DE69316715D1 - Mehrschichtige Matrixsysteme mit kontrollierter Wirkstoffabgabe - Google Patents

Mehrschichtige Matrixsysteme mit kontrollierter Wirkstoffabgabe

Info

Publication number
DE69316715D1
DE69316715D1 DE69316715T DE69316715T DE69316715D1 DE 69316715 D1 DE69316715 D1 DE 69316715D1 DE 69316715 T DE69316715 T DE 69316715T DE 69316715 T DE69316715 T DE 69316715T DE 69316715 D1 DE69316715 D1 DE 69316715D1
Authority
DE
Germany
Prior art keywords
layer
active principles
drug delivery
controlled drug
layer matrix
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69316715T
Other languages
English (en)
Other versions
DE69316715T2 (de
Inventor
Paolo Colombo
Cardona Antonio Corvi
Giorgio Pifferi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis SpA
Original Assignee
Inverni Della Beffa SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11364297&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69316715(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Inverni Della Beffa SpA filed Critical Inverni Della Beffa SpA
Publication of DE69316715D1 publication Critical patent/DE69316715D1/de
Application granted granted Critical
Publication of DE69316715T2 publication Critical patent/DE69316715T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Separation By Low-Temperature Treatments (AREA)
  • Networks Using Active Elements (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cephalosporin Compounds (AREA)
DE69316715T 1992-11-17 1993-11-09 Mehrschichtige Matrixsysteme mit kontrollierter Wirkstoffabgabe Expired - Lifetime DE69316715T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI922617A IT1256393B (it) 1992-11-17 1992-11-17 Forme matriciali multistrato per il rilascio controllato di principi attivi

Publications (2)

Publication Number Publication Date
DE69316715D1 true DE69316715D1 (de) 1998-03-05
DE69316715T2 DE69316715T2 (de) 1998-07-16

Family

ID=11364297

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69316715T Expired - Lifetime DE69316715T2 (de) 1992-11-17 1993-11-09 Mehrschichtige Matrixsysteme mit kontrollierter Wirkstoffabgabe

Country Status (9)

Country Link
US (1) US5549913A (de)
EP (1) EP0598309B1 (de)
JP (2) JP3496961B2 (de)
AT (1) ATE162711T1 (de)
DE (1) DE69316715T2 (de)
DK (1) DK0598309T3 (de)
ES (1) ES2112946T3 (de)
GR (1) GR3026546T3 (de)
IT (1) IT1256393B (de)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1264696B1 (it) * 1993-07-09 1996-10-04 Applied Pharma Res Forme farmaceutiche destinate alla somministrazione orale in grado di rilasciare sostanze attive a velocita' controllata e differenziata
DE19524753A1 (de) * 1995-07-07 1997-01-23 Lohmann Therapie Syst Lts Schichttablette zur kontrollierten Freisetzung von Wirkstoffen
US5783212A (en) * 1996-02-02 1998-07-21 Temple University--of the Commonwealth System of Higher Education Controlled release drug delivery system
IT1282650B1 (it) * 1996-02-19 1998-03-31 Jagotec Ag Compressa farmaceutica,caratterizzata da elevato aumento di volume a contatto con liquidi biologici
GB9611328D0 (en) * 1996-05-31 1996-08-07 Zeneca Ltd Pharmaceutical compositions
EP0951279A1 (de) * 1997-01-10 1999-10-27 Abbott Laboratories Tablette für kontrollierte wirkstoffabgabe
IT1295271B1 (it) * 1997-10-03 1999-05-04 Chiesi Farma Spa Monolita contenente uno o piu'farmaci costituito da tre strati a meccanismo di rilascio differenziato
US6337091B1 (en) * 1997-10-27 2002-01-08 Temple University - Of The Commonwealth System Of Higher Education Matrix for controlled delivery of highly soluble pharmaceutical agents
US6110500A (en) * 1998-03-25 2000-08-29 Temple University Coated tablet with long term parabolic and zero-order release kinetics
US6555139B2 (en) 1999-06-28 2003-04-29 Wockhardt Europe Limited Preparation of micron-size pharmaceutical particles by microfluidization
US6245913B1 (en) 1999-06-30 2001-06-12 Wockhardt Europe Limited Synthetic procedure for 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-IH-benzimidazole hydrochloride and its conversion to omeprazole
WO2001056544A2 (en) * 2000-02-04 2001-08-09 Depomed, Inc. Shell-and-core dosage form approaching zero-order drug release
DE10031043A1 (de) * 2000-06-26 2002-02-14 Bayer Ag Retardzubereitungen von Chinolonantibiotika und Verfahren zu ihrer Herstellung
KR100685945B1 (ko) 2000-12-29 2007-02-23 엘지.필립스 엘시디 주식회사 액정표시장치 및 그 제조방법
CA2409552A1 (en) 2001-10-25 2003-04-25 Depomed, Inc. Gastric retentive oral dosage form with restricted drug release in the lower gastrointestinal tract
US20030104052A1 (en) * 2001-10-25 2003-06-05 Bret Berner Gastric retentive oral dosage form with restricted drug release in the lower gastrointestinal tract
US20030091630A1 (en) * 2001-10-25 2003-05-15 Jenny Louie-Helm Formulation of an erodible, gastric retentive oral dosage form using in vitro disintegration test data
US20030152622A1 (en) * 2001-10-25 2003-08-14 Jenny Louie-Helm Formulation of an erodible, gastric retentive oral diuretic
ITMI20012481A1 (it) * 2001-11-23 2003-05-23 Univ Parma Sistemi modulari per il rilascio controllato di sostanza a controllo spaziale e temporale
US6682759B2 (en) 2002-02-01 2004-01-27 Depomed, Inc. Manufacture of oral dosage forms delivering both immediate-release and sustained-release drugs
US7309444B2 (en) * 2002-08-29 2007-12-18 Stellar Technology Company Layered tablet water treatment compositions and method of use
US6852238B2 (en) * 2002-08-29 2005-02-08 Steller Technology Company Layered tablet water treatment compositions and method of use
PL2316456T3 (pl) 2003-04-29 2017-12-29 Orexigen Therapeutics, Inc. Kompozycje wpływające na utratę masy zawierające antagonistę opioidów i bupropion
US20040241234A1 (en) * 2003-06-02 2004-12-02 Alpharma, Inc. Controlled release press-coated formulations of water-soluble active agents
US20050013863A1 (en) 2003-07-18 2005-01-20 Depomed, Inc., A Corporation Of The State Of California Dual drug dosage forms with improved separation of drugs
JP2008508227A (ja) * 2004-07-29 2008-03-21 サノフイ−アベンテイス 高ｐｈ依存性溶解度を有する有効成分の放出制御のための医薬品多層錠剤
US20060024368A1 (en) * 2004-07-30 2006-02-02 Reza Fassihi Compressed composite delivery system for release-rate modulation of bioactives
NZ552841A (en) * 2004-08-04 2009-07-31 Alza Corp Controlled release dosage form comprising two layers, wherein the delay layer is substanially free of non-microencapsulated drug
JP2008520726A (ja) * 2004-11-19 2008-06-19 スミスクライン・ビーチャム・コーポレイション 医薬製品
EP1946780B1 (de) * 2005-11-11 2012-01-11 Asahi Kasei Chemicals Corporation Feste zubereitung mit kontrollierter freisetzung
JP4999858B2 (ja) 2005-11-18 2012-08-15 グラクソ グループ リミテッド 薬剤製品及び薬剤的製品の組み立てを行う機械及び方法
CN101351195A (zh) * 2005-11-18 2009-01-21 阿库布莱克科技公司 分段的药物剂量形式
DK2135603T3 (da) 2005-11-22 2013-03-25 Orexigen Therapeutics Inc Sammensætninger og fremgangsmåder til øgning af insulinsensitivitet
US8916195B2 (en) 2006-06-05 2014-12-23 Orexigen Therapeutics, Inc. Sustained release formulation of naltrexone
WO2007149860A1 (en) * 2006-06-19 2007-12-27 Accu-Break Technologies, Inc. Segmented pharmaceutical dosage forms
WO2008060964A2 (en) 2006-11-09 2008-05-22 Orexigen Therapeutics, Inc. Unit dosage package and methods for administering weight loss medications
US8088786B2 (en) * 2006-11-09 2012-01-03 Orexigen Therapeutics, Inc. Layered pharmaceutical formulations
US20100322978A1 (en) * 2006-12-27 2010-12-23 Fujifilm Corporation Medical composition
KR100885029B1 (ko) * 2007-02-07 2009-02-23 지엘팜텍 주식회사 경구투여용 서방성 삼중정제
ES2579229T3 (es) 2007-03-13 2016-08-08 Jds Therapeutics, Llc Procedimientos y composiciones para la liberación sostenida de cromo
WO2009002867A2 (en) 2007-06-26 2008-12-31 Nutrition 21, Inc. Multiple unit dosage form having a therapeutic agents in combination with a nutritional supplement
US20130079749A1 (en) * 2007-08-29 2013-03-28 Advanced Bionics, Llc Modular Drug Delivery System for Minimizing Trauma During and After Insertion of a Cochlear Lead
LT2249757T (lt) * 2008-02-04 2017-09-25 Ferring B.V. Vientisi intravaginaliniai žiedai, apimantys progesteroną, ir jų gamybos bei panaudojimo būdai
WO2009118763A1 (en) * 2008-03-28 2009-10-01 Panacea Biotec Limited Multilayered pharmaceutical compositions and processes thereof
US20110144145A1 (en) 2008-05-30 2011-06-16 Orexigen Therapeutics, Inc. Methods for treating visceral fat conditions
AU2009268934A1 (en) * 2008-06-16 2010-01-14 Appian Labs, Llc Composition and method of preparation of release systems for constant (zero-order) release of active agents
WO2010020856A2 (en) * 2008-08-19 2010-02-25 Adcock Ingram Healthcare (Pty) Limited Rate modulated delivery of drugs from a composite delivery system
EP2163240A1 (de) 2008-09-12 2010-03-17 Universita' Degli Studi Di Genova Verfahren zur Herstellung von bioadhesiven Kompaktmatrizen
US20100112054A1 (en) * 2008-10-23 2010-05-06 Appian Labs, Llc Tablets and discs with compartments with two or more drugs for release at certain intervals and with specific rates
BRPI0906820A2 (pt) * 2009-12-21 2013-07-30 Inst Presbiteriano Mackenzie matriz cerÂmica para incorporar fÁrmacos de liberaÇço controlada, comprimido, mÉtodo para obtenÇço da matriz cerÂmica e mÉtodo para produzir um comprimido
US9248123B2 (en) 2010-01-11 2016-02-02 Orexigen Therapeutics, Inc. Methods of providing weight loss therapy in patients with major depression
MY166034A (en) 2010-12-22 2018-05-21 Purdue Pharma Lp Encased tamper resistant controlled release dosage forms
CA2822769C (en) 2010-12-23 2016-10-04 Purdue Pharma L.P. Tamper resistant solid oral dosage forms
EP2726062A1 (de) * 2011-06-29 2014-05-07 Ranbaxy Laboratories Limited Mehrschichtige darreichungsform
TW201311296A (zh) * 2011-07-01 2013-03-16 Gelita Ag 新穎明膠膠囊組合物及其製備方法
WO2013111070A1 (en) 2012-01-23 2013-08-01 Ranbaxy Laboratories Limited In-situ multilayered tablet technology
ES2802048T3 (es) 2012-06-06 2021-01-15 Nalpropion Pharmaceuticals Llc Composición para uso en un método para el tratamiento de sobrepeso y obesidad en pacientes con alto riesgo cardiovascular
KR101840526B1 (ko) 2013-02-05 2018-03-20 퍼듀 퍼머 엘피 내변조성 제약 제제
US10751287B2 (en) 2013-03-15 2020-08-25 Purdue Pharma L.P. Tamper resistant pharmaceutical formulations
CN109069532A (zh) 2016-02-11 2018-12-21 营养21有限责任公司 含铬组合物用于改善健康和健身

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL109293C (de) * 1955-12-22
US4869908A (en) * 1987-01-09 1989-09-26 K.V. Pharmaceutical Co. Fibre formulations
US4786503A (en) * 1987-04-06 1988-11-22 Alza Corporation Dosage form comprising parallel lamine
US5085865A (en) * 1989-04-12 1992-02-04 Warner-Lambert Company Sustained release pharmaceutical preparations containing an analgesic and a decongestant
IT1237904B (it) * 1989-12-14 1993-06-18 Ubaldo Conte Compresse a rilascio a velocita' controllata delle sostanze attive

Also Published As

Publication number Publication date
IT1256393B (it) 1995-12-04
ITMI922617A0 (it) 1992-11-17
ITMI922617A1 (it) 1994-05-17
ES2112946T3 (es) 1998-04-16
EP0598309A2 (de) 1994-05-25
JPH072649A (ja) 1995-01-06
EP0598309A3 (en) 1994-06-01
US5549913A (en) 1996-08-27
DE69316715T2 (de) 1998-07-16
EP0598309B1 (de) 1998-01-28
JP3496961B2 (ja) 2004-02-16
GR3026546T3 (en) 1998-07-31
JP2004107351A (ja) 2004-04-08
ATE162711T1 (de) 1998-02-15
DK0598309T3 (da) 1998-09-21

Similar Documents

Publication Publication Date Title
DE69316715D1 (de) Mehrschichtige Matrixsysteme mit kontrollierter Wirkstoffabgabe
CA2029383C (en) Swelling modulated polymeric drug delivery device
ES2138584T3 (es) Sistema de suministro de farmacos que implica la reaccion entre una proteina o un polipeptido y un polimero biodegradable hidrofobo.
EP0213083A3 (de) Tablette mit gesteuerter Wirkstoffabgabe
DK288987D0 (da) Et afgivelsessystem til doseringsformerne forhalet afgivelse, samt dettes fremstilling
PT887074E (pt) Dispositivo de administracao intravaginal de farmaco
CA2269707A1 (en) Soluble form osmotic dose delivery system
IT1201136B (it) Compressa per uso farmaceutico atta al rilascio in tempi successivi di sostanze attive
FR2784583B1 (fr) Composition pharmaceutique a residence gastrique et a liberation controlee
IT1241417B (it) Composizioni terapeutiche a rilascio controllato di farmaci supportatisu polimeri reticolati e rivestiti con film polimerici,e loro processodi preparazione
DE69918310D1 (de) Tablette mit verzögerter freigabe enthaltend einen blutzuckersenkenden wirkstoff und einen antihyperglyzemischen wirkstoff
PT1176961E (pt) Sistemas de administracao de nicotina
ATE310450T1 (de) Auslösbares wirkstoffabgabesystem
DK318788A (da) Generisk nul'te-ordens-styret laegemiddelafgivelsessystem
AR065073A2 (es) Una formulacion medicamentosa de sistema de matriz que tiene liberacion controlada de un compuesto activo
ATE306910T1 (de) Tablette mit verlängerter wirkstoffabgabe im magen
DE59706576D1 (de) Orale zubereitung, enthaltend in einer in wässrigem medium quellbaren matrix wenigstens einen pharmazeutischen wirkstoff
DE3772954D1 (de) Arzneimittel mit verzoegerter wirkstoffabgabe.
IT1275267B (it) Forme farmaceutiche a rilascio modificato di canrenoato di potassio costituite da matrici idrofile rivestite

Legal Events

Date Code Title Description
8363 Opposition against the patent
8327 Change in the person/name/address of the patent owner

Owner name: SANOFI-AVENTIS S.P.A., MILANO, IT