DE69319693D1 - Formulierung zur Stabilisierung der enzymatischen Aktivität und immunreaktivität von Creatinkinase und Creatinkinase-Isoenzymen - Google Patents
Formulierung zur Stabilisierung der enzymatischen Aktivität und immunreaktivität von Creatinkinase und Creatinkinase-IsoenzymenInfo
- Publication number
- DE69319693D1 DE69319693D1 DE69319693T DE69319693T DE69319693D1 DE 69319693 D1 DE69319693 D1 DE 69319693D1 DE 69319693 T DE69319693 T DE 69319693T DE 69319693 T DE69319693 T DE 69319693T DE 69319693 D1 DE69319693 D1 DE 69319693D1
- Authority
- DE
- Germany
- Prior art keywords
- creatine kinase
- immunoreactivity
- stabilize
- formulation
- enzymatic activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
- C12Q1/50—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving creatine phosphokinase
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Enzymes And Modification Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/939,861 US5298406A (en) | 1992-09-14 | 1992-09-14 | Formulation for stabilizing enzymatic activity and immunoreactivity of creatine kinase and creatine kinase isoenzymes |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69319693D1 true DE69319693D1 (de) | 1998-08-20 |
DE69319693T2 DE69319693T2 (de) | 1998-12-10 |
Family
ID=25473861
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69319693T Expired - Fee Related DE69319693T2 (de) | 1992-09-14 | 1993-09-09 | Formulierung zur Stabilisierung der enzymatischen Aktivität und immunreaktivität von Creatinkinase und Creatinkinase-Isoenzymen |
Country Status (5)
Country | Link |
---|---|
US (1) | US5298406A (de) |
EP (1) | EP0596218B1 (de) |
JP (1) | JP2930277B2 (de) |
CA (1) | CA2106167A1 (de) |
DE (1) | DE69319693T2 (de) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE221919T1 (de) * | 1994-05-06 | 2002-08-15 | Beckman Coulter Inc | In flüssiger form stabiler thiolaktivator |
JP3625503B2 (ja) | 1994-11-11 | 2005-03-02 | 旭化成ファーマ株式会社 | 臨床検査用複合酵素含有組成物 |
AU6764196A (en) * | 1995-08-31 | 1997-03-19 | First Medical, Inc. | Methods and antibodies for detecting creatine kinase |
WO1998040749A1 (fr) * | 1997-03-12 | 1998-09-17 | Yamasa Corporation | Procede de detection de la vasculopathie |
JP3750955B2 (ja) * | 1997-04-18 | 2006-03-01 | 富士写真フイルム株式会社 | クレアチンキナーゼまたはそのmbアイソザイムの定量用乾式分析素子 |
US5998158A (en) * | 1997-05-14 | 1999-12-07 | Fuji Photo Film Co., Ltd. | Glucose free, stable dry analytical element for quantitative analysis of creatine kinase MB isozyme |
DE19755079A1 (de) | 1997-12-11 | 1999-06-17 | Roche Diagnostics Gmbh | Stabilisiertes Reagenz und Verfahren zur Bestimmung von Creatin-Kinase |
US5908864A (en) * | 1998-05-28 | 1999-06-01 | Dymatize Enterprises | Creatine gel |
JP2000154200A (ja) * | 1998-11-20 | 2000-06-06 | Kanegafuchi Chem Ind Co Ltd | 化合物の固定化方法 |
JP2001299361A (ja) * | 2000-04-28 | 2001-10-30 | Oriental Yeast Co Ltd | 溶液安定性の組換えヒトクレアチンキナーゼヘテロダイマー |
CA2484876C (en) * | 2002-05-13 | 2011-11-22 | Becton, Dickinson And Company | Protease inhibitor sample collection system |
EP1435241A1 (de) * | 2002-12-30 | 2004-07-07 | Kyokuto Pharmaceutical Industrial Co. Ltd | Methode zur Stabilisierung von Blut-, Serum- oder Plasmaproben und Behälter enthaltend einen Puffer |
CN105974117B (zh) * | 2016-05-04 | 2017-09-01 | 同昕生物技术(北京)有限公司 | Ck‑mb校准品稀释液及其在临床ck检测中的应用 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1102225A (en) * | 1976-09-13 | 1981-06-02 | Ivan E. Modrovich | Stabilized liquid enzyme and coenzyme compositions and method of preparing same |
DE2831390C2 (de) * | 1978-07-17 | 1980-08-14 | Boehringer Mannheim Gmbh, 6800 Mannheim | Kontrollserum für die klinisch-chemische Analyse mit einem bestimmten Gehalt an Creatin-kinase |
US4325832A (en) * | 1979-03-05 | 1982-04-20 | Beckman Instruments, Inc. | Enzyme reference composition |
JPS5653465A (en) * | 1979-10-05 | 1981-05-13 | Toyo Jozo Co Ltd | Improved method in measurement of enzyme immunity |
DE3174456D1 (en) * | 1980-07-18 | 1986-05-28 | Du Pont | Monothioglycerol as thiol-protector in lyophilized materials |
US4339533A (en) * | 1980-07-30 | 1982-07-13 | Technicon Instruments Corporation | Stabilization of creatine kinase (CK) and its application as a reference standard |
US4442212A (en) * | 1980-11-10 | 1984-04-10 | E. I. Du Pont De Nemours & Company | Monothioglycerol as thiol-protector in lyophilized materials |
DE3540076A1 (de) * | 1985-11-12 | 1987-05-14 | Boehringer Mannheim Gmbh | Verfahren zur stabilisierung von creatinkinase |
JPS62228272A (ja) * | 1986-03-27 | 1987-10-07 | Amano Pharmaceut Co Ltd | 安定なペルオキシダ−ゼ製剤 |
US4994375A (en) * | 1988-07-11 | 1991-02-19 | Baxter International Inc. | Stable human serum based control and/or calibrant |
US5102788A (en) * | 1988-11-21 | 1992-04-07 | Hygeia Sciences, Inc. | Immunoassay including lyophilized reactant mixture |
GB9010742D0 (en) * | 1990-05-14 | 1990-07-04 | Quadrant Bioresources Ltd | Stabilization of biological macromolecular substances |
-
1992
- 1992-09-14 US US07/939,861 patent/US5298406A/en not_active Expired - Fee Related
-
1993
- 1993-09-09 EP EP93114468A patent/EP0596218B1/de not_active Expired - Lifetime
- 1993-09-09 DE DE69319693T patent/DE69319693T2/de not_active Expired - Fee Related
- 1993-09-14 CA CA002106167A patent/CA2106167A1/en not_active Abandoned
- 1993-09-14 JP JP5228586A patent/JP2930277B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE69319693T2 (de) | 1998-12-10 |
JP2930277B2 (ja) | 1999-08-03 |
JPH06189760A (ja) | 1994-07-12 |
US5298406A (en) | 1994-03-29 |
EP0596218A3 (de) | 1994-06-01 |
EP0596218A2 (de) | 1994-05-11 |
EP0596218B1 (de) | 1998-07-15 |
CA2106167A1 (en) | 1994-03-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: DADE BEHRING, INC.(N.D.GES.DES STAATES DELAWARE), |
|
8339 | Ceased/non-payment of the annual fee |