DE69319693D1 - Formulierung zur Stabilisierung der enzymatischen Aktivität und immunreaktivität von Creatinkinase und Creatinkinase-Isoenzymen - Google Patents

Formulierung zur Stabilisierung der enzymatischen Aktivität und immunreaktivität von Creatinkinase und Creatinkinase-Isoenzymen

Info

Publication number
DE69319693D1
DE69319693D1 DE69319693T DE69319693T DE69319693D1 DE 69319693 D1 DE69319693 D1 DE 69319693D1 DE 69319693 T DE69319693 T DE 69319693T DE 69319693 T DE69319693 T DE 69319693T DE 69319693 D1 DE69319693 D1 DE 69319693D1
Authority
DE
Germany
Prior art keywords
creatine kinase
immunoreactivity
stabilize
formulation
enzymatic activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69319693T
Other languages
English (en)
Other versions
DE69319693T2 (de
Inventor
Joseph Loyd
Barbara A Search
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dade Behring Inc
Original Assignee
Dade Chemistry Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dade Chemistry Systems Inc filed Critical Dade Chemistry Systems Inc
Application granted granted Critical
Publication of DE69319693D1 publication Critical patent/DE69319693D1/de
Publication of DE69319693T2 publication Critical patent/DE69319693T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/50—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving creatine phosphokinase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
DE69319693T 1992-09-14 1993-09-09 Formulierung zur Stabilisierung der enzymatischen Aktivität und immunreaktivität von Creatinkinase und Creatinkinase-Isoenzymen Expired - Fee Related DE69319693T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/939,861 US5298406A (en) 1992-09-14 1992-09-14 Formulation for stabilizing enzymatic activity and immunoreactivity of creatine kinase and creatine kinase isoenzymes

Publications (2)

Publication Number Publication Date
DE69319693D1 true DE69319693D1 (de) 1998-08-20
DE69319693T2 DE69319693T2 (de) 1998-12-10

Family

ID=25473861

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69319693T Expired - Fee Related DE69319693T2 (de) 1992-09-14 1993-09-09 Formulierung zur Stabilisierung der enzymatischen Aktivität und immunreaktivität von Creatinkinase und Creatinkinase-Isoenzymen

Country Status (5)

Country Link
US (1) US5298406A (de)
EP (1) EP0596218B1 (de)
JP (1) JP2930277B2 (de)
CA (1) CA2106167A1 (de)
DE (1) DE69319693T2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU692547B2 (en) * 1994-05-06 1998-06-11 Beckman Instruments, Inc. Liquid stable thiol activator
JP3625503B2 (ja) 1994-11-11 2005-03-02 旭化成ファーマ株式会社 臨床検査用複合酵素含有組成物
WO1997008551A1 (en) * 1995-08-31 1997-03-06 First Medical, Inc. Methods and antibodies for detecting creatine kinase
WO1998040749A1 (fr) * 1997-03-12 1998-09-17 Yamasa Corporation Procede de detection de la vasculopathie
US5998158A (en) * 1997-05-14 1999-12-07 Fuji Photo Film Co., Ltd. Glucose free, stable dry analytical element for quantitative analysis of creatine kinase MB isozyme
JP3750955B2 (ja) * 1997-04-18 2006-03-01 富士写真フイルム株式会社 クレアチンキナーゼまたはそのｍｂアイソザイムの定量用乾式分析素子
DE19755079A1 (de) 1997-12-11 1999-06-17 Roche Diagnostics Gmbh Stabilisiertes Reagenz und Verfahren zur Bestimmung von Creatin-Kinase
US5908864A (en) * 1998-05-28 1999-06-01 Dymatize Enterprises Creatine gel
JP2000154200A (ja) * 1998-11-20 2000-06-06 Kanegafuchi Chem Ind Co Ltd 化合物の固定化方法
JP2001299361A (ja) * 2000-04-28 2001-10-30 Oriental Yeast Co Ltd 溶液安定性の組換えヒトクレアチンキナーゼヘテロダイマー
WO2003097237A2 (en) * 2002-05-13 2003-11-27 Becton, Dickinson, And Company Protease inhibitor sample collection system
EP1435241A1 (de) * 2002-12-30 2004-07-07 Kyokuto Pharmaceutical Industrial Co. Ltd Methode zur Stabilisierung von Blut-, Serum- oder Plasmaproben und Behälter enthaltend einen Puffer
CN105974117B (zh) * 2016-05-04 2017-09-01 同昕生物技术（北京）有限公司 Ck‑mb校准品稀释液及其在临床ck检测中的应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1102225A (en) * 1976-09-13 1981-06-02 Ivan E. Modrovich Stabilized liquid enzyme and coenzyme compositions and method of preparing same
DE2831390C2 (de) * 1978-07-17 1980-08-14 Boehringer Mannheim Gmbh, 6800 Mannheim Kontrollserum für die klinisch-chemische Analyse mit einem bestimmten Gehalt an Creatin-kinase
US4325832A (en) * 1979-03-05 1982-04-20 Beckman Instruments, Inc. Enzyme reference composition
JPS5653465A (en) * 1979-10-05 1981-05-13 Toyo Jozo Co Ltd Improved method in measurement of enzyme immunity
EP0044532B1 (de) * 1980-07-18 1986-04-23 E.I. Du Pont De Nemours And Company Monothioglycerol als Thiolschützer in lyophilisierten Materialien
US4339533A (en) * 1980-07-30 1982-07-13 Technicon Instruments Corporation Stabilization of creatine kinase (CK) and its application as a reference standard
US4442212A (en) * 1980-11-10 1984-04-10 E. I. Du Pont De Nemours & Company Monothioglycerol as thiol-protector in lyophilized materials
DE3540076A1 (de) * 1985-11-12 1987-05-14 Boehringer Mannheim Gmbh Verfahren zur stabilisierung von creatinkinase
JPS62228272A (ja) * 1986-03-27 1987-10-07 Amano Pharmaceut Co Ltd 安定なペルオキシダ−ゼ製剤
US4994375A (en) * 1988-07-11 1991-02-19 Baxter International Inc. Stable human serum based control and/or calibrant
US5102788A (en) * 1988-11-21 1992-04-07 Hygeia Sciences, Inc. Immunoassay including lyophilized reactant mixture
GB9010742D0 (en) * 1990-05-14 1990-07-04 Quadrant Bioresources Ltd Stabilization of biological macromolecular substances

Also Published As

Publication number Publication date
EP0596218A2 (de) 1994-05-11
JPH06189760A (ja) 1994-07-12
CA2106167A1 (en) 1994-03-15
JP2930277B2 (ja) 1999-08-03
EP0596218B1 (de) 1998-07-15
EP0596218A3 (de) 1994-06-01
DE69319693T2 (de) 1998-12-10
US5298406A (en) 1994-03-29

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: DADE BEHRING, INC.(N.D.GES.DES STAATES DELAWARE),

8339 Ceased/non-payment of the annual fee