enterale formulierung
JP2004527529A (ja) * 2001-04-04 2004-09-09 クリティカル セラピューティックス インコーポレイテッド 急性腎不全を予防するための方法
US6608196B2 (en) 2001-05-03 2003-08-19 Galileo Pharmaceuticals, Inc. Process for solid supported synthesis of pyruvate-derived compounds
US8076373B2 (en) * 2001-09-11 2011-12-13 North Cell Pharmacetical Method for treating mammalian diseases and injuries caused by the over-expression of peroxynitrite
CA2481753A1 (en) * 2002-04-17 2003-10-30 Critical Therapeutics, Inc. Method for treating ileus with an alpha -ketoalkanoic acid or - ester or - amide
US7273616B2 (en) * 2002-05-10 2007-09-25 The Trustees Of Columbia University In The City Of New York Genetically engineered cell lines and systems for propagating Varicella zoster virus and methods of use thereof
EP1807069B1 (de) * 2004-11-02 2017-03-22 Oragenics, Inc. Verfahren zur regulierung der grösse und des gewichts von tieren mit glycin
US20120129785A1 (en) * 2009-07-21 2012-05-24 Hill's Pet Nutrition, Inc. Companion animal nutrition system
US8450090B2 (en) 2009-10-06 2013-05-28 The Regents Of The University Of Colorado, A Body Corporate Compositions and methods for promoting fatty acid production in plants
CA2785642C (en) 2009-12-29 2014-12-02 Hill's Pet Nutrition, Inc. Compositions including pyruvate for companion animals and methods of use thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE372006B (de) * 1971-09-13 1974-12-09 Haessle Ab
US4197316A (en) * 1975-07-23 1980-04-08 Scott Eugene J Van Treatment of dry skin
US4296127A (en) * 1979-04-18 1981-10-20 The Johns Hopkins University Mixed salts of essential or semi-essential amino acids and nitrogen-free analogs thereof
IT1120033B (it) * 1979-10-05 1986-03-19 Sigma Tau Ind Farmaceuti Composizione farmaceutica comprendente-carnitina adatta per l'alimentazione parenterale
US4548937A (en) * 1981-04-01 1985-10-22 Montefiore Hospital Method for preventing body fat deposition in mammals
US4351835A (en) * 1981-04-01 1982-09-28 Montefiore Hospital Method for preventing body fat deposition in mammals
DE3438455A1 (de) * 1984-10-19 1986-06-26 Institut Dr. Ziegler, Bettingen L-lysin- und l-histidinpyruvat
FR2626276B1 (fr) * 1988-01-22 1990-05-11 Hoechst France Perfectionnement au procede de fabrication de pyruvates d'alkyle
US4874790A (en) * 1988-08-15 1989-10-17 Montefiore Hospital Association Of Western Pennsylvania Method for improving the glucose metabolism of an animal having diabetic tendencies
DE3917880A1 (de) * 1989-06-01 1990-12-06 Kali Chemie Ag Neue acylaminosaeurederivate enthaltende arzneimittel und diaetetika
US5256697A (en) * 1992-04-16 1993-10-26 Abbott Laboratories Method of administering pyruvate and methods of synthesizing pyruvate precursors

Also Published As

Publication number Publication date
JPH07501830A (ja) 1995-02-23
EP0636117B1 (de) 1999-06-23
MX9302191A (es) 1994-03-31
AU3659993A (en) 1993-11-18
EP0636117A1 (de) 1995-02-01
US5312985A (en) 1994-05-17
US5256697A (en) 1993-10-26
CA2130198A1 (en) 1993-10-28
ES2135468T3 (es) 1999-11-01
JPH082854B2 (ja) 1996-01-17
EP0636117A4 (de) 1995-07-26
DE69325451T2 (de) 2000-01-20
US5472980A (en) 1995-12-05
WO1993021147A1 (en) 1993-10-28
US5283260A (en) 1994-02-01

Similar Documents

Publication Publication Date Title
DE69325451T2 (de) Verwendung von pyruvamid und ausgewählten pyruvyl-aminosäuren
DE69329717D1 (de) Erzeugung und Aufnahme von Bildern
DE59310276D1 (de) Verwendung von Polyasparaginsäure und ihrer Salze
DK392487A (da) Anvendelse af carboxysyreestere og -amider
BR9300720A (pt) Combinacao de agulha e sutura
DE69309713D1 (de) Ammonolyse von nylon
DE69430662T2 (de) Zusammensetzungen von fluorkohlenwasserstoffen und kohlenwasserstoffen
DE69220382T2 (de) Verwendung von Peptidderivaten
DE69223984T2 (de) Zusammensetzungen von difluormethan und tetrafluorethan
DE59302386D1 (de) Verwendung von polykondensaten und neue polykondensate
DE59708905D1 (de) Injektionsformulierungen von avermectinen und milbemycinen
NO964758D0 (no) Anvendelse av von Willebrand-faktor og farmasöytiske preparater
DE69123345T2 (de) Sequenzielle c-termin degradierung von peptiden und proteinen
DE69524590D1 (de) Zusammensetzung von 5htida und 5htid antagonisten
DE59307396D1 (de) Dichtring und verwendung desselben
BR9306359A (pt) Azocorantes aplicação do azocorante e modificação cristalina
DE69629027D1 (de) Kosmetische zubereitung zur prävention und beseitigung von hautschäden
DE69213637T2 (de) Herstellung von 2-Hydroxymandelsäuren und 2-Hydroxybenzaldehyden
DE59107525D1 (de) Peptidamidase und deren Verwendung
DE69328467D1 (de) Polyamidzusammensetzung und Verwendung
ITRM940124V0 (it) "brandina o cuccia pieghegole e/o smontabile"
DE69227639T2 (de) Nachweis von malignen und prämalignen zuständen
ATE218343T1 (de) Verwendung von substituierten und nichtsubstituierten n-(pyrrol-1-yl)pyridinaminen als antikonvulsiva
FI945493A0 (fi) Ti (III)-pitoisen liuoksen valmistus ja sen käyttö
DE69322081D1 (de) Salze von chinolon carbonsäuren

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee